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Onset of CRP levels to normal range: A decrease in C-reactive protein (CRP) levels to within normal ranges occurred as early as week 2 following initiation of therapy for either 4 or 8 mg/kg doses. ... Patients with absolute neutrophil count (ANC) < 2000/mm3, platelet count < 100,000/mm3, AST/ALT > 1.5 x ULN should NOT be started on tocilizumab ... ................
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