Curriculum Vitae



Curriculum Vitae

Mariusz Karbowski, Ph. D.

Associate Professor,

Department of Biochemistry and Molecular Biology,

Center for Biomedical Engineering and Technology,

Center for Stem Cell Biology and Regenerative Medicine,

University of Maryland School of Medicine

Date 04/13/2017

Contact Information

20 N. Pine Street

Room 542S

Baltimore, MD 21201

Tel: (410) 706-4018

Fax: (410) 706-8184

e-mail: mkarbowski@umaryland.edu

Education

1989-1994 M.Sc., Biochemistry and Molecular Biology, Adam Mickiewicz University,

Poznan, Poland

1996-1997 Research Student at Nagoya University School of Medicine, Nagoya,

Japan

1997-2001 Ph.D., Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, Japan

Post Graduate Education and Training

2001-2006 Postdoctoral position at the BSSNB, NINDS, National Institutes of Health, Bethesda, MD

Positions and Employment

2006-2009 Assistant Professor (tenure track), Medical Biotechnology Center, University of Maryland Biotechnology Institute

2009-Present Member of the Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine

2010-Present Member of the Center for Biomedical Engineering and Technology, University of Maryland School of Medicine,

2010-2014 Assistant Professor (tenure track), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine

2014-Present Associate Professor (tenure track), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine

Honors and Awards

1991-1994 Scholarship for the Best Students (Adam Mickiewicz University, Poznan, Poland)

1996-2001 Fellowship of Japanese Ministry of Education (Monbusho, Japan)

1999-2001 Fellowship for young scientists “Tskushi” (Amino-Up Pharmaceutical Company, Sapporo, Japan)

2004 National Institutes of Health Special Act Award for Sustained High Quality Work Performance

2005 National Institutes of Health Fellows Award for Research Excellence

2009 Elected as an international member of the newly formed European Research

Institute for Integrated Cellular Pathology (ERI-ICP) (this list comprises of ~100 scientists active in United States, including several members of the US National Academy of Sciences, Nobel Price Recipients and senior scientists from leading US universities)

2016 Invited to serve as a founding editor of the journal “Cell Stress”; journal of the European Research Institute for Integrated Cellular Pathology (ERI-ICP). Will be launched in January 2017.

Institutional Service

2008-2011 Director of MBC seminar series

2011 Department of Biochemistry and Molecular Biology Seminar Committee

2012, 2013 Department of Biochemistry and Molecular Biology the Political Advisory and Liaison Committee

2012-2016 Co-Director - Department of Biochemistry and Molecular Biology Seminar Committee

2013-2016 Judge at the Annual Graduate Research Conferences, University of Maryland Baltimore

2013-2015 Department of Biochemistry and Molecular Biology Recruitment Committee

2013 Co-director of the Advanced Biochemistry Course (GPLS 701)

2014-2016 Director of the Advanced Biochemistry Course (GPLS 701)

2014-2017 Director of Biochemistry Seminar Course (GPLS 608)

2015 Invited to participate in a round table discussion with a Nobel Prize Laureate Dr. Randy Scheckman (September 11, 2015)

2015-2017 Judge for Elijah Adams Awards for medical students (together with Dr. R. Thompson)

2015-2017 School of Medicine Council, Department of Biochemistry and Molecular Biology, Alternate Representative.

2015-2017 Hosted seminars for the following speakers:

Hiromi Sesaki (John Hopkins University, Baltimore, MD)

Craig Blackstone (NINDS, NIH, NINDS, Bethesda, MD)

Zu-Hang Sheng (NINDS, NIH, Bethesda, MD)

Yihong Ye (NIDDK, NIH, Bethesda, MD)

J. Marie Hardwick (John Hopkins University, Baltimore, MD)

International and National Service

Editorial board member:

2008-2009 Invited as a guest co-editor for the special issue of The International Journal of Biochemistry and Cell Biology; “Mitochondrial Dynamics and Function in Biology and Medicine” (volume 41, issue 10, October 2009)

2013-current Journal of Cancer Research and Therapeutic Oncology

2015-current Journal of Cancer Studies & Research

2016 Cell Stress-founding editor

Grant application reviewer and study section member for the following organizations:

2008, 2009 Reviewer and study section member for American Cancer Society.

2008, 2009 Academy of Finland, Research Council for Health; Helsinki, Finland, review panel of the Academy of Finland Fellow grant applications, EU

2008 Reviewer for National Centre for the Replacement, Refinement and

Reduction of Animals in Research (NC3Rs), United Kingdom

2010 Reviewer for Vascular and Hematology Integrated Review Group; NIH

2010 Invited to evaluate grants for European Research Council, Brussels, EU

2010 Invited to evaluate grants for the Italian Ministry of Health (MOH), Italy, EU; recommended by NIGMS, NIH

2011-2015 Reviewer and study section member American Heart Association (Membrane & Sub Cellular Organelles Committee) (2 sessions each year)

2011 NIH, Committee member/reviewer special emphasis panel: “Biomarkers Indicative of Mitochondrial Dysfunction”.

2012 NIH Committee member/reviewer for special emphasis panel: “Molecular, Cellular and Developmental Neuroscience Integrated Review Group”

2012 Reviewer for Division of Molecular and Cellular Biosciences National Science Foundation (NSF)

2012 Reviewer for 'Molecular and Structural Biology and Biochemistry' section of European Research Council, EU

2013 NIH, MBPP study section; committee member/reviewer.

2013-2015 Reviewer for The German-Israeli Foundation for Scientific Research and Development (GIF), EU

2013 Reviewer for Natural Sciences and Engineering Research Council of Canada (NSERC)

2013 Reviewer for the French Muscular Dystrophy Association (AFM) Research Council, EU

2014 NIH, Committee member/reviewer for ZRG1 EMNR-V (02) Special Emphasis Panel (October)

2014 NIH, Committee member/reviewer for Cellular Mechanisms in Aging and Development (CMAD) study section (November)

2015 NIH, Committee member/reviewer for ZRG1 F05-R study section (February)

2015 NIH, Committee member/reviewer Special Emphasis Panel/Scientific Review Group 2015/05 ZRG1 EMNR-S (02)

2015 Reviewer/committee member for the Italian Ministry of Health (MOH), Italy, EU

2015 NIH, Committee member/reviewer Special Emphasis Panel/Scientific Review Group 2015/10 ZRG1 F05-U (20) L.

2016 NIH, Committee member/reviewer Special Emphasis Panel/Scientific Review Group ZRG1 F05-U 2016 (February)

2016 Reviewer for ATIP-Avenir program of CNRS and INSERM, France, EU

2016 NIH, Committee member/reviewer Special Emphasis Panel/Scientific Review Group ZRG1 F05-U 2016 (October 2016)

2017 NIH, Committee member/reviewer Special Emphasis Panel/Scientific Review Group 2017/05 ZRG1 F05-U (20) (February)

Manuscript reviewer for the following journals (2006-2017):

Science, Science Signaling, Cancer Cell, EMBO Journal, eLIFE, PloS Biology, PloS Genetics, Cell Reports, Cell Metabolism, EMBO Reports, The Journal of Cell Biology, Molecular Biology of the Cell, Trends in Biochemistry, Trends in Endocrinology, Cell Death and Differentiation, The Journal of Neuroscience, Molecular and Cellular Biology, FASEB Journal, Biophysical Journal, Bioassays, Journal of Cellular and Molecular Medicine (regular), Antioxidants and Redox Signaling, Experimental Cell Research, Apoptosis, Mitochondrion, PloS ONE, The International Journal of Biochemistry & Cell Biology, Journal of Environmental Monitoring, Cancer Research, Current Pharmaceutical Design, Proceedings in National Academy of Sciences USA, International Journal of Molecular Sciences, BBA, Mitochondrion, Microscopy Research Techniques, Oncogene, Molecular Cell, Cell Metabolism, Journal of Cell Sciences, Frontiers in Neurodegeneration, Molecular and Cellular Neuroscience.

Teaching and Mentoring Service

Teaching Service

2010-2017 medical students Clinical Conference preceptor (Cell and Molecular Biology; 3 conferences 2010, 2013, 2014 and 2015, 5 conferences in 2011, 2012, and 2016)

2010-2016 GPLS 701 Advanced Molecular Biology course teaching; 4 lectures and 2 conference classes each year

2010-2016 GPLS Core course teaching (Section 7 - Protein Processing, Targeting and Vesicle Trafficking); 2 lectures each year

2013-2017 Cell and Molecular Biology (CMB) course for medical students (2 lectures)

2014-2016 GPLS 713 Advanced Topics in Biochemistry (2 lectures; 3 lectures in 2016)

Mentoring students (PhD candidates) and Postdoctoral fellows

2007-2015 mentoring Postdoctoral Research associates:

Giovanni Benard-currently Associate Professor at University of Bordeaux, France,

Guihong Peng-currently Senior research assistant at John Hopkins University (Baltimore, MD)

Brian Roelofs-currently at FDA (Bethesda, MD)

2010-2015 Sunan Li (MEES program, University of Maryland College Park); graduated in July 2015; currently postdoctoral fellow at NINDS, NIH, (lab of Dr. Zu-Hang Sheng)

2013-current Edward Cherok, Molecular Medicine Program student

2014-2015 Shweta Das, Molecular Medicine Program Master student (start September, 2014); graduated on July 10th 2015.

Short-term students and thesis committee Service

2008, 2009 mentoring two high school summer interns

2011, 2012 mentoring an undergraduate student intern (Nina Mezu, Towson University)

2010, 2011 Ph.D. thesis committee for 2 students [Tiffany Scharadin (mentor Dr. R. Eckert) and Gong Li (mentor Dr. J. Kao)]

2011 mentoring a summer intern (Nicole Veltre, a high school teacher) under the Baltimore Excellence in STEM Teaching (BEST) project (sponsored by NASA and Towson University)

2012 mentoring a summer intern Mr. Siddarth Plakot (student of University of Maryland College Park)

2012, 2013 Ph.D. thesis committee for Moradeke Bamgboye (mentor Dr. J. Lederer)

2013 mentoring two Molecular Medicine Program rotation students (Edward Cherok and Nicholas Mello)

2013 mentoring a Baltimore community college intern Tsvi Palmer (April-September; 2015)

2013 mentoring 3 summer interns (Meghan Loughry, Akira Shepard and Lindsey Petrelle)

2013 GPILS Molecular Medicine Program Qualifying Examination Committee (Raymond Peroutka).

2013-current Ph.D. thesis committee for Evan Bordt (mentor Dr. B. Polster; Department of Anesthesiology)

2014 mentoring two rotation students (MaggiePrescott, Saddef Haq)

2014 GPILS Molecular Medicine Program Qualifying Examination Committee (Eugene Gardner).

2014-2016 Ph.D. thesis committee for Ari Landon (Graduate Program in Molecular Medicine)

2015/2016 Ph.D. thesis committee for Saddef Haq (Graduate Program in Toxicology)

2015-current Ph.D. thesis committee for Ben Portney (Graduate Program in Biochemistry)

2017-current Ph.D. thesis committee for Nina Klimova (Graduate Program in Neuroscience)

Grant Support

Active Grants

R01GM102177 NIH/NIGMS 6/30/2012 - 6/31/2017

“Control of mitochondrial proteostasis by AAA-ATPase p97”

Costs: Annual Direct costs: $190,000

Role: PI (effort 33%); currently no cost extension

R01NS098243-01A1 Monteiro, MJ (PI) 1/15/2017 - 12/31/2021

“Mechanistic studies and therapeutics for ALS-FTD linked to UBQLN2 mutations”

Role: Co-Investigator (effort 3.75%).

Completed Grants

R01GM083131 NIH/NIGMS 09/01/2008-08/31/2014

“Role of mitochondria associated RING finger proteins in mitochondrial quality control”

Costs: Annual Direct costs: $180,000

Role: PI (effort 37%)

TEDCO MSRF 07/2009-06/2011 “Maintenance of mitochondrial fusion and fission as a critical factor in stem cell viability, differentiation capacity and differentiation-induced mitochondrial biogenesis”

Costs: Annual Direct costs: $100,000

Role: PI (effort 15%)

Publications (h-index 30; total number of articles citing my work >5500; according to Reuters Web of Knowledge; January 1, 2017)

Peer reviewed articles

1. Matsuhashi T, Liu X, Karbowski M, Woznak M, Antosiewicz J, Wakabayashi T. Role of free radicals in the mechanism of the hydrazine-induced formation of megamitochondria. Free Radic. Biol. Med. 1997, 23: 285-93

2. Karbowski M, Kurono C, Nishizawa Y, Horie Y, Soji T, Wakabayashi T. Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocytes. Biochim. Biophys. Acta 1997, 1349: 242-250

3. Matsuhashi T, Karbowski M, Liu X, Usukura J, Wozniak M, Wakabayashi T. Complete suppression of ethanol-induced formation of megamitochondria by 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl (4-OH-TEMPO). Free Radic. Biol. Med. 1998, 24: 139-147 Teranishi M, Karbowski M, Kurono C, Soji T, Wakabayashi T. Two types of the enlargement of mitochondria related to apoptosis: simple swelling and the formation of megamitochondria. J. Electron Microsc. (Tokyo). 1999, 48: 637-651

4. Karbowski M, Kurono C,Wozniak M, Ostrowski M, Teranishi M, Nishizawa Y, Usukura J, Soji T, Wakabayashi T. Free radical-induced megamitochondria formation and apoptosis. Free Radic. Biol. Med. 1999, 26: 396-409

5. Karbowski M, Kurono C,Wozniak M, Ostrowski M, Teranishi M, Soji T, Wakabayashi T. Cycloheximide and 4-OH-TEMPO suppress chloramphenicol-induced apoptosis in RL-34 cells via the suppression of the formation of megamitochondria. Biochim. Biophys. Acta. 1999,1449: 25-40

6. Teranishi M, Karbowski M, Kurono C, Nishizawa Y, Usukura J, Soji T, Wakabayashi T. Effects of coenzyme Q10 on changes in the membrane potential and rate of generation of reactive oxygen species in hydrazine- and chloramphenicol-treated rat liver mitochondria. Arch. Biochem. Biophys. 1999, 366: 157-167

7. Wakabayashi T, Teranishi M, Karbowski M, Nishizawa Y, Usukura J, Kurono C, Soji T. Functional aspects of megamitochondria isolated from hydrazine- and ethanol-treated rat livers. Pathol. Int. 2000, 50: 20-33

8. Teranishi M, Spodnik JH, Karbowski M, Kurono C, Soji T, Wakabayashi T. Swelling of free-radical-induced megamitochondria causes apoptosis. Exp. Mol. Pathol. 2000, 68: 104-123

9. Karbowski M, Spodnik JH, Teranishi M, Wozniak M, Nishizawa Y, Usukura J, Wakabayashi T. Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. J. Cell Sci. 2001, 114: 281-291

10. Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle JR. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J. Cell Biol. 2002, 23:159, 931-938

11. Kaminski M, Masaoka M, Karbowski M, Kedzior J, Nishizawa Y, Usukura J, Wakabayashi T. Ultrastructural basis for the transition of cell death mode from apoptosis to necrosis in menadione-treated osteosarcoma 143B cells. J Electron Microsc (Tokyo). 2003, 52: 313-325

12. Arnoult D, Karbowski M, Youle RJ. Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor. Cell Death Differ. 2003, 10: 845-849

13. Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, and Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J. 2003, 22: 4385-4399

14. Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N. The Solution Structure of human mitochondria fission protein Fis1 reveals a novel TPR-Like helix bundle. J. Mol. Biol. 2003, 334: 445-458

15. Karbowski M, Youle R J. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 2003, (Review) 10: 870-880

16. Kaminski M, Niemczyk E, Masaoka M, Karbowski M, Hallmann A, Kedzior J, Majczak A, Knap D, Nishizawa Y, Usukura J, Wozniak M, Klimek J, Wakabayashi T. The switch mechanism of the cell death mode from apoptosis to necrosis in menadione-treated human osteosarcoma cell line 143B cells. Microsc Res Tech. 2004, 64:255-258

17. Karbowski M, Arnoult D, Chen H, Chan DC, Smith CL, Youle RJ. Quantification of mitochondrial dynamics by photolabeling of individual organelles shows mitochondrial fusion is blocked during Bax activation phase of apoptosis. J. Cell Biol.2004, 164: 493-499 (“Apoptotic mitochondria blow a fuse”, an editorial on the article was published in J. Cell Biol.2004, 164:477)

18. Karbowski M, Jeong SY, Youle RJ. Endophilin B1 is required for the maintenance of mitochondrial morphology. J. Cell Biol. 2004,166:1027-1039

19. Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell 2004, 15: 5001-5011

20. Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang H-G. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 2005, 25: 9369-9382

21. Youle RJ, Karbowski M. Mitochondrial morphogenesis and apoptosis. Nature Rev. Mol. Cell Biol. 2005, (Review) 6: 657-663

Articles published after joining University of Maryland:

22. Karbowski M*, Norris K, Cleland M, Jeong SY, Youle RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006, 443: 658-662 (“Cell biology: mitochondria shape up”, an editorial on the article was published in Nature 2006, 443:646-7). *M. Karbowski is a co-corresponding author

23. Karbowski M, Neutzner A, Youle RJ. The mitochondria associated ubiquitin ligase MARCH5 is required for Drp1-dependent division of mitochondria. J. Cell Biol. 2007, 178: 71-84 (“Mitochondria on the MARCH”, an editorial on the article was published in J. Cell Biol. 2007, 178:3)

24. Zanna C, Ghelli, A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain 2008, 131: 352-67

25. Neutzner A, Benard G, Youle R J and Karbowski M. Role of ubiquitin conjugation system in the maintenance of mitochondrial homeostasis; Annals NY Acad. Sci. 2008, (Review) 1147:242-53 (cited 32 times)

26. Wang H, Lim PJ, Karbowski M, and Monteiro MJ. Effects of overexpression of huntingtin proteins on mitochondrial integrity. Human Molecular Genetics, 2009, 18:737-52

27. Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Youle R, Chan DC, Alexander C, Langer T, Bauer C, Martinou JC. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J, 2009, 8(11): 1589-600

28. Benard G, Karbowski M. Mitochondrial fusion and fission: regulation and involvement in cell fitness. Seminars in Cell and Developmental Biology. 2009, (Review) 20: 365-374

29. Park Y-Y, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through Drp1 and Mfn1. J. Cell Sci., 2010, 123:619-26

30. Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J. 2010, 29: 1458-71 (all data comes from Karbowski’s lab, R. Youle lab supplied some critical reagents)

31. Ryu SW, Jeong HJ, Choi M, Karbowski M, Choi C. Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation. Cell Moll. Life Sci. 2010, 67: 2839-50

32. Tanaka A, Cleland MC, Xu S, Narendra DP, Suen D-F, Karbowski M*, Youle R. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J. Cell Biol. 2010, 191(7): 1367-80. PMCID: PMC3010068, *M. Karbowski is a co-corresponding author (p97-related data and initial discovery come from Karbowski’s lab)

33. Cleland MM, Norris KL, Karbowski M, Wang C, Jiao S, George NM, Luo X, Li Z, Youle RJ. Bcl-2 family protein interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 2011,18(2): 235-47.

34. Xu S, Peng G, Wang Y, Fang S, Karbowski M. The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol. Biol. Cell 2011, 22(3): 291-300 PMCID: PMC3031461

35. Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M. A systematic search for ER membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J. Biol. Chem. 2011, 286(10):8633-43. PMCID: PMC3048745

36. Karbowski M* and Youle RJ Regulating Mitochondrial Outer Membrane Proteins by Ubiquitination and Proteasomal Degradation. (Review) Current Opinions in Cell Biology. 2011 23(4): 476-82. *M. Karbowski is a co-corresponding author; PMCID: PMC3155757

37. Karbowski M and Netzner A. Neurodegeneration as consequence of failed mitochondrial maintenance. (Review) Acta Neuropathologica 2012; 123(2): 157-71. *M. Karbowski is a co-corresponding author; PMID: 22143516; PMCID not available

38. Neutzner A, Li S, Xu S and Karbowski M. Role of selective protein degradation in the regulation of apoptosis. (Review) Seminars in Cell and Developmental Biology: Issue: Cell Regulation by Selective Protein Degradation. 2012, 23(5): 499-508; PMID: 22516642

39. Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proc Natl Acad Sci U S A. 2012,109(47): 19426-31. PMCID: PMC3511152

40. Chen Z, Zhong Y, Wang Y, Xu S, Liu Z, Baskakov I, Monteiro MJ, Karbowski M*, Shen Y, Fang S. Ubiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cells. Plos ONE. 2013 Sep 5;8(9):e73482.*M. Karbowski is a co-corresponding author

41. Roelofs B, Cleland MM, Karbowski M. Visualization and quantification of mitochondrial fusion. Methods Enzymol. 2014; 547:57-73. PMID: 25416352

42. Li S, Xu S, Roelofs BA, Boyman L, Lederer WJ, Sesaki H, Karbowski M. Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission; J Cell Biol. 2015; 208:109-123. (“Actin is good at long division”, an editorial on the article was published in J. Cell Biol.2015 208:2)

43. Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M. Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein; Mol. Biol. Cell. 2016; 27(2):349-59

44. Roelofs BA, Bordt EA, Loughry M, Palmer T, Polster BM, Karbowski M. Npl4 is required for the outer mitochondrial membrane associated degradation pathway and regulates mitochondrial bioenergetic performance; BBA 2016; under revision.

45. Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, Wang C, Karbowski M. Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics; Mol. Biol. Cell. 2017; 28(3):396-410; early release article published on December 8, 2016.

46. Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K1, Karbowski M, Sesaki H, Hill RB, Polster BM. The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species; Dev. Cell. 2017:40(6):583-594

Book chapters and editorials:

1. Wakabayashi T, Karbowski M. Structural changes of mitochondria related to apoptosis. Biol. Signals Recept. 2001,1-2: 26-56

Published after joining University of Maryland:

2. Neutzner A, Youle RJ and Karbowski M. Outer Mitochondrial Membrane Protein Degradation by the Proteasome; chapter in the book “Frontiers of mitochondrial biology” 2008

3. Rossignol R, Karbowski M. Editorial of the directed issue on mitochondrial dynamics in biology and medicine; The International Journal of Biochemistry & Cell Biology 41 (2009) 1748–1749

4. Benard G, Peng G, Karbowski M. Mitochondrial fusion and fission; chapter in the book “Cell Death” edited by Gerry Melino and David Vaux. Published by Wiley (March, 2010)

5. Karbowski M. “Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis” chapter in the book “BCL2 Protein Family: Essential Regulators of Cell Death”; also available on line at Madame Curie Bioscience Database

6. Wang H, Karbowski M, Monteiro M. Mitochondrial Dynamics and Huntington’s

Disease: A Dance of Fate; chapter in the book “Mitochondrial Dynamics and Neurodegeneration” (2011) published by Springer, ISBN 978-94-007-1290-4; 235-258.

Symposia and International Meetings

2003

1. NIH Research Festival 2003, Bethesda, MD, USA, symposium “Programmed Cell Death: Methods and Pathways”, invited presentation: “Visualizing signaling by Bcl-2 family proteins in vivo”

2004

2. 13th European Bioenergetics Conference, Pisa, Italy, poster presentation: “Quantification of mitochondrial fusion”

2005

3. Biophysical Society 49th Annual Meeting, Long Beach, CA, USA, symposium “Mitochondria in the Cellular Dynamics” invited presentation “Mitochondrial dynamics during cell death”

4. NIH Neurobiology Interest Group Seminar, Bethesda, MD, USA, “Mitochondrial dynamics in neurological disorders”

5. NIH Research Festival 2005, Bethesda, MD, USA, symposium “The Dynamin Family, Endocytosis, Apoptosis and Neurological Diseases”, invited presentation: “Regulation of outer mitochondrial membrane dynamics by Dynamin-related protein 1”

2006

6. NIH Molecular Pulmonary Interest Group meeting, Bethesda, MD, USA, invited presentation: “Mitochondrial dynamics and quality control in cell life and death”

2007

NIH Apoptosis Interest Group, Bethesda, MD, USA, invited presentation: “GTP- and Ubiquitin-dependent regulation of mitochondrial membranes”

7. NIH Research Festival 2007, Bethesda, MD, USA, symposium “Organelle Trafficking and Dysfunction in Diseases”; invited presentation: “Regulation of Organelle Homeostasis by Membrane-associated RING Finger E3 Ubiquitin Ligases”

8. “MITOCHONDRIA & OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS”, a satellite meeting of the International Society of Neurochemistry, New York, USA; invited presentation: “Mitochondrial Membrane Quality Control in Cell Life and Death”

9. NIHLB, NIH, Bethesda, MD, USA; invited seminar presentation: “Ubiquitin-dependent mitochondrial quality control”

2008

10. Cell Death: Molecules That Specify The Variety Of Cell Death Mechanisms

Gordon Research Conference, Lucca, Italy; invited presentation: "Identification of a novel E3 ubiquitin ligase that controls turnover of Bax and apoptosis"

2009

11. Institute for Research in Biomedicine, Barcelona, Spain; invited presentation: “Role of the ubiquitin conjugation system in the control of mitochondrial integrity”

12. University of Maryland School of Medicine, Center for Vascular and Inflammatory Diseases, Baltimore, MD; invited presentation “Role of the Ubiquitin Conjugation System in the Control of Mitochondrial Functional Integrity”

2010

13. 16th European Bioenergetics Conference - Warsaw, Poland; oral presentation: “Outer mitochondrial membrane protein degradation by the proteasome/ubiquitin system”

14. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine; oral presentation: “Role of Ubiquitin and proteasome system in mitochondrial quality control”

15. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine; invited presentation: “Ubiquitin- and proteasome-dependent regulation of mitochondrial homeostasis”

2011

16. 1st Annual Ubiquitin Research and Drug Discovery in Cancer Conference; San Diego, CA; invited presentation: “Mitochondrial protein regulation and degradation by ubiquitin/proteasome system”

17. 8th Conference on Mitochondrial Physiology; Bordeaux, France; invited talk (September)

18. International conference “Mitochondrial dynamics; from mechanism to disease” Sardinia, Italy; invited talk (September)

19. The Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD; (September 28)

20. John Hopkins University Mitochondrial Interest Group; Baltimore, MD; invited talk (October, 10).

21. University of Maryland/John Hopkins University Mitochondrial Research Retreat; Baltimore, MD; invited talk (October 29)

22. 12th annual retreat of the Medical and Scientific Advisory Board of MPM Capital, LP. Boston, MA; invited presentation (November 3)

2012

23. 2nd Ubiquitin Research and Drug Discovery Conference• Feb 27-28, 2012 • Las Vegas, Nevada, USA; invited presentation

2013

24. The 4th International Symposium on Dynamics of Mitochondria: from Molecular Mechanisms to Physiological Functions and Disease; Okinawa, Japan, October 28th, 2013: selected oral presentation.

2014

25. Keystone Meeting: Mitochondrial Dynamics and Physiology; Santa Fe, February 18-23, 2014; selected talk (abstract of my lab’s postdoctoral fellow Brian A. Roelofs has been also selected for a talk).

26. American Society of Cell Biology Annual Meeting; Philadelphia, December 6-11, 2014; two invited presentations at different sessions

2015

27. Graduate Program in Life Sciences Department of Biochemistry & Molecular Biology; University of Maryland School of Medicine, February 2, 2015; seminar title: New insights into the outer mitochondria membrane-associated degradation (OMMAD) pathway.

2016

28. Department of Biochemistry and Molecular Biology Retreat; January 8, 2016; talk title: Novel insights into regulation of mitochondrial fission and fusion in mammalian cells.

29. University of Maryland School of Medicine Council Meeting, February 24, 2016; talk title: Control of mitochondrial proteostasis by the ubiquitin proteasome system.

2017

30. Department of Biochemistry and Molecular Biology seminar series

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