Genetic Defects in Thyroid Hormone Synthesis and Action
The population-based newborn screening measures TSH or TSH and total T4 in dried blood spots obtained in the first 3 days of life. In newborns with a screening result suspicious for hypothyroidism, the diagnosis of primary CH is confirmed when serum TSH levels are above and free T 4 levels are below the age-related reference ranges. Hypothalamic-pituitary hypothyroidism is more difficult to ... ................
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