SPS
SedativeMax. concentration sedativeAnalgesicMax.concentration analgesicMax. known stability timeExpected compatibilityNotes and referencesPropofol 1%10?mg/mLalfentanil hydrochloride0.5?mg/mL6?hoursMay be compatible Check brandData based on Diprivan brand. [1] No diluent.Propofol (Diprivan) 1% mixed with alfentanil injection 0.5?mg/mL. Ratio 20:1 to 50:1 v/v.Propofol 1%9.5mg/mLfentanyl citrate2?micrograms/mL90?minutesMay be compatible Check brandData based on Diprivan brand. [2]Propofol 1%10?mg/mLfentanyl citrate50micrograms/mL12?hoursMay be compatible Check brandData based on Fresenius Kabi brand. Fentanyl diluted with sodium chloride 0.9%. [3]Propofol 2%20?mg/mLfentanyl citrate50micrograms/mL12?hoursMay be compatible Check brandData based on Fresenius Kabi brand. Fentanyl diluted with sodium chloride 0.9%. [3]Propofol morphine sulfateNot compatibleNo data foundMidazolam hydrochloride 0.2?mg/mLalfentanil hydrochloride0.5?mg/mL24?hoursCompatible[4] Sodium chloride 0.9% diluent.Midazolam hydrochloride 1.1?mg/mLalfentanil hydrochloride2.7?mg/mL12?hoursCompatible[5] Sodium chloride 0.9% diluent.Midazolam hydrochloride 2.5mg/mLfentanyl citrate30micrograms/mL24 hoursCompatible[6]Midazolam hydrochloride 2?mg/mLmorphine sulfate8?mg/mL24 hoursCompatible[6] Sodium chloride 0.9% diluent.Higher medicines concentration have a faster rate of interaction, therefore compatibility data for lower concentrations may not be transferable.Mixing propofol with other medicines is high risk. All propofol formulations are emulsions and hence signs of physical incompatibility may be masked. In addition, pH and formulation vary between manufacturers, making extrapolating compatibility between products complex. See information: known stability time is based on what is known about chemical, physical and microbiological stability. It is assumed that these will be prepared in clinical areas, which have a maximum stability of 12?hours for propofol-containing infusions and 24?hours for other infusions.For detailed information about mixing critical care injectable medicines: The information on this page has been put together rapidly to help colleagues during the COVID-19 pandemic, if you spot anything that's wrong or needs improving contact us through the SPS website.References[1] Summary of Product Characteristics. Diprivan Propofol 1%; [2] Drugdex; [3] Nemec et al 2009 Pharmazie; 64(2): 94; [4] Handbook of Injectable Drugs;[5] [6] The Syringe Driver, Dickman.Original document prepared by SPS 9 April 2020; updated 14/4/20; 15/4/20Uncontrolled when printed ................
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