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Example: Invasive ductal carcinoma, nuclear grade 3 and histologic grade 2. Histologic grade = Tubule formation +Nuclear grade+ Mitotic rate. Total score = 3-5: Grade 1 (Low grade or well differentiated) Total score = 6–7: Grade 2 (Intermediate grade or moderately differentiated) Total score = 8–9: Grade 3 (High grade or poorly differentiated) ................
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