MIRJANA D
MIRJANA D. PAVLOVIC
1541 NW 18th Avenue, Bldg. # 101, Apt. # 204
DELRAY BEACH, FL, 33445
Phone: 561-278-8430; Cell: 561-542-3953; Fax: 561-330-8711, Office at FAU: 561-297-2348
E-mail: pmirjana@, mpavlovi@fau.edu
SUMMARY
o Biomedical scientific research with particular expertise in cell biology, biochemistry, stem-cell research experimental immunology and clinical hematology.
o MD in general medicine, M.S. in Clinical Hematology and Experimental Immunology, Ph.D. in Cell Biology with Biochemistry (Metabolic Endocrinology) all from the University of Belgrade, Yugoslavia.
o Extensive experience in cord blood and adult (peripheral) blood stem cell banking and isolation, purification and functional characterization of lupus anti-DNA antibodies.
o National and International University teaching experience in Biochemistry, Tumor Growth Factors, Diffuse Neuroendocrine System, Autoimmunity, Bioengineering, Chemistry for engineers (theory and lab combined, Introduction into Bioengineering and Tissue Engineering at FAU)
o Postdoctoral studies at Yale and University of Pennsylvania University Schools of Medicine (USA) in the fields of antitumor therapy.
o Within last ten years involved in Immunology-Structure, Function and Pathogenicity of Lupus anti-DNA autoantibodies, and Stem Cell Research.
For last three years involved in Bioinformatics and Bioengineering with creation of Introduction to Bioingeneering Spring Course (2010), and Fall Tissue Engineering Course (2010) and design for new Bioengineering Lab.
ACCOMPLISHMENTS (RESEARCH & DEVELOPMENT)
Co-founder in establishment of Stem Cell Cryopreservation Laboratory (SFBMSCTI, Boynton Beach, FL)
Founder of Tissue Culture Laboratory (Institute for Molecular Biology and Endocrinology-Vinca-Belgrade)
Co-Founder of Neuroscience Research Institute, Inc.(NRI) for studying Autism (West Palm Beach, FL)
Co-laborator with Dr Shihong Huang and Dr Emmanuelle Tognoli in designing ongoing project on Autism Spectrum Disease and computer interaction in order to understand learning patterns of patients with ASD, evaluate the efficacy of the methodological approach and find eventual biomarker for that
Profound contribution with development of different programs and scientific stem cell research projects in SFBMSCTI (Boynton Beach)
Established the hypothesis and model for association of Parvovirus B19 and SLE at molecular level
Founder of the hypothesis and the model on the molecular association of Parvovirus B19 and Lupus disease, accepted for publication in LUPUS and as idea for grant proposal(LOI) from Lupus Alliance Foundation (2009)
Applied and modified the original method for cryopreservation of peripheral blood and bone marrow stem cells and introduced and modified the original Rubinstein’s method for cord blood cell cryopreservation for clinical purposes.
Modified the method for cord blood preservation for research studies with Dr J .X. Hartmann of FAU
Co-inventor in designing a novel fluorescent method for continuous measurement of hydrolytic activity of anti-DNA antibodies (2005)
Creator in designing Agilent (lab-on chip) method for determination of hydrolytic activity of anti-DNA antibodies
Co-creator of magnetic beads for extraction of lupus anti-DNA antibody producing cells and lupus anti-DNA antibodies
Patent # P0082930, February, 2011, FAU (Pavlovic et al.,)
Modified the method for isolation of aortic macrophages
Isolated and purified anti-ssDNA autoantibody from sera of the patients with SLE via SA – oligo- (dT) magnetic beads
Determined basic conditions for maintenance of binding and hydrolytic activities of isolated anti-DNA antibodies
Established quantitative ELISA system for determination of anti-ssDNA and anti-dsDNA antibodies
Evaluated the role of glutamine transport and metabolism in rat kidney mitochondria
Identified the role of fatty acids in uncoupling effects within Ehrlich Ascites Tumor Cells
Developed protocols for high-dietary fiber diets in treatment of diabetic patients
Developed a rat model for studying direct and metabolic alcohol effects in combination with different protein diets
Modified a broad spectrum of histochemical, immunohistochemical and electron microscopy methods
Identified and purified the autocrine growth factors in mouse melanoma model systems important for targeted antitumor therapy
Characterized kinetic properties of a particular carrier for antifolate drug 5,10-DDATHF in human leukemia cells important for tumor chemotherapy
Developed animal models for tumor glucose-metabolism modification studies related to radiation therapy
Introduced assays for apoptosis related to radiation therapy
Published over 90 papers in scientific journals and attended over 40 International scientific meetings
MANAGEMENT
• Research : Scientist/ Associate/Coordinator/Physician/Assistant Professor/Research Professor(visiting)
• Directed and supervised the work of university students (undergraduate, and graduate) and technicians
• Advisor to 5 honor student thesis in LUPUS (Dr Hartmann’s Lab –Biology)
• Secondary Advisor for ten MS and five PhD studies (thesis) at FAU
• Collaborated on research projects with other research groups at Yale and Univ of Penn and at International level (FAU/France/, Serbia/ Israel)
• Created the experimental designs for numerous grant applications in Lupus research (Autoimmunity) and written 27 grant applications at FAU as PI and Co-PI
• Establishment of liaisons for external collaboration/Belgrade, Serbia/ Bordoux, France in Stem Cell Research with the ultimate goal of making the bridge between basic and clinical sciences
• Establishment of liaisons with Dr Yehuda Shoenfeld, /Israel fountainhead of Autoimmunity with the ultimate goal to develop further the anti-DNA antibody research plan and write the Book on it.
• Establishment of liaisons with Nirma University, Ahmadabad, India (Institutes of Pharmacology, Biotechnology) and Science Center for further collaboration and University –based scholar exchange
• Development, Introduction and Perpetuation of 2 classes for Bioengineering : Introduction to Bioengineering and Tissue Engineering for postgraduate student
• Chemistry for Engineers combined with Lab Activities with Dr D.Meeroff
PROFESSIONAL EXPERIENCE
FLORIDA ATLANTIC UNIVERSITY-Dept. of computer sciences and engineering
Boca Raton, FL
Research and Adjunct Professor in Bioengineering 2009-present
FLORIDA ATLANTIC UNIVERSITY-Dept. of Biomedical Sciences, Boca Raton, FL 2008-2009
Consultant
FLORIDA ATLANTIC UNIVERSITY-Dept. of Biomedical Sciences, Immunology Laboratory, Boca Raton, FL
Research Assistant Professor in Immunology (Dr Shibata’s Lab) 2007-2008
FLORIDA ATLANTIC UNIVERSITY-Dept. of Biology, Immunology Laboratory, Boca Raton, FL
Research Associate (2001-5 officially-2007 on voluntary basis) 2001-2007
BONE MARROW STEM CELL TRANSPLANT INSTITUTE, Boynton Beach, FL
Research Coordinator (Research Physician) for Stem cell Research and Lab 2002-2008
NEUROSCIENCE RESEARCH INSTITUTE, INC., WEST PALM BEACH, FL (Non-Profit Org.)
Executive Research Director (Autism) 1998-2000
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE, PHILADELPHIA, PA
Postdoctoral Research Associate II 1994-1997
YALE UNIVERSITY SCHOOL OF MEDICINE, New Haven, CT
Visiting Scientist (Scholar) 1990-1991
Postdoctoral Associate I 1992-1993
INSTITUTE FOR NUCLEAR SCIENCES – VINCA
(Laboratory for Molecular Biology and Endocrinology) Belgrade, Yugoslavia
Senior Research Scientist/Associate Professor 1988-1990
INSTITUTE FOR MEDICAL RESEARCH,
Department of Nutrition, Belgrade, Yugoslavia
Research Scientist/Assistant Professor 1980-1988
INSTITUTE OF BIOCHEMISTRY, Medical Faculty, Novi Sad, Yugoslavia
Research Assistant Professor 1977-1980
INSTITUTE FOR MEDICAL RESEARCH AND CLINICAL HEMATOLOGY
Belgrade, Yugoslavia
Research Fellow 1973-1977
EDUCATION
SFBMSCTI
Stem cell and cord blood cell cryopreservation certified 2002 and 2004
Apheresis (PBMNC) collection certified 2002 and 2005
Worked as Research Physician and Research Coordinator 2002- 2008
UNIVERSITY OF BELGRADE, Belgrade, Yugoslavia
Ph.D. in BIOCHEMISTRY (METABOLIC ENDOCRINOLOGY) 1984
MS in HEMATOLOGY & EXPERIMENTAL IMMUNOLOGY 1980
National Board Exam for licensed Physicians (Yugoslavian) 1976
Internship 1973
MD 1972
TEACHING EXPERIENCE:
NIRMA UNIVERSITY AND SCIENCE CENTER-AHMADABAD INDIA:
LECTURES ON: AUTOIMMUNITY AND STEM CELL RESEARCH: FUNDAMENTAL AND COMPUTATIONAL APPROACHES
Sept.14-28-2009
A. The topics from Autoimmunity area
1. Autoimmunity: new concepts and classical diseases (with the best known examples)
2. Systemic lupus erythematosus (SLE): clinical features and immunological scenario
3. Immunotherapy of SLE: classical approach and new concepts-did they fail and why, if so?
4. Lupus anti-DNA -autoantibodies: Structure, Function and Pathogenicity:
a) Theory (compilation)
b) Experimental results
5. Parvovirus B19 and lupus: new insights into molecular aspects (association)
6. Recent Development of research field in anti-DNA antibody phenomenology in Autoimmune Diseases (AIDs)
B. The topics from Stem Cell research in:
1. Stem cells: spectrum and new concepts in basic research and regenerative therapy
2. Hypoxia and Stem cell therapy (research project proposal and preliminary data)
C. Additional topics
1. Apoptosis
2. Sickle cell anemia
3. Rheumatoid arthritis, Sjogren Syndrome, Multiple Sclerosis as examples of Autoimmune Diseases
4. Practical Consideration on the techniques: ELISA, Western Blot, Lab-on-Chip, Confocal Microscopy (Immunostaining)
5. Cancerogenesis
6. Tissue culture (animal and plant)
FLORIDA ATLANTIC UNIVERSITY, Boca Raton, USA
Engineering Chemistry and Lab Fall Course (EGN2095) 2011
Introduction into Bioengineering Spring Course 2010, 2011
Tissue Engineering Fall Course 2010, 2011
Systemic Lupus Erythematosus (Dr Hartmann’s Immunology classes) 2002-2005
UNIVERSITY OF BELGRADE, DEPT. OF MOLECULAR BIOLOGY, BELGRADE, YUGOSLAVIA
Oncogenes and Growth Factors in Malignant Cells 1988-1990
MILITARY ACADEMY MEDICAL SCHOOL, BELGRADE, YUGOSLAVIA
Structure, Function and Pathology of D-iffuse N-euro E-endocrine S-system 1986-1990
UNIVERSITY OF NOVI SAD MEDICAL SCHOOL, YUGOSLAVIA
Biochemistry 1977-1980
INVITED SPEAKER:
• FAU: From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: new horizons in the light of new data VGIT Workshop, October 14 2011
• FAU: Bio-Med : Immunology Journal Club Seminars : Anti DNA antibodies: 2011
What is the role of anti-DNA antibodies in lupus?
• FAU : CENTER FOR COMPLEX SYSTEMS AND BRAIN SCIENCES Journal
Discussion Club: NEUROBIOLOGY OF AUTISM SPECTRUM DISORDERS 2011
• FAU: The origin and theories of DNA 2011
Dr Van Hilst’s Class for freshmen
• FAU: Dr Shihong Huang’s Lab
AUTISM: DIRECTIONS 2011
• DERMIKIND OPEN HOUSE (Dr Natalia Hegedosh and Dr Rajendra Gupta)
How to bridge time: stem-cell application in aging 2011
• FAU: CENTER FOR COMPLEX SYSTEMS AND BRAIN SCIENCES
-HBBL/Dr Scott Kelso’s Lab 2011
AUTISM DIRECTIONS (20 min within Dr Shihong Huang’s presentation on the PROJECT)
• FAU: Dr Nurgun Erdol’s Classes:
Biosignal Processing: excitable tissues 2011
• FAU: Dr Grazyna Pajunen’s Classes 2010
Stem-cell regenerative therapy
Regeneration, Degeneration and dedifferentiation
Biomagnetism
• NIRMA UNIVERSITY AND SCIENCE INSTITUTE, AHMEDABAD,INDIA:
Hypoxia and Stem Cell Therapy for Myocardial Repair and Revascularization, Sept.24th, 2009
▪ FLORIDA ATLANTIC UNIVERSITY-Vice President of the Research Invitation
Hypoxia and Stem Cell Therapy for Myocardial Repair and Revascularization
December 19th, 2005
▪ FLORIDA ATLANTIC UNIVERSITY-BIOMED March 17th, 2005
Structure, Binding and Function of anti-DNA antibodies
▪ CALIFORNIA PACIFIC MEDICAL CENTER-RESEARCH DEPARTMENT June 9th, 2000
Molecular Form and Kinetic Properties of the Phosphate Dependent Glutaminase (PDG)
And Transport of Glutamine in Mitochondria Isolated From Kidneys of Normal and
Acidotic Rats
▪ UNIVERSITY OF NOVI SAD, DEPT. OF PEDIATRICS –YUGOSLAVIA 1986
Structure, Function and Pathology of Diffuse Neuroendocrine System: Electron Microscopy Study
AWARDS AND HONORS
▪ Guest Editor for IJBRA Special Issue on “Viral DNA Analysis and Rational Vaccine Design”, 2010-2011
▪ Republic Fund of Serbia Fellowship, Yale University School of Medicine
▪ Department of Dermatology Dr. Ruth Halaban & Dr. John Pawelek 1990-1991
▪ Republic Fund of Serbia Fellowship, London, UK, Hammersmith Hospital
▪ Department of Immunocytochemistry, Dr.Julia Polak 1985
▪ Federal European Biochemistry Society Fellowship, ETH, Zurich, Switzerland
▪ Laboratory for Bioenergetics, Dr. Ernesto Carafoli 1978
▪ Research Council of Serbia Fellowship for Young Talents 1973-1977
▪ Nirma University Center, Ahmadabad, India, Teaching grant September, 2009 ($15,000)
MEMBERSHIPS:
▪ Member of International Review Board for MDMedical Data Journal 2009-present
▪ Member of International Advisory Board Scripta Medica 2010-present
▪ Member of Union of Serbian professional writers/poets 2006-present
▪ Member of International Poetry Society 2005-2008
RESEARCH INTEREST AND EXPERTISE
A. Stem Cell Research : Fundamental studies including bioinformatics and medical engineering and clinical application (stem cell therapy)
B. Autoimmunity and autoimmune diseases: fundamental studies and clinical application
C. Anti-DNA autantibodies and Immunotherapy
D. Autism and Asperger’s Syndrome ( molecular and clinical aspects)
E. Mitochondrial Respiration (transport, bioenergetics and mitochondrial diseases)
F. Nutrition and Metabolism ( metabolic diseases, direct and metabolic effects of alcohol)
G. D-iffuse N-euro-Endocrine S-ystem : morphological and functional aspects
H. Cancerogenesis: differentiation, immunological, metabolic, and antitumor therapy aspects
I. Bioengineering, Tissue Engineering and Bioinformatics
RECENT MENTORSHIP AND THESIS COMMEETEE MEMBERSHP:
DIS MS and PhD theses in different stages, with different degree of help:
• (DIS)
Michaela Drinkwater MS-Coordinator (The role of Iodine in ASD)
Rafia Saqib: Co-adviser with Dr Roth as adviser (Energetic metabolism in mitochondria-beginning)
• (MS)
Francisco Amador (Consultant, Committee member graduated)
Vivek Tyagi, (Consultant, Committee member, 2 papers on stem cells, graduated)
Baishali Chaudury, (Co-mentor with Dr A.Pandya, 1 paper, graduated)
Jake Peterson (Co-mentor with Dr S, Huang, MS thesis defended, paper writing in progress)
Deepty Papusetti (Consultant –Committee member, 2 papers)
• (PhD)
Sophie Banton (Consultant with Dr Roth as a mentor, 3 papers, 3 presentations, PhD thesis in procress)
Army Ambrose, (Committee member, PhD thesis done)
Sharmistha Chatterjee, (Co-menthor w, Dr Neelakanta 2 papers, in progress, thesis proposal)
Anna Kats, (Co-mentor with Dr Hartmann 4 papers, 6 International presentations, one patent filed, twelve grants written, in progress)
George Morales, (Consultant and Committee member with Dr Zhuang, 2 papers and 2 presentations, graduated)
Reena Cherukuri, (Committee member with Dr A.Pandya, based upon Baishali’s studies, in progress)
Alex Kotlarchyk, (Consultant and Committee member with Dr Pandya,1 NIH grant written, 1 presentation accepted, one paper accepted, PhD thesis defended)
Sheryl LaFleur (Consultant with Dr Cardei, 1 grant written, switched to different problem, in progress)
TECHNICAL SKILLS
A. BLOOD BANKING
o Adult peripheral blood stem cell collection and freezing
o Stem cell thawing and re-infusion (transplantation-autologous transplant)
o Cord blood cell banking for clinical and research studies
o SOPs development
o Establishment of liaisons with different companies and organizations (WIRB, AnorMed, PPD, Maxim, Dendreon, Holy Cross, Baxter, etc).
B. IMMUNOLOGICAL TECHNIQUES
o Lymphocyte blastic transformation (with PHA)
o Macrophages migration inhibition test (MIF)
o ELISA
o Immunomagnetic beads techniques for positive and negative cell selection (Dynal beads)
o Separation of PBMCs from the whole blood
o T and B lymphocyte separation through nylon wool
o Separation and immunofluorescent staining of mouse alveolar, peritoneal and bone marrow macrophages to Cox1 , Cox-2 and iNOS
o Growing dendritic cells
o Cell fusion using PEG
o Cytotoxicity assays (MTTX and radioactive chromium release)
o Proliferation Assay using 3H Thymidine
o Immunostaining for FC
o Antibody isolation via magnetic beads (co-creator of the method)
o Hydrolytic assay for anti-DNA antibodies- using dual labeled fluorescent probe and Fluoroskan II
o Viability assays
C. CELL BIOLOGY TECHNIQUES AND EQUIPMENTS
a. OPTICAL, CONFOCAL AND ELECTRON MICROSCOPY
1. Cytology and cytochemistry of peripheral blood cells (smears and EM samples)
2. Morphological, histochemical and immunohistochemical evaluation of various cell and tissue integrity (especially blood cells and cells and tissues of Diffuse Neuroendicrine System under optical e.g., light & confocal) and electron microscope
3. Histochemical and immunohistochemical detection of enzymes, receptors, peptide hormones and amines
4. Co-localization and coexistence studies
5. Apoptosis studies (PI staining, electron microscope micrographs)
6. Immunofluorescent labeling of Cox1 and Cox2 for confocal microscopy : visualization and photography
7. Fixation, embedding, cutting and staining procedures for both optical and electron microscopy
8. Handling the equipment.
b. FLOW CYTOMETRY
1. Prep acquisition and Propidium Iodide Staining
2. The basic use of Flow equipment for PI staining (FACS-Course at PENN Cancer Center)
c. CELL TISSUE CULTURE TECHNIQUES
1. Primary melanocyte and melanoma cultures production from both mice and humans
2. Maintenance and processing both
Cell suspension (CCRF-CEM, HL-60 lymphocytic) and
Cell monolayer (melanocytes, melanoma, 9-L-glioma, colon 38 and 26 adenocarcinoma, mammary adenocarcinoma) tissue culture
3. Growth curves in normal and pathological conditions
4. Determination of ED50 after drug application
5. Plating efficiency experiments
6. Irradiation
D. BIOCHEMICAL TECHNIQUES
a) MITOCHONDRIAL STUDIES (BIOENERGETICS)
1. Isolation of mitochondria in sucrose medium
2. Purification of mitochondria through Ficoll gradient
3. Oxygen electrode respiration studies (the use of transport and ATP-ase inhibitors)
4. Transport studies followed by double-beam spectrophotometer
5. HPLC separation of nucleotides (ADP, ATP, CTP, CDP, UTP, UDP)
6. The use of ion-selective electrodes
7. Radioactive labeling and calculation of mitochondrial compartments
b) ENZYME STUDIES
1. Investigation of the biochemical nature, molecular form and kinetic properties of intramitochondrial enzyme P-hosphate D-ependent G-lutaminase (PDG)
▪ Michaelis-Manten kinetics (V max, Michaelis constant –Km-, Hill’s coefficient, Arrhenius plot)
▪ radioactive labeling (3H, 14C)
▪ purification through anion-exchange chromatography (Dowex)
▪ the use of Geiger-Muller and Scintillation counter
▪ the use of sulphydryl inhibitors (NEM, Mersalyl, etc.)
2. Histochemical, immunohistochemical and biochemical (spectrophotometric) detection of enzymes in peripheral blood cells, DNES and tumor tissues (glycolytic enzymes, ALP, myeloperoxidase, acid phosphatase, etc.)
3. Quantitative detection of Tyrosinase enzyme activity through radioactive labeling and charcoal-column (Dowex) chromatography in melanoma cell extract.
c) RECEPTOR and CARRIER STUDIES
1. Identification and Scatchard analysis for gluccocorticoid receptors in melanoma cells
2. Transport studies (3H labeling & Michaelis Manten & Scatchard analysis) of intramembrane protein carrier for antifolate drug 5, 10-DDATHF
3. HPLC analysis of metabolic products of DDATHF (polyglutamates)
4. Receptor visualization through EM studies
d) PROTEIN (ENZYME) PURIFICATION AND DETERMINATION
1. Elementary steps in protein (enzyme) separation and differentiation
▪ pH sensitivity
▪ temperature sensitivity
▪ protease digestion
▪ CaCO3 binding
▪ affinity chromatography purification through Wheat-Germ-Agglutinin/NAGA buffer elution
▪ purification through Biogel P-60 (column chromatography) and SDS-PAGE electrophoresis analysis after fraction collector and lyophylisation
▪ the use of sulphydryl reagents in evaluation of the nature of protein
▪ (These techniques were applied to identification of proteinaceous factor in melanoma cells postulated to transduce the UV signal, and to the growth factors isolated from mouse melanoma cells)
▪ the use of magnetic beads (Dynal) such as SA coated and protein G beads for antibody isolation
2. Protein concentration determination (Bradford, Lowry, Biuret, BioRad, etc.)
3. Electrophoresis
▪ disc-gel (LDH enzyme isoforms)
▪ SDS-PAGE, Laemmli (melanoma growth factors)
▪ PhastGel Electrophoresis (Native PAGE-, SDS-PAGE0 gradient 4-15)
▪ PhastGel Isoelectric Focusing
▪ Agarose (3%) gel with ethidium bromide staining for DNA and nucleotides
4. Protein concentration procedure (Centricon, Amicon filters)
5. Melon-gel and ssDNA IgG and anti-DNA antibody purification
E. MOLECULAR BIOLOGY TECHNIQUES
1. DNA isolation
2. RNA isolation
3. PCR(classical version)
4. Western Blott (Phast-Gel System) and classical WB
F. LABORATORY ANIMAL PROCEDURES (Mice & Rats)
1. Injection (i.p., s.c. and i.m.)
2. Dissection and tissue sample processing for histochemical, immunohistochemical, HPLC, NMR and fluorescence studies
3. Heart puncture
4. Retro-orbital bleeding
5. Manipulation with anesthetics
6. Tumor transplantation
7. Irradiation
8. NMR in vivo studies
G, COMPUTER SKILLS (MAC and PC, beside common)
1. Chemintosh
2. Ovid-Medline(PubMed)
3. Publisher
4. Visitrax (Data Entry), etc.
TRACK OF GRANT PROPOSALS WRITING at FAU (2002-2010):
1. Stimmulation of the donor immune system with dendritic cells (dcs) developed by the use of Flt-3 ligand. NIH, 2002
2. Immunotherapy using autologous immature dendritic cells. NIH 2004
3. A novel method for detection of Lupus Anti-DNA Antibody Hydrolytic Activity. Alliance Lupus Research Grant, 2006
4. A novel methodological approach to discriminate molecular mechanisms involved in pathogenicity of anti-DNA Abs in SLE. NIH AREA GRANT, 2006
5. Development of Fluorescence-based Assay for detection and Testing of Hydrolytic
Activity of Anti-DNA Antibodies in Patients with Systemic Lupus Erythematosus.Lupus Foundation Grant, 2006
6. Pavlovic M,PI: Th-17 cell-IL23-mediated responses: proposed regulation (modulation) by spleen PGE-2 releasing macrophages in BCG-immunized mice, 2008 (prepared for Dr Shibata)
7. Development of Fluorescence-Based Assay for detection and Testing of Hydrolytic Activity of Anti-DNA Antibodies in Patients with Systemic Lupus Erythematosus. Lupus Alliance grant, 2008
8. The use of iodine in Asperger Syndrome: An electrophysiological study. Autism Speaks Grant Proposal ,LOI (the idea) accepted December 1st, 2008, grant proposal in writing, sent date February 10th,2009
9. The electropysiological profiling in group of youngsters with Asperger Syndrome (Grant for Department of Defense, LOI (idea) sent out on March 17th. Rejected.
10. A novel approach in Improvement of auditive and cognitive functions in Aphasia due to stroke. Grant in writing for NIH, 2009
11. The electropysiological profiling in group of youngsters with ASD. ( NIH Grant )
12. Designing computer-based interaction for children with Asperger’s Syndrome (Grant for NIH , 2009)
13. microRNAs as potential biomarkers off B-lymphocytes activation in SLE determined by combined bioinformatics and molecular approaches. ( NIH Callenge grant, submitted April 27th, 2009)
14. Development of Novel highly sensitive Assays for Measurement of Hydrolytic Activity of Lupus Anti-DNA antibodie’s (NIH Challenge grant, submitted April 27th, 2009)
15. Open Source Wearable Computing and Real-time Sensing Platform for Continuous Health Monitoring and Feedback( NIH Callenge grant, submitted April 27th, 2009)
16. Analysis of the Hydrolytic and Apoptotic Activities of Highly Purified Anti-DNA Antibodies from Lupus Patients (Real-time measurement of anti-DNA antibody hydrolytic activity) (Lupus Research Foundation, submitted April, 2009 expected, November, 2009)
17. The molecular association between Parvovirus B19 and and SLE : Platform for preventive and curative vaccination (LOI for ALR, accepeted; grant submitted July 30th)
18. Utilizing health Information technology (IT) to improve Agency for health Care Research and Quality(NIH Challange grant, resubmition), 2009
19. FAU Priority Grant: Dr Rhodes, IMAGING : Dr Pavlovic, 2010 : The use of FRET in molecular and stem cell bioengineering
20. FAU Priority Grant: Dr West, 2010 Medicines from the OCEAN; Dr Pavlovic: Development of highly sensitive assays for detection of anti-DNA antibodies in autoimmune diseases and determination of the effect of drugs from the ocean upon their secretion and activity
21. Priority Grant: Dr Huang, Dr Pavlovic: Development of Atavar for treatment of Asperger’s Syndrome, 2010
22. Asperger March, Huang, Pavlovic, Danesh, (LOI) 2010 (similar)
23. LRI, May 28th, Pavlovic, Hartmann, Neelakanta, Shoenfeld, 2010: Development of novel assay for real-time measurement, monitoring and prediction of hydrolytic activities of lupus anti-DNA antibodies
24. Shihong Huang,PI, Mirjana PavlovicCo-PI, Ali Danesh, Co-PI: Web-based Interaction System for Children with Asperger's Syndrome .Asperger, June 5th, 2010, RO1NIH grant proposal
25. Monitoring Childhood Obesity for School Food Program Participants Using a Wireless Body Area Network June 29th,PI, I.Cardei,Co-PI, Mirjana Pavlovic, 2010,USDA
26. Pavlovic M, Roth Z, Blanks J,Nouri-Shirazi M, Hartmann J, Neelakanta P, Hartmann J and Zhuang H: Development of novel assay for real-time measurement, monitoring and prediction of hydrolytic activities of lupus anti-DNA antibodies EARMARK, 2010
27. Pavlovic, M : Topics in Autoimmunity and Cancer/Stem cell research – Nirma University, Ahmedavad, India, Teaching grant, $15000, 2009
28. MMS-STE Curriculum for Middle Schools Biomedical Engineering Development : 2 Modules in development :close to end :1.Cells and genes and 2. Gene Therapy and Immuno-Therapy (Form: done, LAB MANUAL: Teacher guiding part, Lab activities part , PP for teachers , Activities ).
WORK ON DEVELOPMENT OF BIOENGINEERING AND TISSUE ENGINEERING LAB
(during Winter-Spring time of 2011, in Civil Engineering Building, #36) under supervision of Dr Zvi Roth
Leading and creative role:
• Conceptual design
• Design of Lab Manuels
• Work with vendors and representatives
• Distinction between Teaching and Research Lab
• Key instrumentation including conversation, meetings and all kind of contacts with representatives
• Key chemicals and other stuff- necessities for teaching and research (each possible called and found)
• Classification of all data-designs and materials
• Meetings with Brenda and Architects
• Collaboration with Drs Dan Meeroff and Zvi Roth
SELECTED PUBLICATIONS:
1. Pavlovic M , et al.: Hydrolysis of Lupus anti-DNA antibody(in preparation) :
2. Lloyd B, Kats A, Caruso J, Milton S, Hartmann J and Pavlovic, M: Hydrolysis of viral DNA by IgM and IgY immunoglobulines from Trachemys scripta plasma.( in preparation )
3. Pavlovic M and Roshanak Hashemiyoon: Progress in Neurobiology of autism (in preparation)
4. Anna Kats and Pavlovic M: Inflammasomes (in preparation)
5. Pavlovic M and Shoenfeld Y: Safe vaccine for lupus (in preparation)
6. Yehuda Shoenfeld and Pavlovic M: Vaccines that are not safe in lupus (in preparation)
7. Pavlovic, M., Caruso, J.P., (equal contributors) Milton, S., Barahona, L., Kats, A.M., and Hartmann, J.X.: Free immunoglobulin light and heavy chains in normal Trachemys scripta plasma. (Ready for submission to Journal of Developmental & Comparative Immunology).
8. Pavlovic M, Michaela Drinkwater and Danesh A: The role of iodine in normalcy and Autism (New Hypothesis). Accepted for publication in MD Medical Data (November, 2011)-to be condensed for final submission
9. Kats A., Pavlovic M, Michelle Cavallo and James X.Hartmann : Comparison of two different methods for isolation and purification of anti –DNA autoantibody reactive with ssDNA ( submitted to ISRN Immunology, # 694760- in revision)
10. Chen R, Pavlovic M, (equal contributors) Kats A, Cavallo M, and Hartmann JX: Modification of a novel Approach to the Study of Anti-DNA Antibody from Normal and Diseased Human Sera. (Submitted to JBB # Manuscript ID JBB/842304).
11. Koltarchyk A., Koshgaftaar T, Pavlovic M, Zhuang H, Pandya A: Identification of MicroRNA Biomarkers for Cancer by Combining Multiple Feature Selection Techniques. (accepted for publicarion in JCMSE),2011
12. Stanojkovic Z, Balint B, Antic A, Todorovic M, Pavlovic M: Clinical efficacy of riboflavin and ultraviolet light inactivated fresh frozen plasma evaluated with INR-quantification. Submitted to Trans Afer Sci # not given yet)
13. Chatterjee S, Pappusetty D, Neelakanta PS, and Pavlovic M: A Cohesive Effort in Analysing Genomic Sequences and a Bioinformatics-inspired Suite for Image Classification. Submitted to IJCTE
14. Balint B, Stamatovic D, Todorovic M, Elez M, Vojvodic D,Pavlovic M ,Cucuz-Jokic Ml: Autologous Transplant in Aplastic Anemia:A case report. Quantity of CD34+/CD 90+ subsets as the predictor of clinical outcome.in press: Trans Afer Sci.2011(Epub ahead of print) PMID218711837
15. Pavlovic M, Cavallo M, Kats A, Kotlarchyk A, Zhuang H and Shoenfeld Y: From Pauling’s Abzyme Concept to the New era of Hydrolytic Anti-DNA autoatnibodies: A link to the rational vaccine design? Special Issue of IJBRA (guest editor), 7,3:220-238, 2011
16. Morales G, Zhuang H , Pavlovic M: Modeling N-Node Myelinated Neuron Axon with System Identification Approach MD Medical data ,2011, Vol.3, No2, pp: 119-126
17. Morales G, Zhuang H, Pavlovic M: An N-Node Myelinated Axon Model: A System Identification Approach, Proceedings of the 5th International IEEE-EMBS Conference on Neural Engineering, Cancun, Mexico, April 27-May 1, 2011:161-165
18. Neelakanta P, Pavlovic M, Zhuang H: It is imperative that therapeutic options in modern medical science emphasise on strategies. Introduction. International journal of bioinformatics research and applications IJBRA) 01/2011; 7(3):217-9.
19. Neelakanta PS, Chatterjee S, Pavlovic M, Pandya A, de Groff D: Fuzzy splicing in precursor-mRNA sequences : prediction of abberant splice-junctions in viral DNA context. J. Biomed.Sci Eng. 4:270-279, 2011
20. Neelakanta PS, Chatterjee S, Papusetty D., Pavlovic M and Pandya A.: Information-theoretic Algorithms in Bioinformatics and Bio-/Medical-imaging : A review. International Conference on Recent Trends in Information Technology (ICRTIT 2011), MIT, Anna University, Chennai, India, June 03-05, 2011.Best paper presentation.
21. Banton S, Pavlovic M and Roth Z: Novel Epitopes of the Ebola Virus for Rational Vaccine Design: Therapeutic Development and Protein Conservation. Submitted to ISBM-2010 Conference paper, 2010 (accepted)
22. Banton S, Pavlovic M and Roth Z: A bioengineering approach for rational vaccine design towards the Ebola Virus. Sixth International Society for Computational Biology (ISCB) Student Council Symposium Boston, MA, USA. 9 July 2010. BMC Bioinformatics 2010, 11(Suppl 10):O12 –2105/11/S10/O12
23. Banton S, Roth Z, Pavlovic M: Mathematical Modeling of Ebola Virus Dynamics as a Step toward Rational Vaccine Design .26th Southern Biomedical Engineering Conference SBEC 2010, April 30 – May 2, 2010, College Park, Maryland, USA by Keith E. Herold, Jafar Vossoughi and William E. Bentley. Berlin: Springer, 2010. ISBN: 978–3–642–14997–9
24. Chaudhury, B, Pandya A, Pavlovic, M and Danesh A: Development of an Interactive Tinnitus Analyzer Tool for Individual Profiling of Tinnitus Perception”, accepted in 32nd Annual International IEEE EMBS, Conference of the IEEE Engineering in Medicine and Biology Society, Buenos Aires, Argentina during August 31 - September 4, 2010.
25. Chaudhury,B, Pandya, A, Pavlovic M and Danesh A: Individual Profiling of Tinnitus Perception by developing Interactive Tinnitus Analyzer Software”, accepted in 4th International TRI Tinnitus Conference 2010, Dallas, Texas, June 9th to 11th.
26. Pavlovic M., Kats A, Cavallo M, Chen R, Shoenfeld Y and Hartmann JX.: Epiphenomenal and pathogenic Anti-DNA antibodies: Structure , Binding, Function , and Pathogenicity. Autoimmune Diseases, SAGE-Hindawi Access to ResearchAutoimmune Diseases, Volume 2010, Article ID 462841, 18 pages, doi:10.4061/2010/462841
27. Danesh, A. A., Cocchiola, E. & Pavlovic, M. (2010). Clinical Update: Hearing Loss and Advancements in Cochlear Hair Cell Regeneration. Med Data Rev, Vol 2, No 1. pp 25-28.
28. Pavlovic M, Kats A, Cavallo M, Shoenfeld Y: Clinical and molecular evidence for association of SLE with parvovirus B19. LUPUS; 2010, 19, 7: 783-792 (2010)
29. Balint B, Pavlovic M et al.: The use of simplified ex vivo immunoadsorption and
"multi-manner" apheresis in ABO/H-mismatched kidney transplant setting
phase II clinical study. Transf. Apher. Science, 2010, 43 (2):pp141-8.
30. Pavlovic M, Todorovic M, Todorovic V, Tyagi V, and Balint B: Adult Stem Cell Research and Regenerative Therapy in Neurological Diseases : Limitations and Perspectives Part I. Basic Research data necessary for Understanding Stem cell Treatment Approaches in Neuro-Regenerative Therapy. Anest Reanim Transfuziol vol. 55, iss. 1-2, pp. 4-14, 2009
31. Pavlovic M, Todorovic M, Todorovic V, Tyagi V, and Balint B: Adult Stem Cell Research and Regenerative Therapy in Neurological Diseases : Limitations and Perspectives Part II. Neurological Diseases and Stem Cell Therapy Anest Reanim Transfuziol 55, iss. 1-2, pp. 15-30, 2009
32. Ivanovic Z, Ardilouze L, Jeanne M, Bertot A, Lafarge X, Duchez P, Vlaski M, Milpied N, Pavlovic, M, Kovacevic-Filipovic M, Boiron JM, Praloran V.: CD34+ cells obtained from "good mobilizers" are more activated and exhibit lower ex vivo expansion efficiency than their counterparts from "poor mobilizers". Transfusion, 2009 50(1):pp.120-127
33. Todorovic, M., Balint B., Pavlovic M, et al: Splenectomy with chemotherapy vs. surgery alone as the initial treatment for splenic marginal zone lymphoma: a pilot clinical study. WJG, (ISSN 1007-9327), 2009, 15(32): 4009-4015
34. Pavlovic M. : Biomineralization and nanobacteria: at the door of the new concept? Med Data Rev: 1, 2: 21-24, 2009
35. Pavlovic, M: The role of anti-DNA antibodies in Systemic Lupus Erythematosus : ranges and perspectives .Mel Data Rev,1,1 :7-11, 2009
36. Pavlovic, M.: Th-17 cell IL-23 pathway - mediated immune responses : is there a regulation by PGE2-releasing macrophages in BCG-immunized mice ?Literature review and up-date. Med Data Rev, 1,1,: 24-31, 2009
37. Pandya AS, Nitta Y, Kinouchi Y and Pavlovic M: Intelligent systems for prediction of Hematocrit value during blood transfusion, Proceedings of International Symposium on Biomedical Engineering Hematocrit value during blood transfusion, Proceedings of International Symposium on Biomedical Engineering and Related Technologies, Tokushima, Japan, March 7, 2009 , pp. 52-66, 2009. and Related Technologies, Tokushima, Japan, March 7, 2009, pp. 58-72,
38. Pavlovic, M.: VSELs concept (Review) 2008 , MNE Medica, No 1, Year I, Jul 2008, pp 16-17,ref. p.43
39. Balint*,B, Marika Ljubenov*, Dragana Stamatović†, Milena Todorović║, Pavlovic M, Gordana Ostojić*, Miodrag Jocić*, Miroljub Trkuljić*. Stem Cell Harvestiing Protocol research: in autologous transplantation setting: large volume versus conventional cytapheresis, Vojnosanit Pregl.(VSP) 2008 Jul;65(7):545-51
40. Shibata, Y, Ruth Ann Henriksen, Quentin N Myrvik, Harni Pate1, Pavlovic, MD, Shizuka Shinohara, Traci Pantuso and Tsutomu Shinohara. Persistent pulmonary inflammation and cyclooxygenase -1 and -2 modifications in alveolar macrophages following in vivo phagocytosis of mycobacteria The FASEB Journal. 2008;22:860.5
41. Todorovic,M, B. Balint, N. Suvajdzic, M. Jevtic, Pavlovic, M, M. Petrovic, M. Krstic, V. Popovic, B. Ivanovic, I. Elezovic, R. Milenkovic and M. Colovic: 2008 Triple–way therapeutic approach for paraganglioma–dependent erythrocytosis: drugs and surgery plus "multi–manner" apheresis Medical Oncology 25,2:148-53
42. Pavlovic M, R.Chen, A. Kats, M.Cavallo, S. Saccocio, P. Keating and J. X.Hartmann: Highly specific novel method for isolation and purification of lupus anti -DNA antibody via oligo- (dT) magnetic beads, 2007. (ID Annals-1381-002, Vol.title: The Science of Autoimmunity: Cutting Edge: Advances in Basic Sciences). Ann. N.Y. Acad. Sci. 2007, 1108: 203–217
43. Milićevic Z T, Petković M.Z., Drndarević NC, Pavlović, MD, Todorović VN. (2007): Expression of heat shcok protein 70 (HSP70) in patients with colorectal adenocarcinoma - Immunochemistry and Western-blot analysis. Neoplasma, 54 (1) : 37-45
44. Todorovic M, Pavlovic M, Balint B, Kraguljac N, Mihaljevic B, Bogdanovic A, Elezovic I, Boskovic D, Colovic M. Immunophenotypic Profile and Clinical Characteristics in Patients with Advanced Stage of Mantle Cell Lymphoma . Med Oncol, 2007;24,4:413-8
45. Krstic N M, Bjelakovic SM. Zizak Z, Juranic Z, Pavlovic MD and Pavlovic V: Synthesis of Some Steroidal Oximes, Lactams, Thiolactams and their Antitumor Activities. Steroids. 2007 May; 72 (5):406-14.
46. Balint B,Stamatovic D,Todorovic M,Jevtic M,Ostojic G ,Pavlovic M, Lojpur Z, Jocic M:Stem cells in the arrangement of bone marrow repopulation and regenerative medicine. Vojnosanit Pregl. (VSP) 2007,64,7:481-4
47. Balint B, Pavlovic, M, Jevtic M, Hrvacevic R, Ignjatovic Lj , Mijuskovic Z, Blagojevic R, Trkuljic M.
Simple "Closed-cirquit" group–specific immunoadsorption system for ABO–Incompatible kidney transplants Transfus Apher Sci 2007, 36(3):225-33
48. Pavlovic M, Balint B. The use of stem cells to repair cardiac tissue. Anest Reanim Transfuziol 2006; 34: 129–50.
49. Balint B, Todorovic M, Pavlovic M, Elez M, Urošević I, Obradovic S, Rafajlovski S. Stem cells – application for marrow repopulation and in regenerative medicine. Anest Reanim Transfuziol 2006; 34: 151–6.
50. Balint B, Pavlovic M. Stem cells – biology, harvesting, extracorporeal purification and some aspects of their clinical application. Bilt Transf. 2006; 52(2–3): 2–10.
51. Balint, B., Vucetic D., Draskovic B.,Vojvodic D., Brajuskovic G.,Colic, M., Pavlovic M. (2006). Cytapheresis in the treatment of cell-affected blood disorders and abnormalities” Transfus Apher Sci, 2006, 35 (1) : 25-31
52. Vukavic T, Dosen R, Pavlovic M, Skaro-Milic N (2002). Enterocyte ultrastructural features in neonatal pig preceeding guts closure. J Pediatr Gastroenterol Nutr; 34(4):455
53. Wroblewski, K., Fujioka H., Pavlovic, M., Schmidt, N., Jenkins, T, Graczyk-Milbrand G., Chance B. and Biaglow J.E (1998) : Effect of Meta-iodobenzguanidine on pH and Oxygenation of 9L Glioma in vivo. Proceedings of the International Society for Magnetic Resonance in Medicine (Sixth Scientific Meeting and Exhibition ) Sydney, Australia, April 18-24,1998,3, ISSN1065-9889 : 1645
54. Pavlovic, M., Wroblewski K., Manevich, Y., Kim S., and Biaglow J.E. (1996): The Importance of Choice of Anesthetics in Studying Radiation Effects in the 9L rat Glioma. Br J Cancer, Suppl. XXVII, SS222-S225
55. Pavlovic, M., Leffert J.J., Russello O., Bunny MA, Priest DG, Beardsley G.P., and Pizzorno G (1993): Altered Transport of Folic Acid and Antifolates through The Carrier Mediated Reduced Folate Transport System in a Human Leukemia Cell Line Resistant to 5, 10-Dideazatetrahydrofolic Acid (DDATHF) 1993. In: Chemistry and Biology of Pteridines (Ailing, Blau and Nair, eds.). Plenum Press, New York. Adv Exp Med Biol : 775-778
56. Koko, V., Pavlovic, M., Laban, A., Radovanovic, J., Nikolic, A., Petronijevic, J., and Ristic, M. (1992): A Stereological Investigation of Rat Endocrine Pancreas after a Long-Term Low-Protein Diet. Pancreas, 7 (6) : 672-679
57. Ristic, A., Djordjevic-Markovic, R., Pavlovic, M., Krsmanovic, B., and Kanazir, D (1991): The Effect of Glucocorticoid and Antiglucocorticoid Hormones on the Growth of Mouse Melanoma Cells. In: Anticarcenogenesis and Radiation Protection 2. Strategies in Protection from Radiation and Cancer. (ed. O.F. Nygard and A.C. Upton) Plenum Press, New York : 401-403
58. Todorovic, V., Pavlovic, M., and Ristic, M (1989): The effect of hypoprotein nutrition upon the alkaline phosphatase enzyme activity and glycogen content in the rat peripheral blood granulocytes. Food and Nutrition (Hrana i Ishrana) 5-6 : 34-41,
59. Koko, V., Pavlovic, M., Laban, A., Radovanovic, J., Milanovic, M., and Ristic, M (1988): Rat endocrine pancreas after chronic alcohol treatment. Stereological Analysis. Yug Physiot Pharmacol Acta 24, Suppl. 6 : 195-196 (Proceedings of the 14th Congress of the Yugoslav Physiological Society, Belgrade, September 20-24)
60. Pavlovic, M., Todorovic, V., and Spasic, P (1989): The Ultrastructural Study of Rat Enterocytes During Chronic Ethanol Intake. Proceedings of III Balkan Congress on Electron Microscopy, Athens, Greece, 18-22 September, 1989 : 420-421
61. Todorovic, V., Varagic, J., Koko, V., Pavlovic, M. and Ristic, M (1989): Hypoprotein nutrition and ultrastructural features of the rat gastric fundus mucosal endocrine cells. Proceedings of the 6th Yugoslavian Symposium for Electron Microscopy, Sarajevo-Igman, May 29-June 1, 1989. 11-112.
62. Pavlovic, M., Todorovic, V., Koko, V. and Spasic, P. (1989): The effect of long-term hypoprotein diet upon quantitative and ultrastructural status of the rat duodenal APUD-system cells. Proceedings of the 6th Yugoslavian Symposium for Electron Microscopy, Sarajevo-Igman, May 29-June 1, 1989 : 11-112
63. Todorovic, V., Pavlovic, M., and Ristic, M. (1989). : The effect of hypoprotein nutrition upon the alkaline phosphatase enzyme activity and glycogen content in the rat peripheral blood granulocytes. Food and Nutrition,(Hrana i Ishrana)5-6,:34-41
64. Pavlovic, M., Todorovic, V., Petrovic, G., and Ristic, M. (1988). Normoprotein diet, long-term hydrocortisone intake and histological-histochemical features of the rat gastric mucosa. Srp Arh Celok Lek, 116 (11-12) : 957-966
65. Todorovic, V., Pavlovic, M., and Ristic, M. (1988): Hypoprotein nutrition, phospholipid content and phagocytic ability of the rat peripheral blood granulocytes. Acta med. Iug., 42(5) : 363-372
66. Todorovic, V., Pavlovic, M., Manojlovic, D., and Risitc, M (1987). Medical application of dietary fibers in the cure of diabetes mellitus. Nutrition, health and working capacity, 4 and 5
67. Manojlovic, D., Todorovic, V., Pavlovic, M., Ristic, V. and Ristic, M. (1986): The effect of high-fiber diet upon glucoregulation and lipidaemia in diabetic patients. CAS. Lek. Ces. 125, 47 : 1437-1441
68. Todorovic, V., Pavlovic, M., Manojlovic, D. and Ristic, M. (1986): The effect of long-term fiber diet upon serum lipids and lipoproteins in diabetic patients. Diabet. Croat., 15 - 2 : 78-89
69. Pavlovic, M., Todorovic, V., Manojlovic, D., Ristic, V and Ristic, M. (1986): The effect of long-term high-fiber diet upon blood glucose levels in diabetic patients. Diabet. Croat. 15 - 2 : 91-96
70. Todorovic, V., Pavlovic, M., and Ristic, M. (1986): The effect of hypoprotein nutrition upon cationic granular proteins and myeloperoxidase and lactic acid dehydrogenase enzyme activities in rat peripheral blood granulocytes. Acta. Med. Iug., 40 (1) : 57-70
71. Pavlovic, M., Todorovic, V., Manojlovic, D., Ristic, and M. (1986): Dietary fiber and human intestinal flora. Hrana i Ishrana (Food and Nutrition) 5-8 : 149-152
72. Pavlovic, M., Spasic, P., Todorovic, V., Ristic, M. (1986): Histochemical and ultrastructural features of the epithelial cell populations from duodenal mucosa following hypoprotein nutrition and chronic ethanol intake. Proceedings of the 30th years of Electron Microscopy in Serbia : 155-156
73. Pavlovic, M., Spasic, P., Todorovic, V., Ristic, M. (1986): Ultrastructural properties of rat duodenal mucosa during long-term normoprotein nutrition and ethanol intake. Zbornik radova V jugoslovenskog simpozija iz elektronske mikroskopije, : 237-238
74. Manojlovic, D., Todorovic, V., Pavlovic, M., and Ristic, M. (1985): The effect of long-term high-fiber diet upon serum glucose levels, lipid and lipoprotein in diabetic patients. Iug. Physiol. Pharmacol. Acta. Suppl. 4 : 179 -180
75. Todorovic, V., Pavlovic, M., and Ristic M. (1985.): Protein nutrition and some components of antibacterial and antibactericidal systems in rat preipheral blood granulocytes. Iug. Physiol. Pharmacol. Acta. Suppl.4 : 353-354
76. Pavlovic, M., and Todorovic, V. (1985): Protein nutrition, chronic ethanol intake and ultrastructural properties of rat duodenal mucosa enterocytes. Iug. Physiol. Pharmacol. Acta. Suppl. 4 : 245-246
77. Pavlovic, M., and Todorovic, V., and Ristic, M. (1985): Glycogen and phospholipid content in peripheral blood lymphocytes during protein malnutrition. Acta. Med. Iug., 39 (3) : 197-207
78. Pavlovic, M., and Todorovic, V. and Ristic, M. (1985): Evaluation of the quantitative statement of individual cell types in rat gastric and duodenal mucosa during normoprotein nutrition and chronic ethanol intake. Acta med. Iug., 39(1) : 57-73
79. Todorovic, V., Pavlovic, M., and Ristic M. (1985): Integrity, histological organization and renewal ability of rat gastric and duodenal mucosa under conditions of a normoprotein dietary regime and chronic ethanol ingestion. Acta med. Iug., 39 (1) : 41-45
80. Pavlovic, M., Matic, V., Koko, V., Laban, A. and Ristic, M. (1983) : Quantitative evaluation of rat gastric and duodenal mucosa cell types and alkaline phosphatase enzyme activity during normoprotein nutrition and chronic ethanol intake) Zbornik radova IV kongresa patologa Jugoslavije, : 167-168
81. Matic, V., Pavlovic, M., Koko, V., and Ristic, M. (1983): Integrity, histological organization and regeneration ability of rat gastric and duodenal mucosa during normoprotein diet and chronic alcohol intake). Zbornik radova IV kongresa patologa Jugoslavije,: 165-166
82. Ristic, M., Pavlovic, M., Matic, V. and Koko, V. (1983): Mucous and Paneth cells of rat duodenal mucosa under normoprotein dietary regime and chronic ethanol intake. Zbornik radova IV kongresa patologa Jugoslavije, : 167-170
83. Pavlovic, M., Todorovic, V., Manojlovic, D., and Ristic, M. (1983): The importance of high fiber diet in treatment of diabetic patients.) Saopcenja, 42 : 169 - 190
84. Pavlovic, M. (1984): Protein nutrition, chronic ethanol intake and some histologic-histochemical properties of rat duodenal mucosa cell types). PhD dissertation, University of Belgrade School of Medicine.
85. Ristic, V., Pavlovic, M., Todorovic, V., Ristic, M., and Ivanovic, D. (1984): Serum lipids and glucose in obese persons. Acta med. Iug. 38 ( 4) : 24 - 253
86. Todorovic, V., Pavlovic, M., and Risitc, M (1984). Hypoprotein nutrition and phagocytic ability of rat peripheral blood granulocytes. Food and Nutrition (Hrana I ishrana), 45-6 : 93-9
87. Pavlovic M., Todorovic, V., Manojlovic, D. and Risitc, M. (1984): Dietary fiber and the importance of its application in clinical practice. Diab. Croat. 133 : 199-211
88. Pavlovic, M., Matic, V., Koko, V., and Risitc, M. (1983): Protein nutrition, chronic ethanol intake and histologic-histochemical properties of rat adrenal cortical cell). Hrana I ishrana (Food and Nutrition), 9-12 : 225-228
89. Pavlovic, M., Matic, V., Koko, V., and Risitc, M., and Laban, A. (1983): Various protein nutrition and histologic-histochemical characteristics of rat duodenal mucosa. Acta. Med. Iug. 37 (2) : 139-154
90. Matic, V., Pavlovic, M., Koko, V., Laban, A. and Risitc, M. (1983): Various protein nutrition and histologic-histochemical characteristics of rat gastric mucosa. Acta. Med. Iug.37 ( 2) : 127-138
91. Koko, V., Pavlovic, M., and Ristic, M. (1983): The effect of various types and amounts of carbohydrates on morphological characteristics characteristics of the pancreas in the rat. Acta. Med. Iug., 36 (1) : 47-56
92. Matic, V., Pavlovic, M., Ristic, M and Bankovic, S. (1982): Incidence of megalocytic anemia in patients with Billroth I and Billroth II resection. Acta. Med. Iug 36 (4): 289-95
93. Pavlovic, M., and Matic, V. (1982): Hypoprotein nutrition and some properties of rat peripheral blood lymphocytes. Acta. Med. Iug. 36 (5) : 381-393
94. Pavlovic, M. (1980): PAS-positivity of rat lymphocytes and protein nutrition. Master thesis, University of Belgrade School of Medicine(Library)
95. Kovacevic, Z., Bajin, K. and Pavlovic, M. (1980): Volume changes of rat kidney mitochondria: transport of glutamine and its inhibition by mersalyl. Int. J. Biochem. 12 (1-2) : 139-143
96. Kovacevic, Z., Pavlovic, M. and Bajin, K. (1979): Some basic questions regarding transport of metabolites across the inner mitochondrial membrane. Int. J. Biochem. 10 : 2
97. Kovacevic, Z., Breberina, Pavlovic, M, Bajin, K. (1979): Molecular form and kinetic properties of phosphate-dependent glutaminase in the mitochondria isolated from the kidneys of normal and acidotic rats. Biochim. Biophys. Acta, 567 (1) :216-224
BOOK CHAPTERS
1. Kovacevic, Z., Pavlovic, M. and Bajin, K (1979): The use of sulphydryl reagents in the elucidation of glutamine transport across the inner mitochrondrial membrane. Function and Molecular Aspects of Biomembrane Transport. Ed. Klinnberger, Elsevier, North Holand Biomedical Press, : 415-450
2. Pavlovic M, R.Chen, A. Kats, M.Cavallo, S. Saccocio, P. Keating and J. X.Hartmann: Highly specific novel method for isolation and purification of lupus anti -DNA antibody via oligo- (dT) magnetic beads, 2007. (ID Annals-1381-002, Vol.title: The Science of Autoimmunity: Cutting Edge: Advances in Basic Sciences). Ann. N.Y. Acad. Sci. 2007, 1108: 203–217
3. Pavlovic M, R.Chen, A. Kats, M.Cavallo, S. Saccocio, P. Keating and J. X.Hartmann: Highly specific novel method for isolation and purification of lupus anti -DNA antibody via oligo- (dT) magnetic beads,
Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis (Yehuda Shoenfeld; M. Eric Gershwin, eds.) Wiley ISBN 9781573317085, 2008:
4. Mathematical Modeling of Ebola Virus Dynamics as a Step towards Rational Vaccine Design Sophia Banton, Zvi Roth, Mirjana Pavlovic. Eds. Herold, Keith E.; Vossoughi, Jafar; Bentley, William E.ISBN (PDF): 9783642149986. 26th Southern Biomedical Engineering Conference SBEC 2010, April 30 - May 2, 2010, College Park, Maryland, USA:
5. Neelakanta P(ed) : Introduction to Bioinformatics: Algorithms and Computational
Methods :Pavlovic M. Rational Vaccine design: A contribution to be considered(not published yet)
BOOKS :
1. Guest Editors: Perambur S. Neelakanta, Mirjana D. Pavlovic, and Hanqi Zhuang, Florida Atlantic University, USA: Special Issue on: "Viral DNA Analysis and Rational Vaccine Design", International Journal of Bioinformatics Research and Applications (IJBRA), 2011
3. Eds:Springer Brief : Mirjana Pavlovic, Bela Balint: : Stem cells and their application in bioengineering and regenerative therapy (in preparation-close to end)
4. Eds:Springer Brief Pavlovic M: Introduction to bioengineering : basic concepts (in preparation-from notes)
5. Eds:Springer Brief Pavlovic M:Tissue engineering : basic concepts (in preparation-from notes)
6. Pavlovic M: Biology for bioengineers : Engineering biological principles (in preparation-from notes)
SELECTED ABSTRACTS:
1. Mirjana Pavlovic, Anna Kats, Ran Chen, Sharmistha Chatterjee, Alex Kotlarchyk, Perambur Neelakanta, James Hartmann: Possible interplay between anti-ssDNA binding autoantibodies and Parvoviral B19 DNA in the light of new hypothesis: laboratory and computational approach. Submitted to 8th International Congress on Autoimmunity, Granada, Spain, May 9-13, 2012. A-383-0021-01012.
2. Neelakanta PS, Chatterjee S, Papusetty D., Pavlovic M and Pandya A.: Information-theoretic Algorithms in Bioinformatics and Bio-/Medical-imaging : A review. International Conference on Recent Trends in Information Technology (ICRTIT 2011), MIT, Anna University, Chennai, India, June 03-05, 2011.Best paper presentation.
3. Morales, G. Zhuang, H. and Pavlovic,M: FAU Graduate Student Research Day, April, 2011
4. Morales G., Zhuang H. and Pavlovic M: Mexico, Cancun, aPRIL-mAY, 2011
5. Banton, S.A., Roth, Z., Pavlovic, M. Rational Vaccine Design of the Ebola Virus; A Bioengineering Approach. FAU Graduate Student Research Day, April 9, 2010.
6. Banton, S.A., Roth, Z., Pavlovic, M. A Bioengineering Approach to Rational Vaccine Design towards the Ebola Virus. 6th Annual International Society for Computational Biology (ISCB) Student Council Symposium, Boston, Massachusetts, July 9, 2010.
7. Banton, S.A., Roth, Z., Pavlovic, M. “Novel Epitopes of the Ebola Virus Towards Rational Vaccine Design: Virus Evolution and Protein Conservation. 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB). Boston, Massachusetts, July 11-13, 2010.
8. Lloyd B, Hartmann J, Caruso J, Milton S, Pavlovic M: Hydrolysis of viral DNA by IgM and IgY immunoglobulines from Trachemys scripta plasma. FAU Graduate Student Research Day, April 9, 2010.
9. Pavlovic M, Kats, A.M., Chatterjee, S., Thegum-Palil, G., Kotlarchyk, A., Neelakanta, P., Hartmann, J.X: Possible molecular association of parvovirus B19 and Systemic Lupus Erythematosus (SLE): wet lab and computational approach. Presented at the 7th International Congress on Autoimmunity, Ljubljana, Slovenia, May 5 – 9, 2010 (A-205-0005-00715)Oral presentation
10. Kats, A., Chatterjee, S., Chen, R., Thegum-Palil, G., Kotlarchyk, A., Hartmann, J.X., Neelakanta, P., Pavlovic, M. Patients with Systemic Lupus Erythematosus show different pattenrs of anti-ssDNA autoantibodies with their hydrolytic activity for parvovirus B19 ssDNA sequence. Presented at the 7th International Congress on Autoimmunity, Ljubljana, Slovenia, May 5 – 9, 2010 (A-205-0005-00759)
11. Pavlovic M, Kats A, Chen, R., Thegum-Palil, G., Kotlarchyk, A., Hartmann, J.X., Neelakanta, P., The possible interplay between anti-ssDNA binding autoantibodies and parvoviral B19 DNA in the light of new hypothesis: wet lab and computational approach.9th International Congress in SLE, Vancouver, 2010. Poster presentatiom.PO1.M.7
12. Pandya AS, Nitta Y, Kinouchi Y and Pavlovic M: Intelligent systems for prediction of Hematocrit value during blood transfusion, Proceedings of International Symposium on Biomedical Engineering Hematocrit value during blood transfusion, Oral presentation
13. Pavlovic M, Kats AM, Cavallo M and HartmannJX: "Real time fluorescent novel developed method for detection and monitoring of hydrolytic activities of lupus anti-DNA antibodies". 6th International Congress on Autoimmunity Porto, Portugal, September 10-14, 2008 A-103-0005-0045, Oral presentation
14. Kats A, Pavlovic M, Cavallo MF, Mari F and Hartmann JX:
"Subclass determination of lupus anti-DNA antibodies obtained by two different purification methods" 6th International Congress on Autoimmunity , Porto, Portugal, September 10-14, 2008 A-103-0005-00450 poster presentation
15. Shibata Y, Yamashita M, Patel H, Pavlovic MD, Huang K, Myrvik KN, Henriksen RA, Shinohara T: Mycobacterium bovis BCG activates macrophage subpopulations differently by inducing catalytically active and inactive cyclooxygenase 2- possibly inhibiting or promoting anti-tumor immunity. Florida Atlantic University Research Day, October 10th,2007 poster presentation
16. Pavlovic M,Cavallo M, KatsA, Chen R, JXHartmann : Differences between kinetic parameters of hydrolytic activity between DNA-se1 and lupus anti-DNA antibody using a novel approach. Florida Atlantinc University. Second International Symposium on Enviroment, Athenes, Greece, 2007
17. Pavlovic M, Cavallo M, Kats A M, Chen R , Mari F and JX Hartmann. Differences between kinetic parameters of hydrolytic activity between DNAse 1 and lupus anti-DNA antibody using novel approach. Accepted for poster discussion on the 8th International meeting on lupus , Shangai, China, 2007, 23-27May. Abstract code # PO037, poster presentation and poster discussion-started session
18. Kats A, Pavlovic, M, Cavallo, M, Chen R, Mari F and J. X. Hartmann. : Subclass determination and functional features of anti-DNA antibodies obtained by two different purification methods Presented at Forum poster discussion on the 8th International meeting on lupus , Shangai, China, 2007, 23-27May. Abstract code # PO038
19. Yoshimi Shibata, Ruth Ann Henriksen, Quentin N. Myrvik, Harni Patel. Pavlovic, M D, Shizuka Shinohara, Traci Pantuso and Tsutomu Shinohara: Persistent pulmonary inflammation and cyclooxygenase -1 and -2 Traci Pantuso and Tsutomu Shinohara: Persistent pulmonary inflammation and cyclooxygenase -1 and -2 modifications in alveolar macrophages following in vivo phagocytosis of mycobacteria, Experimental Biology , San modifications in alveolar macrophages following in vivo phagocytosis of mycobacteria, Experimental Biology, San Diego, CA, USA, April 2008. Diego, CA, USA, April 2008, Oral presentation
20. Balint B, Pavlovic, M, Todorovic M: Stem cells in regenerative medicine :Current knowledge.May 10-12 , 2007, Belgrade, Serbia Minisimposium: Intermedica & Dental, Oral presentation
21. Pavlovic,M., Chen,R., Kats, A.M. ,Cavallo, M.F., Saccocio, S Keating, P., and Hartmann, J. X Highly specific novel method for purification of Lupus anti-DNA antibody via oligo(dT) magnetic beads. Poster and oral presentation .Presented on 5th International Meeting on Autoimmunity, Sorento, Italy, November 29-December 3rd, 2006 # : 4.AUTO06.000264 & Oral presentation
22. Kats, A., M., Cavallo M., F., Chen R., Pavlovic, M., Saccocio S., Keating P. and Hartmann J. X.: Dramatic differences in electrophoretic patterns between normal donor and lupus patient anti-DNA antibodies isolated via novel oligo-(dT) magnetic beads method. Poster presented on 5th International Meeting on Autoimmunity, Sorento, Italy, November29-December 3rd, 2006 # : 4.AUTO06.000265
23. Pavlovic M., Caruso J.P., Milton, S., Barahona L. ,Hartmann JX: Free immunoglobulin Light chains in Normal Trachemys scripta Plasma.70th Annual Meeting of the Florida Academy of Sciences, Melbourne, FL, 10-11 March, 2006 (Sess D)
24. Cavallo M., Hartmann J., and Pavlovic M: Monitor: A Kit to monitor Autoimmune Diseases.2nd Annual Florida Tech Transfer Conference, Orlando, FL, May 18-19th, 2005, poster presentation
25. VukavicT, Dosen R., Pavlovic M., Skaro-Milic N: Enterocyte ultrastructural features preceeding gut closure.35th ESPGHAN Meeting, Taormina, Sicily, from 5th to 8th June, 2002, P171, published in JPGN, April, 2002
26. Bello – Espinosa L., and Pavlovic M., Characterization of the Magnetic Resonance Images in the Group of Children with Autistic Spectrum Disorder. Xth PAN AMERICAN Congress of Neurology, Cartagena de Indias, Colombia, October 9-14,1999, Abstr 11B, P:38
27. Pavlovic M: Progress in Neurobiology of autism. World Conference on Pediatric Neuropsychology, February 24-28, 1999, West Palm Beach, FL, USA Oral presentation
28. Ristic-Fira, A., Pavlovic, M., Ribarac-Stepic, N., Kanazir, D., and Spasic, P.: Glucocorticoid-induced apoptosis in B 16 mouse melanoma cells: ultrastructural analysis. Proceedings of II Meeting of Electron Microscopy, Belgrade, Yugoslavia, October 2-5,1996, Oral presentation, Abstr. P. 8.
29. Ristic-Fira, A., Pavlovic, M., Ribarac-Stepic, N., Kanazir, D., and Spasic, P.: Apoptosis in B16 melanoma cells: ultrasctuctural study. Biochemical Society Transactions, 4th IUMB Conference on the life and death of the cell, Edinburgh, 1996, Abstr. 24, p. 619 S
30. Aleksandra Ristić-Fira, Pavlović, M, Nevena Ribarac- Stepić, Dušan Kanazir, Petar Spasić (1996): Glukokortikoidima indukovana apoptoza B16 ćelija melanoma miša: Ultrastrukturna analiza, II Kongres za Elektronsku mikroskopiju, Beograd, Program, p.8.
31. Wroblewski, K., Pavlovic, M., Schmidt, N., Jenkins, T., Manevich, J., and Biaglow, J.E.: 31P NMR Study of the Bioenergetics of 9L Glioma During Induced pH changes in vivo. Proceedings of the International Society for Magnetic Resonance in Medicine. Fourth Scientific Meeting and Exhibition, New York, New York, USA, April 27-May 3, 1996, Vol 2, ISSN 1065-9889, p. 1114.
32. Ristic-Fira, A., Djordjevic-Markovic, R., Pavlovic, M., Ribarac-Stepic, N., Spasic, P and Kanazir, D.: Apoptosis of Mouse Melanoma Cells Induced by Glucocorticoid Treatment: Ultrastructural Study. Fifth International Congress “Hormones and Cancer”, September 16-20, 1995, Quebec City, Canada, Abstract Book, Abstr. #100, p. 12.
33. Pavlovic, M., Wroblewski, K. Manevich, Y., Kim, S. and Biaglow, J.E.: The Importance of Choice of Anesthetics in Studying Radiation Effects in the 9L Rate Glioma: Fundamental Consideration. Chemical Modifiers, Autosafe 19024, 1995, Oxford, Great Britain.Oral presentation.
34. Pavlovic, M., Wroblewski, K., Kim S., Hoxworth, R and Biaglow J.E.: Effects of Anesthetics on Glucose Physiology. The Dr. George W. Raiziss 12th Annual Retreat. The Department of Biochemistry and Biophysics University of Pennsylvania School of Medicine, June 29-30, 1995 at Swarthmore College, Poster #70.
35. Pavlovic, M., Wroblewski, K., Manevich, Y., and Biaglow J.E.: Influence of anesthetics on the bioenergetics of 9L- glioma: 31P NMR Studies. The Dr. George W. Raiziss 12th Annual Retreat. The Department of Biochemistry and Biophysics University of Pennsylvania School of Medicine, June 29-30, 1995 at Swarthmore College, Poster #58.
36. Wroblewski, K., Pavlovic, M., Manevich, Y., and Biaglow, J.E.: Influence of Anesthetics on the Bioenergetics of 9L Glioma: 31P NMR Studies. Advances in Physiological Chemistry by in vivo NMR, March 22-24, Woods Hole, MA 1995.
37. Pavlovic, M., Manevich, Y., Kim S., Wroblewski, K and Biaglow J.E.: The Importance of Choice of Anesthetics in Studying Radiation Effects in the 9L Rat Glioma. University of Pennsylvania Cancer Center Meeting, February 10, 1995. Scientific Symposium and Retreat Abstract Book, p. 104.
38. Pavlovic, M., Leffert, J., Russello, O., Beardsley, P.G. and Pizzorno, G.: Elevated Transport of Antifolates and Folic Acid Through the Reduced Folate Transport System in a 5, 10-Dideazatetrahydrofolic Acid (DDATHF) Resistant Human Leukemia Cell Line. Eighty Four Annual Meeting of American Association for Cancer Research, Orlando, Florida, 1993 (vol. 34, Abstr 3126, p.21).
39. Pavlovic, M., Leffert, J., Russello, O., Bunni, M.A., Priest, D.G., Beardsley, G.P. and Pizzorno G.: Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6-R)-5, 10-Dideazatetrahydrofolic Acid (DDATHF). Tenth International Symposium on Chemistry and Biology of Pteridines and Folates, Orange Beach, Alabama, 1993 (Abstr #J14, p. 205).
40. Ristic, A., Djordjevic-Markovic, R., Pavlovic, M., Krsmanovic, V. and Kanazir, D.: The effect of glucocorticoid and antiglucocorticoid hormones on the growth of B16/C3 mouse melanoma cells. Third International Conference on Anticarcenogenesis and Radiation Protection, Dubrovnik, Yugoslavia, 1989, Abstr. P. 77.
41. Pavlovic, M., Ristic-Fira, A. and Krsmanovic, V.: Modulation of melanin synthesis in B16 and B16/C3 spontaneous melanoma cells by autocrine factor. V kongres saveza biohemijskih drustava Jugoslavije, Novi Sad, 26-29 septembra, 1989. (Abstr. US 3.2)
42. Ristic-Fira, A., Pavlovic, M., and Krsmanovic, V.: The properties of an autocrine factor isolated from B16 and B16/C3 mouse melanoma cells. V kongres saveza biohemijskih drustava Jugoslavije, Novi Sad, 26-29 septembra, 1989. (Abstr. US 3.1)
43. Pavlovic, M., Ristic, A., Keserovic, B., Spasic, P and Krsmanovic, V.: The change in melanin production during mouse melanoma cell growth and differentiation. 19th Meeting of the FEBS, Rome, July 2-7, 1989 (Abstr. TU266)
44. Ristic-Fira, A., Pavlovic, M., Fasciotto, B and Krsmanovic, V.: The contribution to the autocrine nature of the mouse melanoma cells. . 19th Meeting of the FEBS, Rome, July 2-7, 1989 (Abstr. TU267)
45. Todorovic, V., Pavlovic, M., and Ristic, M.: Protein nutrition and some components of antibacterial and bactericydal systems in rat peripheral blood granulocytes. XIII Meeting of UYPS with International Participation, Skopje, 18-21 Sept. Abs. 50.
46. Pavlovic, M., Spasic, P., Todorovic, V and Ristic, M.: The ultrastructural changes of the duodenal cell membranes during chronic ethanol intake. 25th International conference on the biochemistry of lipids. “A jubilee conference, Antwerp, Belgium, September 4-7, 1984.
47. Todorovic, V., Pavlovic, M., and Ristic, M.: The phoshoplipid content of the peripheral blood granulocytes during protein malnutrition. 25th International conference on the biochemistry of lipids. “A jubilee conference, Antwerp, Belgium, September 4-7, 1984.
48. Kovacevic, Z and Pavlovic, M.: The study of cellular energy metabolism and the function of mitochondria in intact ascites carcinoma cells. XI Kongres fiziologa Jugoslavije, Pristina, Septembar, 1979. Proc. Of XI Con. Un. Yug. Physiol. Soc., 1980,Oral presentation.
49. Kovacevic, Z., Pavlovic, M., and Breberina, M.: Regulation of phosphate transport through mitochondria. First International Workshop on ammoniagenesis, Montreal, Canada, 1978, Oral presentation.
PATENT:
Pavlovic M, Cavallo M, Kats A, Hartmann J: COMPOSITIONS, METHODS AND KITS FOR ANALYZING HYDROLYTIC ANTIBODIES AND FOR DETECTING, PREDICTING AND TREATING HYDROLYTIC ANTIBODY-RELATED DISEASES. AAD-6818-186, PROVIS.APPLIC. # P0082930, FAU, Filed, February 2011
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