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Online Table 1.??Selected Relevant Published Studies That Have Used Echo Prior to or During Chemotherapy in Risk Stratification for the Development of CTRCD.?First Author, Year (Ref. #)MethodSample Size, Age (years)?Cancer/TreatmentPrediction Threshold of Cardiac Events?Wang et al., 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA (1)Retrospective ?2,285, 53±16?Breast (31%), blood (49%), others (20%)/ anthracyclines?2.4% symptomatic HF and cardiac death, HR of 2.72 if pre-tx LVEF between LLN* and LLN+5 (p < 0.01), every decrement of 5% LVEF = 40% more risk, every increment of 5mm LVID = 40% more risk Romond et al., 2012PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb21vbmQ8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (2)Prospective randomized944, 49Breast/ anthracyclines + trastuzumab4% symptomatic HF and cardiac death, HR of 6.72 if pre-tx LVEF 50% to 54% (p < 0.01) and 11.84 if post AC LVEF 55% to 64% (p < 0.001)Negishi et al., 2013 ADDIN EN.CITE <EndNote><Cite><Author>Negishi</Author><Year>2013</Year><RecNum>89</RecNum><DisplayText>(3)</DisplayText><record><rec-number>89</rec-number><foreign-keys><key app="EN" db-id="zd9ffxrs22dpebe5ftqp5w2j0xsf220rddsr" timestamp="1510785286">89</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Negishi, K.</author><author>Negishi, T.</author><author>Hare, J. L.</author><author>Haluska, B. A.</author><author>Plana, J. C.</author><author>Marwick, T. H.</author></authors></contributors><auth-address>Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.</auth-address><titles><title>Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity</title><secondary-title>J Am Soc Echocardiogr</secondary-title></titles><periodical><full-title>J Am Soc Echocardiogr</full-title></periodical><pages>493-8</pages><volume>26</volume><number>5</number><keywords><keyword>Antibodies, Monoclonal, Humanized/*adverse effects</keyword><keyword>Antineoplastic Agents/*adverse effects</keyword><keyword>Breast Neoplasms/drug therapy</keyword><keyword>*Echocardiography</keyword><keyword>Female</keyword><keyword>Heart/*drug effects</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Trastuzumab</keyword><keyword>Ventricular Function, Left/*drug effects</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1097-6795 (Electronic)
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ADDIN EN.CITE.DATA (4)Retrospective158, 53±15Breast (32%), blood (49%), others (20%)/ anthracyclinesAll patients had baseline LVEF of 50% to 59%. 7.6% symptomatic HF and cardiac death. LVEF not predictive. LVEDV, indexed LVEDV (LVEDVI), LVESV, indexed LVESV (LVESVI), and GLS HR of 1.03 (p < 0.02), 1.04 (p < 0.04), 1.07 (p < 0.003), 1.11 (p < 0.02), and 1.36 (p < 0.007) per unit change, respectively. GLS ≤16%, HR: 4.7 (p < 0.004). Ali et al., 2016 ADDIN EN.CITE <EndNote><Cite><Author>Ali</Author><Year>2016</Year><RecNum>61</RecNum><DisplayText>(5)</DisplayText><record><rec-number>61</rec-number><foreign-keys><key app="EN" db-id="zd9ffxrs22dpebe5ftqp5w2j0xsf220rddsr" timestamp="1510778629">61</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ali, M. T.</author><author>Yucel, E.</author><author>Bouras, S.</author><author>Wang, L.</author><author>Fei, H. W.</author><author>Halpern, E. F.</author><author>Scherrer-Crosbie, M.</author></authors></contributors><auth-address>Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Institute for Technology Assessment, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: marielle@.</auth-address><titles><title>Myocardial Strain Is Associated with Adverse Clinical Cardiac Events in Patients Treated with Anthracyclines</title><secondary-title>J Am Soc Echocardiogr</secondary-title></titles><periodical><full-title>J Am Soc Echocardiogr</full-title></periodical><pages>522-527 e3</pages><volume>29</volume><number>6</number><keywords><keyword>Anthracycline</keyword><keyword>Chemotherapy</keyword><keyword>Echocardiography</keyword><keyword>Heart failure</keyword><keyword>Left ventricular function</keyword><keyword>Strain</keyword></keywords><dates><year>2016</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1097-6795 (Electronic)
0894-7317 (Linking)</isbn><accession-num>27068546</accession-num><urls><related-urls><url>;(5)Retrospective450, 59 ± 18Blood/ anthracyclines6% symptomatic HF and cardiac death. LVEF (HR: 0.93; p = 0.005), and GLS (HR: 1.47; p < 0.0001). GLS < 17.5%, HR: 6.00 (p < 0.0001).*LLN; lower limits of normal= 52% in men and 54% in womenAC = anthracycline/cyclophosphamide; AUC = area under curve; GLS = global longitudinal strain; HF = heart failure; HR = hazard ratio; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; LVID = left ventricular internal diameter in diastole; tx = treatment. Online Table 2. Selected Relevant Published Studies That Have Used Echo to Describe the Phenotype of CTRCD During Cancer TreatmentFirst Author , Year (Ref. #)MethodSample Size, Age?(years)Cancer/TreatmentEcho Timing Echo PhenotypePerez et al., 2008PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZXJlejwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
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ADDIN EN.CITE.DATA (6) Prospective randomized1,944, 49Breast cancer/AC-T*; AC-T+H; AC-TH HBaseline, 3, 6, 9, 18-21 mAsymptomatic LVEF decrease >10% to <50%: AC-T:4.0% to 5.1%AC-T+H: 4.0% to 7.8%AC-THH: 5.8% to 10.4%Slamon et al., 2011PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbGFtb248L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (7) Prospective randomized 3,222;<50 in >50% of patientsBreast cancer/AC-T; AC-T+H; TCHBaseline, 7 times over study duration Asymptomatic LVEF decrease >10 %to <50%:9.4 to 18.6%Cardinale et al., 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJkaW5hbGU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy
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ADDIN EN.CITE.DATA (8)Prospective2,625, 51±13Breast cancer, HL, NHL, myeloma, other types of solid tumors/AC;EC;CEF;ACOD;VAD;ChIVPP;ABVVPBaseline, every 3 m during chemotherapy, at the end of treatment, every 3 m during the first year after chemotherapy, every 6 m afterwards for 4 yearsIncidence of cardiotoxicity 9% (LVEF decrease >10 absolute points to <50%); 98% of cases occurred within the first year and was associated with anthracycline dose and LVEF at the end of treatment.Procter et al., 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qcm9jdGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48
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ADDIN EN.CITE.DATA (9)Prospective randomized 1,698,49Breast cancer/Chemotherapy H x 1 yrChemotherapy H x 2 yr3, 6, 12, 18, 24, 30, and 36 m, and annually thereafter up to 10 years Asymptomatic LVEF decrease >10 %to <50%:4.1% to 7.2%*AC-T denotes doxorubicin and cyclophosphamide followed by docetaxelAC-T+H = doxorubicin and cyclophosphamide followed by paclitaxel then Herceptin; AC-TH H = doxorubicin and cyclophosphamide followed by paclitaxel plus herceptin then herceptin alone, LVEF = left ventricular ejection fraction; TCH = docetaxel, carboplatin, and Herceptin; HL = Hodgkin lymphoma; NHL = non-Hodgkin lymphoma; CEF = cyclophosphamide, epirubicin, 5-fluorouracil; ACOD = doxorubicin, cyclophosphamide, vincristine, dexamethasone; VAD = vincristine, doxorubicin, dexamethasone; ChlVPP/ABVVP = chlorambucil, vinblastine, procarbazine, doxorubicin, bleomycin, vincristine, etoposide; A = doxorubicin; H = herceptin; A+H = doxorubicin and herceptin. Online Table 3. Selected Relevant Published Studies That Have Used Echo to Assess the Role of Heart Failure Pharmacotherapy in the Prevention or Treatment of CTRCDFirst Author, Year (Ref. #)MethodSample Size, Age (years)Drugs Used for Protection Cancer/TreatmentEcho TimingEndpointsCardinale et al., 2006PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJkaW5hbGU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy
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ADDIN EN.CITE.DATA (8)Prospective randomized 114, Tx (n = 56) 47±11,Control (n = 58) 44±13Enalapril AML, BC, E, HL, M, NHL/HDCBaseline; at 1, 3, 6, and 12 mos after the end of HDCLVEF decrease >10% to <50%:Enalapril vs. control: 43% vs. 0%( p < 0.001) Bosch et al., 201PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb3NjaDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl
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ADDIN EN.CITE.DATA (10)Prospective randomized 80,Tx (n = 45) 49.7 ± 14, Control (n = 45) 51 ± 13Enalapril and carvedilol vs. control AL, HL, non-HL, MM/HSCT Baseline and 6 mos after randomization Absolute change from baseline in LVEF:No change in the treatment group but significant decrease in controls, resulting in a 3.1% absolute difference (p = 0.035)Seicean et al., 2013PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWljZWFuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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AG==
ADDIN EN.CITE.DATA (11)Retrospective106,5710Any BB given uninterrupted during A and/or TBC/AC trastuzumabNAHF admissions during 3.2 yrs of follow-up:BB vs. controls: 5 vs. 27 (p < 0.008)Tx = treatment; BB = beta blocker; LVEF = left ventricular ejection fraction; HF = heart failure; BC = breast cancer; AML = acute myeloid leukemia; AL = acute leukemia; HL = Hodgkin Lymphoma; MM = multiple myeloma; E= Ewing’s sarcoma; HDC = high dose chemotherapy including ARAC indicates cytarabine; BEAM = carmustine-etoposide-cytarabine-melphalan; DAUNO = daunorubicin; ESAP = etoposide-carboplatin-cytarabine-dexamethasone; ICE = ifosfamide-carboplatin-etoposide; IDA = idarubicin; MEL = melphalan; MITOX = mitoxantrone; SEQ = sequential; TEC = taxotere-epirubicin-cyclophosphamide; TICE = taxotere-ifosfamide-carboplatin-etoposide; AC = anthracyclines; ; HSCT = hematopoietic stem-cell transplantation; A= anthracycline; T= trastuzumab.Online Table 4. Selected Relevant Published Studies That Have Used Echo to Assess Cardiac Function After Cancer TreatmentFirst Author, Year (Ref. #)MethodSample Size, Age (years)Cancer/TreatmentEcho Timing?Since DiagnosisKey FindingsLipshultz et al., 2005PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaXBzaHVsdHo8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFy
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ADDIN EN.CITE.DATA (12)Prospective 499, age at cancer diagnosis = 4.4 Acute lymphoblastic, leukemia/doxorubicin11.8 yrsProgressive and persistent cardiac abnormalities years after doxorubicin treatment. Significantly reduced LV mass, fractional shortening, dimension. Results expressed as z scores calculated based on cardiac values of normal children. Romond et al., 2012PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb21vbmQ8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (2)Prospectiverandomized2,119, 49Breast cancer/ anthracycline and trastuzumab7 yrsThe cumulative incidence of heart failure/ cardiac death among trastuzumab treated evaluable patients was 4.0% (95% CI: 2.8% to 5.2%). Relative risk 3.3 (95% CI: 1.63 to 6.66 p < 0.001). Most relevant risk factors for end point were age, treatment with anthracyclines and baseline and post-anthracycline LVEF.Armstrong et al., 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm1zdHJvbmc8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy
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ADDIN EN.CITE.DATA (13)Retrospective1,820,31 (18-65)Blood malignancies, sarcomas, melanoma, Retinoblastoma, Wil’s tumor, carcinoma, CNS, bone tumor/ anthracyclines, radiation>10 yrs5.8% of the population had 3D LVEFs <50%.Cardiac dysfunction detected by GLS (31.8%), GCS (23.1%) and diastolic dysfunction (11%) was more prevalent than abnormal LVEF.Narayan et al., 2017PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXJheWFuPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48
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ADDIN EN.CITE.DATA (14)Prospective277, 48 (41-57)Breast cancer/doxorubicin, trastuzumab3 yrsWith Doxorubicin, there was a 3-year change in LVEF of -3.8% (95% CI: -5.1% to -2.5%). With trastuzumab, a -2.8%(95% CI:-5.3% to -0.4%). Changes in volumes, strain and ventriculo-arterial coupling were consistently associated with concurrent and subsequent LVEF declines and recovery across therapies. GLS = global longitudinal strain; GCS = global circumferential strain.Online Table 5 Guidelines on Cardiac Surveillance Before, During and After Cancer TherapyGuidelinesSpecific Cancer AgentPre-Tx LVEF evaluationCardiotoxicityDefinitionMonitoringFrequencyIntervention: Stopping/restarting recommendationsMonitoring post TxFDA ADDIN EN.CITE <EndNote><Cite><RecNum>5</RecNum><DisplayText>(15, 16)</DisplayText><record><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="zd9ffxrs22dpebe5ftqp5w2j0xsf220rddsr" timestamp="1510775373">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">Food and Drug Administration. Adriamycin (DOXOrubicin HCl) for Injection. Version 2.0, 2012. Available online </style><style face="underline" font="default" size="100%"> face="normal" font="default" size="100%">. Accessed November 15, 2017</style></title></titles><dates></dates><urls></urls></record></Cite><Cite><RecNum>6</RecNum><record><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="zd9ffxrs22dpebe5ftqp5w2j0xsf220rddsr" timestamp="1510775628">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">Food and Drug Administration. HERCEPTIN (trastuzumab) Label. 2010. Available Online </style><style face="underline" font="default" size="100%">;(15, 16)Doxorubicin YesDrop of 10% to below the LLN, or an absolute LVEF of 45%, or a 20% decline in LVEF at any levelRepeat LVEF measurement for higher cumulative anthracycline doses; frequency not specifiedCarefully weigh risk/benefit of continued therapy Not specifiedTrastuzumab Yes≥ 16% absolute decrease in LVEF from pre-treatment values; LVEF below institutional LLN and ≥ 10% absolute decrease in LVEF from pretreatment values. LVEF measurements every 3 months during and upon completion of trastuzumabWithhold for at least 4 weeks, repeat LVEF measurement at 4 week intervals if trastuzumab is withheld for LV dysfunction, may be resumed if, within 4?8 weeks, the LVEF returns to normal limits and the absolute decrease from baseline is ≤ 15%.LVEF measurementevery 6 months for at least 2 years following completion of trastuzumab as a component of adjuvant therapy.NCCN ADDIN EN.CITE <EndNote><Cite><RecNum>29</RecNum><DisplayText>(17)</DisplayText><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="zd9ffxrs22dpebe5ftqp5w2j0xsf220rddsr" timestamp="1510776972">29</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">National Comprehensive Cancer Network. NCCN Guidelines Version 2.2017. Anthracycline-Induced Cardiac Toxicity. Available online: </style><style face="underline" font="default" size="100%">;(17)TrastuzumabYesNot specifiedDuring therapy*Same as FDANot specifiedASEPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QbGFuYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA (19)- AC **(eg doxorubicin >250 mg/m2); - RT (>/= 30 Gy where the heart is in the tx field)- low dose AC (<250mg/m2)+ low dose RT (< 30Gy)- AC + Trast- low dose AC or trast+ RF***YesAdjudication to Stage B Heart FailureFrequency to be determined by health care providers based on clinical judgment and patient circumstancesWeighing risk/benefit and decision of cancer treatment at the discretion of the oncologistFU may be considered 6 to 12 months after completion of treatment among patients at increased riskNCCN = national comprehensive cancer network; FDA = Federal Drug Administration; ASE = American Society of Echocardiography; ASCO = American Society of Clinical OncologyTx = treatment; AC = anthracycline; RT = radiation therapy; trast = trastuzumab; LLN = lower limit of normal; RF = risk factors; FU = follow-up* Replaced cardiac monitoring at baseline, 3, 6, 9 months with “Evaluate LVEF prior to and during treatment” in the recent NCCN guideline update. ** Doxorubicin equivalent*** Risk factors included age ≥ 60, compromise cardiac function (eg history of myocardial infarction, moderate valvular disease, borderline LVEF) or ≥ 2 cardiovascular risk factors (smoking, HTN, DM, hyperlipidemia)References ADDIN EN.REFLIST 1.Wang L, Tan TC, Halpern EF, Neilan TG, Francis SA, Picard MH, et al. Major Cardiac Events and the Value of Echocardiographic Evaluation in Patients Receiving Anthracycline-Based Chemotherapy. Am J Cardiol. 2015;116(3):442-6.2.Romond EH, Jeong JH, Rastogi P, Swain SM, Geyer CE, Jr., Ewer MS, et al. Seven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2012;30(31):3792-9.3.Negishi K, Negishi T, Hare JL, Haluska BA, Plana JC, Marwick TH. Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. J Am Soc Echocardiogr. 2013;26(5):493-8.4.Mousavi N, Tan TC, Ali M, Halpern EF, Wang L, Scherrer-Crosbie M. Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50-59% treated with anthracyclines. Eur Heart J Cardiovasc Imaging. 2015;16(9):977-84.5.Ali MT, Yucel E, Bouras S, Wang L, Fei HW, Halpern EF, et al. Myocardial Strain Is Associated with Adverse Clinical Cardiac Events in Patients Treated with Anthracyclines. J Am Soc Echocardiogr. 2016;29(6):522-7 e3.6.Perez EA, Suman VJ, Davidson NE, Sledge GW, Kaufman PA, Hudis CA, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008;26(8):1231-8.7.Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Press M, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med. 2011;365(14):1273-83.8.Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131(22):1981-8.9.Procter M, Suter TM, de Azambuja E, Dafni U, van Dooren V, Muehlbauer S, et al. Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial. J Clin Oncol. 2010;28(21):3422-8.10.Bosch X, Rovira M, Sitges M, Domenech A, Ortiz-Perez JT, de Caralt TM, et al. Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies). J Am Coll Cardiol. 2013;61(23):2355-62.11.Seicean S, Seicean A, Alan N, Plana JC, Budd GT, Marwick TH. Cardioprotective effect of beta-adrenoceptor blockade in patients with breast cancer undergoing chemotherapy: follow-up study of heart failure. Circ Heart Fail. 2013;6(3):420-6.12.Lipshultz SE, Lipsitz SR, Sallan SE, Dalton VM, Mone SM, Gelber RD, et al. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 2005;23(12):2629-36.13.Armstrong GT, Joshi VM, Ness KK, Marwick TH, Zhang N, Srivastava D, et al. Comprehensive Echocardiographic Detection of Treatment-Related Cardiac Dysfunction in Adult Survivors of Childhood Cancer: Results From the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65(23):2511-22.14.Narayan HK, Finkelman B, French B, Plappert T, Hyman D, Smith AM, et al. Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations With Ejection Fraction Decline, Recovery, and Heart Failure Symptoms Over 3 Years of Follow-Up. Circulation. 2017;135(15):1397-412.15.Food and Drug Administration. Adriamycin (DOXOrubicin HCl) for Injection. Version 2.0, 2012. Available online . Accessed November 15, 2017.16.Food and Drug Administration. HERCEPTIN (trastuzumab) Label. 2010. Available Online Comprehensive Cancer Network. NCCN Guidelines Version 2.2017. Anthracycline-Induced Cardiac Toxicity. Available online: JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2014;27(9):911-39.19.Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N, et al. Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2017;35(8):893-911. ................
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