EURAXESS



HEA Funded TU4D INITIATIVEResearch PhD Scholarships - Spring 2018 Start DateSupervisor Name & Contact Details: Dr. Bernie CreavenTel: 00 353-1-4042889Email : Bernie.Creaven@ittdublin.ie Scholarship DetailsCandidates appointed under HEA Funded TU4D INITIATIVE 2017 will qualify for a Scholarship providing a 48 month stipend for the student of €10,000 Per annum, full EU college fees* for 4 years and a contribution towards Materials costs. *Note: Non-EU students must pay an additional non-EU postgraduate fee per annumSubject AreaBioinorganic ChemistryProject Code & Title of the ProjectPHEA1705Targeting Therapies for Gram-Negative Bacterial InfectionsProject Description (max 300 words) Antimicrobial resistance (AMR) has been identified by the World Health Organisation as one of the biggest threats to human health in the 21st century. Pharmaceutical companies have been quite effective in producing antibiotics for the treatment of Gram-positive infections; however, no new class of antibiotics for Gram-negative bacterial infections has been introduced since quinolones in 1968. The collaborators in this project have been working for a number of years on the development of novel chemotherapeutics to treat antimicrobial infection and have identified separately a series of coumarin-derived silver(I) complexes, and a series of N-heterocyclic carbene (NHC) silver(I) acetate complexes, which have shown excellent activity against Gram-positive bacteria, particularly the clinically important MRSA. A recent informal collaboration has resulted in the isolation of a new adduct, a complex made by the addition of two separate moieties into a new entity, whereby Ag(I) is coordinated by both a NHC and a coumarin carboxylate ligand. Unfortunately the reaction has a low yield, probably as a result of the low solubility of the coumarin silver complex. The approach to be taken here, introducing structural features which would increase accumulation of the target compounds in Gram-negative cells, should allow the isolation in greater yields of the target compounds, since these structural features will improve the solubility of the coumarin moiety. Therefore, we will design, synthesise and assess the antimicrobial activity of new series of coumarin-derived silver complexes using a targeted approach to develop compounds which will have greater accumulation in Gram-negative bacteria with hopefully a concomitant increase in antimicrobial activity. These compounds will then be assessed for their antimicrobial activity and mode of action. Please indicate the student requirements for this project:The candidate chosen hold a cognate Level 8 qualification with a minimum award level of 2:1 in a relevant discipline which has a strong chemistry focus and be able to demonstrate at interview a strong record in organic synthesis and bioinorganic chemistry and together with a good knowledge of standard spectroscopic characterisation techniques. A background in medicinal chemistry would also be an advantage. If from a non-English speaking country, have an IELTS score of >6.0 or equivalent at the time of application.Deadline to submit applications Friday 2nd February 2018 @ 17:00Sponsoring Department Name: ScienceApplicants must fill in the application form and return it to researchadministration@it-tallaght.ie on or before the deadline aboveInsert Passport Size PhotoCONTACT DETAILSName:Address:Email:Mobile:PRIMARY DEGREE QUALIFICATIONSPlease attach copies of FINAL transcripts of results / Parchment. For non-nationals, please provide evidence of competency in English language – an IELTS score of >6.0 or equivalent is required.Degree title:College & Location:Years from - to:Level of Award:Place in class if known:Final Year Project Title:Key skills developed in your degree programme: POSTGRADUATE QUALIFICATIONSPlease attach copies of FINAL transcripts of results / Parchment. For non-nationals, please provide evidence of competency in English language – an IELTS score of >6.0 or equivalent is required.Degree title:College & Location:Years from - to:Level of Award:Research Project Title:Key skills developed in your degree programme: OTHER RELEVANT QUALIFICATIONSList qualification:Duration & Year of award:Relevance to the position applied for:MOST RECENT WORK EXPERIENCE Position held:Responsibilities:Period from - to:Relevance to the position applied for:Position held:Responsibilities:Period from - to:Relevance to the position applied for:Position held:Responsibilities:Period from - to:Relevance to the position applied for:WHAT ARE THE KEY / CORE COMPETENCIES YOU POSSESS RELEVANT TO THIS PROJECT AREA? List the top 512345Provide a brief personal statement on why you are the best candidate for this project (250 words only – persons exceeding this may be disqualified from the process)Referees - provide names and contact details for two independent persons who can attest to your suitability for this postgraduate research project (note: referees may be contacted without your consent)NameNameAddressAddressEmailEmailMobileMobileAvailability – the following questions relate to your availability and requirements for a study visaWhat is your Nationality?Do you hold a student visa to allow study in Ireland?Will you be available to start 26th February 2018?Signed:Date:Documents to include with your application: tick if attachedCopy of your final degree award certificate or official transcript of final examination results*Copy of IELTS certificate (must be >6.0) or equivalent** If offered a post-graduate place, original copies must be provided before student registration can be completed; failure to provide them will result in any offer of a studentship being withdrawn. ................
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