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Table S1. List of International Classification of Diseases, 10th revision, German Modification (ICD-10-GM) codes used to identify cases of hip-pelvis fracture and other fractures.ICD-10-GM CodeDescriptionHip-pelvis fractureS32.0Fracture of lumbar vertebraS32.00Fracture of lumbar vertebra: position not specifiedS32.01Fracture of lumbar vertebra: L1S32.02Fracture of lumbar vertebra: L2S32.03Fracture of lumbar vertebra: L3S32.04Fracture of lumbar vertebra: L4S32.05Fracture of lumbar vertebra: L5S32.1Fracture of sacrumS32.2Fracture of coccyxS32.3Fracture of iliumS32.4Fracture of acetabulumS32.5Fracture of pubisS32.7Multiple fractures of lumbar spine and pelvisS32.8Fracture of other and unspecified parts of lumbar spine and pelvisS32.81Fracture: ischiumS32.82Fracture: lumbosacral spine NOSS32.83Fracture: pelvis NOSS32.89Fracture: multiple and unspecified parts of pelvis S72.0Fracture of neck of femurS72.00Fracture of neck of femur: unspecified partS72.01Fracture of neck of femur: intracapsularS72.02Fracture of neck of femur: (proximal) epiphysis, epiphysiolysisS72.03Fracture of neck of femur: subcapitalS72.04Fracture of neck of femur: mediocervicalS72.05Fracture of neck of femur: baseS72.08Fracture of neck of femur: NOSS72.1Pertrochanteric fractureS72.10Fracture of neck of femur : trochanteric fracture NOSS72.11Fracture of neck of femur : intertrochanteric fractureS72.2Subtrochanteric fractureOther fracturesS22.3Fracture of ribS22.4Multiple fractures of ribsS42.0Fracture of clavicleS42.2Fracture of upper end of humerusS42.3Fracture of shaft of humerusS42.4Fracture of lower end of humerusS42.7Multiple fractures of clavicle, scapula and humerusS52.0Fracture of upper end of ulnaS52.1Fracture of upper end of radiusS52.2Fracture of shaft of ulnaS52.3Fracture of shaft of radiusS52.4Fracture of shafts of both ulna and radiusS52.5Fracture of lower end of radiusS52.6Fracture of lower end of both ulna and radiusS62.0Fracture of navicular [scaphoid] bone of handS62.1Fracture of other carpal bone(s)S62.2Fracture of first metacarpal boneS62.3Fracture of other metacarpal boneS62.4Multiple fractures of metacarpal bonesS62.5Fracture of thumbS62.6Fracture of other fingerS62.7Multiple fractures of fingersS62.8Fracture of other and unspecified parts of wrist and handS72.0Fracture of neck of femurS72.1Pertrochanteric fractureS72.2Subtrochanteric fractureS72.3Fracture of shaft of femurS72.4Fracture of lower end of femurS72.7Multiple fractures of femurS72.8Fractures of other parts of femurS72.9Fracture of femur, part unspecifiedS82.0Fracture of patellaS82.1Fracture of upper end of tibiaS82.2Fracture of shaft of tibiaS82.3Fracture of lower end of tibiaS82.4Fracture of fibula aloneS82.5Fracture of medial malleolusS82.6Fracture of lateral malleolusS92.0Fracture of calcaneusS92.1Fracture of talusS92.2Fracture of other tarsal bone(s)S92.3Fracture of metatarsal boneS43.0Dislocation of shoulder jointS43.1Dislocation of acromioclavicular jointS43.2Dislocation of sternoclavicular jointS43.3Dislocation of other and unspecified parts of shoulder girdleS53.0Dislocation of radial headS53.1Dislocation of elbow, unspecifiedS63.0Dislocation of wristS83.0Dislocation of patellaS83.1Dislocation of kneeTable S2. List of Anatomical Therapeutical Chemical (ATC) codes used to identify dispensations of antidepressants (ADs)1.ATC codeDescriptionTCAN06AA01DesipraminN06AA02ImipraminN06AA03ImipraminoxidN06AA04ClomipraminN06AA05OpipramolN06AA06TrimipraminN06AA07LofepraminN06AA08DibenzepinN06AA09AmitriptylinN06AA10NortriptylinN06AA11ProtriptylinN06AA12DoxepinN06AA13IprindolN06AA14MelitracenN06AA15ButriptylinN06AA16DosulepinN06AA17AmoxapinN06AA18DimetacrinN06AA19AmineptinN06AA20NoxiptilinN06AA21MaprotilinN06AA23QuinupraminN06AA25AmitriptylinoxidSSRIN06AB02ZimeldinN06AB03FluoxetinN06AB04CitalopramN06AB05ParoxetinN06AB06SertralinN06AB07AlaproclatN06AB08FluvoxaminN06AB09EtoperidonN06AB10EscitalopramNaSSAN06AX03MianserinN06AX11MirtazapinN06AX16VenlafaxinMAON06AF01IsocarboxazidN06AF02NialamidN06AF03PhenelzinN06AF04TranylcyprominN06AF05IproniazidN06AF06IproclozidN06AG02MoclobemidN06AG03ToloxatonNARIN06AX18ReboxetinN06AX09ViloxazinHerbal antidepressantsN06AH01HypericumN06AH10VariousN06AP01St. John’s WortN06AP51St. John’s Wort, combinationsOther antidepressantsN06AX01OxitriptanN06AX02TryptophanN06AX04NomifensinN06AX05TrazodonN06AX06NefazodonN06AX07MinaprinN06AX08BifemelanN06AX10OxaflozanN06AX12BupropionN06AX13MedifoxaminN06AX14TianeptinN06AX15PivagabinN06AX17MilnacipranN06AX19GepironN06AX21DuloxetinN06AX22AgomelatinN06AX23DesvenlafaxinN06AX24VilazodonN06AX26VortioxetinN06AX27Pipofezin570865959485Figure S1. Definition of the different exposure periods in cases and in controls based on the interval between index date (ID) and the end of the most recent prior treatment episode.00Figure S1. Definition of the different exposure periods in cases and in controls based on the interval between index date (ID) and the end of the most recent prior treatment episode.306133542722801 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.001 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.3091815611505002952750121920Figure S2. Odds Ratio (OR) with 95% confidence interval (95% CI) of hip-pelvis fracture in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by sex.020000Figure S2. Odds Ratio (OR) with 95% confidence interval (95% CI) of hip-pelvis fracture in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by sex. 2969041-221703Figure S3. Odds Ratio (OR) with 95% confidence interval (95% CI) of other non-vertebral fractures in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by sex.020000Figure S3. Odds Ratio (OR) with 95% confidence interval (95% CI) of other non-vertebral fractures in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by sex.296608538004751 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.001 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.308546511747500 2953275211652Figure S4. Odds Ratio (OR) with 95% confidence interval (95% CI) of hip-pelvis fracture in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by age.020000Figure S4. Odds Ratio (OR) with 95% confidence interval (95% CI) of hip-pelvis fracture in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by age.295656038741351 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.001 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.3056255161925002937510140729Figure S5. Odds Ratio (OR) with 95% confidence interval (95% CI) of other non-vertebral fractures in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by age.00Figure S5. Odds Ratio (OR) with 95% confidence interval (95% CI) of other non-vertebral fractures in current, recent and past users of antidepressants (ADs)1 compared with current users of mirtazapine, by age.298513542824401 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.001 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA). *° Model adjusted for all variables listed in Table 2.306197056388000Table S3. Odds Ratio (OR), with 95% confidence interval (95% CI), of hip and pelvis fracture and other fractures in current users of individual antidepressants (AD)1 compared with current users of mirtazapine.?Treatment episodes estimated based on the dispensed DDDs.Hip and pelvis fracturesOther fracturesMatched OR295% CIAdjusted OR395% CIMatched OR295% CIAdjusted OR395% CITCADoxepine0.68(0.59 – 0.80)0.84(0.72 – 0.98)0.72(0.60 – 0.86)0.81(0.67 – 0.97)Amitriptyline1.19(1.11 – 1.27)1.38(1.29 – 1.48)1.24(1.15 – 1.35)1.28(1.18 -1.39)Opipramol0.61(0.55 – 0.67)0.88(0.80 – 0.97)0.71(0.64 – 0.79)0.93(0.83 – 1.04)Trimipramine0.82(0.71 – 0.93)1.07(0.93 – 1.22)0.98(0.84 – 1.13)1.17(1.01 – 1.36)SSRISertraline1.34(1.24 – 1.46)1.33(1.23 – 1.45)1.33(1.20 – 1.47)1.36(1.23 – 1.51)Citalopram1.36(1.29 – 1.42)1.35(1.28 – 1.42)1.52(1.43 – 1.61)1.50(1.41 – 1.60)Paroxetine1.10(0.95 – 1.27)1.25(1.08 – 1.45)1.33(1.15 – 1.55)1.52(1.30 -1.77)Fluoxetine1.11(0.96 – 1.30)1.28(1.09 – 1.49)1.27(1.07 – 1.51)1.43(1.20 – 1.71)Escitalopram1.38(1.24 – 1.53)1.35(1.21 – 1.51)1.52(1.34 – 1.72)1.48(1.31 – 1.68)SSNRIDuloxetine1.42(1.28 – 1.57)1.36(1.22 – 1.51)1.54(1.37 – 1.73)1.50(1.33 – 1.69)Venlafaxine1.37(1.25 – 1.50)1.37(1.25 – 1.51)1.46(1.31 – 1.63)1.46(1.31 – 1.63)1 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA).2 Adjusted for age, sex and length of follow-up by matching. 3 Model adjusted for all variables listed in Table 2.Table S4. Odds Ratio (OR), with 95 confidence interval (95% CI), of hip and pelvis fracture and other fractures in users of individual antidepressants (AD)1 compared with remote users of any AD. Hip and pelvis fracturesOther non-vertebral fracturesMatched OR2 (95% CI)Adjusted OR3 (95% CI)Matched OR2 (95% CI)Adjusted OR3 (95% CI)Remote users of any AD4(reference)(reference)(reference)(reference)TCADoxepine0.71 (0.63 - 0.80)0.87 (0.77 - 0.98)0.80 (0.70 - 0.93)0.91 (0.78 - 1.05)Amitriptyline1.76 (1.68 - 1.84)1.46 (1.39 - 1.53)1.49 (1.41 - 1.57)1.23 (1.17 - 1.30)Opipramol0.97 (0.90 - 1.04)1.00 (0.94 - 1.08)0.93 (0.87 - 1.00)0.98 (0.91 - 1.06)Trimipramine1.23 (1.12 - 1.35)1.14 (1.04 - 1.26)1.24 (1.12 - 1.37)1.21 (1.09 - 1.34)SSRISertraline2.06 (1.92 - 2.21)1.45 (1.35 - 1.55)1.67 (1.53 - 1.82)1.38 (1.27 - 1.51)Citalopram2.17 (2.10 - 2.23)1.51 (1.47 - 1.56)1.97 (1.90 - 2.04)1.56 (1.50 - 1.62)Paroxetine1.68 (1.49 - 1.90)1.36 (1.20 - 1.55)1.72 (1.52 - 1.96)1.55 (1.37 - 1.77)Fluoxetine1.78 (1.56 - 2.02)1.45 (1.27 - 1.66)1.66 (1.44 - 1.92)1.51 (1.30 - 1.75)Escitalopram2.14 (1.95 - 2.35)1.48 (1.34 - 1.63)1.83 (1.64 - 2.04)1.46 (1.30 - 1.63)SSNRIDuloxetine2.20 (2.02 - 2.40)1.51 (1.38 - 1.65)2.03 (1.85 - 2.23)1.61 (1.46 - 1.77)Venlafaxine2.06 (1.90 - 2.24)1.47 (1.35 - 1.61)1.81 (1.65 - 1.99)1.47 (1.33 - 1.61)NASSAMirtazapine1.37 (1.21 - 1.56)1.13 (1.08 - 1.17)1.27 (1.21 - 1.33)1.02 (0.97 - 1.07)1 Abbreviations: tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), selective serotonin-noradrenaline reuptake inhibitors (SSNRI), noradrenergic and specific serotonergic antidepressants (NASSA).2 Adjusted for age, sex and length of follow-up by matching. 3 Model adjusted for all variables listed in Table 2. ................
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