Hypersensitivity Reactions (Types I, II, III, IV)
[Pages:70]Hypersensitivity Reactions (Types I, II, III, IV)
April 15, 2009
Inflammatory response - local, eliminates antigen without extensively damaging the host's tissue.
Hypersensitivity - immune & inflammatory responses that are harmful to the host (von Pirquet, 1906)
- Type I
Produce effector molecules
Capable of ingesting foreign Particles
Association with parasite infection
Modified from Abbas, Lichtman & Pillai, Table 19-1
Type I hypersensitivity response
IgE
VL CL
VH C1
Binds to mast cell
Normal serum level = 0.0003 mg/ml
Binds Fc region of IgE
Link
Intracellular
signal trans.
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