Recent Advances and New Directions in Cancer Therapy”
13 th ANNUAL CALIFORNIA CANCER
CONSORTIUM CONFERENCE
"Recent Advances and New Directions in Cancer Therapy"
August 18-20, 2017
The Langham Hotel Pasadena, CA
Presented by the California Cancer Consortium
University of California Davis Comprehensive Cancer Center Sacramento, CA
City of Hope Comprehensive Cancer Center Duarte, CA
University of Southern California/Norris Comprehensive Cancer Center Los Angeles, CA
Stanford Cancer Institute Comprehensive Cancer Center Stanford, CA
Conference Chairs: Primo Lara, Jr., M.D. | Edward Newman, Ph.D.
Educational Steering Committee: David Gandara, M.D. Shivaani Kummar, M.D. Heinz-Josef Lenz, M.D.
Sponsored by:
THE MEDICAL EDUCATOR CONSORTIUM
PROGRAM CHAIRS
Primo Lara, Jr., M.D. Acting Director, UCD Comprehensive Cancer Center Professor of Medicine University of California Davis School of Medicine Associate Director for Translational Research University of California Davis Comprehensive Cancer Center
Edward Newman, Ph.D. Associate Professor, Cancer Biology Co-Leader of the Development Cancer Therapeutics Program City of Hope Comprehensive Cancer Center Duarte, CA
STEERING COMMITTEE
David Gandara, M.D. Professor of Medicine University of California Davis School of Medicine Senior Advisor to the Director, University of California Davis Comprehensive Cancer Center
Shivaani Kummar, M.D. Professor of Medicine Stanford University School of Medicine
Heinz-Josef Lenz, M.D. Professor of Medicine and Preventive Medicine, Section Head of GI Oncology University of Southern California, Keck School of Medicine Associate Director for Clinical Research, University of Southern California Norris Comprehensive Cancer Center
DISTINGUISHED FACULTY
Afsaneh Barzi, MD, PhD Assistant Professor of Medical Oncology Department of Medicine Division of Oncology USC Norris Comprehensive Cancer Center Los Angeles, CA
Robert Chen, MD Associate Professor City of Hope Medical Center Duarte, CA
Helen Chew, MD Professor of Medicine, Division of Hematology/Oncology UC Davis Comprehensive Cancer Center Sacramento, CA
Vincent Chung, MD, FACP Associate Clinical Professor City of Hope Department of Medical Oncology Duarte, CA
A. Dimitrios Colevas, MD Associate Professor of Medicine Stanford University School of Medicine Stanford, CA
Mihaela Cristea, MD Assistant Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Tanya Dorff, MD Assistant Professor USC Keck School of Medicine Norris Comprehensive Cancer Center Los Angeles, CA
Oliver Dorigo, MD, PhD Professor Stanford University School of Medicine Stanford, CA
Anthony El-Khoueiry, MD Assistant Professor USC California Keck School of Medicine Norris Comprehensive Cancer Center Los Angeles, CA
Marwan Fakih, MD Interim Chair and Professor, Medical Oncology and Therapeutics Research Section Head, GI Medical Oncology Co-Director, GI Cancers Program City of Hope Comprehensive Cancer Center Duarte, CA
Paul Frankel, PhD Staff Scientist, Division of Biostatistics Department of Information Sciences Beckman Research Institute, City of Hope Comprehensive Cancer Center Duarte, CA
David Gandara, MD Professor of Medicine Division of Hematology and Oncology UC Davis Comprehensive Cancer Center Sacramento, CA
Susan Groshen, PhD Professor of Medicine and Director Biostatistics Core USC Norris Comprehensive Cancer Center Los Angeles, CA
James Hu, MD USC Norris Comprehensive Cancer Center Hematology/Oncology Services Los Angeles, CA
Brian Jonas, MD, PhD Assistant Professor, Division of Hematology/Oncology UC Davis School of Medicine Sacramento, CA
Kevin Kelly, MD, PhD Associate Professor of Clinical Medicine Assistant Medical Director of Clinical Investigations Support Office, Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases University of Southern California Los Angeles, CA
Edward Kim, MD, PhD Assistant Professor Division of Hematology and Oncology UC Davis Comprehensive Cancer Center Sacramento, CA
Mariana Koczywas, MD Clinical Professor of Medicine City of Hope Comprehensive Cancer Center Duarte, CA
Shivaani Kummar, MD Professor, Department of Medicine Director, Phase I Clinical Research Program Stanford University School of Medicine Stanford, CA
Primo Lara, Jr., MD Professor of Medicine, Associate Director for Translational Research UC Davis Comprehensive Cancer Center Sacramento, CA
Peter Lee, MD Billy Wilder Endowed Professor Chair, Department if Immuno-Oncology City of Hope Comprehensive Cancer Center Duarte, CA
Heinz-Josef Lenz, MD, PhD Professor of Medicine and Preventive Medicine Section Head of GI Oncology University of Southern California Keck School of Medicine Associate Director for Clinical Research USC Norris Comprehensive Cancer Center Los Angeles, CA
Jeffrey Longmate, PhD Professor and Director, Division of Biostatistics Department of Information Sciences Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte, CA
Philip Mack, PhD Associate Professor of Medicine, UC Davis School of Medicine Director, Cancer Molecular Pharmacology UC Davis Comprehensive Cancer Center Sacramento, CA
Guido Marcucci, MD Professor of Medicine, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Kim Margolin, MD Professor of Medicine, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Erminia Massarelli, MD, PhD Associate Clinical Professor Department of Medical Oncology & Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Arta Monjazeb, MD, PhD Associate Professor Department of Radiology Oncology City of Hope Comprehensive Cancer Center Duarte, CA
Edward Newman, PhD Associate Professor, Molecular Pharmacology Co-director, Analytical Pharmacology Core Facility City of Hope Comprehensive Cancer Center Duarte, CA
Sumanta Pal, MD Assistant Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Mamta Parikh, MD, MS Assistant Professor Hematology & Oncology UC Davis Comprehensive Cancer Center Sacramento, CA
Mark Pegram, MD Professor of Medicine Director of the Breast Cancer Program Co-Director of Molecular Therapeutic Program Stanford University Stanford, CA
Christiane Querfeld, MD, PhD, FAAD Chief, Division of Dermatology Director, Cutaneous Lymphoma Program Assistant Professor/Dermatology/ Dermatopathology City of Hope Comprehensive Cancer Center Duarte, CA
David Quinn, MBBS, PhD Associate Professor and Head Section of GU Medical Oncology USC Keck School of Medicine Leader Developmental Therapeutics Program USC Norris Comprehensive Cancer Center Los Angeles, CA
Sunil Reddy, MD Clinical Assistant Professor Medicine-Oncology Stanford Cancer Center Stanford, CA
Jonathan Riess, MD Assistant Professor UC Davis School of Medicine Sacramento, CA
Sarmad Sadeghi, MD, PhD Assistant Professor, University of Southern California Division of Oncology Norris Comprehensive Cancer Center Los Angeles, CA
Ravi Salgia, MD, PhD Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Sandy Srinivas, MD Associate Professor Stanford University School of Medicine Stanford, CA
Joseph Tuscano, MD Professor of Medicine, Division of Hematology and Oncology, UC Davis School of Medicine UC Davis Comprehensive Cancer Center Sacramento, CA
Przemyslaw Twardowski, MD Associate Professor, Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, CA
Jeff Weitzel, MD Professor of Oncology & Population Sciences Chief, Division of Clinical Cancer Genomics City of Hope Comprehensive Cancer Center Duarte, CA
Yuan Yuan, MD, PhD Assistant Professor Department of Medical Oncology & Therapeutic Research City of Hope Comprehensive Cancer Center Duarte, CA
13th Annual California Cancer Consortium Conference
"Recent Advances and New Directions in Cancer Therapy"
COURSE DESCRIPTION
This conference aims to provide up-to-date information to the clinician regarding new advances in cancer biology, diagnosis, and treatment. It will bring together respected opinion leaders, practicing clinicians and scientists engaged in clinical cancer research to discuss the latest cancer diagnostic and therapeutic advances. Topics focus on the major cancers and drug development areas, including signal transduction/CDK inhibition, angiogenesis inhibition, PI3K/mTOR inhibition, antibody-drug conjugates, and immunotherapy, among others. This annual conference also includes interactive roundtable discussion forums with participation of cancer care experts from the California Cancer Consortium, and features renowned professionals from academia, patient advocacy, government, payer, industry, and business realms of cancer care.
EDUCATIONAL OBJECTIVES
After participating in this educational activity, you should be able to:
? Identify signaling and immunotherapeutic pathways that are involved in the growth and metastases of various tumor types, and identify specific opportunities for therapeutic intervention.
? Describe recent advances in the molecular phenotyping of cancer and relate these to the optimal management of patients with cancer.
? Based on recent clinical trials, assess the efficacy of novel therapeutic strategies in the treatment of patients with cancer.
? Discuss new and emerging clinical trial designs that can test and validate new therapeutic strategies for cancer patients.
TARGET AUDIENCE
This program will be of interest to medical oncologists, hematologists, surgical oncologists, radiation oncologists, diagnostic radiologists, pulmonologists, urologists, gastroenterologists, pathologists, fellow and resident trainees, advanced care practitioners, registered nurses, physician assistants, clinical research coordinators, biostatisticians, and others involved in oncologic drug development and clinical care.
NEEDS ASSESSMENT
This course was developed in cooperation with the academic faculty and scientists belonging to the California Cancer Consortium to provide an annual in-depth exposure and review of new advances in cancer drug development, biology, biomarkers, diagnosis, and therapy. The agenda and format was specifically designed to address knowledge gaps identified from prior course participant evaluations and unsolicited comments from practicing oncologists (from private practice, academia) as well as scientists involved in cancer clinical trials. This area of knowledge will be best addressed by an in-depth conference on systemic therapy of malignancies (both solid and hematologic), with ample time provided for interaction by attendees with expert faculty. It is expected that this course will enhance the clinical competence of clinicians in managing the care of the cancer patient, and subsequently, improve patient outcomes.
ACCREDITATION
The Medical Educator Consortium is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The Medical Educator Consortium designates this live educational activity for a maximum of 13.5 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
DISCLOSURE
The Medical Educator Consortium (MEC) adheres to the ACCME Standards for Commercial Support. All persons that will be in a position to control the content of the CME Activity are required to disclose all relevant financial relationships. Faculty disclosure forms outlining this information will be made available to all participants prior to educational Activity. MEC has also implemented a mechanism to identify and resolve all conflicts of interest prior to the education activity being delivered to learners. The source of all support from commercial interests will also be disclosed to learners prior to the beginning of the educational activity.
NURSING CONTINUING MEDICAL EDUCATION
Continuing Medical Education is acceptable for meeting RN continuing education requirements, as long as the course is AMA PRA Category 1 CreditsTM, and has been taken within the appropriate time frames.
CONFERENCE AGENDA
13th Annual California Cancer Consortium Conference
"Recent Advances and New Directions in Cancer Therapy"
FRIDAY, AUGUST 18th, 2017
11:30 am Registration & Visit Exhibits
12:45 pm - 1:55 pm 2:00 pm
Product Showcase Lunch (Non CME) Welcome and Introductions
Session 1: Everything Old is New Again: Targeting DNA Repair Pathways in Oncology Chairs: Primo Lara (UC Davis) and Edward Newman (City of Hope)
2:15 pm DNA Repair (PARP, Wee1, ATM, ATR, etc) as a Therapeutic Target Jeff Weitzel, City of Hope 2:35 pm Question-and-Answer Session 2:40 pm BER Inhibitors (TRC102) Marianna Koczywas, City of Hope 3:00 pm Question-and-Answer Session 3:05 pm ATR Inhibition (VX-970) Sumanta Pal, City of Hope 3:25 pm Question-and-Answer Session 3:30 pm Novel Cytotoxics in Development Sarmad Sadeghi, USC 3:50 pm Question-and-Answer Session
3:55 pm ? 4:25 pm Product Showcase (Non-CME )
4:25 pm ? 4:40 pm
Refreshment Break; Visit Exhibits
Session 2: Clinical Trial Design Chairs: Susan Groshen (USC) and Paul Frankel (City of Hope)
4:40 pm Design of Phase I Trials 101: Beyond Modified Fibonacci (CRM, TITE-CRM, etc) Shivaani Kummar, Stanford 5:00 pm Question-and-Answer Session 5:05 pm Design of Phase 2 Trials 101: Promise and Pitfalls of Interim Analysis Susan Groshen, USC 5:25 pm Question-and-Answer Session 5:30 pm Statistical Considerations for Molecular Correlative Studies in Phase I and II Trials Jeff Longmate, City of Hope 5:50 pm Question-and-Answer Session 5:55 pm Roundtable Discussion Moderator: Edward Newman (City of Hope) Participants: Jeff Longmate, Paul Frankel, Susan Groshen, Shivaani Kummar 6:15 pm Adjourn for the Day
6:30 pm ? 7:30 pm 7:30 pm ? 9:00 pm
Welcome Reception Product Showcase ? Dinner (Non CME)
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