UvA-DARE (Digital Academic Repository)

[Pages:7]UvA-DARE (Digital Academic Repository)

Biomarkers in premalignant conditions of the gastrointestinal tract: Studies on Barrett's esophagus and primary sclerosing cholangitis

Timmer, M.R.

Publication date 2016 Document Version Final published version

Link to publication

Citation for published version (APA): Timmer, M. R. (2016). Biomarkers in premalignant conditions of the gastrointestinal tract: Studies on Barrett's esophagus and primary sclerosing cholangitis. [Thesis, fully internal, Universiteit van Amsterdam].

General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: , or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.

UvA-DARE is a service provided by the library of the University of Amsterdam () Download date:16 Jan 2023

BIOMARKERS IN PREMALIGNANT CONDITIONS OF THE GASTROINTESTINAL TRACT

BIOMARKERS IN PREMALIGNANT CONDITIONS OF THE GASTROINTESTINAL TRACT

Studies on Barrett's Esophagus and Primary Sclerosing Cholangitis

Margriet Timmer

Margriet Timmer

Biomarkers in premalignant conditions of the gastrointestinal tract

Studies on Barrett's esophagus and primary sclerosing cholangitis

Margriet Timmer

Biomarkers in premalignant conditions of the gastrointestinal tract Thesis, University of Amsterdam, the Netherlands

Cover design: Rissa Philip About the cover: Figure adapted from a spatial model for tumor evolution described by Waclaw et al. in Nature, 2015. Image courtesy of Bartlomiej Waclaw. Lay-out and printing: Off Page, Amsterdam, offpage.nl ? Copyright 2016 by Margriet Timmer, all rights reserved. ISBN: 978-94-6182-732-6

Printing of this thesis was financially supported by the Academic Medical Center, Amsterdam, de Nederlandse Vereniging voor Gastroenterologie, U.S. Endoscopy, Erbe Nederland B.V., Olympus Nederland B.V., Dr. Falk Pharma Benelux B.V., ChipSoft en Zambon Nederland B.V.

Biomarkers in premalignant conditions of the gastrointestinal tract

Studies on Barrett's esophagus and primary sclerosing cholangitis

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op donderdag 10 november 2016, te 10:00 uur

door

Margriet Roelien Timmer

geboren te Nijeveen

P r o m ot i e c o m m i ss i e

Promotores: Copromotores: Overige leden:

Prof. dr. K.K. Krishnadath Prof. dr. P. Fockens Prof. K.K. Wang Dr. S. Calpe Prof. dr. B.L.A.M. Weusten Prof. dr. G.R. van den Brink Prof. dr. M.J. van de Vijver Prof. dr. E.J. Kuipers Prof. dr. J.G.P. Tijssen Prof. dr. U.H.W. Beuers

Universiteit van Amsterdam Universiteit van Amsterdam Mayo Clinic Universiteit van Amsterdam Universiteit van Amsterdam Universiteit van Amsterdam Universiteit van Amsterdam Erasmus Universiteit Rotterdam Universiteit van Amsterdam Universiteit van Amsterdam

Faculteit der Geneeskunde

Table of Contents

Chapter 1 General introduction and outline of this thesis

7

Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8

Predictive biomarkers for Barrett's esophagus: so near and yet so far

13

Diseases of the esophagus 2013 Aug;26(6):574-81

Derivation of genetic biomarkers for cancer risk stratification in Barrett's 29 oesophagus: a prospective cohort study Gut. 2015 Jun 23. pii: gutjnl-2015-309642

Longitudinal single cell clonal analysis reveals evolutionary stasis and

59

predetermined malignant potential in non-dysplastic Barrett's esophagus

Nature Communications. Nat Commun. 2016 Aug 19;7:12158.

Prediction of response to endoscopic therapy of Barrett's dysplasia

111

by using genetic biomarkers

Gastrointestinal Endoscopy 2014 Dec;80(6):984-91

Genetic abnormalities in the Barrett's mucosa and response to

127

radiofrequency ablation; an interim analysis from a multicenter study

Manuscript in preparation

Genetic and epigenetic abnormalities in primary sclerosing cholangitis- 139 associated cholangiocarcinoma Inflammatory Bowel Disease 2013 Jul;19(8):1789-97

Genetic abnormalities in biliary brush samples for distinguishing

157

cholangiocarcinoma from benign strictures in primary sclerosing

cholangitis

Gastroenterol Res Pract. 2016;2016:4381513.

Addendum

Summary, general discussion and future perspectives

177

Nederlandse samenvatting

185

Contributing Authors

189

List of publications

193

PhD Portfolio

195

Dankwoord197

Curriculum Vitae

200

Stellingen201

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download