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The 2012 SLICC (Systemic Lupus International Collaborating Clinics) Classification Criteria for Systemic Lupus Erythematosus Classify a patient as having SLE if:a) The patient satisfies four of the following criteria, including at least one clinical criterion and one immunologic criterion?orb) The patient has biopsy-proven nephritis compatible with SLE and with ANA or anti-dsDNA antibodiesCLINICAL CRITERIA1.?Acute Cutaneous LupusLupus malar rash (do not count if malar discoid)Bullous lupusToxic epidermal necrolysis variant of SLEMaculopapular lupus rashPhotosensitive lupus rash (in the absence of dermatomyositis)Subacute cutaneous lupus (nonindurated psoriaform and/or annular polycyclic lesions that resolve without scarring, occasionally with post-inflammatory dyspigmentation or telangiectasias)2. Chronic CutaneousLupusClassical discoid rash: localized (above the neck) or generalized (above and below the neck)Hypertrophic (verrucous)lupusLupus panniculitis (profundus) Mucosal lupusLupus erythematosus tumidusChillblains lupusDiscoid Lupus-lichen planus overlap3. Oral ulcersPalate, Buccal, Tongue or Nasal ulcers (in the absence of other causes, such as vasculitis, Behcets, infection (herpes), IBD, reactive arthritis, and acidic foods)4. Non-scarring alopeciaDiffuse thinning or hair fragility with visible broken hairs (in the absence of other causes such as alopecia areata, drugs, iron deficiency and androgenic alopecia)5. Synovitis involving>2 jointsCharacterized by swelling or effusion or tenderness in 2 or more joints and thirty minutes or more of morning stiffness.6. SerositisTypical pleurisy for more than 1 day or pleural effusions or pleural rub.Typical pericardial pain (pain with recumbency improved by sitting forward) for more than 1 day or pericardial effusion ORPericardial rub or pericarditis by ECG (in the absence of other causes, such as infection, uremia, and Dressler’s pericarditis)7. Renal manifestationsUrine protein/creatinine (or 24 hr urine protein) representing 500 mg of protein in 24 hr ORRed blood cell casts 8. Neurological ManifestationsSeizuresPsychosisMononeuritis multiplex (in the absence of other known causes such as primary vasculitis)MyelitisPeripheral or cranial neuropathy (in the absence of other known causes such as primary vasculitis, infection and diabetes mellitus)Acute confusional state (in the absence of other causes, including toxic-metabolic, uremia, drugs)9. Hemolytic anemia10. Leukopenia/ LymphopeniaLeukopenia <4000mm3 at least once (in the absence of other known causes)Lymphopenia <1000mm3 at least once (in the absence of other known causes)11. Thrombocytopenia<100,000mm3 at least once (in the absence of other known causes such as drugs, portal hypertension, and TTP)IMMUNOLOGICAL CRITERIAANAAbove the reference range of the laboratoryAnti-dsDNAAbove laboratory reference range, except ELISA: twice above laboratory reference rangeAnti-SmithAnti-phospholipidAntibodyAny of the following:Lupus anticoagulantFalse positive RPRMedium or high titer anticardiolipin (IgA, IgG or IgM)Anti-beta 2 glycoprotein I (IgA, IgG or IgM)Low ComplementsLow C3, C4 or CH50Direct Coombs TestIn the absence of hemolytic anemiaCriteria are cumulative and need not be present concurrentlyPetri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin FR et. al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012. ................
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