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Ff Fe/TIBC > 45%, check ferritin. Ferritin > 400 ng/ml in men and > 300 ng/ml in women suggestive; then send for HFE genotype. Hepatic iron index (ratio of liver concentration of iron to age of patient) > 2.0 is diagnostic. Autoimmune hepatitis. Screen with SPEP; 80% patients will have hypergammaglobulinemia (2x upper limit of normal is specific) ................
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