School of Medicine | University of Colorado



Curriculum VitaeTomas Majtan, PharmD PhDPERSONAL HISTORYCurrent position:Assistant Research ProfessorAddress:University of Colorado DenverSchool of Medicine, Department of Pediatrics12800 E 19th Ave, Mail Stop 8313Bldg. RC1-North, Rm. P18-4127Aurora, CO 80045United States of AmericaTel (office):+1-303-724-3813Fax: +1-303-724-3838E-mail:tomas.majtan@cuanschutz.eduWWW: – 2002 Undergraduate studies at the Faculty of Pharmacy, Comenius University, Bratislava, Slovakia2002 MSc degree in Pharmacy (graduated Summa Cum Laude (With Highest Honor))Thesis title: “Antimicrobial efficacy of new bisquaternary ammonium salts on Salmonella Typhimurium.” (in Slovak)2003PharmD degree (graduated Summa Cum Laude (With Highest Honor))Thesis title: “The effectiveness of new commercially manufactured disinfectant substances on Salmonella enterica serotype Enteritidis.” (in Slovak)2002 – 08/2006 PhD study at the Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia; topics:? Expression profiling of bacteriophage BFK20 using DNA microarrays? Microarray genotyping of virulence factors and resistance genes in Salmonella spp.09/2006 PhD degree in Molecular BiologyThesis title: “Transcriptional profiling of bacteriophage BFK20: expression motifs in assignation of gene functions” (in English)2007 –2012Postdoctoral fellow, Department of Pediatrics, University of Colorado, Aurora, CO, USAACADEMIC APPOINTMENTS2007 – 2011Research Associate, Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia2011 – 2013Senior Research Associate, Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia2012 – 2013Instructor, Department of Pediatrics, University of Colorado, Aurora, CO, USA2013 – presentAssistant Research Professor, Department of Pediatrics, University of Colorado, Aurora, CO, USAHONORS, SPECIAL RECOGNITIONS AND AWARDS2001Academic award of the Rector of Comenius University2002Academic award of the Dean of Faculty of Pharmacy, Comenius University2007The Scientist of the Year 2007 – Honorable Mention2008The Best Publication of the Year 2008, Slovak Medical Chamber, Section of Clinical Microbiology2018The FEBS Journal award for the outstanding poster prepared for the 43rd FEBS congressMEMBERSHIP IN PROFESSIONAL ORGANIZATIONS2002 – 2013Slovak Society for Biochemistry and Molecular Biology, member2015 – 2019American Heart&Stroke Association, memberINVENTIONS, INTELLECTUAL PROPERTY AND PATENTS HELD OR PENDINGKraus JP, Majtan T, Bublil E: Chemically Modified Cystathionine Beta-Synthase Enzyme for Treatment of Homocystinuria. U.S. Patent 9,034,318 (2015)Carrillo RS, Kraus JP, Majtan T, Naveh D: Purification of Cystathionine Beta-Synthase. U.S. Patent 9,243,239 (2016)Kraus JP, Majtan T, Bublil E: Chemically Modified Cystathionine Beta-Synthase Enzyme for Treatment of Homocystinuria. U.S. Patent 9,447,406 (2016)Kraus JP, Majtan T, Bublil E: Compositions and Methods for Treatment of Homocystinuria. U.S. Patent 9,675,678 (2017)Kraus JP, Majtan T, Collard R: Propionyl-CoA Carboxylase Compositions and Uses Thereof. Provisional application PCT/US2017/030904 (2017)Kraus JP, Majtan T: Optimization of Enzyme Replacement Therapy for Treatment of Homocystinuria. Patent application WO 2018/195006 A1 (2018)Kraus JP, Majtan T, Bublil E: Chemically Modified Cystathionine Beta-Synthase Enzyme for Treatment of Homocystinuria. U.S. Patent 10,046,036 (2018)Carrillo RS, Kraus JP, Majtan T, Naveh D: Purification of Cystathionine Beta-Synthase. U.S. Patent 10,160,962 (2018)Kraus JP, Majtan T, Bublil E: Compositions and Methods for Treatment of Homocystinuria. U.S. Patent 10,265,387 (2019)REVIEW AND REFEREE WORKReview work done for the following:Funding agencies:Czech Science FoundationEuropean Research Council (ERC)Peer-reviewed journals:Applied Microbiology & BiotechnologyAntioxidants and Redox SignalingActa Biochimica et Biophysica SinicaBiochemistryFASEB BioadvancesFASEB JournalGeneHuman Molecular GeneticsHuman MutationInternational Journal of Developmental NeuroscienceInternational Journal of Infectious DiseasesJournal of Inherited Metabolic DiseaseJournal of Inborn Errors of Metabolism and ScreeningJournal of Microbial & Biochemical TechnologyLetter in Drug Design and DiscoveryMolecular Genetics and MetabolismMolecular Genetics and Metabolism ReportsOxidative Medicine and Cellular LongevityScientific ReportsZoonoses and Public HealthINVITED EXTRAMURAL LECTURES, PRESENTATIONS, VISITING PROFESSORSHIPSMajtan T, Timko J, Majtan V: DNA Microchip for Virulence and Antibiotic Resistance Gene Identification. VII. Conference of Slovak Society for Clinical Microbiology, Dudince, February 10 – 12, 2006TEACHING RECORDMajor presentations to medical (or other undergraduate) students:Functional Genomics and DNA microarrays. Faculty of Pharmacy, Comenius University, Bratislava, April 20, 2004DNA Microarray: Transcriptional Profiling of Bacteriophage BFK20. Faculty of Natural Sciences, Comenius University, Bratislava, December 09, 2005Molecular Biology Methods in Clinical Microbiology. Faculty of Medicine, Slovak Medical University, Bratislava, February 20, 2006Enzyme replacement therapy for homocystinuria. Department of Physical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain, June 6, 2019Enzyme replacement therapy for homocystinuria. Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia, June 19, 2019Major presentations for medical professionals and patient outreach:Looking forward – enzyme replacement therapy for homocystinuria. 2nd International Homocystinurias Patient – Expert Meeting 2017 as a satellite symposium to the 13th International Congress for Inborn Errors of Metabolism (ICIEM), Rio de Janeiro, Brazil, September 5 – 8, 2017Enzyme replacement therapy for classical homocystinuria. 3rd International Homocystinurias Patient – Expert Meeting 2019, Rome, Italy, February 28 – March 1, 2019Enzyme replacement therapy for homocystinuria. Center for Cooperative Research in Biosciences (CIC Biogune), Technology Park of Bizkaia, Derio, Bizkaia, Spain, June 14, 2019Mentoring:Andrea Soltysova (graduate student; 2006) – research mentor and advisor during her PhDNina Frank (PRA; 2007-2008) – research mentor during her studies on CBSMichael A. Swanson (graduate student; 2008) – research mentor during his PhDSarah A. Venezia (PRA; 2008-2012) – research mentor during her studies on CBS and PCCAaron T. Smith (graduate student; 2010-2012) – research mentor during his PhDYang Su (graduate student; 2010-2012) – research mentor during his PhDKatherine M. Freeman (graduate student; 2010-2012) – research mentor during her PhDAles Hnizda (graduate student; 2011-2012) – research mentor during his PhDJune Ereno-Orbea (graduate student and post-doctoral fellow; 2013) – research mentor and scientific advisor during her short-term fellowship related to her PhD and later postdoc studies on CBS crystallographyMegan K. Thorson (graduate student; 2013-2015) – research mentor and advisor during her PhD studies focused on developing a high-throughput screening assay for inhibitors of CBSRichard S. Carrillo (BSc level industry professional; 2010-2016) – research mentor and scientific supervisor during his work developing a purification procedure for PEG-CBS, an enzyme replacement therapy for homocystinuriaErez M. Bublil (post-doctoral fellow; 2011-2014) – research mentor and advisor during his post-doctoral work on developing and enzyme replacement therapy for homocystinuriaInsun Park (PRA; 2011-present) – research mentor, director and supervisor of her work with multiple mouse models of homocystinuria, propionic acidemia and OTC deficiencyRenata Collard (research associate; 2013-present) – research mentor, director and supervisor of her work on propionic acidemia models and developing chaperone therapy for homocystinuriaPaula Gimenez-Mascarell (graduate student; 2017-present) – research mentor during her PhDDhruti Patel (summer research intern; 2018) – research mentorAneesh Karsanbhai (summer research intern; 2018) – research mentorGRANT SUPPORTOn-going projects:“Evaluation of benefits of thiol-based reductants in classical homocystinuria”Role: principal investigatorHCU Network America and HCU Network Australia research grantDates: 01/01/2020 – 12/31/2020Percent effort: 20%Total direct cost: $ 40,000“Toward targeted pharmacological chaperone therapy for CBS-deficient homocystinuria”Role: principal investigatorAmerican Heart Association, Scientist Development Grant 16SDG30040000Dates: 07/01/2016 – 06/30/2020Percent effort: 5%Total direct cost: $ 210,000Completed projects:“The Sponsored Research Agreement – Pharmacological chaperone for homocystinuria (Pharmacoperones for HCU) project”Role: principal investigatorOrphan Technologies Ltd., Contract# AWD-182790Dates: 01/01/2018 – 12/31/2018Percent effort: 35%Total direct costs: $ 50,000“The Sponsored Research Agreement – Cystathionine Beta-Synthase (CBS) Project”Role: key scientist, co-principal investigator (PI: Kraus JP)Orphan Technologies Ltd., Contract# AWD-111186Dates: 11/01/2010 – 12/31/2018Percent effort: 60%Total direct costs: $ 2,380,724“The Sponsored Research Agreement – Propionyl-CoA Carboxylase (PCC) Project”Role: key scientist, co-investigator (PI: Kraus JP)Orphan Technologies Ltd., Contract# AWD-140850Dates: 10/01/2013 – 12/31/2016Total direct costs: $ 669,062“Homocysteine & Heme: A Role in Thrombosis”Role: postdoctoral fellow, key scientist (PI: Kraus JP)The National Institute of Health NIH/NHBLI, R01 HL065217Dates: 09/05/2000 – 08/31/2014Total direct costs: $ 1,250,000“Homocysteine and Thrombosis”Role: key scientist (PI: Kraus JP)American Heart Association, Grant-In-Aid 09GRNT2110159Dates: 07/01/2009 – 06/30/2012Total direct costs: $ 180,000“Chaperone therapy for enzyme misfolding in homocystinuria”Role: principal investigator (mentor: Kraus JP)American Heart Association, Postdoctoral fellowship 0825772G and 0920079GDates: 07/01/2008 – 12/31/2011Total direct costs: $ 145,272“Occurrence, mobilization and dissemination of resistance and virulence genes among Salmonellae.”Role: principal investigator (mentor: Timko J)Slovak Research and Development Agency, Award# LPP-0097-07Dates: 06/01/2008 – 05/31/2011Total direct costs: $28,620BIBLIOGRAPHYPeer-reviewed papers (* = contributed equally, ** = corresponding author):Majtan T, Majtanova L, Mlynarcik D: The Effect of Bisquaternary Ammonium Salts on the Growth and Metabolic Processes of Salmonella enterica Subspecies Enterica Serovar Typhimurium DT104. Chem Papers 98, 148-151 (2004)Majtan T**, Bukovska G, Timko J: DNA microarray – Technique and Applications in Microbial Systems. (Review) Folia Microbiol 49 (6), 635-664 (2004)Halgasova N, Majtan T, Ugorcakova J, Timko J, Bukovska G: Resistance of Corynebacterial Strains to Infection and Lysis by Corynephage BFK20. J Appl Microbiol 98 (1), 184-92 (2005)Majtan V, Majtan T, Majtan J, Szaboova M, Majtanova L: Salmonella enterica Serovar Kentucky: Antimicrobial Resistance and Molecular Analysis of Clinical Isolates from Slovak Republic. Jpn J Infect Dis 59, 358-362 (2006)Majtan T**, Halgasova N, Bukovska G, Timko J: Transcriptional Profiling of Bacteriophage BFK20: Coexpression Interrogated by ?Guilt-by-Association” Algorithm. Virology 359, 55-65 (2007)Majtanova L, Majtan T, Majtan V: Molecular Characterization of Class 1 Integrons in Clinical Strains of Salmonella Typhimurium Isolated in Slovakia. Pol J Microbiol 56 (1), 17-21 (2007)Majtan T**, Majtanova L, Timko J, Majtan V: Oligonucleotide Microarray for Molecular Characterization and Genotyping of Salmonella spp. Strains. J Antimicrob Chemother 60(5), 937-46 (2007)Majtan T, Singh LR, Wang L, Kruger WD, Kraus JP: Active CBS Can Be Expressed in Heme-free Systems in the Presence of Metal-substituted Porphyrins or a Chemical Chaperone. J Biol Chem 283(50), 34588-34595 (2008)Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS: DEER Distance Measurement Between a Spin Label and a Native FAD Semiquinone in Electron Transfer Flavoprotein. J Am Chem Soc 131(44), 15978-15979 (2009)Majtan T, Liu L, Carpenter JF, Kraus JP: Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. J Biol Chem 285(21), 15866-15873 (2010)Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J: Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol 19(8), E73-E79 (2010)Majtanova L, Majtan T, Majtan V: Detection of the Class 1 Integrons and SGI1 among Salmonella enterica Serovar Typhimurium DT104, U302, DT120, DT193, and Nontypable Human Isolates. Jpn J Infect Dis 63, 292-295 (2010)Majtan T, Frerman FE, Kraus JP: Effect of cobalt on Escherichia coli metabolism and metalloporphyrin formation. Biometals 24(2), 335-347 (2011)Majtan T, Freeman KM, Smith AT, Burstyn JN, Kraus JP: Purification and characterization of cystathionine beta-synthase bearing a cobalt protoporphyrin. Arch Biochem Biophys 508, 25-30 (2011)Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS: Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor and spin labels. Protein Sci 20(3), 610-620 (2011)Smith AT, Majtan T, Freeman KM, Su Y, Kraus JP, Burstyn JN: Cobalt cystathionine b-synthase: A cobalt-substituted heme protein with a unique thiolate ligation motif. Inorg Chem 50(10), 4417-4427 (2011)Majtan T, Kraus JP: Folding and activity of mutant cystathionine b-synthase depends on the position and nature of the purification tag: Characterization of the R266K CBS mutant. Protein Exp Purif 82(2), 317-324 (2012)Hnizda A*, Majtan T*, Liu L, Pey AL, Carpenter JF, Kodicek M, Kozich V, Kraus JP: Conformational properties of nine purified cystathionine beta-synthase mutants. Biochemistry 51(23), 4755-4763 (2012). Correction in: Biochemistry 51(27), 5540 (2012)Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN: The Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of Human Cystathionine b-Synthase. Biochemistry 51(32), 6360-6370 (2012)Oyenarte I*, Majtan T*, Ereno J, Corral-Rodriguez MA, Klaudiny J, Majtan J, Kraus JP, Martinez-Cruz LA: Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine beta-synthase from Apis mellifera. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 11), 1323-1328 (2012)Oyenarte I*, Majtan T*, Ereno J, Corral-Rodriguez MA, Kraus JP, Martinez-Cruz LA: Purification, crystallization and preliminary crystallographic analysis of human cystathionine beta-synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 11), 1318-1322 (2012)Pey AL, Majtan T, Sanchez-Ruiz JM, Kraus JP: Human cystathionine beta-synthase (CBS) contains two classes of binding sites for S-adenosyl-L-methionine (SAM): complex regulation of CBS activity and stability by SAM. Biochem J 449(1), 109-121 (2013)Su Y, Majtan T, Freeman KM, Linck RC, Ponter S, Kraus JP, Burstyn JN: Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine beta-synthases. Biochemistry 52(4), 741-751 (2013)Thorson MK, Majtan T, Kraus JP, Barrios AM: Identification of Cystathionine beta-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe. Angew Chem Int Ed Engl 52(17), 4641-4644 (2013)Majtan J, Bohova J, Garcia-Villalba R, Tomas-Barberan FA, Madakova Z, Majtan T, Majtan V, Klaudiny J: Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. Arch Dermatol Res 305 (7), 619-627 (2013)Ereno-Orbea J*, Majtan T*, Oyenarte I, Kraus JP, Martinez-Cruz LA: Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc Natl Acad Sci USA 110 (40), E3790-3799 (2013)Ereno-Orbea J*, Majtan T*, Oyenarte I, Kraus JP, Martinez-Cruz LA: Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun 70 (Pt 3), 320-325 (2014)Pey AL, Majtan T, Kraus JP: The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein. Biochim Biophys Acta 1844 (9), 1453-1462 (2014)Valachova I, Majtan T, Takac P, Majtan J: Identification and characterization of different proteases in Lucilia sericata medicinal maggots involved in maggot debridement therapy. J Appl Biomed 12, 171-177 (2014)Majtan T, Pey AL, Fernandez R, Fernandez JA, Martinez-Cruz LA, Kraus JP: Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases. PLOS One 9 (8), e105290 (2014)Ereno-Orbea J*, Majtan T*, Oyenarte I, Kraus JP, Martinez-Cruz LA: Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine. Proc Natl Acad Sci USA 111(37), E3845-3852 (2014)Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM: Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett 25(5), 1064-1066 (2015)Kozich V, Krijt J, Sokolova J, Melenovska P, Jesina P, Vozdek R, Majtan T, Kraus JP: Thioethers as markers of hydrogen sulfide production in homocystinurias. Biochimie 126, 14-20 (2016)Majtan T*, Pey AL*, Kraus JP: Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria. Biochimie 126, 6-13 (2016)Bublil EM, Majtan T, Park I, Carrillo RS, Hulkova H, Krijt J, Kozich V, Kraus JP: Enzyme replacement with PEGylated cystathionine beta-synthase ameliorates homocystinuria in murine model. J Clin Invest 126(6), 2372-2384 (2016)Majtan T**, Pey AL, Ereno-Orbea J, Martinez-Cruz LA, Kraus JP: Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions. Curr Drug Targets 17(13), 1455-1470 (2016)Pey AL, Martinez-Cruz LA, Kraus JP, Majtan T**: Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding. FEBS Lett 590(24), 4461-4471 (2016)Majtan T**, Park I, Carrillo RS, Bublil EM, Kraus JP: Engineering and characterization of an enzyme replacement therapy for classical homocystinuria. Biomacromolecules 18(6), 1747-1761 (2017)Majtan T**, Hulkova H, Park I, Krijt J, Kozich V, Bublil EM, Kraus JP: Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria. FASEB J 31, 5495-5506 (2017)Majtan T**, Krijt J, Sokolova J, Krizkova M, Ralat M, Kent J, Gregory JF III, Kozich V, Kraus JP: Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase. Antioxid Redox Signal 28, 311-323 (2018)Majtan T**, Park I, Bublil EM, Kraus JP: Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria. Hum Mutat 39(2), 210-218 (2018)Collard R, Majtan T, Park I, Kraus JP: Import of TAT-conjugated propionyl-CoA carboxylase using models of propionic academia. Mol Cell Biol 38(6), e00491-17 (2018)Gimenez-Mascarell P*, Majtan T*, Oyenarte I, Ereno-Orbea J, Majtan J, Klaudiny J, Kraus JP, Martinez-Cruz LA: Crystal structure of cystathionine β-synthase from honeybee Apis mellifera. J Struct Biol 202, 82-93 (2018)Majtan T**, Jones W Jr., Krijt J, Park I, Kruger WD, Kozich V, Bassnett S, Bublil EM, Kraus JP: Enzyme replacement therapy ameliorates multiple symptoms of murine homocystinuria. Mol Ther 26(3), 834-844 (2018)Majtan T**, Bublil EM, Park I, Arning E, Bottiglieri T, Glavin F, Kraus JP: Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria. Life Sci 200, 15-25 (2018)Majtan T**, Park I, Cox A, Branchford BR, di Paola J, Bublil EM, Kraus JP: Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy. FASEB J 33, 12477-12486 (2019)Kozich V, Majtan T: A key leader in homocystinuria research: Jan P. Kraus (1942-2019). Hum Mutat 40, 1909 (2019)Bublil EM, Majtan T**: Classical homocystinuria: from cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie XX, XXXX (2020)Monographs and book chapters (* = contributed equally, ** = corresponding author):Majtan T**, Majtan V: Class 1 Integrons and Dissemination of Antibiotic Resistance Genes Among Salmonellae: From PCR- to DNA Microarray-Based Approach. In: Yoshida K, Aoki M, Eds. DNA Transposable Elements Research, Nova Science Publishers, Hauppage, NY, ISBN 978-1-60456-531-7, p.109-131 (2008)Majtan V, Majtan J, Drahovska H, Majtan T, Majtanova L: Phenotypic and Molecular Characterization of Salmonella Enterica Serovar Typhimurium Human Isolates in Slovakia (1997–2006). In: Giordano LS, Moretti MA, Eds. Salmonella Infections: New Research, Nova Science Publishers, Hauppage, NY, ISBN 978-1-60456-735-9, p.107-126 (2009)Majtan T**: DNA microarray transcriptional profiling of bacteriophage BFK20. LAMBERT Academic Publishing, Saarbrucken, Germany, ISBN 978-3-8383-8941-7 (2010)Majtan T**, Kraus JP: Novel aspect of cobalt toxicity in Escherichia coli: production of cobalt protoporphyrin IX and its incorporation into heme proteins. In: Kobayashi Y, Suzuki H, Eds. Cobalt: Occurrence, Uses and Properties, Nova Science Publishers, Hauppage, NY, ISBN 978-1-62808-278-4, p.167-190 (2013)Majtan T**: Enzyme misfolding as a common pathogenic mechanism in cystathionine beta-synthase (CBS)-deficient homocystinuria: rescue of CBS mutant enzymes with chemical chaperones. In: McCully KS, Eds. Homocysteine: Biosynthesis and Health Implications, Nova Science Publishers, Hauppage, NY, ISBN 978-1-62948-639-0, p.1-28 (2014)Pey AL, Majtan T, Kraus JP: Calorimetric approaches to studying complex protein structure–function–stability relationships in conformational diseases: The case of cystathionine beta-synthase. In: Bastos M, Eds. Biocalorimetry: Foundations and Contemporary Approaches, CRC Press, Boca Raton, FL, ISBN 978-1-4822-4665-0, p.301-319 (2016)Majtan T**, Pey AL, Gimenez-Mascarell P, Martinez-Cruz LA, Szabo C, Kozich V, Kraus JP: Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. In: Ulloa-Aguirre A, Tao YX, Eds. Targeting Trafficking in Drug Development. Handbook of Experimental Pharmacology, vol. 245, Springer, Cham, ISBN 978-3-319-74164-2, p.345-383 (2018).Kozich V, Kraus JP, Majtan T: Cystathionine Beta-Synthase (CBS) Deficiency: Genetics. In: eLS, John Wiley & Sons Ltd, Chichester, DOI: 10.1002/9780470015902.a0005935.pub3, p.1-12 (2018).Oral presentations (presented in person when listed as the first author):Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS: DEER Distance Measurements Between a Spin Label and a Native FAD Semiquinone in Electron Transfer Flavoproteine. 8th International Workshop on EPR Biology and Medicine, Krakow, October 4 – 7, 2010Majtan T, Smith AT, Burstyn JN, Kraus JP: [OC6] Purification and characterization of R266K cystathionine beta-synthase (CBS) mutant: Impact of short affinity tag on enzyme properties. 8th International Conference on Homocysteine Metabolism, Lisbon, June 19 – 22, 2011Oyenarte I*, Majtan T*, Ereno J, Corral-Rodriguez MA, Kraus JP, Martinez-Cruz LA: Crystal structures of the full-length cystathionine beta-synthases from Apis mellifera and Homo sapiens. Folic Acid, Vitamin B12 & One Carbon Metabolism, FASEB SRC, Chania, Crete, Greece, July 22 – 27, 2012Kraus JP, Bublil EM, Park I, Majtan T, Salzman AL: Enzyme Replacement Therapy for Homocystinuria. 12th International Congress of Inborn Errors of Metabolism (ICIEM 2013), Barcelona, Spain, September 03 – 06, 2013Majtan T, Pey AL, Fernandez R, Fernandez JA, Sanchez-Ruiz JM, Kraus JP: Eukaryotic Cystathionine Beta-Synthases in Evolutionary Context: Domain Cooperativity, Catalysis, and Regulation. 9th International Conference on Homocysteine and One-Carbon Metabolism (Hcy2013), Dublin, Ireland, September 08 – 12, 2013Kozich V, Vozdek R, Krijt J, Sokolova J, Majtan T, Kraus JP: Hydrogen sulfide production by mutant CBS enzymes. Society for Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium, Innsburck, Tyrol, Austria, September 2 – 5, 2014Majtan T, Bublil EM, Park I, Carrillo RS, Ereno-Orbea J, Martnez-Cruz LA, Hulkova H, Krijt J, Kozich V, Kruger W, Kraus JP: CBS Update: Structure, CBS Replacement Therapy, and H2S Production. 3rd European Conference on the Biology of Hydrogen Sulfide (H2S 2015), Athens, Greece, May 03 – 06, 2015 and 10th International Conference on One-Carbon Metabolism, vitamins B6 and Homocysteine (Hcy2015), Nancy, France, July 07 – 11, 2015Kozich V, Krijt J, Sokolova J, Vozdek R, Melenovska P, Majtan T, Kraus JP: Promiscuity of Enzymes in Sulfur Amino Acid Metabolism: Hydrogen Sulfide Production in Homocystinurias. 10th International Conference on One-Carbon Metabolism, vitamins B6 and Homocysteine (Hcy2015), Nancy, France, July 07 – 11, 2015Majtan T, Pey AL, Sanchez-Ruiz JM, Kraus JP: Allosteric regulation of cystathionine beta-synthase and ligand-mediated stabilization of its regulatory domain. 10th International Conference on One-Carbon Metabolism, vitamins B6 and Homocysteine (Hcy2015), Nancy, France, July 07 – 11, 2015Majtan T, Park I, Carrillo RS, Krijt J, Kozich V, Kruger WD, Kraus JP: Efficacy of enzyme replacement therapy for murine homocystinuria. Folic acid, vitamin B12 and one-carbon metabolism FASEB conference, Steamboat Springs, CO, USA, August 7 – 12, 2016Majtan T, Park I, Carrillo RS, Kraus JP: Effect of enzyme replacement therapy on osteoporosis in several CBS-deficient homocystinuric mouse models. Society for Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium, Rome, Italy, September 6 – 9, 2016Majtan T, Park I, Kraus JP: Engineering and characterization of an enzyme replacement therapy for classical homocystinuria. 11th International Conference on Homocysteine and One-Carbon Metabolism, Aarhus, Denmark, May 14 – 18, 2017Kozich V, Krizkova M, Krijt J, Sokolova J, Jesina P, Majtan T, Kraus JP: Hydrogen sulfide metabolism in homocystinurias. Plant and Human Sulfur Biology Conference 2017 (SBIO), Balatonfured, Hungary, September 10 – 14, 2017Majtan T, Park I, Bublil EM, Kraus JP: Interplay of enzyme replacement therapy, diet and betaine in murine cystathionine beta-synthase-deficient homocystinuria. Society for Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium, Athens, Greece, September 4 – 7, 2018Posters (presented in person when listed as the first author):Majtan T, Mlynarcik D: The Effect of Bisquaternary Ammonium Salts on surface hydrophobicity and motility of Salmonella Typhimurium DT104. XII. Congress of the Czechoslovak Society for Microbiology: ?Health and Microorganisms“, Ko?ice, September 5 – 9, 2001Halgasova N, Majtan T, Ugorcakova J, Timko J, Bukovska G: [3P24] Phage-host interactions between corynephage BFK20 and diverse corynebacterial strains. XIX. Meeting of Czech and Slovak Societies for Biochemistry and Molecular Biology, Olomouc, August 31 – September 3, 2004Majtan T, Majtan V: [7P04] Applicability of the Bacterial Short-Term Tests to Detect Genotoxic Activity of Bisquaternary Ammonium Salts. XIX. Meeting of Czech and Slovak Societies for Biochemistry and Molecular Biology, Olomouc, August 31 – September 3, 2004Majtan T, Bukovska G, Timko J: [3P27] Microarray Data Normalization: Development of new positive control based on red fluorescent protein. XIX. Meeting of Czech and Slovak Societies for Biochemistry and Molecular Biology, Olomouc, August 31 – September 3, 2004Majtan V, Majtan T, Majtanova L: [13.012] Characterization of Class 1 Integrons in Clinical Strains of Salmonella Typhimurium Isolated in Slovakia. 12th International Congress on Infectious Diseases (ICID), Lisabon, June 15 – 18, 2006Majtan J, Majtan T, Ofukana A, Majtan V: [R2415] Antibiotic Resistance and Virulence Markers of Human Salmonella Enterica Serovar Kentucky Isolates from Slovakia. 18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, April 19 – 22, 2008Majtan T, Majtan J, Majtanova L, Majtan V: [BP-128] Phage Typing and Antimicrobial Resistance Profile of Human Salmonella Enterica Serovar Typhimurium Isolates In Slovakia. 12th International Congress of Bacteriology and Applied Microbiology (IUMS), Istanbul, August 5 – 9, 2008Majtanova L, Majtan T, Majtan V: [303/64A] Molecular and Biological Characterization of Salmonella Enterica Serovar Paratyphi B dT+, or Salmonella Java Human Isolates. 28e Reunion Interdisciplinaire de chimiotherapie anti-infectieuse (RICAI), Paris, December 4 – 5, 2008Majtan V, Majtan T, Majtanova L: [R2113] Distribution of Integrons and SGI1 among Antibiotic-Resistant Human Isolates of Salmonella Typhimurium Phage Types DT104 and U302. 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Helsinki, May 16 – 19, 2009Majtan T, Freeman KM, Smith AT, Burstyn JN, Kraus JP: [P69] Purification and Characterization of Cystathionine beta-synthase with a Cobalt Protoporphyrin: Implications for the Structural Role of Heme. 7th International Conference on Homocysteine Metabolism, Prague, June 21 – 25, 2009Majtan T, Kozich V, Kraus JP: [P70] Chemical Chaperones Improve Folding and Restore Activity of Some Cystathionine beta-synthase Mutants: Consequences for Therapy of Pyridoxine Non-responsive Homocystinuria? 7th International Conference on Homocysteine Metabolism, Prague, June 21 – 25, 2009; [240] 11th International Congress on Inborn Errors of Metabolism (ICIEM), San Diego, August 29 – September 2, 2009Smith AT, Freeman KM, Majtan T, Su Y, Kraus JP, Burstyn JN: [66] Cobalt Cystathionine beta-synthase: A Cobalt-Substituted Heme Protein with a Unique Thiolate Ligation Motif. Frontiers in Metallobiochemistry (29th Summer Symposium in Molecular Biology), Pennsylvania State University, Philadelphia, June 2 – 5, 2010; [40] Chemistry & Biology of Tetrapyrroles (Gordon Research Conference), Salve Regina University, Newport, July 25 – 30, 2010Soltysova A, Drahovska H, Ficek A, Majtan T, Turna J: [P07.11] Use of the DNA Microarray in Study of Genetic Variability of Salmonella spp. 36th FEBS Congress, Biochemistry for Tomorrow's Medicine, Lingotto Conference Center, Torino, Italy, June 25 – 30, 2011Smith AT, Majtan T, Freeman KM, Scheske MJ, Kraus JP, Burstyn JN: [21] The Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of the Human Enzyme Cystathionine β-Synthase. 15th International Conference on Biological Inorganic Chemistry (ICBIC15), Vancouver, Canada, August 7 – 12, 2011Aggarwal P, Swanson MA, Kathirvelu U, Majtan T, Frerman FE, Eaton GR, Eaton SS: Orientation of electron transfer flavoprotein domain II monitored using Q-band double electron-electron resonance. ACS National Meeting, Denver, CO, August 28 – September 1, 2011Su Y, Majtan T, Linck R, Ponter S, Kraus JP, Burstyn JN: Comparative Study of Enzyme Activity and Heme Reactivity in Fruit Fly and Human Cystathionine b-Synthases. Chemistry & Biology of Tetrapyrroles (Gordon Research Conference), Salve Regina University, Newport, July 22 – 27, 2012Bohova J, Majtan T, Majtan V, Takac P, Kozanek M, Majtan J: An antibiofilm activity of maggots excretions/secretions against wound pathogens biofilms: the role of larval proteases. II International Conference on Antimicrobial Research (ICAR2012), Lisbon, Portugal, November 21 – 23, 2012Kozich V, Krijt J, Sokolov J, Vozdek R, Melenovska P, Hansikova H, Kratochvilova H, Rodinova M, Majtan T, Kraus JP: Changes in Hydrogen Sulfide Production in Cystathionine Beta-synthase Deficiency. 3rd European Conference on the Biology of Hydrogen Sulfide (H2S 2015), Athens, Greece, May 03 – 06, 2015Melenovska P, Krijt, J, Sokolova J, Vozdek R, Hnizda A, Kraus JP, Majtan T, Kozich V: Diversity of reactions catalyzed by human and nematode cystathionine gamma-lyase. The European Human Genetics Conference, Copenhagen (EHSG2017), Denmark, May 27 – 30, 2017Majtan T, Pey AL, Kraus JP: Kinetic stabilizers of the cystathionine beta-synthase regulatory domain as potential pharmacological chaperones for homocystinuria. 42nd Congress of the Federation of the European Biochemical Societies (FEBS2017), Jerusalem, September 10 – 14, 2017Collard R, Kraus JP, Majtan T: Disruption of protein folding machinery by pathogenic cystathionine beta-synthase mutants. Cold Spring Harbor Laboratory meeting on Protein Homeostasis in Health & Disease, Cold Spring Harbor, NY, April 17 – 21, 2018Collard R, Kraus JP, Majtan T: Disruption of protein folding machinery by pathogenic cystathionine beta-synthase mutants. 43rd Congress of the Federation of the European Biochemical Societies (FEBS2018), Prague, Czech Republic, July 7 – 12, 2018Majtan T, Park I, Bublil EM, Kraus JP: Normalization of plasma homocysteine in homocystinuric mice: PEG-CBS versus methionine restriction. 12th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine, Montbrio del Camp, Tarragona, Spain, June 9 – 13, 2019Majtan T, Hulkova H, Krijt J, Park I, Bublil EM, Kozich V, Kraus JP: Longitudinal study on efficacy of ERT to rescue liver disease in CBS KO mice. Society for Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium, Rotterdam, Netherland, September 3 – 6, 2019Last update: JAN 2020 ................
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