Pharmacology: Basics for RNs

Lisinopril: 12hrs Losartan: 1-2hrs Duration of Action Enalapril: peak after 3-4hrs Distribution Metabolism Prodrugs converted by hydrolysis in liver Excretion Renal (except fosinpril and moexipril) so decr dose in renal insufficiency Side effects ACEi: Severe 1st dose hypotension if hypovolaemic (diuretics, salt restriction, GI fluid loss ... ................
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