AusPAR Attachment 1: Product Information for Neratinib (as ...

When NERLYNX was administered 2 hours following a 300 mg dose of an H-2 receptor antagonist (ranitidine), the neratinib C max and AUC were reduced by 55% and 47%, respectively. When NERLYNX was administered 2 hours prior to ranitidine 150 mg twice daily (administered in the morning and evening, approximately 12 hours apart), the neratinib C max ... ................
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