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Chapter 9 Musculoskeletal DrugsQuiz Yourself1.A balance between new bone deposition and bone resorption is supported by parathyroid hormone from the parathyroid glands and calcitonin hormone from the thyroid gland, calcium in the diet, vitamin D in the diet and from exposure to the sun, exercise, and—in women—by the hormones progesterone and estradiol from the ovaries.2.Bone resorption inhibitor drugs inhibit osteoclasts.3. Alendronate and risedronate tablets are taken orally every morning, 30 minutes before eating. Ibandronate is taken daily the 2.5-mg tablet), but its selling point is that it can also be taken just once a month (the 150-mg tablet). Zoledronic acid is now approved to treat osteoporosis in postmenopausal women with a single dose just once a year, but that dose can only be given intravenously, which necessitates a visit to the doctor’s office or clinic.4.Hormone replacement therapy with estrogen drugs can increase the risk of endometrialcancer, breast cancer, stroke, and myocardial infarction; this has limited the use of these drugs for the long-term treatment of osteoporosis in postmenopausal women.5. The abbreviation ASA stands for acetylsalicylic acid. The abbreviation COX stands forcyclooxygenase-2. The abbreviation NSAID stands for nonsteroidal anti-inflammatory drug.6. Salicylate drugs: aspirin (Bayer, Ecotrin); diflunisal (Dolobid); magnesium salicylate (Doan’s); salsalate (Salsitab); Acetaminophen acetaminophen (Tylenol).Nonsteroidal anti-inflammatory drugs (NSAIDs) :diclofenac (Cataflam, Voltaren); etodolac fenoprofen (Nalfon); flurbiprofen (Ansaid); ibuprofen (Advil, Motrin),;ndomethacin (Indocin); ketoprofen, meclofenamate, meloxicam (Mobic); nabumetone,; naproxen (Aleve, Naprosyn); oxaprozin (Daypro); piroxicam (Feldene); sulindac (Clinoril); tolmetinCOX-2 inhibitor drugs:celecoxib (Celebrex)Corticosteroid drugs:betamethasone (Celestone); cortisone; dexamethasone (Decadron); hydrocortisone (Cortef, Solu-Cortef);methylprednisolone (Depo-Medrol, Medrol); prednisolone (Orapred, Prelone); prednisone (Deltasone, Meticorten);triamcinolone (Aristospan Intra-articular. Kenalog-10)Hyaluronic acid, hyaluronic acid (Hyalgan, Synvisc)7. Aspirin is an anti-inflammatory, analgesic, and antipyretic drug. Acetaminophen is ananalgesic and antipyretic, but not an anti-inflammatory drug.8. An enteric-coated tablet does not dissolve in gastric acid; therefore the aspirin it contains is not released in the stomach. It dissolves only when the tablet comes in contact with the higher pH environment of the duodenum. This prevents the aspirin from irritating the stomach and causing gastric ulcers in patients with osteoarthritis who regularly take aspirin.9.True.10.Gold compound drugs inhibit the activity of the immune system’s macrophages thatattack and damage cartilage in rheumatoid arthritis. The cartilage damage in osteoarthritis is caused by degenerative wear and tear, not an immune systemresponse, so gold compounds are not effective in treating osteoarthritis.11.Strains, sprains, pulled muscles, muscle spasms, and stiffness.12. To what category of drugs does each of these drugs belong?a. monoclonal antibody drugb. bone resorption inhibitor drugc. drug for goutd. gold compound druge. natural substance from chile pepper plantsf. muscle relaxant drug g. COX-2 inhibitor drugh. NSAID i. bone resorption inhibitor drugj. NSAIDk. selective estrogen receptor modulator drugl. corticosteroid drugm. bone resorption inhibitor drugClinical Applications Questions1. a. magnesium salicylateb. salicylate drugsc. caplet2. a. Motrinb. ibuprofenc. nonsteroidal anti-inflammatory drugsd. 400 mge. tablets (tabs)f. Dispense 40. Write on the label: 400 milligrams to 800 milligrams, three times a day, with food, as needed for pain.3. a. Feldeneb. piroxicamc. nonsteroidal anti-inflammatory drugsd. 20 mge. capsules (caps)f. Dispense number 30. Write on the label: take one every day with food or milk.4. Robaxin 500 milligrams, take 1–2 by mouth four times a day as needed. Dispense 40.Three refills.5. a. ibuprofenb. NSAIDc. Advild. This drug, being a generic drug, would be less expensive than the trade name drug.e. Motrin ................
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