Lecture 18: Skin synthesis in vivo (induced regeneration)
KC suspensions grafted on dermis-free surface failed to adhere (“avulsion”).-- 1977 Rheinwald and Green (RG) achieved KC culture expansion to KC sheets by 10,000X in 3 weeks.-- 1980-95 Clinical studies of KC sheets prepared by RG method were terminated after completing 105 of them. Problem: avulsion of KC sheets from muscle substrate. ................
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