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Job Title: Post-doctoral researcher in bioinformatics and genomicsPlant Science Centre, Plant Genome Evolution Research GroupPost Responsible To: Pat Heslop-HarrisonThe post – bioinformatics and genomicsA new Research Group for Plant Genome Evolution is being established in the South China Botanical Garden (SCBG), Chinese Academy of Sciences (CAS). Our website, , indicates some of the current research projects. SCBG, founded in 1929, is one of the top botanical research institutions, having world-recognized achievements in ecology, systematic and evolutionary botany, plant genetics, biotechnology and genetic resources, as well as landscape, public garden, and educational programmes. Over 2500 scientific publications, many patents, and more than 90 plant varieties have resulted from the research programmes.The Plant Genome Evolution Laboratory is led by Pat Heslop Harrison with a five-year programme targeted at high-profile research and publications, involving cross-disciplinary research work using genomics, molecular cytogenetics and bioinformatics. Specific research areas include examining genome evolution, measuring diversity, determining the role and evolutionary history of repetitive DNA, measuring inter-genomic interactions, and studying three-dimensional genome modulation at meiosis and during gene expression. The focus of research will use diploid and polyploid crop species and their wild relatives, taking a comparative approach.Due to job requirements, two (three) staff members for research-based post-doctoral positions, based in the gardens in Guangzhou, China, will be recruited. This position will have a focus on bioinformatics with a broader role in maintaining computer facilities and limited molecular biology. Another position will include research on molecular cytogenetics and molecular biology.Job Purpose: bioinformatics and genomicsYou will join the Plant Genome Evolution Research Group, working on bioinformatics and genomics, with focus on comparative and polyploid evolution and the repetitive DNA component of the genome. Repetitive DNA motifs make up more than half of plant genomes, but are usually collapsed or ignored in genome assembly and evolutionary research. You will work on development of new algorithms to characterize the repetitive DNA component of chromosomes in various diploid and polyploid species. The projects will include new algorithms for repetitive sequences assembly using high-throughput sequence data, and the identification of transposable elements and tandem repeat arrays. You will use established and new approaches to analyse biodiversity, relationships and phylogeny at DNA and RNA level. An important project will develop algorithms to identify hybrids and polyploids, and their ancestral species, in sequence reads and marker data. You will also administer the IT resources of the group, and be involved with some experimental, lab-based, work to help choose and optimize sampling strategies for understanding genome evolution in plants. There will also be a possibility to work with analysis of microscope, crop breeding, and ecological images, including three-dimensional reconstruction. The research will require excellent knowledge of DNA sequence analysis, algorithm development, modern computational approaches and languages, along with recent literature. The project will lead to the joint preparation of manuscripts for publication in high-profile journals, and publication of computational resources for use world-wide. Educated to doctoral level, you will have proven experience in bioinformatics, molecular biology, markers, genomics and phylogenetic analysis. Within the group, you will be involved with collaborative work and working with students and other fellows, although you will be expected to be self-motivated and work independently. Ideally, your work would involve species, including crops, will little background data. The working language of the Group will be English.Principal Accountabilities: (approx. % of time; 10% is half-day per week)35% Analyse genomic and RNA sequence data, assemble chromosome scaffolds, characterize population structures and genotypic diversity (GBS)35% Develop novel approaches for identification of repetitive DNA sequences and improve sequence assembly approaches; Develop novel approaches for phylogenetic analysis of hybrid species10% Experimental work involving molecular biology (DNA, RNA, PCR) and cytogenetics, microscope and plant imaging10% Writing publications and preparing presentations; build and maintain laboratory website, blog, and public relations10% Maintain within-laboratory computer network (including microscope and equipment controls, printers and cameras; implementing disk networks, cloud storage, and appropriate network servers in the context of the institutional network), ensuring high security and backup; recommend, acquire, install and update hardware and software including security/virus patches.Resources Managed: Maintenance and updating of IT resourcesCo-management and recommendation of use of research budget, including outsourcing of eg sequencing and analysis.Management of research programmes of traineesPlanning and Organising: You will be self-motivated and able to advance researchYou will be able to collaboratePreparation of research publicationsPlanning of research programme and definition of short-term and longer-term milestones.Qualifications, Knowledge and Experience:EssentialPhD involving genomics, bioinformatics and/or molecular biologyAbility to deliver research outcomes relevant to the positionExperience of bioinformatics and genomic analysis of DNA sequencesKnowledge of literature related to crop genomics, bioinformatics, evolution, biodiversity, and statistics Experience with building and maintaining small PC networksAbility with Python, Java and/or R; PC and computer network experienceExcellent communication skills in English, including the ability to write for publication, present research proposals and results, represent the research group at meetings, teach, and prepare timely reportsAwareness and maintenance of the high ethical standards and keeping excellent records, ensuring appropriate data handing and safe working practices in an international, publicly-funded, research environmentPublications using bioinformatics in relevant areas of plant and crop genomics.DesirableResearch on use of molecular markers and phylogenetic analysisExperience of molecular cytogenetics including microscopy and image analysisExperiencer working in collaborative research groups and training othersExperience of independently managing a discrete area of research.Skills, Abilities and Competencies:EssentialHigh level of proficiency in English, sufficient to undertake research, administrative and writing activities utilising English Language materials and to communicate effectively with the English-speaking Principal Investigator, collaborators, visitors, staff and students. High level of experience of bioinformatics and DNA analysis.DesirableExperience in molecular biology and microscopyExperience in collaboration and training researchersWriting publications and presenting project reports.Contact Information:In the first instance, please send by e-mail a CV and letter of application to Professor JS (Pat) Heslop-Harrison, South China Botanical Garden, at phh@ with a copy to Dr Qing Liu, liuqing@scib.. Please include “SCBG Postdoc” in the Subject line.Other requirementsExcellent in both personality and academic qualifications, PhD degree, 35 or younger than 35 years old, being first author of SCI publication(s). Having related subject knowledge and background, fluent in English; full-time job without part-time job in other occupation. This is a full-time appointment.You may on occasion be expected to work overtime and overseas as required. ................
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