Clincancerres.aacrjournals.org
Avelumab binds PDL1 and blocks the interaction between PDL1 and the programmed death 1 (PD1) and B7.1 receptors. This removes the suppressive effects of PDL1 on cytotoxic CD8+ Tcells, resulting in the restoration of antitumour Tcell responses. In syngeneic mouse tumour models, blocking PDL1 … ................
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