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PBS7100 - PHARMACEUTICAL CALCULATIONSSummer Practice ProblemsCHAPTER 1PRACTICE PROBLEMS1.In a clinical study of niacin as a lipid-altering agent, 60% of the 90 patients in the study group developed flushing. Calculate the number of patients having this reaction.2.In a clinical study of divalproex sodium (DEPAKOTE) in patients prone to migraine headaches, nausea occurred in 62 of 202 patients whereas the use of a placebo resulted in nausea in 8 of 81 patients. Compare these data in terms of percent of subjects reporting nausea in each study group.3.If a clinical study of a new drug demonstrated that the drug met the effectiveness criteria in 646 patients of the 942 patients enrolled in the study, express these results as a decimal fraction and as a percent.4.Ritonavir (NORVIR) oral solution contains, in addition to ritonavir, 43.2% alcohol and 26.57% propylene glycol. Calculate the quantities of each of these two ingredients in a 240-mL bottle of the oral solution.5.If a 60-gram tube of an ointment contains 2.5 grams of active ingredient, calculate the percent concentration of active ingredient in the ointment.6.The literature for a pharmaceutical product states that 26 patients of the 2103 enrolled in a clinical study reported headache after taking the product. Calculate (a) the decimal fraction and (b) the percentage of patients reporting this adverse response.PRACTICE PROBLEMS1.If an insulin injection contains 100 units of insulin in each milliliter, how many milliliters should be injected to receive 40 units of insulin?2.An injection contains 2 mg of medication in each milliliter (mL). If a physician prescribes a dose of 0.5 mg to be administered to a hospital patient three times daily, how many milliliters of injection will be required over a 5-day period?3.In a clinical study, a drug produced drowsiness in 30 of the 1500 patients studied. How many patients of a certain pharmacy could expect similar effects, based on a patient count of 100?4.A formula for 1250 tablets contains 6.25 grams of diazepam. How many grams of diazepam should be used in preparing 550 tablets?5.If 100 capsules contain 400 mg of an active ingredient, how many milligrams of the ingredient will 48 capsules contain?6.Each tablet of TYLENOL WITH CODEINE contains 30 mg of codeine phosphate and 300 mg of acetaminophen. By taking 2 tablets daily for a week, how many milligrams of each drug would the patient take?7.A cough syrup contains 10 mg of dextromethorphan hydrobromide per 5 mL. How many milligrams of the drug are contained in a 120-mL container of the syrup?8.If an intravenous fluid is adjusted to deliver 15 mg of medication to a patient per hour, how many milligrams of medication are delivered per half minute?9.The biotechnology drug filgrastim (NEUPOGEN) is available in syringes containing 480 micrograms (mcg) of filgrastim per 0.8 mL. How many micrograms of the drug would be administered by each 0.5 mL injection?10.An oral solution contains, in each milliliter, 80 mg of lopinavir and 20 mg of ritonavir. How many milligrams of each drug would be contained in a calculated dose of 0.4 mL?11.Aripiprazole (ABILIFY) injection is available in single-dose vials containing 9.75 mg of aripiprazole in each 1.3 mL of injection. Calculate the volume of injection that would provide a dose of 5.25 mg of aripiprazole.12.Acyclovir (ZOVIRAX) suspension contains 200 mg of acyclovir in each 5 mL. How many milligrams of acyclovir are contained in a pint (473 mL) of suspension?13.A metered dose inhaler contains 225 mg of metaproterenol sulfate, which is sufficient for 100 inhalations. How many micrograms (mcg) of metaproterenol sulfate would be administered with each inhalation if there are 1000 micrograms in each milligram?14.A pediatric vitamin drug product contains the equivalent of 0.25 mg of fluoride ion in each milliliter. How many milligrams of fluoride ion would be provided by a dropper that delivers 0.6 mL?15.If a pediatric vitamin contains 1500 units of vitamin A per milliliter of solution, how many units of vitamin A would be administered to a child given 2 drops of the solution from a dropper calibrated to deliver 20 drops per milliliter of solution?16.An elixir contains 25 mg of drug in each 5 mL. How many milligrams of the drug would be used in preparing 4000 mL of the elixir?17.An elixir of ferrous sulfate contains 220 mg of ferrous sulfate in each 5 mL. If each milligram of ferrous sulfate contains the equivalent of 0.2 mg of elemental iron, how many milligrams of elemental iron would be represented in each 5 mL of the elixir?18.An estradiol transdermal patch is available in various patch sizes. The patch size is closely proportional to the amount of drug contained in the patch. If the patch containing 0.025 mg of estradiol is 6.5 cm2 in size, calculate the approximate size of the patch containing 0.1 mg of estradiol.19.If an ophthalmic solution contains 1 mg of dexamethasone phosphate in each milliliter of solution, how many milligrams of dexamethasone phosphate would be contained in 2 drops if the eyedropper used delivered 20 drops per milliliter?20.A 15-mL package of nasal spray delivers 20 sprays per milliliter of solution, with each spray containing 1.5 mg of drug. (a) How many total sprays will the package deliver? (b) How many milligrams of drug are contained in the 15-mL package of the spray?21.A penicillin V potassium preparation provides 400,000 units of activity in each 250-mg tablet. How many total units of activity would a patient receive from taking 4 tablets a day for 10 days?22.If a 5-g packet of a potassium supplement provides 20 milliequivalents of potassium ion and 3.34 milliequivalents of chloride ion, (a) how many grams of the powder would provide 6 milliequivalents of potassium ion, and (b) how many milliequivalents of chloride ion would be provided by this amount of powder?23.If a potassium chloride elixir contains 20 milliequivalents of potassium ion in each 15 mL of elixir, how many milliliters will provide 25 milliequivalents of potassium ion to the patient?24.The blood serum concentration of the antibacterial drug ciprofloxacin increases proportionately with the dose of drug administered. If a 250-mg dose of the drug results in a serum concentration of 1.2 micrograms of drug per milliliter of serum, how many micrograms of drug would be expected per milliliter of serum following a dose of 500 mg of drug?25.The dosage of the drug thiabendazole (MINTEZOL) is determined in direct proportion to a patient’s weight. If the dose of the drug for a patient weighing 150 pounds is 1.5 grams, what would be the dose for a patient weighing 110 pounds?26.If 0.5 mL of a mumps virus vaccine contains 5000 units of antigen, how many units would be present in each milliliter if the 0.5 mL of vaccine was diluted to 2 mL with water for injection?27.A sample of Oriental ginseng contains 0.4 mg of active constituents in each 100 mg of powdered plant. How many milligrams of active constituents would be present in 15 mg of powdered plant?NOTE: Solve problems 28 to 32 by dimensional analysis, using the following equivalencies as needed:1 gram (g) = 1000 milligrams (mg)1 mg = 1000 micrograms (mcg)1 kilogram (kg) = 2.2 pounds (lb)28.If 120 mL of a syrup contains 1.2 g of rimantadine HCl, and if a 2.5-mL dose of the syrup is administered, how many milligrams of rimantadine HCl would be given?29.How many milliliters of an injection containing 0.25 mg of drug in each milliliter should be administered to provide a dose of 10 mcg?30.An injection intended for pediatric use contains 100 mcg of digoxin per milliliter. What volume of injection should be administered to provide a dose of 0.04 mg?31.A patient is to receive 2 mg of drug from an injection labeled to contain 150 mcg/mL. Calculate the milliliters of injection to administer.32.The dose of a drug is 0.05 mg for each kilogram of a patient’s weight. The drug is available as an oral liquid containing 50 mcg/0.1 mL. Calculate the dose of the oral liquid, in milliliters, for a patient who weighs 132 lb.PRACTICE PROBLEMS1.State the number of significant figures in each of the italicized quantities:(a)One fluidounce equals 29.57 milliliters.(b)One liter equals 1000 milliliters.(c)One inch equals 2.54 centimeters.(d)The chemical costs $1.05 per pound.(e)One gram equals 1,000,000 micrograms.(f)One microgram equals 0.001 milligram.2.Round each of the following to three significant figures:(a)32.75(b)200.39(c)0.03629(d)21.635(e)0.009443.Round each of the following to three decimal places:(a)0.00083(b)34.79502(c)0.00494(d)6.129634.If a mixture of seven ingredients contains the following approximate weights, what can you validly record as the approximate total combined weight of the ingredients?26.83 grams, 275.3 grams, 2.752 grams, 4.04 grams, 5.197 grams, 16.64 grams, and 0.085 gram.5.Perform the following computations, and retain only significant figures in the results:(a)6.39 ? 0.008(b)7.01 ? 6.0(c)5.0 × 48.3 grams(d)24 × 0.25 gram(e)56.824 ÷ 0.0905(f)250 ÷ 1.109 PRACTICE PROBLEMS1.Estimate the sums:(a) 5641(b) 3298(c) $75.82217736837.92294519214.69826662745.983503483528.91??49.872.Estimate the products:(a)42 × 39 =(b)596 × 204 =(c)8431 × 9760 =(d)0.0726 × 6951 =(e)6.1 × 67.39 =3.Estimate the quotients:(a)171 ÷ 19 =(b)184 ÷ 2300 =(c)98,000 ÷ 49 =(d)1.0745 ÷ 500 =(e)458.4 ÷ 8 =CHAPTER 2PRACTICE PROBLEMS1.What is the weight, in milligrams, of 100 tablets, each containing 20 mcg of a therapeutic agent?2.Add 7.25 L and 875 cL. Reduce the result to milliliters.3.Add 0.0025 kg, 1750 mg, 2.25 g, and 825,000 μg, and express the answer in grams.4.Reduce 1.256 g to micrograms, to milligrams, and to kilograms.5.Are the terms mcg/mL and mg/L equivalent or not equivalent?6.A low-strength aspirin tablet contains 81 mg of aspirin per tablet. How many tablets may a manufacturer prepare from 0.5 kg of aspirin?7.Adhesive tape made from fabric has a tensile strength of not less than 20.41 kg/2.54 cm of width. Reduce these quantities to grams and millimeters.8.In a clinical study, the drug methotrexate produced a blood level of 6.6 μg of methotrexate in each milliliter of blood (6.6 μg/mL). Express the methotrexate blood level in terms of mg/dL.9.An inhalation aerosol contains 225 mg of metaproterenol sulfate, which is sufficient for 300 inhalations. How many micrograms of metaproterenol sulfate would be contained in each inhalation?10.TRIPHASIL-28 birth control tablets are taken sequentially, 1 tablet per day for 28 days, with the tablets containing the following:Phase 1—6 tablets, each containing 0.05 mg levonorgestrel and 0.03 mg ethinyl estradiolPhase 2—5 tablets, each containing 0.075 mg levonorgestrel and 0.04 mg ethinyl estradiolPhase 3—10 tablets, each containing 0.125 mg levonorgestrel and 0.03 mg ethinyl estradiol; then, 7 inert tablets (no drug).How many total milligrams each of levonorgestrel and ethinyl estradiol are taken during the 28-day period?11.COLCRYS scored tablets each contain 0.6 mg of colchicine. How many micrograms of colchicine would a patient take by administering one-half tablet?12.The following clinical laboratory data are within normal values for an adult. Convert each value to mcg/mL:(a)Ammonia, 30 mcg/dL(b)Folate, 18 pg/mL(c)Serum creatinine, 1.0 mg/dL(d)Prostate-specific antigen (PSA), 3 ng/mL(e)Cholesterol, total, 150 mg/dL13.The package insert for DONNATAL EXTENTABS indicates the amount of phenobarbital present in each tablet, in milligrams and in the equivalent weight (3/4 grains) in the apothecary system. Refer to Appendix A and calculate the milligrams of phenobarbital present in each tablet.14.Levothyroxine sodium tablets (SYNTHROID) are available in 12 different strengths ranging from 25 to 300 μg. Express this range in milligrams.15.Norgestrel and ethinyl estradiol tablets are available containing 0.5 mg of norgestrel and 50 μg of ethinyl estradiol. How many grams of each ingredient would be used in making 10,000 tablets?16.Approximately 0.02% of a 100-mg dose of the drug miglitol (GLYSET) has been shown to appear in human breast milk. Calculate the quantity of drug detected, in milligrams, following a single dose.17.How many grams of digoxin (LANOXIN) would be required to make 25,000 tablets each containing 250 mcg of digoxin?18.Adalimumab (HUMIRA), a recombinant human monoclonal antibody, is available in a prefilled syringe containing 40 mg/0.8 mL of injection. Calculate the concentration of drug on a mg/mL basis.19.If an injectable solution contains 25 μg of a drug substance in each 0.5 mL, how many milliliters would be required to provide a patient with 0.25 mg of the drug substance?20.A patient is instructed to take one 50 μg tablet of pergolide mesylate (PERMAX) a day for the first two days of treatment; 150 μg/day on the third, fourth, and fifth days of treatment; 250 μg/day on the sixth, seventh, and eighth days; and 350 μg on the ninth day and return to the physician for assessment. During this treatment period, how many milligrams of drug were taken?21.Treatment with the drug carvedilol for heart failure is initiated with a dose of 3.125 mg twice daily and then increased every two weeks with twice daily doses of 6.25 mg, 12.5 mg, and 25 mg. How many of each of these tablet strengths should be dispensed for this protocol?22.Digoxin (LANOXIN) is available for parenteral pediatric use in a concentration of 0.05 mg/mL. How many milliliters would provide a dose of 40 μg?23.ROXANOL oral solution contains 0.6 g of morphine sulfate in each 30-mL bottle affixed with a calibrated dropper. Calculate (a) the concentration of morphine sulfate on a mg/mL basis and (b) the milligrams of morphine sulfate delivered by a 0.6-mL dose.24.The starting dose of sodium oxybate oral solution (XYREM) is 4.5 g/night divided into two equal doses and administered 2.5 to 4 hours apart. How many milliliters of the oral solution containing sodium oxybate, 500 mg/mL, should be administered in each divided dose?25.An intravenous solution contains 500 μg of a drug substance in each milliliter. How many milligrams of the drug would a patient receive from the intravenous infusion of a liter of the solution?26.If an intravenous solution containing 123 mg of a drug substance in each 250-mL bottle is to be administered at the rate of 200 μg of drug per minute, how many milliliters of the solution would be given per hour?27.An oral inhalation (DULERA) to treat asthma provides, in each inhalation, 100 μg of mometasone furoate and 5 μg of formoterol fumarate. The recommended dose is “two inhalations twice daily (morning and evening).” Calculate the quantity of each drug inhaled daily and express the answers in milligrams.28.An injection contains 50 mcg/0.5 mL of drug. How many μL of the injection should be administered to deliver 0.04 mg of drug?29.An injection containing 7.5 mg of leuprolide acetate is administered to a patient weighing 25 kg. Calculate the dose on a mcg/lb basis if 1 kg = 2.2 lb.30.A gas chromatograph column measures 1.8 m in length and 3 mm in internal diameter. Convert these measurements to inches.31.A prefilled syringe contains 20 mg of drug in 2 mL of solution. How many micrograms of drug would be administered by an injection of 0.5 mL of the solution?32.A vial contains 80 mg of drug in 2 mL of injection. How many milliliters of the injection should be administered to obtain 0.02 g of drug?33.One-half liter of solution for intravenous infusion contains 2 g of drug. How many milliliters of the solution would contain 0.5 mg of drug?34.A 125-mL container of amoxicillin contains 600 mg/5 mL. How many milliliters would be used to administer 400 mg of amoxicillin?35.An effervescent tablet has the following formula:Acetaminophen325 mgCalcium carbonate280 mgCitric acid900 mgPotassium bicarbonate300 mgSodium bicarbonate465 mg(a)Calculate the total weight, in grams, of the ingredients in each tablet.(b)How many tablets could be made with a supply of 5 kg of acetaminophen?36.A new analytic instrument is capable of detecting picogram quantities of a chemical substance. How many times more capable is this instrument than one that can detect nanogram quantities of the same chemical?37.The rate of drug delivered to the skin by fentanyl transdermal patches is directly proportional to the dimension of the patch. If a patch size of 5.25 cm2 delivers 12 mcg/hour of fentanyl, calculate the delivery rate of drug expected from a 31.5-cm2 patch.38.If an albuterol inhaler contains 18 mg of albuterol, how many inhalation doses can be delivered if each inhalation dose contains 90 μg?39.Acetaminophen, in amounts greater than 4 g per day, has been associated with liver toxicity. What is the maximum number of 500-mg tablets of acetaminophen that a person may take daily and not reach the toxic level?40.A lung tumor measuring 2.1 cm was detected in a patient. What are the equivalent dimensions in millimeters and in inches?41.The recommended dose for a brand of nicotine patch is one 21-mg dose per day for 6 weeks, followed by 14 mg per day for 2 weeks, and then 7 mg per day for 2 more weeks. What total quantity, in grams, would a patient receive during this course of treatment?42.A medical device is sterilized by gamma radiation at 2.5 megarads (Mrad). Express the equivalent quantity in rads.43.A round transdermal patch measures 4.3 cm in diameter. Convert this dimension to inches and millimeters.44.A solution for direct IV bolus injection contains 125 mg of drug in each 25 mL of injection. What is the concentration of drug in terms of μg/μL?45.The total number of human genomic characters is 3.5 billion. Express this quantity numerically without using a decimal point.46.Conjugated estrogen tablets (PREMARIN) are available in strengths of 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, and 1.25 mg. If patient “A” took one tablet daily of the lowest dose and patient “B” took one tablet daily of the highest dose, what is the difference in the total quantities taken between patients “A” and “B” over a period of 30 days?(a)2.85 mg(b)2850 mcg(c)2.85 cg(d)2.85 dg47.Teratogenic studies of insulin glargine were undertaken in rats at doses up to 0.36 mg/kg/day. This is equivalent to which of the following?(a)360 cg/lb/day(b)792 mcg/lb/day(c)360 mg/lb/day(d)163.6 mcg/lb/day48.Pharmacy students, traveling to attend a national pharmacy meeting, were on an airplane with an average air speed of 414 miles per hour. Which is the closest equivalent air speed?(a)6 mi/min(b)257 km/h(c)666 km/h(d)180 m/s49.The product of biotechnology, filgrastim (NEUPOGEN), is available in vials containing 0.3 mg of drug in each milliliter. Which choice is equivalent in concentration?(a)0.03 mg/0.1 dL(b)300 mcg/0.01 dL(c)3 mcg/0.01 cL(d)300 mcg/10 cL50.In a clinical study of finasteride (PROSCAR), a single oral dose of 5 mg resulted in an average blood concentration of 37 ng of drug per milliliter (37 ng/mL) of blood plasma. This is equivalent to which of the following?(a)37,000 mcg/mL(b)0.037 mcg/mL(c)0.000037 mg/cL(d)0.0037 mcg/dL All practice problems from Ansel, Howard C. Pharmaceutical Calculations, 15th Edition. Wolters Kluwer Health, 03/2016, chapters 1 and 2. ................
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