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Supplementary tablesTable 1: Characteristics of Studies evaluating incidence of RSV infection in general populationCountryStudy PeriodStudy populationStudy designSettingOutcomesDiagnostic methodReferenceEgypt2009-2012All agesPopulation-Based SurveillanceHospitalOutpatientARIILIRT-PCRRowlinson et al. 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3dsaW5zb248L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy
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ADDIN EN.CITE.DATA [6]ALRI=acute lower respiratory infection; ARI=acute respiratory infection; ED=emergency department; ILI=influenza-like illness; qRT-PCR=quantitative reverse transcription polymerase chain reaction; RT-PCR=reverse transcription polymerase chain reaction; SARI=severe acute respiratory infectionTable 2: Characteristics of studies evaluating the proportion of RSV among respiratory infection in general populationCountryPeriodPopulationDesign SettingOutcomesDiagnostic methodReferenceAfricaEgypt2009-2012All agesPopulation-Based SurveillanceHospitalOutpatientARIILIRT-PCRRowlinson et al. 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3dsaW5zb248L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy
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ADDIN EN.CITE.DATA [4]Senegal2009-2011>50 yearsProspective Descriptive(Influenza sentinel)OutpatientILIRT-PCRDia et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaWE8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [14]Colombia2000-2011All agesRetrospective descriptiveLocal health centers, HospitalARIRT-PCRBarbosa Ramirez et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJib3NhIFJhbWlyZXo8L0F1dGhvcj48WWVhcj4yMDE0
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ADDIN EN.CITE.DATA [20]China2005-2007≥14 yearsProspective descriptiveOutpatientARIMultiplex nested RT-PCRRen et al. 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [35]Taiwan2008-2009≥65 yearsActive surveillance (Influenza65 trial cohort)Community / Retirement homeILIMultiplex RT-PCRFalsey et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYWxzZXk8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [38]Papua New Guinea2010All agesRetrospective descriptive Hospital ILIRT-PCRKono et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb25vPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA [48]Sweden1971-1980≥16 yearsRetrospective descriptiveHospitalPneumoniaIndirect IFAVikerfors et al. 1987 ADDIN EN.CITE <EndNote><Cite><Author>Vikerfors</Author><Year>1987</Year><RecNum>888</RecNum><DisplayText>[49]</DisplayText><record><rec-number>888</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783197">888</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vikerfors, T.</author><author>Grandien, M.</author><author>Olcen, P.</author></authors></contributors><titles><title>Respiratory syncytial virus infections in adults</title><secondary-title>Am Rev Respir Dis</secondary-title><alt-title>The American review of respiratory disease</alt-title></titles><periodical><full-title>Am Rev Respir Dis</full-title><abbr-1>The American review of respiratory disease</abbr-1></periodical><alt-periodical><full-title>Am Rev Respir Dis</full-title><abbr-1>The American review of respiratory disease</abbr-1></alt-periodical><pages>561-4</pages><volume>136</volume><number>3</number><edition>1987/09/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Antibodies, Viral/analysis</keyword><keyword>Antigens, Viral/analysis</keyword><keyword>Humans</keyword><keyword>Nasopharynx/microbiology</keyword><keyword>Pneumonia, Viral/*epidemiology/etiology</keyword><keyword>Respiratory Syncytial Viruses/isolation & purification</keyword><keyword>Respirovirus Infections/diagnosis/*epidemiology</keyword><keyword>Retrospective Studies</keyword><keyword>Sweden</keyword><keyword>Time Factors</keyword></keywords><dates><year>1987</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0003-0805 (Print)
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ADDIN EN.CITE.DATA [51]UK1981-1982>50 yearsProspective descriptiveHospital(Geriatric wards)ARIFluorescent antibodytechniqueMorales et al. 1983 ADDIN EN.CITE <EndNote><Cite><Author>Morales</Author><Year>1983</Year><RecNum>616</RecNum><DisplayText>[52]</DisplayText><record><rec-number>616</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783195">616</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Morales, F.</author><author>Calder, M. A.</author><author>Inglis, J. M.</author><author>Murdoch, P. S.</author><author>Williamson, J.</author></authors></contributors><titles><title>A study of respiratory infections in the elderly to assess the role of respiratory syncytial virus</title><secondary-title>J Infect</secondary-title><alt-title>The Journal of infection</alt-title></titles><periodical><full-title>J Infect</full-title><abbr-1>The Journal of infection</abbr-1></periodical><alt-periodical><full-title>J Infect</full-title><abbr-1>The Journal of infection</abbr-1></alt-periodical><pages>236-47</pages><volume>7</volume><number>3</number><edition>1983/11/01</edition><keywords><keyword>Aged</keyword><keyword>Antibodies, Viral/analysis</keyword><keyword>Bacteria/isolation & purification</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Orthomyxoviridae/immunology</keyword><keyword>Respiratory Syncytial Viruses/immunology/*pathogenicity</keyword><keyword>Respiratory Tract Infections/*etiology</keyword><keyword>Respirovirus Infections/diagnosis</keyword></keywords><dates><year>1983</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0163-4453 (Print)
0163-4453</isbn><accession-num>6663083</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[52]UK1974-1980>12 yearsDescriptive HospitalPneumoniaComplement fixationWhite et al. 1981 ADDIN EN.CITE <EndNote><Cite><Author>White</Author><Year>1981</Year><RecNum>1297</RecNum><DisplayText>[53]</DisplayText><record><rec-number>1297</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783206">1297</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>White, R. J.</author><author>Blainey, A. D.</author><author>Harrison, K. J.</author><author>Clarke, S. K.</author></authors></contributors><titles><title>Causes of pneumonia presenting to a district general hospital</title><secondary-title>Thorax</secondary-title><alt-title>Thorax</alt-title></titles><periodical><full-title>Thorax</full-title></periodical><alt-periodical><full-title>Thorax</full-title></alt-periodical><pages>566-70</pages><volume>36</volume><number>8</number><edition>1981/08/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Anti-Bacterial Agents/therapeutic use</keyword><keyword>England</keyword><keyword>Female</keyword><keyword>Hospitals, District</keyword><keyword>Hospitals, General</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pneumonia/drug therapy/*microbiology/mortality</keyword><keyword>Sputum/microbiology</keyword><keyword>Time Factors</keyword></keywords><dates><year>1981</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0040-6376 (Print)
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ADDIN EN.CITE.DATA [66]Canada2004-2006AdultsProspective descriptiveHospitalCAPDFA TestingJohnstone et al. 2008 ADDIN EN.CITE <EndNote><Cite><Author>Johnstone</Author><Year>2008</Year><RecNum>428</RecNum><DisplayText>[67]</DisplayText><record><rec-number>428</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783194">428</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Johnstone, J.</author><author>Majumdar, S. R.</author><author>Fox, J. D.</author><author>Marrie, T. J.</author></authors></contributors><auth-address>Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.</auth-address><titles><title>Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation</title><secondary-title>Chest</secondary-title><alt-title>Chest</alt-title></titles><periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1></periodical><alt-periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1></alt-periodical><pages>1141-8</pages><volume>134</volume><number>6</number><edition>2008/08/12</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Alberta</keyword><keyword>Community-Acquired Infections/diagnosis/epidemiology/virology</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Hospitalization</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pneumonia, Viral/diagnosis/*epidemiology/*virology</keyword><keyword>Prevalence</keyword><keyword>Prospective Studies</keyword><keyword>Respiration Disorders/virology</keyword></keywords><dates><year>2008</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0012-3692</isbn><accession-num>18689592</accession-num><urls></urls><electronic-resource-num>10.1378/chest.08-0888</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[67] Table 3: Stratified analysis for the proportion of RSV associated ARI in AsiaVariableSummary estimateLower 95% CIUpper 95% CII2Number of estimatesInter-group heterogeneity (p-value<0.05)Age Group0.0000<50 years0.010.000.0292.6910>=50 years0.020.010.0390.937All Ages0.100.070.1599.1619All Adults0.0100.0282.3616Study Period0.4337Before 2000-----2000-20100.040.020.0698.6930Post 20100.040.020.0799.0921Illness Definition0.0000SARI****CAP0.030.020.0423.146ILI0.040.020.0794.9913ARI0.0200.0399.1020Miscellaneous0.090.030.1699.4811Diagnostic Method0.0150Multiplex PCR0.040.020.0797.9815Other PCR0.050.030.0799.3528DFA/IIF/ELIZA/EIA-----Culture*****Other*****Mixed*****?Note: '-' not calculated by program, low number of estimates in the group, no variation considered between the variables as all estimates from the same study; ‘*’ estimates not provided all the estimates in the group from same studyTable 4: Meta-regression results for AsiaVariableCoefficientStandard errorp-valueAge Group0.0100.0100.302Study Period0.0180.0210.405Illness Definition0.0140.0110.210Diagnostic Method-0.0050.0090.550Table 5: Meta-regression results for the United States and CanadaVariable CoefficientStandard errorp-valueAge Group -0.0230.0100.030Study Period -0.0160.0220.480Illness Definition 0.0130.0090.152Diagnostic Method -0.0050.0630.094Table 6: Study characteristics for proportion of RSV in population with underlying conditions or diseases CountryStudy PeriodPopulationDesign SettingOutcomesDiagnostic methodReferenceAustralia1993-1994Adults?; AsthmaCase controlHospitalAE-asthmaSerology / cultureTeichtahl et al. 1997 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZWljaHRhaGw8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFy
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ADDIN EN.CITE.DATA [78]Sweden2000-2007Allogenic HSCTRetrospective chart reviewHospitalARINot describedAvetisyan et al. 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BdmV0aXN5YW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy
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ADDIN EN.CITE.DATA [80]UK1981-1982Elderly, geriatric long stay patientsProspective descriptiveGeriatric wardsARICultureMorales et al. 1983 ADDIN EN.CITE <EndNote><Cite><Author>Morales</Author><Year>1983</Year><RecNum>616</RecNum><DisplayText>[52]</DisplayText><record><rec-number>616</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783195">616</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Morales, F.</author><author>Calder, M. A.</author><author>Inglis, J. M.</author><author>Murdoch, P. S.</author><author>Williamson, J.</author></authors></contributors><titles><title>A study of respiratory infections in the elderly to assess the role of respiratory syncytial virus</title><secondary-title>J Infect</secondary-title><alt-title>The Journal of infection</alt-title></titles><periodical><full-title>J Infect</full-title><abbr-1>The Journal of infection</abbr-1></periodical><alt-periodical><full-title>J Infect</full-title><abbr-1>The Journal of infection</abbr-1></alt-periodical><pages>236-47</pages><volume>7</volume><number>3</number><edition>1983/11/01</edition><keywords><keyword>Aged</keyword><keyword>Antibodies, Viral/analysis</keyword><keyword>Bacteria/isolation & purification</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Orthomyxoviridae/immunology</keyword><keyword>Respiratory Syncytial Viruses/immunology/*pathogenicity</keyword><keyword>Respiratory Tract Infections/*etiology</keyword><keyword>Respirovirus Infections/diagnosis</keyword></keywords><dates><year>1983</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0163-4453 (Print)
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ADDIN EN.CITE.DATA [83]USA1992-1993Elderly, senior daycare centerProspective descriptiveSenior day care centerARICultureFalsey et al. 1995 ADDIN EN.CITE <EndNote><Cite><Author>Falsey</Author><Year>1995</Year><RecNum>2924</RecNum><DisplayText>[84]</DisplayText><record><rec-number>2924</rec-number><foreign-keys><key app="EN" db-id="vr0e2prxoawe2de0sxoxrv0yxd59vra0ettf" timestamp="1487164328">2924</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Falsey, Ann R</author><author>McCann, Robert M</author><author>Hall, William J</author><author>Tanner, Martin A</author><author>Criddle, Mary M</author><author>Formica, Maria A</author><author>Irvine, Carrie S</author><author>Kolassa, John E</author><author>Barker, William H</author><author>Treanor, John J</author></authors></contributors><titles><title>Acute respiratory tract infection in daycare centers for older persons</title><secondary-title>Journal of the American Geriatrics Society</secondary-title></titles><periodical><full-title>Journal of the American Geriatrics Society</full-title></periodical><pages>30-36</pages><volume>43</volume><number>1</number><dates><year>1995</year></dates><isbn>1532-5415</isbn><urls><related-urls><url>;[84]USA1992-1994Adults, BMTProspective descriptiveCancer centerARICultureWhimbey et al. 1996 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaGltYmV5PC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48
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ADDIN EN.CITE.DATA [86]USA1992-1997Adult, lung transplantRetrospective cohortCancer centerRVINot describedPalmer et al. 1998 ADDIN EN.CITE <EndNote><Cite><Author>Palmer</Author><Year>1998</Year><RecNum>671</RecNum><DisplayText>[87]</DisplayText><record><rec-number>671</rec-number><foreign-keys><key app="EN" db-id="axdaad92s20zvhevf9k5fa0esxw5d5pr0atv" timestamp="1515783195">671</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Palmer, S. M., Jr.</author><author>Henshaw, N. G.</author><author>Howell, D. N.</author><author>Miller, S. E.</author><author>Davis, R. D.</author><author>Tapson, V. F.</author></authors></contributors><auth-address>Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.</auth-address><titles><title>Community respiratory viral infection in adult lung transplant recipients</title><secondary-title>Chest</secondary-title><alt-title>Chest</alt-title></titles><periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1></periodical><alt-periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1></alt-periodical><pages>944-50</pages><volume>113</volume><number>4</number><edition>1998/04/29</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Community-Acquired Infections/diagnosis/epidemiology/virology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Lung Transplantation</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prevalence</keyword><keyword>*Respiratory Tract Infections/diagnosis/epidemiology/virology</keyword><keyword>Retrospective Studies</keyword><keyword>Seasons</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>1998</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0012-3692 (Print)
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ADDIN EN.CITE.DATA [95]USA2009-2010Multiple diseases (Lung disease, Liver disease, Renal disease, Diabetes, Cardiovascular disease, Immunocompromised (any cause)) Retrospective chart reviewHospitalRVIRVP ProFlu+Walker et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYWxrZXI8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
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