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Name of Journal: World Journal of CardiologyManuscript NO: 42942Manuscript Type: ReviewPercutaneous devices for left atrial appendage occlusion: A contemporary reviewMoussa Pacha H et al. Left atrial appendage occlusionHomam Moussa Pacha, Yasser Al-khadra, Mohamad Soud, Fahed Darmoch, Abdulghani Moussa Pacha, M Chadi AlraiesHomam Moussa Pacha, Mohamad Soud, MedStar Washington Hospital Center, Washington, DC 20010, United StatesYasser Al-khadra, Cleveland Clinic, Medicine Institute, Cleveland, OH 44195, United StatesFahed Darmoch, Beth Israel Deaconess Medical center/Harvard medical school, Boston, MA 02215, United StatesAbdulghani Moussa Pacha, University Hospital of Mainz, Mainz 55122, GermanyM Chadi Alraies, Wayne State University, Detroit Medical Center, Detroit Heart Hospital, Detroit, MI 48201, United StatesORCID number: Homam Moussa Pacha (0000-0003-4403-0941); Yasser Al-khadra (0000-0002-6618-1401); Mohamad Soud (0000-0003-2265-0875); Fahed Darmoch (0000-0003-2094-7368); Abdulghani Moussa Pacha (0000-0001-9159-2811); M Chadi Alraies (0000-0002-7874-4566).Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.Conflict-of-interest statement: No potential conflicts of interest. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: source: Unsolicited manuscriptCorresponding author: M Chadi Alraies, MD, Wayne State University, Detroit Medical Center, Detroit Heart Hospital, 311 Mack Ave, Detroit, MI 48201, United States. makraies@Telephone: +1-216-2550008 Fax: +1-313-7453500Received: October 16, 2018 Peer-review started: October 16, 2018First decision: October 26, 2018Revised: December 12, 2018Accepted: December 17, 2018Article in press: December 17, 2018Published online: February 26, 2019AbstractPatient with atrial fibrillation (AF) are at risk of developing stroke with the left atrial appendage (LAA) being the most common site for thrombus formation. If left untreated, AF is associated with 4 to 5 folds increase in the risk of ischemic stroke in all age groups. About 5% to 15% of AF patients have atrial thrombi on transesophageal echocardiography, and 91% of those thrombi are located in the LAA in patient with nonrheumatic AF. Although oral anticoagulants are the gold-standard treatment for stroke prevention in patients with non-valvular AF, some patients are at high risk of bleeding and deemed not candidates for anticoagulation. Therefore, LAA occlusion (LAAO) has emerged as alternative approach for stroke prevention in those patients. Surgical LAAO is associated with high rate of unsuccessful closure and recommended only in patients with AF and undergoing cardiac surgery. Percutaneous LAAO uses transvenous access with trans-septal puncture and was first tested using the PLAATO device. Watchman is the most common and only Food and Drug Administration (FDA) approved device for LAAO. LAAO using Watchman device is non-inferior to warfarin therapy in preventing ischemic stroke/systemic thromboembolism. However, it is associated with lower rates of hemorrhagic stroke, bleeding and death. Amplatzer is another successful LAAO device that has CE mark and is waiting for FDA approval. Optimal antithrombotic therapy post LAAO is still under debate and highly patient-specific. The aim of this paper is to systematically review the current literature to evaluate the efficacy and safety of different LAAO devices. Key words: Left atrial appendage; Atrial fibrillation; Anticoagulation; Stroke; Mortality? The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.Core tip: Left atrial appendage occlusion (LAAO) is a reasonable alternative approach that is used in patients with atrial fibrillation who are not candidates for anticoagulation. A number of key trials have shown that Watchman device is non-inferior to warfarin therapy in preventing ischemic stroke/systemic thromboembolism. However, it is associated with lower rates of hemorrhagic stroke, bleeding and death. Multiple retrospective and prospective studies of Amplatzer device (ACP and Amulet) reported high success rates in device implantation and stroke prevention. Our objective is to consolidate the current literature to better delineate the safety, efficacy and indication of LAAO for stroke prevention.Citation: Moussa Pacha H, Al-khadra Y, Soud M, Darmoch F, Moussa Pacha A, Alraies MC. Percutaneous devices for left atrial appendage occlusion: A contemporary review. World J Cardiol 2019; 11(2): 57-70URL: : fibrillation (AF) affects 2.7 to 6.1 million in the United states and 33.5 million worldwidePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbzwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051

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ADDIN EN.CITE.DATA [1-3]. The projected prevalence of AF in the United states is expected to be 12.1 million by 2030 ADDIN EN.CITE <EndNote><Cite><Author>Colilla</Author><Year>2013</Year><RecNum>703</RecNum><DisplayText><style face="superscript">[4]</style></DisplayText><record><rec-number>703</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1503453136">703</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colilla, S.</author><author>Crow, A.</author><author>Petkun, W.</author><author>Singer, D. E.</author><author>Simon, T.</author><author>Liu, X.</author></authors></contributors><auth-address>Global Health Economics and Outcomes Research, Bristol-Myers Squibb, Princeton, New Jersey.</auth-address><titles><title>Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population</title><secondary-title>Am J Cardiol</secondary-title></titles><periodical><full-title>Am J Cardiol</full-title></periodical><pages>1142-7</pages><volume>112</volume><number>8</number><keywords><keyword>Adult</keyword><keyword>Atrial Fibrillation/*epidemiology</keyword><keyword>Female</keyword><keyword>*Forecasting</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Male</keyword><keyword>*Population Surveillance</keyword><keyword>Prevalence</keyword><keyword>Retrospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Survival Rate/trends</keyword><keyword>United States/epidemiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>Oct 15</date></pub-dates></dates><isbn>1879-1913 (Electronic)0002-9149 (Linking)</isbn><accession-num>23831166</accession-num><urls><related-urls><url>;[4]. AF-associated stroke is the most feared complication and the leading cause of disability in the United statesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW5qYW1pbjwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

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ADDIN EN.CITE.DATA [6,8]. Oral anticoagulants (OACs) remain to be the gold standard treatment for stroke prevention, and their role in preventing AF-related strokes is well establishedPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXJ0PC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA [9,10]. Yet, OACs are contraindicated in a subset of patients who are at high risk of bleeding. As a result, left atrial appendage occlusion (LAAO) has emerged as an alternative approach in this group. In the current article, we present the most updated studies describing safety, efficacy and outcome of different LAAO devices.Literature searchA systematic literature search was conducted using PubMed, EMBASE, and Cochrane Library to identify relevant articles from 1990 to 2018. The following search terms were used: “atrial fibrillation”, “stroke”, “left atrial appendage”, “occlusion” or “closure”, and “percutaneous” or “surgical.” A total of 78 studies were included for review. Of the included studies on LAAO, 3 studies contained surgical LAAO, two contained Atriclip device, two contained Tiger Paw system, 6 contained Lariat device, 4 contained PLAATO device, 19 contained Watchman device, and 12 contained Amplatzer (ACP/Amulet) device.Left atrial appendage and thrombus formationLeft atrial appendage (LAA) is trabeculated long tubular structure that has narrow junction with the venous component of left atrium. it varies greatly in sizes and shapes and has bent or spiral axis in 70% of patients ADDIN EN.CITE <EndNote><Cite><Author>Al-Saady</Author><Year>1999</Year><RecNum>1491</RecNum><DisplayText><style face="superscript">[11]</style></DisplayText><record><rec-number>1491</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1507506294">1491</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Al-Saady, N. M.</author><author>Obel, O. A.</author><author>Camm, A. J.</author></authors></contributors><auth-address>Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. nalsaady@sghms.ac.uk</auth-address><titles><title>Left atrial appendage: structure, function, and role in thromboembolism</title><secondary-title>Heart</secondary-title></titles><periodical><full-title>Heart</full-title></periodical><pages>547-54</pages><volume>82</volume><number>5</number><keywords><keyword>Atrial Appendage/*pathology/*physiopathology/surgery</keyword><keyword>Atrial Fibrillation/pathology/physiopathology</keyword><keyword>Echocardiography</keyword><keyword>Humans</keyword><keyword>Thromboembolism/*pathology/*physiopathology/prevention & control</keyword></keywords><dates><year>1999</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1468-201X (Electronic)1355-6037 (Linking)</isbn><accession-num>10525506</accession-num><urls><related-urls><url>;[11]. Anatomically, LAA is best divided into the ostium, neck, and lobar regionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdW5kZXJsaWNoPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh

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ADDIN EN.CITE.DATA [12]. In patients with chronic AF, remodeling of LAA leads to dilation, stretching and reduction in pectinate muscle volume ADDIN EN.CITE <EndNote><Cite><Author>Shirani</Author><Year>2000</Year><RecNum>1692</RecNum><DisplayText><style face="superscript">[13]</style></DisplayText><record><rec-number>1692</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509335386">1692</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shirani, J.</author><author>Alaeddini, J.</author></authors></contributors><auth-address>Departments of Medicine (Division of Cardiology), Albert Einstein College of Medicine, Bronx, NY 10461, USA. jshirani@</auth-address><titles><title>Structural remodeling of the left atrial appendage in patients with chronic non-valvular atrial fibrillation: Implications for thrombus formation, systemic embolism, and assessment by transesophageal echocardiography</title><secondary-title>Cardiovasc Pathol</secondary-title></titles><periodical><full-title>Cardiovasc Pathol</full-title></periodical><pages>95-101</pages><volume>9</volume><number>2</number><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Atrial Appendage/pathology/*physiopathology</keyword><keyword>Atrial Fibrillation/complications/diagnostic imaging/pathology/*physiopathology</keyword><keyword>Chronic Disease</keyword><keyword>Echocardiography, Transesophageal</keyword><keyword>Embolism/etiology</keyword><keyword>Endocardium/pathology</keyword><keyword>Female</keyword><keyword>Fibrosis</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Myocardium/pathology</keyword><keyword>Thrombosis/etiology</keyword></keywords><dates><year>2000</year><pub-dates><date>Mar-Apr</date></pub-dates></dates><isbn>1054-8807 (Print)1054-8807 (Linking)</isbn><accession-num>10867359</accession-num><urls><related-urls><url>;[13]. Approximately, 5% to 15% of AF patients have atrial thrombi on Transesophageal echocardiography (TEE)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5uaW5nPC9BdXRob3I+PFllYXI+MTk5NTwvWWVhcj48

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ADDIN EN.CITE.DATA [14-17], and 91% of those thrombi are located in LAA in patients with nonrheumatic AF ADDIN EN.CITE <EndNote><Cite><Author>Blackshear</Author><Year>1996</Year><RecNum>779</RecNum><DisplayText><style face="superscript">[18]</style></DisplayText><record><rec-number>779</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1503549621">779</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Blackshear, J. L.</author><author>Odell, J. A.</author></authors></contributors><auth-address>Division of Cardiovascular Diseases, Mayo Clinic Jacksonville, Florida, USA.</auth-address><titles><title>Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation</title><secondary-title>Ann Thorac Surg</secondary-title></titles><periodical><full-title>Ann Thorac Surg</full-title></periodical><pages>755-9</pages><volume>61</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Atrial Fibrillation/*surgery</keyword><keyword>Cerebrovascular Disorders/*prevention & control</keyword><keyword>Heart Atria/*surgery</keyword><keyword>Heart Diseases/diagnosis/*prevention & control</keyword><keyword>Humans</keyword><keyword>Mitral Valve Stenosis/surgery</keyword><keyword>Postoperative Complications/*prevention & control</keyword><keyword>Thrombosis/diagnosis/*prevention & control</keyword><keyword>Warfarin/contraindications</keyword></keywords><dates><year>1996</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0003-4975 (Print)0003-4975 (Linking)</isbn><accession-num>8572814</accession-num><urls><related-urls><url>(95)00887-X</electronic-resource-num></record></Cite></EndNote>[18]. The reason for LAA predilection for thrombus formation in AF is still not well known. One theory suggests that the extent of LAA filling and emptying is influenced more by changes in the left ventricular (which is impaired in AF) than LAA function ADDIN EN.CITE <EndNote><Cite><Year>1992</Year><RecNum>1492</RecNum><DisplayText><style face="superscript">[19]</style></DisplayText><record><rec-number>1492</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1507514127">1492</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Predictors of thromboembolism in atrial fibrillation: II. Echocardiographic features of patients at risk. The Stroke Prevention in Atrial Fibrillation Investigators</title><secondary-title>Ann Intern Med</secondary-title></titles><periodical><full-title>Ann Intern Med</full-title></periodical><pages>6-12</pages><volume>116</volume><number>1</number><keywords><keyword>Aged</keyword><keyword>Analysis of Variance</keyword><keyword>Atrial Fibrillation/complications/*diagnostic imaging</keyword><keyword>Cohort Studies</keyword><keyword>*Echocardiography</keyword><keyword>Female</keyword><keyword>Heart Atria/diagnostic imaging</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Placebos</keyword><keyword>Prognosis</keyword><keyword>Risk Factors</keyword><keyword>Thromboembolism/*diagnostic imaging/etiology/prevention & control</keyword><keyword>Ventricular Function, Left</keyword><keyword>Warfarin/therapeutic use</keyword></keywords><dates><year>1992</year><pub-dates><date>Jan 01</date></pub-dates></dates><isbn>0003-4819 (Print)0003-4819 (Linking)</isbn><accession-num>1727097</accession-num><urls><related-urls><url>;[19]. Ventricular filling creates intracavitary suction effect which influences the emptying and filling of left atrium and LAA. Imaging assessment of LAAAccurate assessment of anatomic LAA characteristics is crucial prior to LAAO due to substantial variations in LAA anatomy that impact device selection and efficacy. TEE is the most widely used imaging tool for periprocedural LAA assessment. It is used for the detection of thrombi in the LA and LAA as well other cardiac masses and thrombi prior to LAAOPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdW5kZXJsaWNoPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh

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ADDIN EN.CITE.DATA [16]. TEE is very important imaging to support fluoroscopy during device implantation. 3D TEE has shown to be more accurate than 2D TEE in LAA assessment and thrombi detectionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdWxsZXI8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [21,22]; and therefore, it is recommended for the guidance of LAAO ADDIN EN.CITE <EndNote><Cite><Author>Perk</Author><Year>2009</Year><RecNum>1698</RecNum><DisplayText><style face="superscript">[23]</style></DisplayText><record><rec-number>1698</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509399960">1698</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Perk, G.</author><author>Lang, R. M.</author><author>Garcia-Fernandez, M. A.</author><author>Lodato, J.</author><author>Sugeng, L.</author><author>Lopez, J.</author><author>Knight, B. P.</author><author>Messika-Zeitoun, D.</author><author>Shah, S.</author><author>Slater, J.</author><author>Brochet, E.</author><author>Varkey, M.</author><author>Hijazi, Z.</author><author>Marino, N.</author><author>Ruiz, C.</author><author>Kronzon, I.</author></authors></contributors><auth-address>New York University School of Medicine, Interventional Cardiology Department, Lenox Hill Heart and Vascular Institute, New York, New York 10016, USA. gila.perk@</auth-address><titles><title>Use of real time three-dimensional transesophageal echocardiography in intracardiac catheter based interventions</title><secondary-title>J Am Soc Echocardiogr</secondary-title></titles><periodical><full-title>J Am Soc Echocardiogr</full-title></periodical><pages>865-82</pages><volume>22</volume><number>8</number><keywords><keyword>Cardiac Catheterization/*methods</keyword><keyword>Computer Systems</keyword><keyword>Echocardiography, Three-Dimensional/*methods</keyword><keyword>Echocardiography, Transesophageal/*methods</keyword><keyword>Humans</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1097-6795 (Electronic)0894-7317 (Linking)</isbn><accession-num>19647156</accession-num><urls><related-urls><url>;[23]. It is used to guide trans-septal puncture, verify catheter and sheath position in the LAA, aid device delivery and positioning, confirm adequate LAA sealing, and detect complicationsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdW5kZXJsaWNoPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh

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ADDIN EN.CITE.DATA [12]. Follow-up TEE is also recommended after LAAO to reassess the implanted device, confirm complete LAA closure, and rule out complications. Intracardiac echocardiography (ICE) is comparable imaging to TEE for guiding LAAO and performing the tasks typically provided by TEE during implantation. In one study LAA measurements by ICE during LAAO were significantly correlated to angiography and TEE (Pearson correlation coefficient r = 0.94, p < 0.0001 for both)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [12]. It provides 3D images of the heart by using numerous planes at different points in time during the cardiac cycle and has 100% sensitivity for excluding LAA thrombusPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0aW5lejwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+

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ADDIN EN.CITE.DATA [25]. However, its use is limited due to ionizing radiation, lower temporal resolution than TEE and inability to perform during device deployment. angiography has been used for in LAA thrombi detection ADDIN EN.CITE <EndNote><Cite><Author>Sakamoto</Author><Year>1996</Year><RecNum>1495</RecNum><DisplayText><style face="superscript">[26]</style></DisplayText><record><rec-number>1495</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508254309">1495</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sakamoto, I.</author><author>Hayashi, K.</author><author>Matsunaga, N.</author><author>Ogawa, Y.</author><author>Matsuoka, Y.</author><author>Okimoto, T.</author><author>Takagi, M.</author><author>Yano, K.</author><author>Toda, G.</author><author>Miyahara, Y.</author></authors></contributors><auth-address>Department of Radiology, Nagasaki University School of Medicine, Japan.</auth-address><titles><title>Coronary angiographic finding of thrombus in the left atrial appendage</title><secondary-title>Acta Radiol</secondary-title></titles><periodical><full-title>Acta Radiol</full-title></periodical><pages>749-53</pages><volume>37</volume><number>5</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>*Coronary Angiography</keyword><keyword>Coronary Disease/complications/diagnostic imaging</keyword><keyword>Female</keyword><keyword>Fistula/complications/diagnostic imaging</keyword><keyword>Heart Atria/diagnostic imaging</keyword><keyword>Heart Diseases/complications/*diagnostic imaging</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Mitral Valve Stenosis/complications</keyword><keyword>Retrospective Studies</keyword><keyword>Thrombosis/complications/*diagnostic imaging</keyword></keywords><dates><year>1996</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0284-1851 (Print)0284-1851 (Linking)</isbn><accession-num>8915287</accession-num><urls><related-urls><url>;[26]. However, it is expensive and invasive procedure, and rarely used nowadays due to presence of TEE and other less invasive imaging modalities. Guideline therapy for stroke preventionThe 2014 American Heart Association/American College of Cardiology (AHA/ACC) guidelines for management of AF recommends the use of anticoagulation for prevention of thromboembolism when CHA2DS2-VASC score is ≥ 2 (class I (A))PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW51YXJ5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE.DATA [27]. While anticoagulation is class I (A) indication for males with a score ≥ 2 and females with a score ≥ 3, it's considered class IIa (B) indication for males with a score of 1 and females with a score of 2. Both American and European guidelines recommend considering surgical excision of LAA in patients who have AF and undergoing cardiac surgery (class IIb (level of evidence is "C" in AHA/ACC and "B" in the ESC guidelines))PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW51YXJ5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE.DATA [16,27]. While AHA/ACC guidelines have no recommendations for LAAO, the ESC guidelines have class IIb (B) recommendation for LAAO in patients with AF and contra-indications for long-term anticoagulationPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaXJjaGhvZjwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+

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ADDIN EN.CITE.DATA [27]. Similarly, National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand state that LAAO may be considered for stroke prevention in patients with non-valvular AF at moderate to high risk of stroke and with contraindications to OAC (GRADE quality of evidence: Low; GRADE strength of recommendation: Strong)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm91cDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [28].LAA surgical closures/excisionSurgical exclusion of LAA is recommended for patients with AF and undergoing concomitant cardiac surgeries. Different surgical methods to isolate LAA include: suture ligation, excision and suture closure, and stapling exclusion with or without excisionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [29,30]. Surgical isolation of LAA is associated with high rate of unsuccessful closure. For instance, a previous study reported only 40% (55 out of 137) complete LAA closure noted on TEE following surgical closure ADDIN EN.CITE <EndNote><Cite><Author>Kanderian</Author><Year>2008</Year><RecNum>1542</RecNum><DisplayText><style face="superscript">[30]</style></DisplayText><record><rec-number>1542</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508460774">1542</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kanderian, A. S.</author><author>Gillinov, A. M.</author><author>Pettersson, G. B.</author><author>Blackstone, E.</author><author>Klein, A. L.</author></authors></contributors><auth-address>Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. kleina@</auth-address><titles><title>Success of surgical left atrial appendage closure: assessment by transesophageal echocardiography</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>924-9</pages><volume>52</volume><number>11</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Atrial Appendage/*diagnostic imaging/surgery</keyword><keyword>Atrial Fibrillation/diagnostic imaging/surgery</keyword><keyword>*Cardiac Surgical Procedures</keyword><keyword>*Echocardiography, Transesophageal</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Thrombosis/diagnostic imaging</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2008</year><pub-dates><date>Sep 09</date></pub-dates></dates><isbn>1558-3597 (Electronic)0735-1097 (Linking)</isbn><accession-num>18772063</accession-num><urls><related-urls><url>;[30]. Despite that, Friedman et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmllZG1hbjwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

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ADDIN EN.CITE.DATA [31] reported a lower risk of readmission for thromboembolism (4.2% vs 6.2%, HR = 0.67; 95%CI: 0.56-0.81) and all-cause mortality (17.3% vs 23.9%, HR = 0.88; 95%CI: 0.79-0.97) among Medicare patients (age > 65) with AF undergoing concomitant cardiac surgery and surgical LAAO, compared with no surgical LAAO. This the largest study to date supporting the role of surgical LAAO during cardiac surgery as a mean of preventing thromboembolism in patients over the age of 65 with AF.The Atriclip Device System (Atricure, Inc., West Chester, OH, United States) is a surgical LAA exclusion device composed of self-closing, sterile, implantable clip with a reusable deployment tool (figure 1). It is applied epicardially by either an open surgical or a minimally-invasive technique and placed at the base of the appendage. The clip is made of 2 parallel rigid titanium tubes with elastic nitinol springs covered with a knit-braided polyester sheath (table 1)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYWx6YmVyZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

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ADDIN EN.CITE.DATA [33]. Tiger Paw System (Terumo Cardiovascular Systems, Ann Arbor, Mi, United States) is another LAA exclusion device that is used as a concomitant procedure during open cardiac surgical procedures (figure 1). The device contains implantable fastener of titanium connectors that staples the LAA tissue and is embedded in two rims of silicone that adapts to the LAA morphology and seals the puncture sites (table 1)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbGF0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [34]. Despite its efficacy in achieving complete LAA closure on prior studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbGF0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [35]. Lariate device closure systemLariat device (SentreHEART, Inc., Redwood City, California) is LAA closure system that is approved by the United States Food and Drug Administration (FDA) for soft tissue closure, but not LAAO (figure 1). It is composed of 15-mm compliant occlusion balloon catheter (EndoCATH), 0.025-inch and 0.035-inch magnet-tipped guidewires (FindrWIRZ), and a 12-F suture delivery device (LARIAT) (table 1). During the procedure, magnet-tipped guidewires are advanced through epicardial and transvenous accesses and connected in the LAA. Then, a suture fashioned as a Lariate or lasso is advanced over the epicardial access guidewire and tightened to occlude LAA basePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ0dXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [29,36]. The largest prospective study of Lariate device included patients who: were ≥ 18-year-old; had nonvalvular AF; had CHADS2 ≥ 1; were poor candidate for or failed warfarin therapy; and had a life expectancy of at least 1 yearPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ0dXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [36]. They reported 95% (81 of 85 patients) complete LAA closure documented on TEE one month after the procedure. 98% of those who underwent TEE (n = 65) had complete LAA closure after 1 year, including cases of incomplete closure at earlier time. Complications in the same study were limited to only two cases of severe pericarditis, two cases of strokes, and one case with pericardial effusionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ0dXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [38] demonstrated that LAAO using Lariate device might improve the mechanical function of the left atrium (LA) and reverse LA remodeling based on 2-dimensional speckle tracking echocardiography (a novel method for functional assessment of the LA). However, due to steep learning curve for device deployment (especially epicardial access), LAA leak and lack of direct efficacy comparison with oral anticoagulation, the device was not widely used in the United StatesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaWVkcmltYXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy

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ADDIN EN.CITE.DATA [39-42]. Percutaneous LAA closureThe most commonly used percutaneous LAAO devices are shown in figure 1 and described in Table 1. Percutaneous LAAO uses transvenous access with trans-septal puncture and was first tested using the Percutaneous LAA Transcatheter Occlusion (PLAATO) device (Appriva Medical Inc., Sunnyvale, CA) in 2001.PLAATO deviceThis device consists of self-expanding nitinol cage that is covered with polymeric membrane in order to close off blood flow into the LAA (Table 1)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaWV2ZXJ0PC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48

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ADDIN EN.CITE.DATA [43,44]. It was first tested on 15 patients with non-valvular AF and contraindication to warfarin therapy and are at high risk of thromboembolism based on CHADS2 scorePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaWV2ZXJ0PC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48

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ADDIN EN.CITE.DATA [43]. Successful occlusion of LAA was observed in all cases and no device related complications were reported. A larger prospective study enrolled patients using similar inclusion criteria to undergo LAAO using PLAATO devicePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pc3Rlcm1heWVyPC9BdXRob3I+PFllYXI+MjAwNTwvWWVh

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ADDIN EN.CITE.DATA [46]. Interestingly, there was no incidence of stroke for 24 mo of follow-up in the same study. Despite this success, the device was discontinued for unspecified reasons and replaced by Watchman device. Watchman deviceThe Watchman device (Boston Scientific, Marlborough, MA), is the only FDA-approved percutaneous device for LAAO. The device is composed of self-expanding nitinol frame structure with fixation barbs and a permeable polyester fabric that covers the atrial facing surface of the device (Table 1) ADDIN EN.CITE <EndNote><Cite><Author>Sick</Author><Year>2007</Year><RecNum>1569</RecNum><DisplayText><style face="superscript">[47]</style></DisplayText><record><rec-number>1569</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508683084">1569</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sick, P. B.</author><author>Schuler, G.</author><author>Hauptmann, K. E.</author><author>Grube, E.</author><author>Yakubov, S.</author><author>Turi, Z. G.</author><author>Mishkel, G.</author><author>Almany, S.</author><author>Holmes, D. R.</author></authors></contributors><auth-address>Krankenhaus der Barmherzigen Bruder, Regensburg, Germany. peter.sick@barmherzige-regensburg.de</auth-address><titles><title>Initial worldwide experience with the WATCHMAN left atrial appendage system for stroke prevention in atrial fibrillation</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>1490-5</pages><volume>49</volume><number>13</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Atrial Appendage</keyword><keyword>Atrial Fibrillation/*complications</keyword><keyword>Feasibility Studies</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Global Health</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pilot Projects</keyword><keyword>*Prostheses and Implants</keyword><keyword>Prosthesis Design</keyword><keyword>Stroke/*etiology/*prevention & control</keyword></keywords><dates><year>2007</year><pub-dates><date>Apr 03</date></pub-dates></dates><isbn>1558-3597 (Electronic)0735-1097 (Linking)</isbn><accession-num>17397680</accession-num><urls><related-urls><url>;[47]. Multiple trials were done to evaluate the safety, efficacy and outcomes of watchmen device. Pilot study was a non-randomized trial that included 75 patients and was done to assess the feasibility and safety of watchman device ADDIN EN.CITE <EndNote><Cite><Author>Sick</Author><Year>2007</Year><RecNum>1569</RecNum><DisplayText><style face="superscript">[47]</style></DisplayText><record><rec-number>1569</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508683084">1569</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sick, P. B.</author><author>Schuler, G.</author><author>Hauptmann, K. E.</author><author>Grube, E.</author><author>Yakubov, S.</author><author>Turi, Z. G.</author><author>Mishkel, G.</author><author>Almany, S.</author><author>Holmes, D. R.</author></authors></contributors><auth-address>Krankenhaus der Barmherzigen Bruder, Regensburg, Germany. peter.sick@barmherzige-regensburg.de</auth-address><titles><title>Initial worldwide experience with the WATCHMAN left atrial appendage system for stroke prevention in atrial fibrillation</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>1490-5</pages><volume>49</volume><number>13</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Atrial Appendage</keyword><keyword>Atrial Fibrillation/*complications</keyword><keyword>Feasibility Studies</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Global Health</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pilot Projects</keyword><keyword>*Prostheses and Implants</keyword><keyword>Prosthesis Design</keyword><keyword>Stroke/*etiology/*prevention & control</keyword></keywords><dates><year>2007</year><pub-dates><date>Apr 03</date></pub-dates></dates><isbn>1558-3597 (Electronic)0735-1097 (Linking)</isbn><accession-num>17397680</accession-num><urls><related-urls><url>;[47]. They enrolled adult patients who: had non-valvular AF for 2 years, were eligible for warfarin therapy, and had CHADS2 of at least 1. Although this was the first human trial to evaluate the efficacy and safety of Watchman device, the success rate of LAAO was very high and complications were relatively low. 88% of patients had successful device implantation and 93% of them had complete LAAO. Reported complications included; device embolization in 2 patients, device-related thrombus formation in 4 patients, and transient ischemic attack in 2 patients. There was no reported major strokes or procedure-related mortality. PROTECT AF study (WATCHMAN LAA System for Embolic Protection in Patients with Atrial Fibrillation) was the first randomized trial to compare the efficacy and safety of LAAO using Watchman device with chronic warfarin therapy in patients with non-valvular AF and had CHADS2 of 1 or morePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [48]. Exclusion criteria included contraindications to warfarin, chronic warfarin use, LAA thrombus, a patent foramen ovale with atrial septal aneurysm and right-to-left shunt, mobile aortic atheroma, and symptomatic carotid artery disease. This trial enrolled 707 patients from 59 centers worldwide and assigned them randomly to LAAO with Watchman device (n = 463) or warfarin therapy (n = 244) with INR goal of 2 to 3. Watchman group was treated with warfarin for 45 d after device deployment to allow proper endothelialization. Warfarin was discontinued if TEE showed complete closure or significantly decreased flow around the device. Afterward, patients were given aspirin and clopidogrel for 6 mo followed by lifelong aspirin. At 1065 patient-years (PY) of follow-up (mean follow up 18 mo), Watchman device was non-inferior to warfarin for primary efficacy endpoint of stroke (either ischemic or hemorrhagic), cardiovascular death, or systemic thromboembolism. The Event rates of primary efficacy endpoint were 3% and 4.9% for Watchman and warfarin groups, respectively. Since then, two studies were published with two different follow up periodPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [49,50]. At 2.3 ± 1.1 years (2621 PY), Watchman device continued to be non-inferior to warfarin therapy with 3% and 4.3% event rates of primary efficacy endpoint for Watchman and warfarin groups, respectivelyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [49]. The second trial with 3.8 ± 1.7 years of follow up (2621 PY) showed event rate of 2.3% in the watchman group and 3.8% in the warfarin group (p = 0.0348), leading to 40% risk reduction in primary efficacy endpoint with Watchman devicePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [51]. Investigators included a higher risk patients than PROTECT AF (CHADS2 score of 1 plus any of the following higher-risk characteristics: female age ≥ 75 years, baseline ejection fraction ≥ 30% but < 35%, age 65 to 74 years and either diabetes or coronary disease, and age ≥ 65 years with congestive heart failure). Patients were assigned randomly to receive LAAO using Watchman (n = 269) or warfarin therapy (n = 138) in 2:l ratio. Warfarin and antiplatelet therapy post device implantion was in a similar fashion to PROTECT AF trial. Although non-inferiority criteria was not achieved for overall efficacy endpoint (stroke, systemic embolization or cardiovascualr death), the rate of second efficacy endpoint (stroke or systemic embolization) was 2.5% in the Watchman group and 2% in the warfarin group at 18 mo follow-up, achieving criteria for non-inferiority. Compared to PROTECT AF study, procedural success increased from 90.9% to 95.1% (p = 0.04), while all 7-d procedure-related complications (composite of cardiac perforation, pericardial effusion with tamponade, ischemic stroke, device embolization, and other vascular complications) decreased from 8.7% to 4.2% in PREVAIL (p = 0.004). PROTECT AF and PREVAIL results were pooled for patient level meta-analysis and with combined follow-up of 5 years (4343 PY)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [52]. The primary efficacy endpoint (stroke, systemic embolization or cardiovascualr death) was similar between LAAO and warfarin groups (2.8 vs 3.4 events/100 PY; p = 0.27). In subgroup analysis of the same meta-analysis, the rate of all stroke or systemic embolism was similar between both groups (1.7 vs 1.8 events/100 PY; p = 0.87). However, there was statistically significant decrease in the rates of hemorrhagic stroke (0.17% vs 0.87%, p = 0.002), disabling / fatal stroke (0.37% vs 0.94%, p = 0.027), cardiovascular/unexplained death (1.3% vs 2.2%, p = 0.027), all-cause death (3.6% vs 4.9%, p = 0.035), and post-procedure bleeding (1.7% vs 3.6%, p = 0.0003) in LAAO arm when compared with warfarin arm. This meta-analysis underscores the mortality reduction and stroke prevention, patrticularly hemorrhagic stroke, associated with LAAO using Wathcman device. Continued Access to PROTECT AF (CAP)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [54] Registries were designed to treat patients with similar baseline characteristics and according to same protocols after PROTECT AF and PREVAIL trials enrollment had been completed. Procedural performance and associated medications were identical in each registry. However, registries did not mandate 1-year neurological assessment. A Meta-analysis of 2406 patients from the PROTECT AF and PREVAIL trials and their respective registries (CAP and CAP2) with 5,931 PY of follow-up (mean of 2.69 years) reported: similar rate of all-cause stroke between both arms (1.75 vs. 1.87 events/100 PY, p = 0.94): higher rate of ischemic stroke in Watchman group (1.6 vs. 0.9 events/100 PY, p = 0.05); and lower rates of hemorrhagic stroke, cardiovascular death (1.1 vs. 2.3 events/100 PY, p = 0.006), and non-procedural bleeding (6.0% vs 11.3%, p = 0.02) in Watchman groupPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [52]. EWOLUTION study (Registry on Watchman Outcomes in Real-Life Utilization) is a multicenter, prospective, non-randomized cohort that aimed to collect peri-procedural and long-term outcome data for patients implanted with Watchman device for LAAOPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA [55]. This world-wide registry enrolled 1025 patients at 47 centers from the United States, Europe, Middle east and Russia who are more than 18-year-old and require LAAO based on ESC guidelinesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA [56,57]. the rates of procedure-related serious adverse events (defined as; perforation, tamponade, embolism, neurological events, thrombosis, and bleeding) were 2.8% at 7 d and 3.6% at 30 d with bleeding being the most common adverse eventPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA [57]. This is lower than the 7-d procedure-related serious adverse events observed in PROTECT AF (8.7%) and PREVAIL (4.2%) trials. At 1 year follow up; mortality was 9.8%, device-related thrombus was seen in 3.7% of patients, and 1.1% of patients suffered from ischemic stroke, leading to 84% risk reduction of stroke. There was no hemorrhagic stroke observed during follow-up[PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48

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AG==

ADDIN EN.CITE.DATA [58]. After the device implantation, participants were given thienopyridine antiplatelet agent (clopidogrel or ticlopidine) for 6 mo and aspirin indefinitely. Out of 150 patients, 142 (94.7%) had successful implantation and 13 (8.7%) developed device-related adverse event. During mean follow up of 14.4 ± 8.6 mo, 4 patients developed stokes (2.3% per year) and 3 of them were ischemic (1.7% per year). There was 77% risk reduction in stroke compared to expected stroke risk based on CHADS2 score (7.3% per year). Till this moment, there is no published randomized data on the safety and efficacy of LAAO in patients with contraindications to anticoagulation. The ASAP TOO study (The Assessment of the Watchman Device in Patients Unsuitable for Oral Anticoagulation) is ongoing multi-center prospective randomized trial plan is to enroll up to 888 patients with non-valvular AF who are not candidate for OAC and have CHA2DS2-VASC ≥2PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS

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RW5kTm90ZT5=

ADDIN EN.CITE.DATA [59]. The study will randomize patients to Watchman vs control. Control patients will be prescribed single antiplatelet therapy, or no therapy based on physician discretion.Amplatzer cardiac plug and amulet Amplatzer cardiac plug (ACP) (AGA, St. Jude Medical, Minneapolis, MN, United States) is another LAAO device that consists of a lobe and disc made of nitinol mesh and polyester patch, connected by central waist. Amulet? is a second-generation device of the Amplatzer with several incremental design improvements. It is larger in size and has higher number of stabilizing wires, which allows successful closure of more LAA anatomies (Table 1). Comparative studies have shown similar results with ACP and Amulet AMPLATZER devices in terms of safety, implantation success and appropriate LAAOPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbG9la2xlcjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

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bmROb3RlPn==

ADDIN EN.CITE.DATA [60,61]. Multiple retrospective and prospective studies for ACP and Amulet reported successful device implantation in 95% to 100% patients, with major periprocedural adverse events (death, stroke/TIA, device embolization, MI/perforation/tamponade/effusion, and major bleeding) ranging from 3.2% to 8%PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW5kbWVzc2VyPC9BdXRob3I+PFllYXI+MjAxNzwvWWVh

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ADDIN EN.CITE.DATA [62-67]. An FDA approval trial is currently ongoing, with the aim of collecting randomized controlled data from the Amulet and Watchman devices from 1,600 patients worldwide. PRAGUE 17 is another ongoing prospective, multicenter, randomized trial That plan to enroll 396 patients with non-valvular AF and assign them to LAAO using Amulet or Watchman vs non-vitamin K oral anticoagulants (NOACs). The aim at 24 mo of follow-up is to determine whether LAAO is non-inferior to NOACs in terms of primary efficacy endpoint and peri-procedural complicationsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pc21hbmNpazwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

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ADDIN EN.CITE.DATA [69]. One single-center retrospective study in Italy compared the use ACP vs Watchman in 156 patients (ACP in 99 and watchman in 66 patients) and demonstrated procedural success in 99.4%. During follow-up, only 1 patient suffered from transient ischemic attack and 2 from cardiac death. Furthermore, the data showed excellent safety and efficacy with similar clinical outcomes in both devices ADDIN EN.CITE <EndNote><Cite><Author>Figini</Author><Year>2017</Year><RecNum>1565</RecNum><DisplayText><style face="superscript">[70]</style></DisplayText><record><rec-number>1565</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508611504">1565</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Figini, F.</author><author>Mazzone, P.</author><author>Regazzoli, D.</author><author>Porata, G.</author><author>Ruparelia, N.</author><author>Giannini, F.</author><author>Stella, S.</author><author>Ancona, F.</author><author>Agricola, E.</author><author>Sora, N.</author><author>Marzi, A.</author><author>Aurelio, A.</author><author>Trevisi, N.</author><author>Della Bella, P.</author><author>Colombo, A.</author><author>Montorfano, M.</author></authors></contributors><auth-address>Interventional Cardiology Department, San Raffaele Hospital, Milan, Italy.EMO-GVM Centro Cuore Columbus, Milan, Italy.Imperial College, London, United Kingdom.</auth-address><titles><title>Left atrial appendage closure: A single center experience and comparison of two contemporary devices</title><secondary-title>Catheter Cardiovasc Interv</secondary-title></titles><periodical><full-title>Catheter Cardiovasc Interv</full-title></periodical><pages>763-772</pages><volume>89</volume><number>4</number><keywords><keyword>antithrombotic agents</keyword><keyword>atrial fibrillation</keyword><keyword>stroke</keyword></keywords><dates><year>2017</year><pub-dates><date>Mar 01</date></pub-dates></dates><isbn>1522-726X (Electronic)1522-1946 (Linking)</isbn><accession-num>27567013</accession-num><urls><related-urls><url>;[70]. Another multicenter retrospective registry for LAAO using various devices showed an overall success of 92.5%. The combined adverse event rate was 3.5%, leading to annual relative risk reduction for ischemic stroke, thromboembolic events, and major bleeding of 90.1%, 87.2%, and 92.9%, respectivelyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXR0czwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [72] reported no differences in death, ischemic stroke, major bleeding, or device related thrombus between Watchman and Amplatzer devices. Those studies underscore the high success rate in placing various LAAO devices, and their safety and efficacy in preventing strokes and adverse events. Antithrombotic therapy after device implantationOptimal anticoagulation/antiplatelet protocol post LAAO is highly patient-specific and recommended for a limited period post LAAO to prevent device associated thrombusPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXVjaGllcjwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

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ADDIN EN.CITE.DATA [72]. Different anticoagulation strategies have been described in multiple studies including: warfarin, NOACs, DAPT, single antiplatelet (SAPT), or no therapy at all (Table 2). The anticoagulation protocol described In PROTECT AF and PREVAIL trials consists of warfarin for 45 d followed by aspirin and clopidogrel for 6 mo, then aspirin indefinitely[PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 48-51]. In EWOLUTION registry for example, anticoagulation regimens post LAAO were variable and included: warfarin in 16%, NOAC in 11%, DAPT in 60%, single antiplatelet (SAPT) in 7%, and no therapy in 6%PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48

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ADDIN EN.CITE.DATA [56]. A study on post LAAO anticoagulation in patients from EWOLUTION registry demonstrated that NOAC and DAPT were similar to warfarin in terms of device thrombus, stroke or bleeding risks ADDIN EN.CITE <EndNote><Cite><Author>Bergmann</Author><Year>2017</Year><RecNum>1596</RecNum><DisplayText><style face="superscript">[73]</style></DisplayText><record><rec-number>1596</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509074063">1596</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bergmann, M. W.</author><author>Betts, T. R.</author><author>Sievert, H.</author><author>Schmidt, B.</author><author>Pokushalov, E.</author><author>Kische, S.</author><author>Schmitz, T.</author><author>Meincke, F.</author><author>Stein, K. M.</author><author>Boersma, L. V. A.</author><author>Ince, H.</author></authors></contributors><auth-address>Cardiologicum Hamburg, Hamburg, Germany.</auth-address><titles><title>Safety and efficacy of early anticoagulation drug regimens after WATCHMAN left atrial appendage closure: three-month data from the EWOLUTION prospective, multicentre, monitored international WATCHMAN LAA closure registry</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>877-884</pages><volume>13</volume><number>7</number><dates><year>2017</year><pub-dates><date>Sep 20</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>28606886</accession-num><urls><related-urls><url>;[73]. Compared with EWOLUTION registry, antithrombotic regimen post LAAO In RELEXAO registry was different and included: OACs 28.8%, SAPT in 36.2%, DAPT in 23.2%, OACs plus DAPT in 4.3%, and no therapy in 7.5%. In ASAP study, patients were given DAPT for 6 mo followed by aspirin indefinitely as they were ineligible for OACsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [74]. Interestingly, 41% of centers would prescribe no therapy and less than 10% followed PROTECT AF and PREVAIL protocol. The European Heart Rhythm Association/European Association of Percutaneous Cardiovascular Interventions (EHRA/EAPCI) expert consensus statement recommends treatment with DAPT for 1 to 6 mo followed by aspirin indefinitely in patients with high bleeding risk ADDIN EN.CITE <EndNote><Cite><Author>Meier</Author><Year>2015</Year><RecNum>1689</RecNum><DisplayText><style face="superscript">[75]</style></DisplayText><record><rec-number>1689</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509314913">1689</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Meier, B.</author><author>Blaauw, Y.</author><author>Khattab, A. A.</author><author>Lewalter, T.</author><author>Sievert, H.</author><author>Tondo, C.</author><author>Glikson, M.</author></authors></contributors><auth-address>Cardiology, Bern University Hospital, 3010 Bern, Switzerland.</auth-address><titles><title>EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>1109-25</pages><volume>10</volume><number>9</number><keywords><keyword>Atrial Appendage/*surgery</keyword><keyword>Atrial Fibrillation/complications/*surgery</keyword><keyword>*Catheter Ablation</keyword><keyword>Catheters</keyword><keyword>*Consensus</keyword><keyword>Humans</keyword><keyword>Stroke/*surgery</keyword></keywords><dates><year>2015</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>25169595</accession-num><urls><related-urls><url>;[75]. ComplicationsComplications related to LAAO are either acute or delayed and most of them can be detect by peri-procedural imaging. Table 3 summarizes LAAO related complications, their incidence and treatment options.ConclusionLAAO is a reasonable alternative approach that is used for preventing embolic events in patients with AF who are deemed not eligible for anticoagulation. While AHA/ACC guidelines have no recommendations for LAAO, the ESC guidelines have class IIb (B) recommendation for LAAO in patients with AF and contra-indications for long-term anticoagulation. Similarly, Australian guidelines recommend considering LAAO in patients with non-valvular AF at moderate to high risk of stroke and with contraindications to OAC. Watchman is the only FDA approved device for LAAO and indicated to reduce the risk of thromboembolism from the LAA in patients with non-valvular AF who: are at increased risk for stroke and systemic embolism based on CHADS2 or CHA2DS2-VASc scores; are deemed by their physicians to be suitable for warfarin; and have an appropriate rationale to seek a non-pharmacologic alternative to warfarin, taking into account the safety and effectiveness of the device compared to warfarin. Amplatzer is another successful LAAO device that has CE mark and is waiting for FDA approval. Optimal antithrombotic regimen post LAAO is highly patient-specific and recommended to prevent device associated thrombus. Due to wide variety of shapes, sizes, indications, and implantation techniques in different LAAO devices, there is a need for further research to identify the best type of LAAO device that suites each patient profile. 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Early results of first versus second generation Amplatzer occluders for left atrial appendage closure in patients with atrial fibrillation. Clin Res Cardiol 2015; 104: 656-665 [PMID: 25736061 DOI: 10.1007/s00392-015-0828-1]61 Abualsaud A, Freixa X, Tzikas A, Chan J, Garceau P, Basmadjian A, Ibrahim R. Side-by-Side Comparison of LAA Occlusion Performance With the Amplatzer Cardiac Plug and Amplatzer Amulet. J Invasive Cardiol 2016; 28: 34-38 [PMID: 26716593]62 Landmesser U, Schmidt B, Nielsen-Kudsk JE, Lam SCC, Park JW, Tarantini G, Cruz-Gonzalez I, Geist V, Della Bella P, Colombo A, Zeus T, Omran H, Piorkowski C, Lund J, Tondo C, Hildick-Smith D. Left atrial appendage occlusion with the AMPLATZER Amulet device: periprocedural and early clinical/echocardiographic data from a global prospective observational study. EuroIntervention 2017; 13: 867-876 [PMID: 28649053 DOI: 10.4244/EIJ-D-17-00493]63 Tzikas A, Gafoor S, Meerkin D, Freixa X, Cruz-Gonzalez I, Lewalter T, Saw J, Berti S, Nielsen-Kudsk JE, Ibrahim R, Lakkireddy D, Paul V, Arzamendi D, Nietlispach F, Worthley SG, Hildick-Smith D, Thambo JB, Tondo C, Aminian A, Kalarus Z, Schmidt B, Sondergaard L, Kefer J, Meier B, Park JW, Sievert H, Omran H. Left atrial appendage occlusion with the AMPLATZER Amulet device: an expert consensus step-by-step approach. EuroIntervention 2016; 11: 1512-1521 [PMID: 27107315 DOI: 10.4244/EIJV11I13A292]64 Korsholm K, Nielsen KM, Jensen JM, Jensen HK, Andersen G, Nielsen-Kudsk JE. Transcatheter left atrial appendage occlusion in patients with atrial fibrillation and a high bleeding risk using aspirin alone for post-implant antithrombotic therapy. EuroIntervention 2017; 12: 2075-2082 [PMID: 27973336 DOI: 10.4244/EIJ-D-16-00726]65 Berti S, Pastormerlo LE, Rezzaghi M, Trianni G, Paradossi U, Cerone E, Ravani M, De Caterina AR, Rizza A, Palmieri C. Left atrial appendage occlusion in high-risk patients with non-valvular atrial fibrillation. Heart 2016; 102: 1969-1973 [PMID: 27492943 DOI: 10.1136/heartjnl-2015-309150]66 Kleinecke C, Park JW, G?dde M, Zintl K, Schnupp S, Brachmann J. Twelve-month follow-up of left atrial appendage occlusion with Amplatzer Amulet. Cardiol J 2017; 24: 131-138 [PMID: 28198520 DOI: 10.5603/CJ.a2017.0017]67 Urena M, Rodés-Cabau J, Freixa X, Saw J, Webb JG, Freeman M, Horlick E, Osten M, Chan A, Marquis JF, Champagne J, Ibrahim R. Percutaneous left atrial appendage closure with the AMPLATZER cardiac plug device in patients with nonvalvular atrial fibrillation and contraindications to anticoagulation therapy. 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Left atrial appendage occluder implantation in Europe: indications and anticoagulation post-implantation. Results of the European Heart Rhythm Association Survey. Europace 2017; 19: 1737-1742 [PMID: 29016910 DOI: 10.1093/europace/eux254]75 Meier B, Blaauw Y, Khattab AA, Lewalter T, Sievert H, Tondo C, Glikson M. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion. EuroIntervention 2015; 10: 1109-1125 [PMID: 25169595]76 Reddy VY, Gibson DN, Kar S, O'Neill W, Doshi SK, Horton RP, Buchbinder M, Gordon NT, Holmes DR. Post-Approval U.S. Experience With Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation. J Am Coll Cardiol 2017; 69: 253-261 [PMID: 27816552 DOI: 10.1016/j.jacc.2016.10.010]77 Singh SM, Douglas PS, Reddy VY. The incidence and long-term clinical outcome of iatrogenic atrial septal defects secondary to transseptal catheterization with a 12F transseptal sheath. Circ Arrhythm Electrophysiol 2011; 4: 166-171 [PMID: 21248245 DOI: 10.1161/CIRCEP.110.959015]P-Reviewer: Barik R, Dai X, Kharlamov AN, Korosoglou G, Ueda H S-Editor: Ma YJ L-Editor: A E-Editor: Wu YXJSpecialty type: Cardiac and Cardiovascular SystemsCountry of origin: United StatesPeer-review report classificationGrade A (Excellent): AGrade B (Very good): B, B, BGrade C (Good): 0Grade D (Fair): DGrade E (Poor): 0Figure 1 Surgical and percutaneous devices that are used for left atrial appendage occlusion.Table 1 Comparison of left atrial appendage occlusion devicesDeviceStudyYear of Introduction DescriptionApproachApprovalAtriclip Device System (Atricure)EXCLUDE studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaWxhd2FkaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

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ADDIN EN.CITE.DATA [34]Introduced in 2009 and recalled in 2015Implantable fastener of titanium connectors that staples the LAA tissue plus rims of silicone that seal the puncture sites.EpicardialRecalledLariat device (SentreHEART)Bartus et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ0dXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [46]Introduced in 2001and discontinued in 2007Self-expanding nitinol cage covered with polymeric membrane (ePTFE) designed to be placed in the orifice of the LAATransvenous, trans-septalDiscontinuedWatchman(Boston Scientific)Pilot study ADDIN EN.CITE <EndNote><Cite><Author>Sick</Author><Year>2007</Year><RecNum>1569</RecNum><DisplayText><style face="superscript">[47]</style></DisplayText><record><rec-number>1569</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1508683084">1569</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sick, P. B.</author><author>Schuler, G.</author><author>Hauptmann, K. E.</author><author>Grube, E.</author><author>Yakubov, S.</author><author>Turi, Z. G.</author><author>Mishkel, G.</author><author>Almany, S.</author><author>Holmes, D. R.</author></authors></contributors><auth-address>Krankenhaus der Barmherzigen Bruder, Regensburg, Germany. peter.sick@barmherzige-regensburg.de</auth-address><titles><title>Initial worldwide experience with the WATCHMAN left atrial appendage system for stroke prevention in atrial fibrillation</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>1490-5</pages><volume>49</volume><number>13</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Atrial Appendage</keyword><keyword>Atrial Fibrillation/*complications</keyword><keyword>Feasibility Studies</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Global Health</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pilot Projects</keyword><keyword>*Prostheses and Implants</keyword><keyword>Prosthesis Design</keyword><keyword>Stroke/*etiology/*prevention & control</keyword></keywords><dates><year>2007</year><pub-dates><date>Apr 03</date></pub-dates></dates><isbn>1558-3597 (Electronic)0735-1097 (Linking)</isbn><accession-num>17397680</accession-num><urls><related-urls><url>;[47]PROTECT AF studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [61]Korsholm et al ADDIN EN.CITE <EndNote><Cite><Author>Korsholm</Author><Year>2017</Year><RecNum>1657</RecNum><DisplayText><style face="superscript">[64]</style></DisplayText><record><rec-number>1657</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509212309">1657</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Korsholm, K.</author><author>Nielsen, K. M.</author><author>Jensen, J. M.</author><author>Jensen, H. K.</author><author>Andersen, G.</author><author>Nielsen-Kudsk, J. E.</author></authors></contributors><auth-address>Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.</auth-address><titles><title>Transcatheter left atrial appendage occlusion in patients with atrial fibrillation and a high bleeding risk using aspirin alone for post-implant antithrombotic therapy</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>2075-2082</pages><volume>12</volume><number>17</number><dates><year>2017</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>27973336</accession-num><urls><related-urls><url>;[64]Berti et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [61]Landmesser et al ADDIN EN.CITE <EndNote><Cite><Author>Landmesser</Author><Year>2017</Year><RecNum>1650</RecNum><DisplayText><style face="superscript">[62]</style></DisplayText><record><rec-number>1650</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509212137">1650</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Landmesser, U.</author><author>Schmidt, B.</author><author>Nielsen-Kudsk, J. E.</author><author>Lam, S. C. C.</author><author>Park, J. W.</author><author>Tarantini, G.</author><author>Cruz-Gonzalez, I.</author><author>Geist, V.</author><author>Della Bella, P.</author><author>Colombo, A.</author><author>Zeus, T.</author><author>Omran, H.</author><author>Piorkowski, C.</author><author>Lund, J.</author><author>Tondo, C.</author><author>Hildick-Smith, D.</author></authors></contributors><auth-address>Department of Cardiology, Charite Universitatsmedizin Berlin (CBF); Berlin Institute of Health (BIH); German Center of Cardiovascular Research (DZHK), Berlin, Germany.</auth-address><titles><title>Left atrial appendage occlusion with the AMPLATZER Amulet device: periprocedural and early clinical/echocardiographic data from a global prospective observational study</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>867-876</pages><volume>13</volume><number>7</number><dates><year>2017</year><pub-dates><date>Sep 20</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>28649053</accession-num><urls><related-urls><url>;[62]Tzikas et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UemlrYXM8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [63]Korsholm et al ADDIN EN.CITE <EndNote><Cite><Author>Korsholm</Author><Year>2017</Year><RecNum>1657</RecNum><DisplayText><style face="superscript">[64]</style></DisplayText><record><rec-number>1657</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509212309">1657</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Korsholm, K.</author><author>Nielsen, K. M.</author><author>Jensen, J. M.</author><author>Jensen, H. K.</author><author>Andersen, G.</author><author>Nielsen-Kudsk, J. E.</author></authors></contributors><auth-address>Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.</auth-address><titles><title>Transcatheter left atrial appendage occlusion in patients with atrial fibrillation and a high bleeding risk using aspirin alone for post-implant antithrombotic therapy</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>2075-2082</pages><volume>12</volume><number>17</number><dates><year>2017</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>27973336</accession-num><urls><related-urls><url>;[64]Berti et alPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [72]2013Self-expanding distal lobe and proximal disc nitinol mesh with articulating waist, and more anchorsTransvenous, trans-septalCE MarkLAAO: left atrial appendage occlusion; FDA: Food and drug administration; ACP: Amplatzer cardiac plug.Table 2 Antithrombotic therapy regimens following left atrial appendage occlusionStudy/referenceRegimenPROTECT AF trialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZXM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA [56]warfarin in 16%, NOAC in 11%, DAPT in 60%, SAPT in 7%, and no therapy in 6%RELEXAO registryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXVjaGllcjwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

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ADDIN EN.CITE.DATA [72]OACs in 28.8%, SAPT in 36.2%, DAPT in 23.2%, OACs plus DAPT in 4.3%, and no therapy in 7.5%.ASAP trialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZWRkeTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA [58]DAPT for 6 mo followed by aspirin indefinitelyEHRA/EAPCI expert consensus ADDIN EN.CITE <EndNote><Cite><Author>Meier</Author><Year>2015</Year><RecNum>1689</RecNum><DisplayText><style face="superscript">[75]</style></DisplayText><record><rec-number>1689</rec-number><foreign-keys><key app="EN" db-id="5xaevwspcvxrzwerf04v05pvaxsx0ezfwa2f" timestamp="1509314913">1689</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Meier, B.</author><author>Blaauw, Y.</author><author>Khattab, A. A.</author><author>Lewalter, T.</author><author>Sievert, H.</author><author>Tondo, C.</author><author>Glikson, M.</author></authors></contributors><auth-address>Cardiology, Bern University Hospital, 3010 Bern, Switzerland.</auth-address><titles><title>EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>1109-25</pages><volume>10</volume><number>9</number><keywords><keyword>Atrial Appendage/*surgery</keyword><keyword>Atrial Fibrillation/complications/*surgery</keyword><keyword>*Catheter Ablation</keyword><keyword>Catheters</keyword><keyword>*Consensus</keyword><keyword>Humans</keyword><keyword>Stroke/*surgery</keyword></keywords><dates><year>2015</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1969-6213 (Electronic)1774-024X (Linking)</isbn><accession-num>25169595</accession-num><urls><related-urls><url>;[75]DAPT for 1 to 6 mo followed by aspirin indefinitelyOAC: Oral anticoagulant; NOAC: Non-vitamin K oral anticoagulant; SAPT: Single antiplatelet; DAPT: Dual antiplatelet; EHRA/EAPCI: European Heart Rhythm Association/European Association of Percutaneous Cardiovascular Interventions.Table 3 complications related to left atrial appendage occlusionComplicationIncidenceTreatmentPericardial effusion/tamponade that require interventionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb2Vyc21hPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA [47,48,51, 53,56-58,76]0% to 1.1%Stroke managementASD: atrial septal defect. ................
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