Cdn-links.lww.com



Table e-1. Co-existing medical conditions that reached the 3% cohort prevalence and Bonferroni level of significance (BONF=True) for association with higher multiple sclerosis severity scores: findings from the independent analysis of the discovery cohort (n=3,439). PheCodeMedical ConditionPrev (%)OROR 95% CIP-valueBONFAnalyzed in Ext.208Benign neoplasm of colon3.90.960.901.030.30FalseYes216Benign neoplasm of skin9.40.890.850.944.93E-06TrueYes241Nontoxic nodular goiter3.60.960.891.030.23FalseNo244Hypothyroidism4.50.980.921.050.60FalseYes244.4Hypothyroidism NOS4.40.980.921.050.56FalseNo250Diabetes mellitus3.61.171.081.254.20E-05TrueYes250.2Type 2 diabetes3.21.201.111.309.04E-06TrueNo272Disorders of lipoid metabolism11.10.990.941.030.55FalseYes272.1Hyperlipidemia110.980.941.030.45FalseYes272.11Hypercholesterolemia3.60.960.891.030.28FalseNo276Disorders of fluid, electrolyte, and acid-base balance3.81.261.161.361.08E-08TrueYes278Overweight, obesity and other hyperalimentation5.61.050.991.110.097FalseYes278.1Obesity4.11.081.011.150.027FalseNo285Other anemias4.91.091.021.160.0066FalseYes290.3Other persistent mental disorders due to conditions classified elsewhere61.071.011.130.019FalseNo292Neurological disorders6.31.201.141.271.64E-10TrueNo296Mood disorders171.161.121.219.70E-15TrueYes296.2Depression14.21.171.121.222.83E-14TrueYes296.22Major depressive disorder7.11.131.071.193.35E-06TrueYes300Anxiety, phobic and dissociative disorders7.31.050.991.100.085FalseYes300.1Anxiety disorder5.71.020.971.080.44FalseYes304Adjustment reaction10.21.151.101.201.86E-09TrueYes334Degenerative disease of the spinal cord26.80.940.910.970.00034TrueYes340Migraine3.41.040.961.120.32FalseYes341Other demyelinating diseases of central nervous system31.80.920.890.953.53E-07TrueYes345Epilepsy, recurrent seizures, convulsions41.191.111.273.31E-07TrueYes345.3Convulsions3.31.211.121.302.60E-07TrueYes346Abnormal findings on study of brain and/or nervous system18.60.880.850.911.14E-10TrueNo346.2Nonspecific abnormal results of function study of brain and central nervous system18.50.880.850.921.25E-10TrueNo348.9Other conditions of brain, NOS31.10.940.910.970.00030TrueNo350Abnormal movement10.81.241.191.301.39E-19TrueYes350.2Abnormality of gait5.81.241.161.323.04E-11TrueNo351Other peripheral nerve disorders4.11.030.971.100.34FalseYes368Visual disturbances3.91.000.941.070.89FalseYes377Disorders of optic nerve and visual pathways6.10.970.921.030.32FalseYes377.3Optic neuritis/neuropathy5.60.970.911.020.24FalseYes386.9Dizziness and giddiness (Light-headedness and vertigo)5.71.010.951.070.70FalseYes401Hypertension11.61.091.041.140.00055FalseYes401.1Essential hypertension11.41.091.041.140.00049FalseYes418Nonspecific chest pain11.21.040.991.090.12FalseYes427Cardiac dysrhythmias10.31.111.061.171.32E-05TrueYes427.5Arrhythmia (cardiac) NOS4.41.241.151.336.86E-09TrueNo427.9Palpitations3.10.900.840.980.011FalseNo433Cerebrovascular disease3.21.070.991.160.070FalseYes465Acute upper respiratory infections of multiple or unspecified sites8.60.910.860.960.00074FalseYes480Pneumonia3.61.331.231.442.84E-12TrueYes495Asthma3.91.000.941.070.99FalseYes512Other symptoms of respiratory system141.061.011.100.012FalseYes512.7Shortness of breath4.71.111.041.180.0015FalseNo512.8Cough7.71.040.981.090.19FalseYes512.9Other dyspnea4.11.000.941.070.89FalseNo530Diseases of esophagus5.61.010.951.070.84FalseYes530.1Esophagitis, GERD and related diseases5.31.000.941.060.92FalseYes530.11GERD4.71.010.951.080.71FalseNo591Urinary tract infection14.51.321.261.387.41E-33TrueYes593Hematuria5.41.291.211.385.48E-15TrueYes596Other disorders of bladder15.91.451.391.524.77E-58TrueYes596.5Functional disorders of bladder15.61.441.381.511.40E-56TrueYes599Other symptoms/disorders or the urinary system18.81.331.281.381.81E-42TrueYes599.2Retention of urine41.351.251.455.28E-14TrueYes599.4Urinary incontinence7.91.401.321.483.83E-28TrueYes599.5Frequency of urination and polyuria11.31.281.221.343.38E-25TrueYes611Abnormal findings on mammogram or breast exam8.60.930.880.980.0037FalseNo611.1Abnormal mammogram4.30.920.860.990.023FalseNo611.3Lump or mass in breast4.60.900.840.960.0020FalseNo613Other nonmalignant breast conditions3.40.950.881.020.14FalseYes614Inflammatory diseases of female pelvic organs4.70.900.840.970.0038FalseYes614.5Inflammatory disease of cervix, vagina, and vulva4.10.880.810.950.0014FalseYes614.52Vaginitis and vulvovaginitis3.60.880.810.960.0035FalseYes619Noninflammatory female genital disorders3.70.950.881.020.19FalseYes625Pain and other symptoms associated with female genital organs3.20.930.861.010.074FalseYes626Disorders of menstruation and other abnormal bleeding from female genital tract8.50.940.891.000.038FalseYes626.1Irregular menstrual cycle/bleeding6.20.940.881.000.045FalseYes627Menopausal and postmenopausal disorders7.21.040.981.100.24FalseYes627.2Symptomatic menopause3.90.980.911.050.56FalseNo681Superficial cellulitis and abscess4.91.171.091.254.26E-06TrueYes687.1Rash and other nonspecific skin eruption3.91.000.941.080.90FalseYes687.4Disturbance of skin sensation11.10.900.860.951.95E-05TrueYes694Dyschromia and Vitiligo3.60.900.830.970.0047FalseNo694.2Other dyschromia3.50.900.830.970.0055FalseNo701Other hypertrophic and atrophic conditions of skin3.40.900.840.970.0069FalseYes702Degenerative skin conditions and other dermatoses4.90.890.830.950.00034TrueYes702.2Seborrheic keratosis3.80.880.810.940.00059FalseNo706Diseases of sebaceous glands4.90.960.901.030.26FalseYes721Spondylosis and allied disorders5.40.960.901.020.15FalseYes721.1Spondylosis without myelopathy4.60.950.891.020.15FalseNo722Intervertebral disc disorders9.90.960.911.000.050FalseYes722.1Displacement of intervertebral disc40.980.921.050.63FalseYes722.6Degeneration of intervertebral disc60.960.901.010.12FalseNo726Peripheral enthesopathies and allied syndromes5.90.990.931.050.65FalseYes740Osteoarthrosis6.90.950.901.010.094FalseYes740.9Osteoarthrosis NOS6.10.960.901.010.14FalseNo741Symptoms and disorders of the joints8.61.161.111.222.26E-09TrueYes741.3Difficulty in walking5.61.261.181.341.37E-13TrueNo743Osteoporosis, osteopenia and pathological fracture12.11.211.161.271.47E-15TrueYes743.1Osteoporosis5.61.401.301.512.08E-19TrueYes743.11Osteoporosis NOS5.41.391.291.501.98E-18TrueNo743.9Osteopenia or other disorder of bone and cartilage8.11.111.051.177.10E-05TrueNo745Pain in joint18.21.000.961.040.98FalseYes760Back pain13.41.020.981.060.36FalseYes761Cervicalgia50.990.931.050.67FalseYes770Myalgia and myositis unspecified3.41.010.931.080.87FalseNo771.1Swelling of limb4.21.141.071.220.00015TrueNo783Fever of unknown origin6.11.231.161.302.18E-11TrueYes785Abdominal pain12.21.020.971.060.48FalseYes789Nausea and vomiting3.31.211.121.301.36E-06TrueYes798Malaise and fatigue12.71.121.071.178.65E-07TrueYes840Sprains and strains3.90.950.891.020.17FalseYes939Atopic/contact dermatitis due to other or unspecified6.11.000.941.060.94FalseYesNote: Related ICD-9 codes of a single medical condition are mapped to a single phenotype code or PheCode (column 1). Prevalence (Prev) is defined as the percentage of the patients in the cohort having a medical condition as indicated by the PheCode. Odds ratio (OR) represents the estimated factor by which the odds of the presence of the given medical condition changes per unit increase of the MSSS (on the decile scale), holding controlled covariates constant. We indicated whether a medical condition reached the Bonferroni (BONF) threshold of significance in an independent analysis of the discovery cohort and extension cohort as True (T) or False (F), respectively. We indicated whether a medical condition was included in discovery analysis and extension analysis (Analyzed in Ext.) as Yes (Y) or No (N), respectively.Table e-2. Co-existing medical conditions that reached the 3% cohort prevalence and Bonferroni level of significance (BONF=True) for association with higher multiple sclerosis severity scores: findings from independent analysis of the extension cohort (n=4,876). PheCodeMedical ConditionPrev (%)OROR 95% CIP-valueBONFAnalyzed in Ext.8Intestinal infection21.30.990.971.010.40FalseNo8.5Bacterial enteritis3.61.151.091.214.01E-07TrueNo38Septicemia8.31.441.381.501.18E-57TrueNo41Bacterial infection NOS23.61.221.191.255.90E-59TrueNo41.1Staphylococcus infections4.41.461.381.564.85E-35TrueNo41.2Streptococcus infection8.71.151.111.193.75E-15TrueNo41.4E. coli8.31.371.321.432.26E-49TrueNo53Herpes zoster6.10.940.900.980.0064FalseNo54Herpes simplex7.30.930.890.960.00016FalseNo78Viral warts & HPV3.70.920.870.980.0048FalseNo79Viral infection230.980.951.000.051FalseNo81Infection/inflammation of internal prostheses 41.511.411.619.43E-33TrueNo110Dermatophytosis / Dermatomycosis14.11.091.061.128.23E-09TrueNo110.1Dermatophytosis5.61.241.181.294.71E-19TrueNo110.11Dermatophytosis of nail4.11.321.241.409.40E-21TrueNo112Candidiasis10.31.051.021.080.0031FalseNo172Skin cancer8.40.960.920.990.023FalseNo172.2Other non-epithelial cancer of skin6.60.960.921.000.033FalseNo174Breast cancer5.20.950.910.990.023FalseNo174.1Breast cancer [female]3.70.950.901.010.082FalseNo174.11Malignant neoplasm of female breast3.70.950.901.010.084FalseNo180Cervical cancer and dysplasia4.10.990.941.040.65FalseNo180.3Cervical intraepithelial neoplasia [CIN]3.70.990.931.040.58FalseNo195Cancer, suspected or other4.40.990.941.040.73FalseNo195.1Malignant neoplasm, other3.20.990.941.050.76FalseNo199Neoplasm of uncertain behavior5.10.930.890.970.0015FalseNo208Benign neoplasm of colon3.60.890.840.946.02E-05TrueYes214Lipoma3.40.960.911.020.21FalseNo216Benign neoplasm of skin30.20.920.900.941.67E-14TrueYes218Benign neoplasm of uterus6.50.960.921.000.050FalseNo218.1Uterine leiomyoma6.20.960.921.000.046FalseNo240Simple and unspecified goiter3.21.030.981.090.22FalseNo242Thyrotoxicosis with or without goiter3.10.940.891.000.046FalseNo244Hypothyroidism10.30.970.931.000.045FalseYes246Other disorders of thyroid7.70.950.910.990.0069FalseNo250Diabetes mellitus15.81.000.981.030.80FalseYes259Other endocrine disorders3.80.980.931.040.56FalseNo272Disorders of lipoid metabolism18.70.920.900.952.39E-09TrueYes272.1Hyperlipidemia3.20.960.901.020.15FalseYes274Gout and other crystal arthropathies3.20.970.911.030.26FalseNo276Disorders of fluid, electrolyte, and acid-base balance8.91.271.221.321.41E-35TrueYes276.1Electrolyte imbalance3.41.321.241.411.10E-18TrueNo276.5Hypovolemia4.81.291.231.363.88E-23TrueNo278Overweight, obesity and other hyperalimentation90.950.920.990.0053FalseYes279Disorders involving the immune mechanism41.000.951.050.94FalseNo280Iron deficiency anemias10.31.020.991.060.20FalseNo281Other deficiency anemia3.81.020.971.070.55FalseNo285Other anemias11.51.091.051.122.07E-07TrueYes286Coagulation defects3.21.091.031.160.0018FalseNo289Other diseases of blood and blood-forming organs4.41.030.981.080.20FalseNo290Delirium dementia and amnestic and other6.91.191.141.248.07E-17TrueNo291Other specified nonpsychotic and/or transient mental disorders19.41.091.061.117.05E-11TrueNo291.4Specific nonpsychotic mental disorders due to brain damage41.131.071.192.16E-06TrueNo291.8Alteration of consciousness14.11.061.031.093.08E-05TrueNo293Symptoms involving head and neck590.940.920.964.43E-09TrueNo295Schizophrenia and other psychotic disorders6.31.121.071.169.94E-08TrueNo295.3Psychosis4.41.141.081.191.69E-07TrueNo296Mood disorders59.41.021.001.040.12FalseYes296.1Bipolar3.51.071.011.130.014FalseNo296.2Depression58.21.010.991.030.24FalseYes296.22Major depressive disorder3.21.071.011.130.019FalseYes300Anxiety, phobic and dissociative disorders56.90.950.940.975.03E-06TrueYes300.1Anxiety disorder10.90.980.951.010.17FalseYes300.4Dysthymic disorder3.91.061.011.120.016FalseNo300.8Acute reaction to stress28.30.950.920.978.86E-07TrueNo301Personality disorders5.31.020.981.070.27FalseNo302Sexual and gender identity disorders3.81.020.971.070.51FalseNo303Psychogenic and somatoform disorders40.960.911.010.13FalseNo304Adjustment reaction19.51.000.971.020.95FalseYes306Other mental disorder8.41.041.001.080.026FalseNo316Substance addiction and disorders91.051.011.080.0071FalseNo317Alcohol-related disorders4.11.020.971.070.37FalseNo323Encephalitis3.11.020.961.080.48FalseNo327Sleep disorders5.91.000.961.050.91FalseNo331Other cerebral degenerations3.21.111.051.170.00039FalseNo333Extrapyramidal disease and abnormal movement disorders4.41.121.071.175.56E-06TrueNo334Degenerative disease of the spinal cord8.31.051.011.090.0090FalseYes340Migraine22.70.970.950.990.015FalseYes340.1Migraine with aura3.10.970.921.030.38FalseNo341Other demyelinating diseases of central nervous system9.11.061.021.100.00098FalseYes342Hemiplegia3.81.161.101.224.36E-08TrueNo344Other paralytic syndromes18.91.421.371.461.85E-10TrueNo345Epilepsy, recurrent seizures, convulsion11.41.131.091.162.65E-14TrueYes345.3Convulsions41.231.171.302.49E-15TrueYes348Other conditions of brain10.41.020.991.060.19FalseNo349Other and unspecified disorders of the nervous system44.81.101.081.128.69E-20TrueNo350Abnormal movement14.91.111.081.149.97E-14TrueYes350.1Abnormal involuntary movements12.81.101.071.131.57E-10TrueNo351Other peripheral nerve disorders16.60.940.920.971.47E-05TrueYes352Disorders of other cranial nerves8.51.031.001.070.075FalseNo352.1Trigeminal nerve disorders [CN5]4.71.101.051.164.00E-05TrueNo353Nerve root and plexus disorders5.80.990.951.040.78FalseNo356Hereditary and idiopathic peripheral neuropathy7.90.990.951.020.46FalseNo357Inflammatory and toxic neuropathy3.11.000.941.050.87FalseNo359Muscular dystrophies and other myopathies6.41.101.061.159.73E-07TrueNo360Disorders of the globe3.30.940.891.000.036FalseNo361Retinal detachments and defects4.30.910.870.960.00049FalseNo362Other retinal disorders15.40.940.910.971.18E-05TrueNo364Corneal opacity and other disorders of cornea7.80.930.890.960.00010TrueNo365Glaucoma23.40.920.900.946.01E-12TrueNo366Cataract16.40.960.930.990.0036FalseNo366.2Senile cataract6.40.930.890.980.0033FalseNo367Disorders of refraction and accommodation49.80.960.940.982.75E-05TrueNo367.1Myopia13.10.950.920.980.00094FalseNo367.2Astigmatism7.80.940.900.970.00083FalseNo367.8Hypermetropia5.80.970.931.020.25FalseNo367.9Blindness and low vision4.31.091.041.150.00023FalseNo368Visual disturbances40.20.950.930.979.33E-07TrueYes368.2Diplopia and disorders of binocular vision4.91.020.971.070.45FalseNo368.4Visual field defects6.40.940.900.980.0024FalseNo368.9Subjective visual disturbances7.10.920.890.969.55E-05TrueNo369Infection of the eye7.50.920.890.966.10E-05TrueNo369.5Conjunctivitis, infectious4.40.910.870.960.00030FalseNo370Keratitis7.40.910.880.956.24E-06TrueNo371Inflammation of the eye31.60.930.910.952.53E-10TrueNo371.3Inflammation of eyelids9.60.930.900.970.00014FalseNo374Other disorders of eyelids7.30.960.921.000.048FalseNo375Disorders of lacrimal system3.10.950.891.000.060FalseNo377Disorders of optic nerve and visual path50.31.000.981.020.86FalseYes377.1Optic atrophy10.11.031.001.070.039FalseNo377.3Optic neuritis/neuropathy12.80.980.951.010.12FalseYes378Strabismus and other disorders of binocular eye movements17.61.041.011.060.0049FalseNo378.2Nystagmus and other irregular eye movements4.61.111.061.178.00E-06TrueNo379Other disorders of eye40.70.960.940.982.61E-05TrueNo379.1Scleritis and episcleritis4.10.960.911.010.093FalseNo379.5Disorders of iris and ciliary body3.50.960.911.010.15FalseNo380Disorders of external ear21.40.990.971.010.36FalseNo381Otitis media and Eustachian tube disorders28.40.930.910.953.00E-10TrueNo381.1Otitis media21.70.950.920.971.36E-05TrueNo381.11Suppurative and unspecified otitis media20.80.950.930.974.40E-05TrueNo386Vertiginous syndromes and other disorder14.30.930.910.964.64E-06TrueNo386.9Dizziness and giddiness (Light-headedness and vertigo)3.90.980.931.040.54FalseYes388Other disorders of ear15.70.960.930.990.0028FalseNo389Hearing loss11.20.960.930.990.0089FalseNo401Hypertension33.40.930.910.955.52E-10TrueYes401.1Essential hypertension32.10.930.910.954.80E-11TrueYes411Ischemic Heart Disease21.70.960.940.990.0029FalseNo411.2Myocardial infarction4.91.010.961.060.63FalseNo411.3Angina pectoris12.30.940.910.970.00015FalseNo411.4Coronary atherosclerosis4.30.910.860.960.00052FalseNo411.8Other chronic ischemic heart disease, unspecified8.10.950.910.980.0060FalseNo414Other forms of chronic heart disease6.10.930.890.970.0016FalseNo415Pulmonary heart disease3.61.131.071.207.69E-06TrueNo418Nonspecific chest pain13.90.920.890.952.87E-08TrueYes427Cardiac dysrhythmias18.10.990.961.010.37FalseYes427.7Tachycardia NOS4.30.990.951.040.83FalseNo428Congestive heart failure; nonhypertensive6.11.081.031.120.0013FalseNo429Ill-defined descriptions and complication46.80.990.971.010.16FalseNo429.3Symptoms involving cardiovascular system46.70.980.961.000.13FalseNo433Cerebrovascular disease10.41.081.041.118.43E-06TrueYes433.2Occlusion of cerebral arteries3.71.030.981.090.23FalseNo433.3Cerebral ischemia3.41.030.971.090.35FalseNo433.31Transient cerebral ischemia3.41.020.971.080.41FalseNo433.6Acute, but ill-defined cerebrovascular disease3.81.061.011.120.023FalseNo443Peripheral vascular disease4.81.151.101.201.28E-08TrueNo451Phlebitis and thrombophlebitis5.91.111.061.162.19E-06TrueNo454Varicose veins7.80.940.910.980.0013FalseNo454.1Varicose veins of lower extremity7.10.930.890.960.00018FalseNo455Hemorrhoids13.60.960.930.990.0052FalseNo459Other disorders of circulatory system41.040.991.090.16FalseNo459.9Circulatory disease NEC3.61.020.971.080.43FalseNo464Acute sinusitis30.20.880.860.906.24E-26TrueNo465Acute upper respiratory infections of multiple or unspecified sites67.10.890.870.911.31E-25TrueYes465.2Acute pharyngitis30.40.890.870.912.87E-25TrueNo465.4Acute laryngitis and tracheitis6.70.920.880.960.00011TrueNo470Septal Deviations/Turbinate Hypertrophy3.20.940.891.000.042FalseNo472Chronic pharyngitis and nasopharyngitis9.70.920.880.957.79E-07TrueNo473Diseases of the larynx and vocal cords3.60.940.890.990.021FalseNo474Acute and chronic tonsillitis11.80.920.890.953.06E-07TrueNo474.1Acute tonsillitis10.40.910.880.941.59E-07TrueNo475Chronic sinusitis6.80.950.910.980.0068FalseNo476Allergic rhinitis180.920.900.952.26E-09TrueNo479Other upper respiratory disease10.60.960.930.990.0083FalseNo480Pneumonia211.161.141.191.04E-32TrueYes480.1Bacterial pneumonia5.21.201.141.253.35E-14TrueNo480.2Viral pneumonia3.51.271.191.343.46E-15TrueNo480.5Bronchopneumonia and lung abscess4.51.201.141.267.28E-13TrueNo481Influenza19.90.980.951.000.047FalseNo483Acute bronchitis and bronchiolitis35.80.950.930.971.13E-05TrueNo495Asthma150.930.900.951.43E-07TrueYes496Chronic airway obstruction8.41.030.991.070.13FalseNo496.2Chronic bronchitis3.61.010.961.070.62FalseNo497Bronchitis23.80.960.940.980.0012FalseNo501Pneumonitis due to inhalation of food or vomitus3.61.761.611.921.41E-36TrueNo512Other symptoms of respiratory system13.91.010.981.040.64FalseYes512.8Cough5.70.930.890.970.0014FalseYes513Respiratory abnormalities6.31.030.991.070.13FalseNo519Other diseases of respiratory system, not elsewhere classified52.30.980.961.000.014FalseNo519.9Symptoms involving respiratory system and other chest symptoms51.70.970.960.990.0098FalseNo520Disorders of tooth development4.11.071.021.120.0089FalseNo521Diseases of hard tissues of teeth5.21.131.081.182.11E-08TrueNo522Diseases of pulp and periapical tissues3.51.071.011.130.013FalseNo523Gingival and periodontal diseases3.41.151.091.218.28E-07TrueNo525Other diseases of the teeth and supporting structures3.11.030.971.090.34FalseNo528Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue6.11.010.971.050.62FalseNo530Diseases of esophagus12.80.960.930.990.010FalseYes530.1Esophagitis, GERD and related diseases5.90.950.910.990.011FalseYes531Peptic ulcer (excl. esophageal)7.41.000.961.040.97FalseNo532Dysphagia4.41.271.201.333.02E-19TrueNo535Gastritis and duodenitis18.10.970.940.990.017FalseNo536Disorders of function of stomach8.40.990.951.020.45FalseNo537Other disorders of stomach and duodenum7.81.030.991.070.14FalseNo540Appendiceal conditions3.61.051.001.110.076FalseNo550Abdominal hernia8.40.920.890.959.86E-06TrueNo550.1Inguinal hernia3.20.920.870.980.0078FalseNo555Inflammatory bowel disease and other gastroenteritis and colitis4.11.020.971.070.47FalseNo558Noninfectious gastroenteritis111.010.981.040.52FalseNo560Intestinal obstruction without mention of hernia4.71.211.161.288.30E-15TrueNo562Diverticulosis and diverticulitis4.20.950.901.000.041FalseNo564Functional digestive disorders17.91.021.001.050.090FalseNo564.1Irritable Bowel Syndrome3.60.920.870.970.0033FalseNo565Anal and rectal conditions7.11.000.961.040.90FalseNo569Other disorders of intestine15.81.000.971.020.76FalseNo573Other disorders of liver3.61.000.951.050.95FalseNo574Cholelithiasis and cholecystitis10.70.990.961.020.45FalseNo574.1Cholelithiasis7.71.020.981.060.33FalseNo574.12Cholelithiasis with other cholecystitis5.71.010.971.060.54FalseNo575Other biliary tract disease60.990.951.040.75FalseNo578Gastrointestinal hemorrhage8.41.061.031.100.00090FalseNo579Other symptoms involving abdomen and pelvis68.40.990.961.010.18FalseNo585Renal failure3.91.131.071.194.32E-06TrueNo586Other disorders of the kidney and ureter3.81.111.061.175.83E-05TrueNo590Pyelonephritis9.61.251.211.303.49E-36TrueNo591Urinary tract infection25.81.361.331.405.90E-11TrueYes592Cystitis and urethritis50.11.121.091.141.17E-24TrueNo592.1Cystitis12.51.161.131.205.34E-22TrueNo592.11Acute cystitis51.101.051.153.18E-05TrueNo592.12Chronic cystitis3.91.171.111.235.08E-09TrueNo593Hematuria5.31.121.071.171.11E-06TrueYes594Urinary calculus151.181.151.213.63E-30TrueNo594.2Calculus of lower urinary tract5.11.631.531.741.34E-47TrueNo594.8Renal colic6.71.071.031.120.00032FalseNo596Other disorders of bladder30.91.251.221.281.82E-78TrueYes596.5Functional disorders of bladder15.61.311.271.356.16E-69TrueYes597Other disorders of urethra and urinary tract35.31.101.081.136.09E-20TrueNo597.1Urethral stricture (not specified as infectious)61.041.001.080.074FalseNo598Abnormal findings on examination of urine11.30.990.961.020.56FalseNo599Other symptoms/disorders or the urinary59.51.131.111.156.57E-30TrueYes599.2Retention of urine6.81.321.261.387.61E-33TrueYes599.4Urinary incontinence9.31.161.121.203.89E-17TrueYes599.5Frequency of urination and polyuria4.41.030.981.080.23FalseYes600Hyperplasia of prostate6.71.040.991.090.14FalseNo601Inflammatory diseases of prostate4.71.000.951.050.99FalseNo602Other disorders of prostate30.970.911.030.31FalseNo604Disorders of penis3.51.081.021.140.010FalseNo608Other disorders of male genital organs4.91.030.981.080.29FalseNo610Benign mammary dysplasias15.90.920.890.945.63E-09TrueNo610.1Cystic mastopathy3.10.960.911.020.22FalseNo610.4Benign neoplasm of breast70.940.900.970.0011FalseNo613Other nonmalignant breast conditions31.30.890.870.911.16E-22TrueYes614Inflammatory diseases of female pelvic organs33.40.950.930.974.39E-05TrueYes614.5Inflammatory disease of cervix, vagina, and vulva310.960.930.980.00019FalseYes614.51Cervicitis and endocervicitis3.60.940.891.000.040FalseNo614.52Vaginitis and vulvovaginitis4.91.000.951.050.97FalseYes615Endometriosis5.80.970.931.010.16FalseNo618Genital prolapse4.30.910.860.960.00022FalseNo619Noninflammatory female genital disorders41.80.910.890.936.60E-15TrueYes619.2Disorders of uterus, NEC5.10.940.890.980.0052FalseNo619.3Noninflammatory disorders of cervix18.40.910.880.938.48E-12TrueNo619.4Noninflammatory disorders of vagina6.40.990.951.030.48FalseNo622Polyp of female genital organs30.960.901.020.15FalseNo624.9stress incontinence, female4.50.920.880.970.0021FalseNo625Pain and other symptoms associated with female genital organs16.80.930.900.969.11E-07TrueYes626Disorders of menstruation and other abnormal bleeding from female genital tract44.60.910.880.932.67E-15TrueYes626.1Irregular menstrual cycle/bleeding14.60.990.961.020.55FalseYes626.11Absent or infrequent menstruation40.920.880.980.0047FalseNo626.12Excessive or frequent menstruation8.21.030.991.060.15FalseNo626.8Infertility, female4.60.890.850.942.85E-05TrueNo627Menopausal and postmenopausal disorders25.70.920.900.951.28E-09TrueYes627.1Postmenopausal bleeding3.30.980.921.030.41FalseNo628Ovarian cyst4.80.980.941.030.46FalseNo634Miscarriage; stillbirth5.30.910.870.960.00019FalseNo636Early or threatened labor; hemorrhage in early pregnancy4.80.930.880.980.0044FalseNo646Other complications of pregnancy NEC7.20.900.860.942.01E-06TrueNo649Other conditions or status of the mother4.60.930.880.980.0044FalseNo653Problems associated with amniotic cavity4.10.900.850.960.00049FalseNo655Known or suspected fetal abnormality affecting management of mother5.10.920.880.970.0016FalseNo681Superficial cellulitis and abscess36.81.071.051.095.33E-10TrueYes681.1Cellulitis and abscess of fingers/toes9.31.111.071.151.77E-09TrueNo686Other local infections of skin and subcutaneous tissue16.81.041.011.070.0048FalseNo686.1Carbuncle and furuncle6.31.051.011.090.015FalseNo687.1Rash and other nonspecific skin eruption6.61.051.011.090.022FalseYes687.4Disturbance of skin sensation8.61.000.971.040.95FalseYes689Disorder of skin and subcutaneous tissue33.10.990.971.010.23FalseNo690Erythematosquamous dermatosis9.71.000.961.030.83FalseNo695Erythematous conditions9.80.990.961.030.69FalseNo696Psoriasis and related disorders6.10.980.941.020.26FalseNo698Pruritus and related conditions40.970.921.020.28FalseNo700Corns and callosities81.010.971.050.58FalseNo701Other hypertrophic and atrophic conditions of skin8.60.970.941.010.16FalseYes702Degenerative skin conditions and other dermatoses12.70.970.941.000.061FalseYes703Diseases of nail, NOS20.21.191.161.222.65E-38TrueNo703.1Ingrowing nail3.11.151.081.222.26E-06TrueNo704Diseases of hair and hair follicles5.40.960.921.000.074FalseNo706Diseases of sebaceous glands16.10.950.930.980.00051FalseYes706.2Sebaceous cyst3.30.980.931.040.45FalseNo707Chronic ulcer of skin8.71.501.431.572.02E-65TrueNo707.1Decubitus ulcer4.91.801.661.947.73E-49TrueNo709Diffuse diseases of connective tissue3.10.950.901.010.10FalseNo714Rheumatoid arthritis and other inflammatory polyarthropathies7.80.960.931.000.038FalseNo716Other arthropathies9.90.950.920.990.0048FalseNo716.9Arthropathy NOS90.960.920.990.014FalseNo720Spinal stenosis30.60.960.940.980.00019FalseNo721Spondylosis and allied disorders4.30.960.921.010.15FalseYes722Intervertebral disc disorders13.30.970.941.000.035FalseYes722.1Displacement of intervertebral disc70.960.921.000.052FalseYes723Other disorders of cervical region27.70.930.910.951.39E-10TrueNo724Other and unspecified disorders of back53.40.920.910.942.21E-14TrueNo726Peripheral enthesopathies and allied syndromes11.80.970.941.000.029FalseYes726.1Enthesopathy5.20.990.951.040.66FalseNo727Other disorders of synovium, tendon, and bursa36.90.930.910.951.38E-11TrueNo727.1Synovitis and tenosynovitis3.50.910.860.970.0021FalseNo728Disorders of muscle, ligament, and fascia28.90.970.951.000.021FalseNo729Other disorders of soft tissues29.80.980.951.000.024FalseNo735Acquired foot deformities7.60.960.931.000.058FalseNo740Osteoarthrosis23.10.940.910.963.29E-07TrueYes740.1Osteoarthritis; localized30.910.860.970.0029FalseNo741Symptoms and disorders of the joints25.50.940.920.965.57E-07TrueYes742Derangement of joint, non-traumatic4.30.940.900.990.022FalseNo742.9Other derangement of joint3.70.940.890.990.023FalseNo743Osteoporosis, osteopenia and pathological fracture12.81.020.991.050.19FalseYes743.1Osteoporosis5.31.061.011.110.010FalseYes745Pain in joint6.20.960.921.000.035FalseYes760Back pain21.90.970.950.990.013FalseYes761Cervicalgia6.50.930.890.970.00097FalseYes769Nonallopathic lesions NEC55.50.930.910.951.47E-13TrueNo781Symptoms involving nervous and musculoskeletal system82.50.980.951.000.070FalseNo782Symptoms involving skin and other integumentary system63.60.950.930.971.32E-06TrueNo782.3Edema3.51.151.091.211.14E-06TrueNo783Fever of unknown origin4.41.281.221.351.89E-20TrueYes785Abdominal pain16.91.000.981.030.73FalseYes788Syncope and collapse31.000.941.060.97FalseNo789Nausea and vomiting7.21.071.041.120.00017FalseYes790Nonspecific findings on examination of blood7.21.000.971.040.87FalseNo798Malaise and fatigue10.80.990.961.020.52FalseYes800Fracture of lower limb9.91.111.071.152.70E-09TrueNo800.1Fracture of neck of femur3.21.201.121.271.88E-08TrueNo800.3Fracture of tibia and fibula4.41.111.061.162.76E-05TrueNo801Fracture of ankle and foot9.11.051.021.090.0030FalseNo801.1Fracture of foot5.31.071.021.120.0023FalseNo803Fracture of upper limb9.10.960.920.990.016FalseNo803.2Fracture of radius and ulna5.10.930.890.980.0042FalseNo803.3Fracture of clavicle or scapula3.60.930.880.980.0075FalseNo804Fracture of hand or wrist5.10.960.911.000.061FalseNo807Fracture of ribs3.70.960.911.020.16FalseNo809Fracture of unspecified bones8.21.030.991.070.12FalseNo817Concussion3.51.081.021.140.0056FalseNo819Skull and face fracture and other intercranial injury4.41.041.001.100.077FalseNo830Dislocation50.950.911.000.046FalseNo835Internal derangement of knee12.30.910.890.942.03E-08TrueNo840Sprains and strains67.50.950.930.978.96E-07TrueYes840.3Joint/ligament sprain9.70.980.941.010.16FalseNo841Sprains and strains of back and neck41.30.920.910.945.35E-14TrueNo842Other sprains and strains17.20.950.920.978.68E-05TrueNo870Open wounds of head; neck; and trunk201.000.981.030.85FalseNo870.3Other open wound of head and face7.31.061.021.100.0021FalseNo871Open wounds of extremities18.60.930.910.961.22E-07TrueNo871.1Open wound of hand except finger(s)3.80.920.870.970.0034FalseNo871.2Open wound of finger(s)90.900.870.945.37E-08TrueNo907Injuries to the nervous system5.51.000.961.050.98FalseNo916Contusion21.81.000.981.020.92FalseNo939Atopic/contact dermatitis due to other or unspecified36.60.980.961.000.065FalseYes947Urticaria6.80.960.920.990.026FalseNo967Adverse effects of sedatives or other ce7.21.030.991.070.16FalseNo979Adverse effects of sedatives or other central nervous system depressants and anesthetics51.081.031.120.0015FalseNoNote: Related ICD-9 codes of a single medical condition are mapped to a single phenotype code or PheCode (column 1). Prevalence (Prev) is defined as the percentage of the patients in the cohort having a medical condition as indicated by the PheCode. Odds ratio (OR) represents the estimated factor by which the odds of the presence of the given medical condition changes per unit increase of the MSSS (on the decile scale), holding controlled covariates constant. We indicated whether a medical condition reached the Bonferroni (BONF) threshold of significance in an independent analysis of the discovery cohort and extension cohort as True (T) or False (F), respectively. We indicated whether a medical condition was included in discovery analysis and extension analysis (Analyzed in Ext.) as Yes (Y) or No (N), respectively. ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download