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Supplementary table 1: The 100 most frequently cited articlesTileJournalCitationsNo.RankAbnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects - a prospective investigationJBJS-Am.12691Magnetic resonance classification of lumbar intervertebral disc degenerationSpine12202Magnetic resonance imaging of the lumbar spine in people without back painNEJM12163Degenerative disk disease - assessment of changes in vertebral body marrow with mr imagingRadiology7864Spine update - aging and degeneration of the human intervertebral discSpine6885Lumbar-disk herniation - a controlled, prospective-study with 10 years of observationSpine6846New in vivo measurements of pressures in the intervertebral disc in daily lifeSpine6567Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral-diskSpine5598TileJournalCitationsNo.RankNegative disc exploration - analysis of causes of nerve-root involvement in 68 patientsJBJS-Am.5549Classification of age-related changes in lumbar intervertebral discsSpine53310The human lumbar intervertebral disc - evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degenerationJ. Clin. Inve.50711Low back pain in relation to lumbar disc degenerationSpine49412Surgical vs nonoperative treatment for lumbar disk herniation - the spine patient outcomes research trial (sport): a randomized trialJAMA49113Imaging of degenerative disk diseaseRadiology46514Nerve ingrowth into diseased intervertebral disc in chronic back painLancet44815Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2Spine435161984 volvo award in clinical sciences - A study of computer-assisted tomography .1. the incidence of positive cat scans in an asymptomatic group of patientsSpine42617TileJournalCitationsNo.RankIntervertebral discs which cause low back pain secrete high levels of proinflammatory mediatorsJBJS –Bi.41718Autologous nucleus pulposus induces neurophysiologic and histologic-changes in porcine cauda-equina nerve rootsSpine41319Osteo-arthrosis and disk degeneration in an urban populationAnn. Rheum. Dis.40620High-levels of inflammatory phospholipase-a2 activity in lumbar-disk herniationsSpine37421'Stress' distributions inside intervertebral discs - the effects of age and degenerationJBJS-Br.36422Disk pressure measurementsSpine36023Surgical vs nonoperative treatment for lumbar disk herniation - the spine patient outcomes research trial (sport) observational cohortJAMA35524The inflammatory effect of nucleus pulposus - a possible element in the pathogenesis of low-back-painSpine35425Inflammatory cytokines in the herniated disc of the lumbar spineSpine35026TileJournalCitationsNo.RankCervical disk lesionsJAMA34927Mechanical initiation of intervertebral disc degenerationSpine34828The prevalence and clinical-features of internal disc disruption in patients with chronic low-back-painSpine34629The treatment of ruptured lumbar intervertebral discs by vertebral body fusion .1. indications, operative technique, after careJ Neurosurgery34030In vivo measurements of intradiscal pressure - discometry, a method for the determination of pressure in the lower lumbar discsJBJS-Am.34030Biology of intervertebral disc aging and degeneration - involvement of the extracellular matrixSpine33732High-intensity zone - a diagnostic sign of painful lumbar-disk on magnetic-resonance-imagingBrit. J Radiol.33633Lumbar-disk degeneration - correlation with age, sex, and spine level in 600 autopsy specimensSpine33234Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degenerationSpine32635TileJournalCitationsNo.RankDeterminants of lumbar disc degeneration - a study relating lifetime exposures and magnetic resonance imaging findings in identical twinsSpine32236The role of interleukin-1 in the pathogenesis of human intervertebral disc degenerationArthritis Res. Ther.32236Matrix metalloproteinases and aggrecanase - their role in disorders of the human intervertebral discSpine31538Analysis of aging and degeneration of the human intervertebral disc - comparison of surgical specimens with normal controlsSpine31139Annulus tears and intervertebral-disk degeneration - an experimental-study using an animal-modelSpine31040Factors involved in nutrition of human lumbar intervertebral-disk - cellularity and diffusion of glucose invitroJ. Anatomy30941Toward a biochemical understanding of human intervertebral disc degeneration and herniation - contributions of nitric oxide, interleukins, prostaglandin e-2, and matrix metalloproteinasesSpine30542Transplantation of mesenchymal stem cells embedded in atelocollagen((r)) gel to the intervertebral disc: a potential therapeutic model for disc degenerationBiomaterials29843Stimulation of mature canine intervertebral-disk by growth-factorsSpine29744TileJournalCitationsNo.RankNutrition of the intervertebral-disk - solute transport and metabolismConnective tissue research29345In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problemsSpine28746Swelling pressure of the lumbar intervertebral disks - influence of age, spinal level, composition, and degenerationSpine282471998 volvo award winner in biomechanical studies - compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element studySpine27948A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degenerationSpine27749Long-term outcomes of standard discectomy for lumbar disc herniation - a follow-up study of more than 10 yearsSpine27650Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individualsSpine27650Effects of torsion on lumbar intervertebral joints - role of torsion in production of disc degenerationJBJS-Am.27352Innervation of ''painful'' lumbar discsSpine27253TileJournalCitationsNo.RankThe effect of disc degeneration and facet joint osteoarthritis on the segmental flexibility of the lumbar spineSpine27054 Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral discSpine26655Investigation of the laminate structure of lumbar-disk anulus fibrosusSpine26556The innervation of the lumbar spineSpine26457Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral discBiomaterials26158The diagnostic accuracy of magnetic resonance imaging, work perception, and psychosocial factors in identifying symptomatic disc herniationsSpine25959MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteersRadiology25959Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorptionJ. Clin. Inve.25959Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral discJ. Pathology25662TileJournalCitationsNo.RankGenetic influences on cervical and lumbar disc degeneration - a magnetic resonance imaging study in twinsArthritis and Rheumatism25363Magnetic-resonance imaging of intervertebral-disk disease - clinical and pulse sequence considerationsRadiology25264Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model - potential and limitations for stem cell therapy in disc regenerationSpine24965Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapySpine24766Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding geneSpine24667Intermediate follow-up after treatment of degenerative disc disease with the bryan cervical disc prosthesis: single-level and bi-levelSpine24468An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc.J. Orthop. Res.24269Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to tgf-beta 1Eep. Cell Res.24170Prolapsed intervertebral disk a hyperflexion injurySpine23971TileJournalCitationsNo.RankImmunohistologic markers for age-related changes of human lumbar intervertebral discsSpine23971The nerve supply to the human lumbar intervertebral disksJ. Anatomy23673Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology - molecular, histologic, and behavioral comparisons in ratsSpine23474Asymptomatic degenerative disk disease and spondylosis of the cervical-spine - mr imagingRadiology23375The natural-history of lumbar intervertebral-disk extrusions treated nonoperativelySpine23276In-vitro diffusion of dye through end-plates and annulus fibrosus ofhuman lumbar inter-vertebral discsActa Orthop. Scand.22977Intradiscal pressure measurements above an instrumented fusion - a cadaveric studySpine22977Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controlsSpine22879Surgical versus nonoperative treatment for lumbar disc herniation four-year results for the spine patient outcomes research trial (sport)Spine22879TileJournalCitationsNo.RankAn allele of col9a2 associated with intervertebral disc diseaseScience22681Disk space narrowing and the lumbar facet jointsJBJS-Br.22582Intervertebral disc cell-mediated mesenchymal stem cell differentiationStem Cells22582Internal intervertebral-disk mechanics as revealed by stress profilometrySpine22384Smoking and lumbar intervertebral-disk degeneration - an mri study of identical-twinsSpine22085MRI of cervical intervertebral discs in asymptomatic subjectsJBJS-Br.21986Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discsAnn. Biomed. Eng.21986The role of abdominal pressure in relieving the pressure on the lumbar intervertebral discsJBJS-Br.21888Disc degeneration - its frequency and relationship to symptomsAnn. Rheum. Dis.21888TileJournalCitationsNo.RankThe natural history of herniated nucleus pulposus with radiculopathySpine21888Disks degenerate before facetsSpine21791Strain on intervertebral discs after anterior cervical decompression and fusionSpine21791Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesisExp. Cell Res.21693Degeneration and the chemical-composition of the human lumbar intervertebral-diskJ. Orthop. Res21294Lumbar discography in normal subjects - a controlled, prospective-studyJBJS-Am..21195Disc degeneration affects the multidirectional flexibility of the lumbar spineSpine21195Intervertebral disc cell death is dependent on the magnitude and duration of spinal loadingSpine21195A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, x-ray, and histologySpine21195TileJournalCitationsNo.RankThe?intervertebral?disc?- its microscopic anatomy and pathology .1. anatomy, development, and physiologyJBJS-Am.21099The Lumbar Disc Herniation: A Computer-Aided Analysis of 2,504Acta Orthop. Scand. 209100 ................
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