Lippincott Williams & Wilkins



eTable 1. Characteristics of included trialsStudiesNumber of Patients RandomizedPopulationInterventionCo-AnalgesiaOutcomes Reported (main underline)Follow-Up PeriodGroups (Number of patients analyzed)SurgeryAnesthesiaDaily pre-operative dosage (mg) Timing Daily post-operative dosage (mg)Post-operative duration (days)Regional analgesia (yes or no)Yoon et al. (2001) ADDIN EN.CITE <EndNote><Cite><Author>Yoon</Author><Year>2001</Year><RecNum>15215</RecNum><DisplayText><style face="superscript">1</style></DisplayText><record><rec-number>15215</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">15215</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoon, K. J.</author><author>Kim, C. S.</author><author>Ryu k, H.</author><author>Kim, E. S.</author><author>Choi, J. H.</author><author>Lee, Y. K.</author></authors></contributors><titles><title>Analgesic effects of gabapentin on post-hysterectomy pain - a double blind study</title><secondary-title>Korean Journal of Anesthesiology</secondary-title></titles><periodical><full-title>Korean J Anesthesiol</full-title><abbr-1>Korean journal of anesthesiology</abbr-1></periodical><pages>S13-18</pages><volume>41</volume><number>6</number><keywords><keyword>Hs-handsrch: hs-acc: hs-koreamed</keyword></keywords><dates><year>2001</year></dates><accession-num>CN-01046695</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> (n = 16)Total hysterectomyGeneral anesthesia4000.5h before surgery--No Postoperative pain Morphine utilization Satisfaction Side effects24hPlacebo (n = 15)0Same--Dirks et al.(2002)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaXJrczwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl

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Pn==

ADDIN EN.CITE.DATA 270Gabapentin (n = 31)Unilateral radical mastectomy with axillary dissectionGeneral anesthesia12001h before surgery--NoMorphine utilizationPostoperative painSide effects4hPlacebo (n = 34)01h before surgery--Fassoulaki et al. (2002)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXNzb3VsYWtpPC9BdXRob3I+PFllYXI+MjAwMjwvWWVh

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ADDIN EN.CITE.DATA 375Gabapentin (n = 22)Modified radical mastectomy or lumpectomywith axillary lymph node dissectionGeneral anesthesia400evening before surgery / Not mentioned120010NoAnalgesic utilizationPostoperative painChronic pain10dMexiletine (n = 21)200Same60010Placebo (n = 24)0Same010Dierking et al. (2004)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaWVya2luZzwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+

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ADDIN EN.CITE.DATA 480Gabapentin (n = 39)Total or subtotal abdominal hysterectomy with or without salpingo-oophorectomyGeneral anesthesia12001h before surgery / 8h after first dose18001NoTotal morphine utilizationPostoperative pain at rest and during mobilizationPostoperative nausea or vomitingSide effects24hPlacebo (n = 32)0Same01Kim et al.(2004) ADDIN EN.CITE <EndNote><Cite><Author>Kim</Author><Year>2004</Year><RecNum>15125</RecNum><DisplayText><style face="superscript">5</style></DisplayText><record><rec-number>15125</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">15125</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kim, S. I.</author><author>Park, D. Y.</author><author>Ok, S. Y.</author><author>Kim, S. C.</author></authors></contributors><titles><title>Effects of preemptive gabapentin on postoperative pain after mastectomy</title><secondary-title>Korean Journal of Anesthesiology</secondary-title></titles><periodical><full-title>Korean J Anesthesiol</full-title><abbr-1>Korean journal of anesthesiology</abbr-1></periodical><pages>527-531</pages><volume>47</volume><number>4</number><keywords><keyword>Hs-handsrch: hs-acc: hs-koreamed</keyword></keywords><dates><year>2004</year></dates><accession-num>CN-01045351</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> (n = 21)MastectomyGeneral anesthesia900before surgery--NoPostoperative painFentanyl utilizationSedationAdverse effects24hPlacebo (n = 20)0Same--Pandey et al. (2004)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kZXk8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 875Gabapentin (n = 38)Vaginal hysterectomyGeneral anesthesia12002-2.5h before surgery--NoPostoperative pain at rest during coughing and during leg elevationFentanyl utilizationSide effects20hOxazepam (n = 37)15Same--Turan et al. (2004)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXJhbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 950Gabapentin (n = 25)Rhinoplasty or endoscopic sinus surgery septal and nasal sinus surgeryMonitored anesthesia care12001h before surgery--NoPostoperative pain and intraoperative painAnalgesic utilization Side effects24hPlacebo (n = 25)0Same--Turan et al. (2004)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXJhbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 1150Gabapentin (n = 25)Total abdominal hysterectomy with salpingo-oophorectomyGeneral anesthesia12001h before surgery--NoPostoperative pain VAS scoresHRSpo2MAPRRSedationTramadol utilization in the studySide effects24hPlacebo (n = 25)0Same--Ménigaux et al. (2005)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nw6luaWdhdXg8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFy

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ADDIN EN.CITE.DATA 1240Gabapentin (n = 20)Arthroscopic anterior cruciate ligament repair using hamstring autograftGeneral anesthesia12001-2h before surgery--NoPostoperative painMorphine utilizationDegrees of active and passive knee flexion and extensionPreoperative anxietySedation scoreSide effects48hPlacebo (n = 20)0Same--Pandey et al. (2005)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kZXk8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 1360Gabapentin postoperation (n = 20)Open donor nephrectomyGeneral anesthesia02h before surgery / after surgical incision6000NoPostoperative painFentanyl requirementSide effects24hGabapentin preoperation (N = 20)600Same00Placebo (n = 20)0Same00Pandey et al. (2005)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kZXk8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 14100Gabapentin 1200 (n = 20)Single-level lumbar disk surgeryGeneral anesthesia12002h before surgery--NoPostoperative painFentanyl requirementSide effects24hGabapentin 900 (n = 20)900Same--Gabapentin 600 (n = 20)600Same--Gabapentin 300 (n = 20)300Same--Placebo (n = 20)0Same--Radhakrishnan et al. (2005)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWRoYWtyaXNobmFuPC9BdXRob3I+PFllYXI+MjAwNTwv

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ADDIN EN.CITE.DATA 1560Gabapentin (n = 30)Lumbar laminectomy and discectomyGeneral anesthesia800night before + 2h before surgery--NoFentanyl and morphine utilizationPostoperative painSide effects8hPlacebo (n = 30)0Same--Tuncer et al. (2005)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdW5jZXI8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 1645Gabapentin 1200 (n = 15)Major orthopedic surgeryGeneral anesthesia12001h before surgery--NoPostoperative painMorphine utilizationSide effects4hGabapentin 800 (n = 15)800Same--Placebo (n = 15)0Same--Adam et al. (2006)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZGFtPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 1760Gabapentin (n = 27)Arthroscopic shoulder surgeryGeneral anesthesia8002h before surgery--YesNumber of Di-Antalvic tablets (48h)Postoperative painPostoperative nausea or vomitingSide effects48hPlacebo (n = 26)0Same--Al-Mujadi et al. (2006)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbC1NdWphZGk8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFy

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ADDIN EN.CITE.DATA 1878Gabapentin (n = 37)Thyroid surgeryGeneral anesthesia12002h before surgery--NoPostoperative painmorphine utilizationAdverse effects24hPlacebo (n = 35)0Same--Bartholdy et al. (2006)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJ0aG9sZHk8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFy

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ADDIN EN.CITE.DATA 2059Gabapentin (n = 25)Abdominal hysterectomyGeneral anesthesia160012PM day before surgery / Not mentioned16005NoPostoperative painopioid utilization1moPlacebo (n = 28)0Same05Mikkelsen et al. (2006)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWtrZWxzZW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFy

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ADDIN EN.CITE.DATA 2155Gabapentin (n = 22)TonsillectomyGeneral anesthesia12001h before surgery / Not mentioned after surgeryOperation day: 1200 and next 5 days: 18006NoMean Postoperative pain at rest. Postoperative pain during swallowingMorphine requirementKetobemidone requirementSedationDizzinessPostoperative nausea or vomitingGait disturbance5dPlacebo (n = 27)0Same06Nikolajsen et al. (2006)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWtvbGFqc2VuPC9BdXRob3I+PFllYXI+MjAwNjwvWWVh

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ADDIN EN.CITE.DATA 2570Gabapentin (n = 35)Knee arthroscopyGeneral anesthesia3002h before surgery--NoPostoperative painTotal rescue analgesicSomnolenceNystagmusTremorDiplopiaNausea24hPlacebo (n = 35)0Same--Paech et al. (2007) ADDIN EN.CITE <EndNote><Cite><Author>Paech</Author><Year>2007</Year><RecNum>16386</RecNum><DisplayText><style face="superscript">26</style></DisplayText><record><rec-number>16386</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067850">16386</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Paech, M. F.</author><author>Goy, R.</author><author>Chua, S.</author><author>Scott, K.</author><author>Christmas, T.</author><author>Doherty, D. A.</author></authors></contributors><auth-address>King Edward Mem Hosp Women, Dept Anaesthesia &amp; Pain Med, Subiaco, WA 6008, Australia. Univ Western Australia, Sch Med &amp; Pharmacol, Pharmacol &amp; Anaesthesiol Unit, Nedlands, WA 6009, Australia. Women &amp; Infants Res Fdn, Res Design &amp; Biostat Unit, Perth, WA, Australia.; Paech, MF (reprint author), King Edward Mem Hosp Women, Dept Anaesthesia &amp; Pain Med, 374 Bagot Rd, Subiaco, WA 6008, Australia.; michael.paech@health..au</auth-address><titles><title>A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery</title><secondary-title>Anesthesia and Analgesia</secondary-title><alt-title>Anesth. Analg.</alt-title></titles><periodical><full-title>Anesth Analg</full-title><abbr-1>Anesthesia and analgesia</abbr-1></periodical><pages>1449-1453</pages><volume>105</volume><number>5</number><keywords><keyword>GABAPENTIN</keyword><keyword>VALIDITY</keyword></keywords><dates><year>2007</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0003-2999</isbn><accession-num>WOS:000250317500045</accession-num><work-type>Article</work-type><urls></urls><electronic-resource-num>10.1213/01.ane.0000286227.13306.d7</electronic-resource-num><language>English</language></record></Cite></EndNote>2690Pregabalin (n = 41)Gynecologic operations involving the cervix and uterusGeneral anesthesia1001h before surgery--NoPostoperative painFentanyl requirementQuality of recoveryAnalgesic requirementSedation scorePostoperative nausea or vomitingSatisfaction scoreHeadacheLight-headednessVisual disturbancesDifficulty walking24hPlacebo (n = 45)0Same--Prabhakar et al. (2007)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmFiaGFrYXI8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy

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ADDIN EN.CITE.DATA 2720Gabapentin (n = 10)Brachial plexus explorationGeneral anesthesia8002h before surgery--NoPostoperative pain VAS score at rest and dynamicHemodynamics variablesIntraoperative fentanyl and propofol utilizationTotal doses of rescue analgesicPostoperative nausea or vomitingExcessive sedation24hPlacebo (n = 10)0Same--Said-Ahmed (2007)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYWlkLUFobWVkPC9BdXRob3I+PFllYXI+MjAwNzwvWWVh

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ADDIN EN.CITE.DATA 2880Gabapentin 1200 (n = 20)MyomectomyGeneral anesthesia12002h before surgery--NoPostoperative pain VASFentanyl utilizationSide effects24hGabapentin 600 (n = 20)600Same--Gabapentin 300 (n = 20)300Same--Placebo (n = 20)0Same--Takmaz et al. (2007)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWttYXo8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 2945Gabapentin 900 (n = 15)Open cholecystectomyGeneral anesthesia9001h before surgery--NoPostoperative painAnalgesic utilizationAdverse effects24hGabapentin 1200 (n = 15)1200Same--Placebo (n = 15)0Same--Tsitsopoulos et al.(2007) ADDIN EN.CITE <EndNote><Cite><Author>Tsitsopoulos</Author><Year>2007</Year><RecNum>16445</RecNum><DisplayText><style face="superscript">30</style></DisplayText><record><rec-number>16445</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067850">16445</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Tsitsopoulos, P. P.</author><author>Kiskira, O.</author><author>Kolotoura, A.</author><author>Bibis, A.</author><author>Anastassiou, E.</author></authors></contributors><auth-address>[Tsitsopoulos, P. Ph.] Aristotle Univ Thessaloniki, Sch Med, Hippokratio Gen Hosp, Dept Neurosurg, GR-54006 Thessaloniki, Greece.; Tsitsopoulos, PP (reprint author), Aristotle Univ Thessaloniki, Sch Med, Hippokratio Gen Hosp, Dept Neurosurg, GR-54006 Thessaloniki, Greece.</auth-address><titles><title>Effects of gabapentin on postoperative pain and morphine consumption after lumbar fusion surgery</title><secondary-title>Proceedings of the 13th European Congress of Neurosurgery</secondary-title></titles><pages>637-640</pages><keywords><keyword>MECHANISMS</keyword></keywords><dates><year>2007</year></dates><pub-location>40128 Bologna</pub-location><publisher>Medimond S R L</publisher><isbn>978-88-7587-385-1</isbn><accession-num>WOS:000251574500105</accession-num><urls></urls><language>English</language></record></Cite></EndNote>3040Gabapentin (n = 20)Lumbar fusion surgeryGeneral anesthesia12001h before surgery--NoPostoperative painMorphine utilization24hPlacebo (n = 20)0Same--Turan et al.(2007)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXJhbjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 3140Gabapentin (n = 20)Hand surgeryRegional anesthesia 12001h before surgery--NoSensory and motor block onsetRecovery timesTourniquet painQuality of anesthesiaPostoperative pain VAS scoreSide effects at discharge24hPlacebo (n = 20)0Same--Agarwal et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ2Fyd2FsPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48

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ADDIN EN.CITE.DATA 3260Pregabalin (n = 27)Laparoscopic cholecystectomyGeneral anesthesia1501h before surgery--NoPostoperative painFentanyl requirementIncidence and severity of side effects24hPlacebo (n = 29)0Same--Brogly et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm9nbHk8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 3560Gabapentin (n = 23)ThoracotomyGeneral anesthesia12002h before surgery--YesPostoperative pain at the surgical site (at rest and while coughing)Shoulder Postoperative pain (at rest and during movement)Side effects24hPlacebo (n = 28)0Same--Jokela et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2tlbGE8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 3691Pregabalin 600 (n = 29)Laparoscopic hysterectomyGeneral anesthesia3001h before surgery / 12h after 1st dose3001NoPostoperative pain VAS scores. VAS scoresfor side effects including Postoperative nausea or vomitingDrowsinessDizzinessLack of concentrationBlurred visionItchingSwelling of limbsPatient satisfaction5dPregabalin 300 (n = 27)150Same1501Diazepam (n = 29)10Same101Jokela et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2tlbGE8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 3790Pregabalin 150 (n = 26)Day-case gynaecological laparoscopic surgeryGeneral anesthesia1501h before surgery--NoPostoperative painAnalgesic requirementSide effects24hPregabalin 75 (n = 30)75Same--Diazepam (n = 28)5Same--Metry et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZXRyeTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 38111Gabapentin postoperation (n = 33)Unilateral modified radical mastectomyGeneral anesthesiaPlacebo2h before surgery / 2h after surgery12001NoPostoperative painMorphine utilizationPostoperative nausea or vomitingSide effects24hGabapentin preoperation (n = 34)1200Same01Placebo (n = 34)PlaceboSame01Mohammadi et al.(2008)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb2hhbW1hZGk8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

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ADDIN EN.CITE.DATA 41140Pregabalin (n = 70)Open inguinal. crural or umbilical hernia repairwith meshGeneral anesthesia753 nights before surgery / night after surgery7512NoChronic painAdverse effects12moPlacebo (n = 70)0Same012Bashir et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXNoaXI8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 42100Gabapentin (n = 50)Laparoscopic CholecystectomyGeneral anesthesia6002h before surgery--NoPostoperative nausea or vomiting24hPlacebo (n = 50)0Same--Chang et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFuZzwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 4380Pregabalin (n = 39)Laparoscopic CholecystectomyGeneral anesthesia1501h before surgery / 12h after 1st dose1500.5NoPostlaparoscopic shoulder painPostoperative painTime to first rescue analgesiaTime in PACURescue ketoralac requirement48hPlacebo (n = 38)0Same00.5Clarke et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 44126Gabapentin postoperation (n = 38)Total hip arthroplastyRegional anesthesia02h before surgery / direct after surgery6000NoMorphine utilizationPostoperative painSide effectsChronic pain6moGabapentin preoperation (n = 38)600Same00Placebo (n = 38)0Same 00Clarke et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 4540Gabapentin 600/300 (n = 7)Total knee arthroplastyRegional anesthesia6002h before surgery / 8h after surgery9004YesMorphine utilizationPostoperative painSide effects48hGabapentin 600/200 (n = 7)600Same6004Gabapentin 600/100 (n = 8)600Same3004Gabapentin 600/0 (n = 7)600Same04Placebo (n = 7)0Same04Grover et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm92ZXI8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 4958Gabapentin (n = 32)TonsillectomyGeneral anesthesia600night before+1h before surgery--NoPostoperative pain VAS at rest and during swallowingFentanyl utilizationSatisfaction scoresSide effects9dPlacebo (n = 26)0Same--Kang et al.(2009) ADDIN EN.CITE <EndNote><Cite><Author>Kang</Author><Year>2009</Year><RecNum>15071</RecNum><DisplayText><style face="superscript">50</style></DisplayText><record><rec-number>15071</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">15071</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kang, H. S.</author><author>Park, H. J.</author><author>Choi, J.</author><author>Park, S. J.</author><author>Lee, Sk</author></authors></contributors><titles><title>The optimal preemptive dose of gabapentin following gynecologic surgery</title><secondary-title>Korean Journal of Anesthesiology</secondary-title></titles><periodical><full-title>Korean J Anesthesiol</full-title><abbr-1>Korean journal of anesthesiology</abbr-1></periodical><pages>309-312</pages><volume>56</volume><number>3</number><keywords><keyword>Hs-handsrch: hs-acc: hs-koreamed</keyword></keywords><dates><year>2009</year></dates><accession-num>CN-01044886</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> 300 (n = 25)Gynecologic surgeryGeneral anesthesia3002h before surgery--NoPostoperative painFentanyl utilization Sedation48hGabapentin 600 (n = 25)600Same--Gabapentin 1200 (n = 25)1200Same--Placebo (n = 25)0Same--Nutt et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OdXR0PC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 5189Pregabalin (n = 27)Dental procedureMonitored anesthesia care1504h before surgery--Not mentionedVAS for anxietyVAS for sedationTime-to-Onset of Action ScaleDental anxiety scale4hAlprazolam (n = 31)0.5Same--Placebo (n = 31)0Same--Sava et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXZhPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 5250Gabapentin (n = 25)Rectocolic surgeryGeneral anesthesia800before surgery--NoAnxietyPostoperative painMorphine utilizationAdverse effects48hPlacebo (n = 25)0before surgery--Sekhavat et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWtoYXZhdDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+

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ADDIN EN.CITE.DATA 5460Gabapentin (n = 20)Abdominal hysterectomy with salpingo-oophorectomyGeneral anesthesia12001h before surgery--NoPostoperative painMorphine utilizationQuality of recoveryBowel functionResumption of normal activitiesPatient satisfactionAdverse effects6moKetamine (n = 20)0.3 mg /kg + 0.05mg/kg/hSame--Placebo (n = 20)0Same--?en et al.(2009)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj7FnmVuPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 5852Gabapentin (n = 23)Arthroscopic rotator cuff repairGeneral anesthesia3002h before surgery--NoPostoperative painFentanyl utilizationPostoperative nausea or vomitingSide effects24hPlacebo (n = 23)0Same--Belhaj et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxoYWo8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 6040Pregabalin (n = 18)Lumbar discectomyGeneral anesthesia3001.5h before surgery / 12h after surgery3001NoChange in pain intensity at 3 monthsPostoperative painFunctional score3moPlacebo (n = 20)0Same01Buvanendran et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXZhbmVuZHJhbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll

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ADDIN EN.CITE.DATA 61240Pregabalin (n = 113)Total knee arthroplastyRegional anesthesia3001-2h before surgery / Not mentionedDays 1-10: 300. days 11-12: 150. days 13-14: 100 14YesChronic painKnee range of motionopioid utilizationPostoperative painSleep disturbanceTime to discharge and adverse effects6moPlacebo (n = 115)0Same014Chowdhury et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaG93ZGh1cnk8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy

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ADDIN EN.CITE.DATA 6460Gabapentin (n = 30)Radical mastectomy surgeryGeneral anesthesia12002h before surgery--NoPostoperative painAnalgesic utilizationEnd-tibial isoflurane concentrationsSide effects24hPlacebo (n = 29)0Same--Gianesello et al.(2010) ADDIN EN.CITE <EndNote><Cite><Author>Gianesello</Author><Year>2010</Year><RecNum>16851</RecNum><DisplayText><style face="superscript">65</style></DisplayText><record><rec-number>16851</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524237933">16851</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gianesello, L.</author><author>Pavoni, V.</author><author>Buoninsegni</author><author>Tadini L.</author><author>Paparella, L.</author><author>Barboni, E.</author></authors></contributors><titles><title>Preemptive analgesia with pregabalin to postoperative pain management after spine surgery for decompression and stabilization: 14ap5–2</title><secondary-title>European Journal of Anaesthesiology</secondary-title></titles><periodical><full-title>Eur J Anaesthesiol</full-title><abbr-1>European journal of anaesthesiology</abbr-1></periodical><pages>204</pages><volume>27</volume><number>47</number><dates><year>2010</year></dates><urls></urls></record></Cite></EndNote>6530Pregabalin (n = 15)Spine surgery for decompression and stabilizationGeneral anesthesia1501h before surgery--NoPostoperative painMorphine utilizationAdverse effects24hPlacebo (n = 15)0Same--Kazak et al.(2010) ADDIN EN.CITE <EndNote><Cite><Author>Kazak</Author><Year>2010</Year><RecNum>15361</RecNum><DisplayText><style face="superscript">66</style></DisplayText><record><rec-number>15361</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">15361</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kazak, Z.</author><author>Mortimer, N. M.</author><author>Sekerci, S.</author></authors></contributors><titles><title>Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery</title><secondary-title>European archives of oto-rhino-laryngology</secondary-title></titles><periodical><full-title>European Archives of Oto-Rhino-Laryngology</full-title></periodical><pages>731-736</pages><volume>267</volume><number>5</number><keywords><keyword>Sr-ent</keyword></keywords><dates><year>2010</year></dates><accession-num>CN-00766444</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> (n = 30)Nasal septal and nasal sinus surgeryMonitored anesthesia care6001h before surgery--NoRemifentanyl utilizationIntraoperative pain VAS scoreLevel of anxietyPostoperative pain scoreLornoxicam utilizationLevel of sedationSide effects24hPlacebo (n = 30)0Same--Khademi et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFkZW1pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

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ADDIN EN.CITE.DATA 6899Pregabalin (n = 47)Robot-assisted endoscopicthyroidectomiesGeneral anesthesia1501h before surgery / 12h after 1st dose1501NoPostoperative pain Verbal numerical rating scaleSide effectsIncidences of chronic pain and hypoesthesia of the anterior chestNumber of participant who required additional analgesics3moPlacebo (n = 47)0Same01Menda et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZW5kYTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 6960Gabapentin (n = 30)Coronary artery bypass graft surgery (median sternotomy)General anesthesia6002h before surgery--NoPostoperative pain verbal rating scaleTotal morphine utilizationSedation scoreSide effectsNumber of patients who required additional morphine or paracetamolrespiratory depressionPostoperative nausea or vomitingPruritus48hPlacebo (n = 30)0Same--Parikh et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJpa2g8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 7060Gabapentin (n = 30)Abdominal surgeryGeneral anesthesia6001h before surgery--NoPostoperative painRescue analgesia utilizationPostoperative nausea or vomitingrespiratory depressionDizzinessSomnolenceHeadachePruritus24hPlacebo (n = 30)0Same--Pavoni et al.(2010) ADDIN EN.CITE <EndNote><Cite><Author>Pavoni</Author><Year>2010</Year><RecNum>16852</RecNum><DisplayText><style face="superscript">71</style></DisplayText><record><rec-number>16852</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524238306">16852</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pavoni, V.</author><author>Vellucci, R.</author><author>Zuppani, B.</author><author>Barboni, E.</author><author>Gianesello, L.</author></authors></contributors><titles><title>The influence of a single preoperative dose of pregabalin on patient-controlled analgesia following surgery for inflammatory bowel diseases: 14AP4–3</title><secondary-title>European Journal of Anaesthesiology</secondary-title></titles><periodical><full-title>Eur J Anaesthesiol</full-title><abbr-1>European journal of anaesthesiology</abbr-1></periodical><pages>201</pages><volume>27</volume><number>47</number><dates><year>2010</year></dates><urls></urls></record></Cite></EndNote>7150Pregabalin (n = 25)Surgery for inflammatory bowel diseasesGeneral anesthesia1502h before surgery--NoPostoperative painMorphine utilizationAdverse effectsSatisfaction3moPlacebo (n = 25)0Same--Peng et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZW5nPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 72165Pregabalin 75 (n = 48)Laparoscopic cholecystectomyGeneral anesthesia751h before surgery / 12h after surgery1501NoPostoperative painTime to first analgesic utilizationDischarge time from PACUAnalgesic utilizationGeneral tolerabilitySleep qualityQuality of recoveryAdverse effectsPatient satisfaction7dPregabalin 50 (n = 48)50Same1001Placebo (n = 46)0Same01Raghove et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWdob3ZlPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

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ADDIN EN.CITE.DATA 7390Gabapentin 1200 (n = 30)Single lower limb surgeryRegional anesthesia12001h before surgery--NoPostoperative pain intensityRescue analgesia utilizationSedationSide effects24hGabapentin 600 (n = 30)600Same--Placebo (n = 30)0Same--Rapchuk et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXBjaHVrPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

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ADDIN EN.CITE.DATA 7460Gabapentin (n = 27)Cardiac surgery via median sternotomyGeneral anesthesia12002h before surgery / morning after surgery12002NoFentanyl utilization (48h)Postoperative painAdjunctive pain medicationSleep satisfactionSide effectsSatisfaction72hPlacebo (n = 27)0Same02Sanin et al.(2010) ADDIN EN.CITE <EndNote><Cite><Author>Sanin</Author><Year>2010</Year><RecNum>16853</RecNum><DisplayText><style face="superscript">75</style></DisplayText><record><rec-number>16853</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524238691">16853</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sanin, L.</author><author>Chelly, J.</author><author>Yang, R.</author><author>Cheung, R.</author><author>Lionberger, D.</author></authors></contributors><titles><title>Efficacy and safety of pregabalin in the treatment of postoperative pain following total knee arthroplasty: 14AP5–9</title><secondary-title>European Journal of Anaesthesiology</secondary-title></titles><periodical><full-title>Eur J Anaesthesiol</full-title><abbr-1>European journal of anaesthesiology</abbr-1></periodical><pages>205-206</pages><volume>27</volume><number>47</number><dates><year>2010</year></dates><urls></urls></record></Cite></EndNote>75292Pregabalin 150 (n = 98)Total knee arthroplastyNot mentioned15012h+2h before surgery / after surgery15014-42NoWorst painCumulative dose of opioidsRange of movementsGeneral activityAdverse effects6moPregabalin 300 (n = 96)300Same30014-42Placebo (n = 98)0Same014-42Schulmeyer et al.?(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2h1bG1leWVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh

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ADDIN EN.CITE.DATA 78210Gabapentin (n = 66)Ear. nose. and throat surgery (22.4%). orthopaedic surgery (21.9%). spinal surgery (19.4%). Gastrointestinal surgery (18.9%). gynaecologic surgery (10.9%). and gastrointestinal endoscopic procedures (6.5%)General anesthesia12002h before surgery--Not mentionedPreoperative anxietySide effectsNot mentionedHydroxyzine (n = 66)75Same--Placebo (n = 69)0Same--Wang et al.(2010)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 79100Pregabalin (n = 36)Unilateral first metatarsal bunionectomy surgeryRegional anesthesia3001h before surgery / 8h after surgery4502NoHydromorphone utilizationTime to first request of analgesia48hNaproxen sodium (n = 34)5501h before surgery / 12h after surgery11001.5Placebo (n = 30)0Not mentioned0Not mentionedGhai et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaGFpPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 8090Pregabalin (n = 30)Abdominal hysterectomyGeneral anesthesia3001-2h before surgery--NoAnalgesic utilizationPostoperative painAdverse effects24hGabapentin (n = 30)900Same--Placebo (n = 30)0Same--Gonano et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb25hbm88L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 82180Pregabalin (n = 60)Laparoscopic cholecystectomyGeneral anesthesia15075-90 min before surgery--NoPreoperative sedation and anxiolysisHemodynamic responses to laryngoscopy and laparoscopyIntraoperative analgesic requirementQuality of postoperative recoveryOccurrence of premedication induced side effects3hClonidine (n = 60)0.2Same--Placebo (n = 60)0Same--Gupta et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdXB0YTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 8380Pregabalin (n=40)Elective surgery General anesthesia1501-1.25h before surgery--Not mentionedHemodynamic stabilityAdverse effects1hPlacebo (n=40)0Same--Hegarty et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZWdhcnR5PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

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ADDIN EN.CITE.DATA 8564Gabapentin (n = 32)Internal fixation of the tibiaRegional anesthesia3002h before surgery--NoPostoperative painMorphine utilizationTime to first bolus of morphine Side effects24hPlacebo (n = 32)0Same--Khan et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFuPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 86175Gabapentin 1200 postoperation (n = 25)Single-level lumbar laminectomyGeneral anesthesiaPlacebo2h before surgery /Immediately after surgery12000NoPostoperative painTotal morphine utilizationPostoperative nausea or vomitingDrowsinessDizziness24hGabapentin 1200 preoperation (n = 25)1200Same00Gabapentin 900 postoperation (n = 25)0Same9000Gabapentin 900 preoperation (n = 25)900Same00Gabapentin 600 postoperation (n = 25)0Same6000Gabapentin 600 preoperation (n = 25)600Same00Placebo (n = 25)0Same00Kim et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW08L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 8884Pregabalin 150 (n = 28)Posterior lumbar spinal fusionGeneral anesthesia1501h before surgery / 12h after surgery1500.5NoPostoperative painKetorolac utilizationSedationHeadacheDizzinessVisual disturbances48hPregabalin 75 (n = 28)75Same750.5Placebo (n = 28)0Same00.5Kohli et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2hsaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 89150Pregabalin 300 (n = 50)HysterectomyRegional anesthesia3001h before surgery--Not mentionedMAPHRTime to first rescue analgesiaAdverse eventsPatient satisfaction1hPregabalin 150 (n = 50)150Same--Placebo (n = 50)0Same--Kuhnle et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdWhubGU8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 9083Gabapentin (n = 41)Photorefractive keratectomyMonitored anesthesia care900During 48h before surgery / 0-8h after surgery9004NoPostoperative painOxycodone-acetaminophen use4dPlacebo (n = 41)048h before surgery (each 8h) / direct after surgery04Macheridou et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNoZXJpZG91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVh

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ADDIN EN.CITE.DATA 9134Pregabalin (n = 17)Radical modified mastectomyGeneral anesthesia150night + 1h before surgery--NoTramadol and paracetamol requirementPostoperative painAdverse effects72hPlacebo (n = 17)0Same--Moore et al.(2011)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb29yZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 10190Pregabalin 600 (n = 30)Total abdominal hysterectomyGeneral anesthesia3001h before surgery / 12h after surgery3001NoMorphine utilization for 24h postoperativelyPostoperative painSedationPatient satisfactionSide effects24hPregabalin 300 (n = 30)150Same 1501Placebo (n = 30)0Same 01Adam et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZGFtPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 10264Gabapentin (n = 32)Orthopedic surgery or open inguinal hernia repairGeneral anesthesia12002-3h before surgery--YesPreoperative anxietyMemoryPostoperative nausea or vomitingSide effectsNot mentionedPlacebo (n = 32)0Same --Ajori et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bam9yaTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 107100Gabapentin 1200 (n = 34)Transurethral resection of bladder tumorRegional anesthesia12001h before surgery--NoIncidence of catheter-relater bladder discomfortSensory and motor blockAdverse effects24hGabapentin 600 (n = 33)600Same --Placebo (n = 33)0Same --Balaban et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWxhYmFuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

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ADDIN EN.CITE.DATA 10890Pregabalin 300 (n = 30)Laparoscopic cholecystectomyGeneral anesthesia3001h before surgery--NoPostoperative painSedationFentanyl utilizationSide effects24hPregabalin 150 (n = 30)150Same --Placebo (n = 30)0Same --Behdad et al.(2012) ADDIN EN.CITE <EndNote><Cite><Author>Behdad</Author><Year>2012</Year><RecNum>14831</RecNum><DisplayText><style face="superscript">109</style></DisplayText><record><rec-number>14831</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">14831</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Behdad, S.</author><author>Ayatollahi, V.</author><author>Bafghi, A. T.</author><author>Tezerjani, M. D.</author><author>Abrishamkar, M.</author></authors></contributors><titles><title>Effect of gabapentin on postoperative pain and operation complications: A randomized placebo controlled trial</title><secondary-title>The West Indian medical journal</secondary-title></titles><periodical><full-title>West Indian Med J</full-title><abbr-1>The West Indian medical journal</abbr-1></periodical><pages>128-133</pages><volume>61</volume><number>2</number><keywords><keyword>Amines [therapeutic use]</keyword><keyword>Analgesics [therapeutic use]</keyword><keyword>Cyclohexanecarboxylic Acids [therapeutic use]</keyword><keyword>Double-Blind Method</keyword><keyword>Hysterectomy</keyword><keyword>Pain, Postoperative [prevention &amp; control]</keyword><keyword>Postoperative Complications [prevention &amp; control]</keyword><keyword>Postoperative Nausea and Vomiting [prevention &amp; control]</keyword><keyword>gamma-Aminobutyric Acid [therapeutic use]</keyword><keyword>Female[checkword]</keyword><keyword>Humans[checkword]</keyword><keyword>Middle Aged[checkword]</keyword><keyword>Sr-menstr</keyword></keywords><dates><year>2012</year></dates><accession-num>CN-00835483</accession-num><work-type>Randomized Controlled Trial; Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url><style face="underline" font="default" size="100%"> 23155956</custom3></record></Cite></EndNote>10961Gabapentin (n = 30)Total abdominal hysterectomyGeneral anesthesia400night before+2h before surgery--NoPostoperative painAdverse effectsBlood pressurePulse rateMorphine use24hPlacebo (n = 31)0Same --Bornemann-Cimenti et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb3JuZW1hbm4tQ2ltZW50aTwvQXV0aG9yPjxZZWFyPjIw

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ADDIN EN.CITE.DATA 112110Pregabalin (n = 50)Cosmetic liposuction. mammoplasty or abdominoplastyGeneral anesthesia150night before + 1h before surgery / after surgery Not mentioned1504NoPostoperative painAdverse effectsPostoperative nausea or vomitingPostoperative analgesic requirement96hPlacebo (n = 49)0Same 04Chiravanich et al. (2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGlyYXZhbmljaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1ll

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ADDIN EN.CITE.DATA 113180Gabapentin (n = 84)Lower extremity orthopedic surgeryRegional anesthesia6002h before surgery--Not mentionedIncidence of pruritusOnset time of pruritusAdverse effects24hPlacebo (n = 84)0Same--?inar et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj7Dh2luYXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 11850Gabapentin (n = 25)Total Abdominal HysterectomyGeneral anesthesia12001h before surgery--NoPostoperative painAnalgesic utilizationAdverse effects24hPlacebo (n = 25)0Same --Ghai et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaGFpPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 11990Pregabalin (n = 30)Abdominal hysterectomy?General anesthesia3001h before surgery--NoPreoperative anxietySedationAdverse effects12hGabapentin (n = 30)900Same--Placebo (n = 30)0Same --Gianesello et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaWFuZXNlbGxvPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh

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ADDIN EN.CITE.DATA 12060Pregabalin (n = 30)Decompressive lumbar laminectomy withspinal fusionGeneral anesthesia3001h before surgery / Not mentioned3002NoPostoperative painSide effectsLong term quality of life12moPlacebo (n = 30)0Same 02Jain et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYWluPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 12140Pregabalin (n = 20)Total knee arthroplastyRegional anesthesia752h before surgery / 6AM after surgery1502YesPostoperative painMorphine utilizationPCEA usageRescue analgesic requirementOverall patient satisfaction Adverse effects48hPlacebo (n = 20)0Same 02Khahi et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFoaTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 12264Gabapentin (n = 32)Internal fixation of the tibiaRegional anesthesia0immediate after surgery3000NoPostoperative painMorphine utilizationTime until first morphine administration24hPlacebo (n = 32)0Same 00Kinney et al. (2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW5uZXk8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 12440Pregabalin (n = 20)Radical modified mastectomyGeneral anesthesia150night + 1h before surgery / Not mentioned758NoTramadol and paracetamol requirementPostoperative painChronic painAdverse effects3moPlacebo (n = 200Same08Mohammed et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb2hhbW1lZDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

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ADDIN EN.CITE.DATA 12580Gabapentin (n = 40)Functional endoscopic sinus surgeryGeneral anesthesia12001h before surgery--NoIntraoperative MAPInfusion rates of the hypotensive agentAssessment of painopioid usageSide effects at 1h interval8hPlacebo (n = 40)0Same --Nella et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZWxsYTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 12856Pregabalin (n = 27)Arthroscopic anterior cruciate ligamentreconstructionRegional anesthesia751h before surgery / 11h after surgery750.5NoPostoperative painSedation scoreRespiratory ratePostoperative nausea or vomitingDizzinessHeadacheBlurred visionGlobal pain reliefSatisfaction of pain reliefLimitation of mobilizationDisturbance of sleepPreference for stronger analgesic24hPlacebo (n = 29)0Same 00.5Pakravan et al.?(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYWtyYXZhbjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

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ADDIN EN.CITE.DATA 129150Gabapentin (n = 50)Post–photorefractive keratectomyMonitored anesthesia care2h after surgery9003NoPostoperative pain VASPercentage of patients with severe painNumber of acetaminophen codeine pills takenSide effects72hPregabalin (n = 50)Same 2253Placebo (n = 50)Same 03Pandey et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kZXk8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 13190Pregabalin 150 (n = 30)SurgeryGeneral anesthesia1501h before surgery--Not mentionedHaemodynamic stabilitypost-operative side-effects3hPregabalin 75 (n = 30)75Same --Placebo (n = 30)0Same --Rimaz et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaW1hejwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 13560Pregabalin (n = 30)Off-pump coronary artery bypass graftingGeneral anesthesia1501h before surgery--NoHemodynamic response to intubation and fentanyl utilization during surgeryPostoperative painSedation scoreSide-effects24hPlacebo (n = 30)0Same --YaDeau et al.(2012)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYWRlYXU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 13660Pregabalin (n = 28)After foot or ankle surgeryRegional anesthesia1001h before surgery / 12h after surgery1003YesNumber of hours that patientsreported moderate to severe painPostoperative painSide effectsopioid utilization48hPlacebo (n = 28)0Same 03Akhavanakbari et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Akhavanakbari</Author><Year>2013</Year><RecNum>11087</RecNum><DisplayText><style face="superscript">137</style></DisplayText><record><rec-number>11087</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11087</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Akhavanakbari, Godrat</author><author>Entezariasl, Masood</author><author>Isazadehfar, Khatereh</author><author>Mirzarahimi, Tiba</author></authors></contributors><auth-address>Akhavanakbari,Godrat. Department of Anesthesiology, Ardabil University of Medical Sciences, Iran.</auth-address><titles><title>The effects of oral pregabalin on post-operative pain of lower limb orthopedic surgery: A double-blind, placebo-controlled trial</title><secondary-title>Perspectives in Clinical Research</secondary-title><alt-title>Perspect Clin Res</alt-title></titles><periodical><full-title>Perspect Clin Res</full-title><abbr-1>Perspectives in clinical research</abbr-1></periodical><alt-periodical><full-title>Perspect Clin Res</full-title><abbr-1>Perspectives in clinical research</abbr-1></alt-periodical><pages>165-168</pages><volume>4</volume><number>3</number><dates><year>2013</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>2229-3485</isbn><accession-num>24010057</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">: NLM. PMC3757580</custom2><electronic-resource-num><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>13760Pregabalin (n = 30)Lower limb surgeryRegional anesthesia1502h before surgery--NoPostoperative painPethidine requirementSedationPostoperative nausea or vomiting24hPlacebo (n = 30)0Same --Aydo?an et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BeWRvx6dhbjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

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dGU+AG==

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ADDIN EN.CITE.DATA 14040Gabapentin (n = 20)Total mastectomy with axillary node dissection for carcinoma breastGeneral anesthesia6002h before surgery--NoDuration of surgeryPropofol requirementduring induction and maintenance of anesthesiaTotal utilization of fentanyl and vecuroniumHemodynamic variablesSide effects24hPlacebo (n = 20)0Same --Clarke et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 14450Gabapentin (n = 25)Abdominal hysterectomyGeneral anesthesia12002h before surgery--NoPostoperative painMorphine utilization24hPlacebo (n = 25)0Same --Jahromi et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYWhyb21pPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

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ADDIN EN.CITE.DATA 145150Metoclopramide (n = 30)Open reduction and internal rigid fixation of their maxillofacial skeletal traumaGeneral anesthesia101h before surgery--NoPostoperative nausea or vomiting24hGabapentin (n = 30)300Same --Chlorpromazine (n = 30)25Same --Dexamethasone (N = 30)5Same --Placebo (n = 30)0Same --Joshi et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb3NoaTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 14640Pregabalin (n = 20)Off-pump coronary artery bypass (OPCAB) surgeryGeneral anesthesia1502h before surgery / after surgery Not mentioned1502NoPostoperative pain VAS at rest and during deep breathingSedation scoresTime to extubationTramadol utilizationSide effectsChronic pain3moPlacebo (n = 20)0Same 02Kavitha et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXZpdGhhPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

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ADDIN EN.CITE.DATA 14756Gabapentin (n = 28)Cataract surgeryRegional anesthesia6002h before surgery--YesSedationAnxietyHRMAPIntraocular pressureMidazolam supplementationRecovery scorePostoperative analgesiaSide effects6hDiazepam (n = 28)0.15 mg/kgSame --Khan et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 15060Pregabalin (n = 30)Radical mastectomy General anesthesia1501h before surgery + 12h after surgery751NoPostoperative painAnalgesic utilizationAdverse effects24hPlacebo (n = 30)01h before surgery01Kumar et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Kumar</Author><Year>2013</Year><RecNum>11088</RecNum><DisplayText><style face="superscript">151</style></DisplayText><record><rec-number>11088</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11088</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kumar, Koramutla Pradeep</author><author>Kulkarni, Dilip Kumar</author><author>Gurajala, Indira</author><author>Gopinath, Ramachandran</author></authors></contributors><auth-address>Kumar,Koramutla Pradeep. Department of Anesthesiology, Balaji Institute of Surgery Research and Rehabilitation for Disabled, Tirupati, AP, India.</auth-address><titles><title>Pregabalin versus tramadol for postoperative pain management in patients undergoing lumbar laminectomy: A randomized, double-blinded, placebo-controlled study</title><secondary-title>Journal of pain research</secondary-title><alt-title>J Pain Res</alt-title></titles><periodical><full-title>J Pain Res</full-title><abbr-1>Journal of pain research</abbr-1></periodical><alt-periodical><full-title>J Pain Res</full-title><abbr-1>Journal of pain research</abbr-1></alt-periodical><pages>471-478</pages><volume>6</volume><dates><year>2013</year></dates><isbn>1178-7090</isbn><accession-num>23837006</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">: NLM. PMC3699253</custom2><electronic-resource-num><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>15175Pregabalin (n = 25)Decompressive lumbar laminectomyGeneral anesthesia1501h before surgery--NoPostoperative painSedation scoreAnxiety scoreBlood pressureHRRRRescue analgesiaPostoperative nausea or vomitingConstipationDrowsiness6hTramadol (n = 25)100Same --Placebo (n = 25)0Same --Lee et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 15280Gabapentin (n = 36)Total or hemi-total thyroidectomyGeneral anesthesia6001h before surgery--NoPostoperative painIncidence of postoperative sore throatNumber of times of rescue analgesiaSide effects24hPlacebo (n = 35)0Same --Maleh et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWxlaDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 15380Gabapentin (n = 40)Laparoscopic CholecystectomyGeneral anesthesia6001h before surgery--NoMorphine utilization (24h)Postoperative painAdverse effects24hPlacebo (n = 40)0Same --Mardani-Kivi et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJkYW5pLUtpdmk8L0F1dGhvcj48WWVhcj4yMDEzPC9Z

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ADDIN EN.CITE.DATA 15550Pregabalin (n = 25)ThoracotomiesGeneral anesthesia1501h before surgery / 12h after surgery15021NoChronic painPostoperative painDiclofenac utilization24wDiclofenac sodium (n = 25)01h before surgery / 8h after surgeryPlacebo7 regular. after: on demandMisra et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXNyYTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 15679Gabapentin (n = 36)Craniotomy for various intracranial tumorsGeneral anesthesia6002h before surgery--NoPostoperative nausea or vomitingPostoperative painFentanyl requirement24hPlacebo (n = 37)0Same --Not mentioned(2013) ADDIN EN.CITE <EndNote><Cite><Author>NM</Author><Year>2013</Year><RecNum>16847</RecNum><DisplayText><style face="superscript">157</style></DisplayText><record><rec-number>16847</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="0">16847</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>NM</author></authors></contributors><titles><title>Study to investigate the effectiveness of pregabalin for management of patients undergoing total hip replacement</title></titles><dates><year>2013</year></dates><pub-location></pub-location><urls><related-urls><url><style face="underline" font="default" size="100%"> (n = 27)Total hip replacementRegional anesthesia0after surgery15014NoPostoperative painAnxietyTime to mobilizationRescue medication usage Adverse effects14dPlacebo (n = 27)0Same 014Paul et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXVsPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 158101Gabapentin (n = 52)Primary total knee arthroplastyRegional anesthesia6002h before surgery / 8h after surgery6002NoMorphine utilizationPostoperative painSide effectsPatient satisfactionKnee range of motionPerioperative hemodynamicRespiratory variables72hPlacebo (n = 49)0Same 02Sagit et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYWdpdDwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 16182Gabapentin (n = 36)Open bowel surgeryGeneral anesthesia6001h before surgery--NoPostoperative painOpioid utilizationLength of staySide effectsOpioid-related symptom distress scale48hPlacebo (n = 36)0Same --Talikoti et al.(2013)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWxpa290aTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

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ADDIN EN.CITE.DATA 16260Pregabalin (n = 30)Not mentionedGeneral anesthesia1501h before surgery--Not mentionedHeart rate and blood pressure following laryngoscopyAdverse effectsNot mentionedPlacebo (n = 30)0Same --Ayatollahi et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BeWF0b2xsYWhpPC9BdXRob3I+PFllYXI+MjAxNDwvWWVh

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ADDIN EN.CITE.DATA 16330Gabapentin (n = 15)Microlaryngeal surgeryGeneral anesthesia900night before+ 1.5h before surgery--Not mentionedHemodyn stability after laryngoscopyAdverse effects25 minsPlacebo (n = 15)0Same --Bafna et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWZuYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 16790Pregabalin (n = 45)Abdominal hysterectomyGeneral anesthesia1501h before surgery--NoPostoperative painAnalgesic requirementPostoperative nausea or vomitingSedation24hPlacebo (n = 45)0Same --Clarke et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 168179Gabapentin (n = 88)Total knee arthroplastyRegional anesthesia6002h before surgery / 8h after surgery6004NoTimed up and go testStair test6 minute walk testWestern Ontario and McMaster Universities Osteoarthritis Index function scoresOpioid utilizationRange of motionAdverse effectsAnxietyDepression score3moPlacebo (n = 77)0Same 04Debaecker et al.(2014) ADDIN EN.CITE <EndNote><Cite><Author>Debaecker</Author><Year>2014</Year><RecNum>15755</RecNum><DisplayText><style face="superscript">169</style></DisplayText><record><rec-number>15755</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067823">15755</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Debaecker, L.</author><author>Roosebeke, A.</author><author>Garot, M.</author><author>Andrieu, G.</author><author>Sanders, V.</author><author>Chalons, N.</author><author>Capron, B.</author><author>Wattier, J. M.</author><author>Lebuffe, G.</author></authors></contributors><titles><title>Administration préopératoire de gabapentine et douleurs résiduelles après chirurgie thyro?dienne: Une étude randomisé double aveugle contre placebo</title><secondary-title>Annales Francaises d&apos;Anesthesie et de Réanimation</secondary-title><alt-title>Ann. Fr. Anest. Reanim.</alt-title><short-title>Preoperative administration of gabapentin and residual pain after thyroid surgery: a double blind randomized against placebo</short-title></titles><periodical><full-title>Ann Fr Anesth Reanim</full-title><abbr-1>Annales francaises d&apos;anesthesie et de reanimation</abbr-1></periodical><pages>A147-A148</pages><volume>33</volume><number>2</number><dates><year>2014</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0750-7658</isbn><accession-num>WOS:000343373500222</accession-num><work-type>Meeting Abstract</work-type><urls></urls><electronic-resource-num>10.1016/j.annfar.2014.07.237</electronic-resource-num><language>French</language></record></Cite></EndNote>16990Gabapentin (n = 41)Thyroid surgeryGeneral anesthesia12002h before surgery--Not mentionedChronic pain6moPlacebo (n = 42)0Same --Eman et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FbWFuPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 17040Pregabalin (n = 20)Total abdominal hysterectomy surgeryGeneral anesthesia1501h before surgery--Nosystolic blood pressurediastolic blood pressureMean blood pressureHRSpO2Postoperative pain VAS scoresRamsay Sedation ScaleTotal morphine utilizationPostoperative nausea or vomitingSide effects24hPlacebo (n = 20)0Same --Ercan et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcmNhbjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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RW5kTm90ZT4A

ADDIN EN.CITE.DATA 17134Gabapentin (n = 16)Carotid endartectomyRegional anesthesia6001h before surgery--YesHemodynamic parameters SedationCooperationCortisol levelAnalgesic requirement24hPlacebo (n = 17)0Same --George et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HZW9yZ2U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 172101Pregabalin 150 (n = 28)Open elective abdominal hysterectomyGeneral anesthesia1502h before surgery / 12h after first dose1500.5NoPostoperative painMorphine utilization Adverse effects24hPregabalin 75 (n = 31)75Same 750.5Placebo (n = 30)0Same 00.5Grosen et al.?(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zZW48L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 173104Gabapentin (n = 30)Anterior thoracotomyGeneral anesthesia12002h before surgery / 12h after surgeryday 1: 600. day 2: 900. day 3-5: 12005YesPersistent post-thoracotomy pain at 6 monthsEarlypostoperative post-thoracotomy painMorphine requirementsRecovery and Analgesia-related adverse effects over the first 3 weeksPersistent post-thoracotomy pain at 3 monthsAdverse effects6moPlacebo (n = 37)0Same 05I?ik et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JxZ9pazwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 17575Gabapentin (n = 25/25)Abdominal hysterectomy with a lower abdominal incisionGeneral anesthesia600night before and 2h before surgery--NoVAS postoperative painMorphine utilizationSedation levelsSide effects24hAlprazolam (n = 25/25)0.5Same--Placebo (n = 25/25)0same--Karbi? et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXJiacSHPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE.DATA 17660Gabapentin (n = 30)Abdominal hysterectomyGeneral anesthesia6001h before surgeryNoPostoperative pain VAS scaleCortisol levelsCathecolamine levels24hPlacebo (n = 30)0SameKhurana et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaHVyYW5hPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE.DATA 17890Gabapentin (n = 30)Functional endoscopic sinus surgeryGeneral anesthesia12001h before surgery--NoPostoperative painAnalgesic utilizationAdverse effects24hNamesulide (n = 30)100Same --Placebo (n = 30)0Same --Kim et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW08L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 17947Pregabalin (n = 24)SeptoplastyGeneral anesthesia1501h before surgery / 12h after 1st dose1500.5NoPostoperative painPostoperative nausea or vomitingSedationHeadacheDizzinessNumber of patients required analgesics48hPlacebo (n = 23)0Same 00.5Ko?ucu et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3N1Y3U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 18062Gabapentin (n = 29)Posterolateral or lateral thoracotomiesGeneral anesthesia12001h before surgery--NoTime to first analgesic requirementPostoperative painChronic pain48hPlacebo (n = 31)0Same --Mahoori et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWhvb3JpPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ZT5=

ADDIN EN.CITE.DATA 18340Pregabalin (n = 20)Laparoscopic adhesiolysis for infertilityGeneral anesthesia1501h before surgery--NoPreoperative level of anxietyPostoperative pain VASAnalgesic utilizationLevel of sedationIncidence of side effects12hMelatonin (n = 20)6Same --Nofal et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ob2ZhbDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 18488Gabapentin (n = 42)Caesarean sectionRegional anesthesia6002h before surgery--NoPostdural puncture headacheParacetamol / diclofenac utilizationAdverse reactionsNeonatal outcomes4dPlacebo (n = 44)0Same--Nutthachote et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OdXR0aGFjaG90ZTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll

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ADDIN EN.CITE.DATA 18556Pregabalin (n = 27)Laparoscopic gynecological surgeryGeneral anesthesia752h before surgery / 12h after surgery1501.5NoPostoperative pain for shoulder and surgical painMeperidine and acetaminophen utilizationNauseaVomitingBlurred visionVertigoAtaxiaOversedation48hPlacebo (n = 27)0Same01.5Ogunnaike(2014) ADDIN EN.CITE <EndNote><Cite><Author>Ogunnaike</Author><Year>2014</Year><RecNum>16848</RecNum><DisplayText><style face="superscript">186</style></DisplayText><record><rec-number>16848</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="0">16848</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>Ogunnaike, Babatunde</author></authors></contributors><titles><title>Postoperative pain and morphine consumption after mastectomy - Lyrica</title></titles><dates><year>2014</year></dates><pub-location></pub-location><urls></urls></record></Cite></EndNote>18680Pregabalin (n = 23)Unilateral modified radical mastectomy or lumpectomy with axillary node dissectionGeneral anesthesia3001-2hrs before surgery +12h after surgery30014NoOpioid requirementPostoperative painAdverse effects14dPlacebo (n = 24)0Same 014Pandey et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kZXk8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 18890Pregabalin (n = 30)Vaginal hysterectomyRegional anesthesia1501.5h before surgery--NoPostoperative painDuration of spinal anesthesiaDiclofenac requirementLevel of sedationSide effects24hClonidine (n = 30)150 Same --Placebo (n = 30)0Same --Rajendran et al.(2014) ADDIN EN.CITE <EndNote><Cite><Author>Rajendran</Author><Year>2014</Year><RecNum>16854</RecNum><DisplayText><style face="superscript">189</style></DisplayText><record><rec-number>16854</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524242658">16854</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rajendran, Induja</author><author>Basavareddy, Asha</author><author>Meher, Bikash Ranjan</author><author>Srinivasan, Srikanth</author></authors></contributors><titles><title>Prospective, randomised, double blinded controlled trial of gabapentin and pregabalin as pre emptive analgesia in patients undergoing lower abdominal and limb surgery under spinal anaesthesia</title><secondary-title>Indian Journal of Pain</secondary-title></titles><periodical><full-title>Indian Journal of Pain</full-title></periodical><pages>155-159</pages><volume>28</volume><number>3</number><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>18990Pregabalin (n = 30)Lower abdominal and limb surgeryRegional anesthesia3001h before surgery--NoTime for first dose of rescue analgesiaTotal dose of rescue of rescue analgesia in 72 hoursAdverse effects72hGabapentin (n = 30)9001h before surgery--Placebo (n = 30)0Same--Singla et al.(2014a)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5nbGE8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 190307Pregabalin 300 (n = 89)Total knee arthroplastyRegional anesthesia30012h+2h before surgery / 12h after surgery30042NoWorst Postoperative painPostoperative painRange of motionOpioid utilizationAdverse effects6moPregabalin 150 (n = 94)150Same 15042Placebo (n = 87)0Same 042Singla et al.(2014c)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5nbGE8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 190501Pregabalin 300 (n = 149)Abdominal hysterectomyGeneral anesthesia30012h+2h before surgery / 12h after surgery30028NoPostoperative painChronic painOpioid utilizationAdverse effects6moPregabalin 150 (n = 151)150Same 15028Placebo (n = 156)0Same 028Srivastava et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tcml2YXN0YXZhPC9BdXRob3I+PFllYXI+MjAxNDwvWWVh

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ADDIN EN.CITE.DATA 19164Pregabalin (n = 31)Spine surgeryGeneral anesthesia1501h before surgery--NoFasciculationMyalgiaFentanyl utilizationSide effects24hPlacebo (n = 30)0Same--Tiwari et al.(2014)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UaXdhcmk8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 195120Gabapentin (n = 40)Total abdominal hysterectomyRegional anesthesia3001.5h before surgery--YesPostoperative painAnalgesic requirementPostoperative nausea or vomitingSide effects24hClonidine (n = 40)0.15Same--Placebo (n = 40)0Same --Bala et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWxhPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 196100Gabapentin 1600 (n = 34)SurgeryGeneral anesthesia1600night before+2h before surgery--Not mentionedHypotensionBradycardiaTachycardiaHypertensionarrhythmia and ST-T wave changesAdverse effects10 minsGabapentin 800 (n = 32)8002h before surgery--Placebo (n = 34)0night before+2h before surgery--Batista et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXRpc3RhPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48

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ADDIN EN.CITE.DATA 19772Gabapentin (n = 36)Abdominal hysterectomyGeneral anesthesia6002h before surgery--NoPostoperative painMorphine utilizationSedationPostoperative nausea or vomitingSide effectsPatient satisfaction24hPlacebo (n = 36)0Same--Bhure et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Bhure</Author><Year>2015</Year><RecNum>16809</RecNum><DisplayText><style face="superscript">198</style></DisplayText><record><rec-number>16809</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523365899">16809</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bhure, R.</author><author>Kshirsagar, J.</author><author>Pawar, A.</author></authors></contributors><titles><title>Evaluation of pre-emptive gabapentin 600 mg for postoperative analgesia for laparoscopic cholecystectomy</title><secondary-title>International Journal of Scientific Study</secondary-title></titles><periodical><full-title>International Journal of Scientific Study</full-title></periodical><pages>78-83</pages><volume>3</volume><number>1</number><keywords><keyword>Gabapentin</keyword><keyword>Laparoscopic cholecystectomy</keyword><keyword>Postoperative analgesia</keyword><keyword>Pre-emptive analgesia</keyword></keywords><dates><year>2015</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>2321-6379</isbn><accession-num>WOS:000422382000017</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000422382000017</style></url></related-urls></urls><electronic-resource-num>10.17354/ijss/2015/160</electronic-resource-num></record></Cite></EndNote>19880Gabapentin (n = 40)Laparoscopic cholecystectomyGeneral anesthesia6002h before surgery --NoTramadol requirement (postoperative)Fentanyl requirement (intraoperative)Adverse effects24hPlacebo (n = 40)0Same--Brulotte et al.?(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcnVsb3R0ZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

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ADDIN EN.CITE.DATA 200184Pregabalin (n = 83)Primary total hip arthroplastyRegional anesthesia1502h before surgery / 8h after first dose1507NoTimed get-up and-go testStair test6 min walk testWestern Ontario and McMaster Universities Osteoarthritis Index functionChronic painOpioid utilizationAdverse effects3moPlacebo (n = 79)0Same07Esmat et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc21hdDwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 20178Pregabalin 300 (n = 25)Laparoscopic cholecystectomyGeneral anesthesia3002h before surgery--NoPostoperative painSedationPostoperative monitoring of heart rateMean systolic and mean diastolic blood pressureSide effects6hPregabalin 150 (n = 25)150Same --Paracetamol (n = 25)1000Same --Faraji et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Faraji</Author><Year>2015</Year><RecNum>16810</RecNum><DisplayText><style face="superscript">202</style></DisplayText><record><rec-number>16810</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523365954">16810</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Faraji, R</author><author>Haryalchi, K</author><author>Fashkhami, F</author><author>Pourmarzi, D</author></authors></contributors><titles><title>Comparison of low dose gabapentin and diclofenac efficacy for postoperative pain reduction after abdominal hysterectomy: A randomized clinical trial</title><secondary-title>Journal of guilan university of med sci</secondary-title></titles><periodical><full-title>Journal of guilan university of med sci</full-title></periodical><pages>63-69</pages><volume>24</volume><number>93</number><keywords><keyword>Sr-menstr</keyword></keywords><dates><year>2015</year></dates><accession-num>CN-01308439</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> (n = 50)Abdominal hysterectomyGeneral anesthesia08 + 16 h after surgery6000NoPostoperative painPethedine utilizationAdverse effects24hPlacebo (n = 50)?0Same00Francois et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Francois</Author><Year>2015</Year><RecNum>16855</RecNum><DisplayText><style face="superscript">203</style></DisplayText><record><rec-number>16855</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524243685">16855</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Francois, Audrice</author><author>Pappas, Ana</author><author>Pawlowski, Julius</author><author>Hartwig, Jeffrey</author></authors></contributors><titles><title>A randomized, double blind placebo controlled study of pregabalin vs placebo for postoperative pain control after knee arthroscopy</title></titles><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>20363Pregabalin 100 (n = 16)Knee arthroscopyGeneral anesthesia10030 mins before surgery / 8h after surgery3002NoTime to first rescue analgesiaOpioid utilizationPACU length of stayPostoperative painAdverse effects48hPregabalin 300 (n = 20)30031 mins before surgery / 8h after surgery9002Placebo (n = 18)032 mins before surgery / 8h after surgery02Hamal et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Hamal</Author><Year>2015</Year><RecNum>11002</RecNum><DisplayText><style face="superscript">204</style></DisplayText><record><rec-number>11002</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11002</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hamal, P. K.</author><author>Shrestha, A. B.</author><author>Shrestha, R. R.</author></authors></contributors><auth-address>Hamal,P K. National Academy of Medical Sciences, Kathmandu, Nepal.; Shrestha,A B. Paropakar Maternity and Women&apos;s Hospital, Thapathali,Kathmandu, Nepal.; Shrestha,R R. National Academy of Medical Sciences, Kathmandu, Nepal.</auth-address><titles><title>Efficacy of preemptive gabapentin for lower extremity orthopedic surgery under subarachnoid block</title><secondary-title>Jnma, Journal of the Nepal Medical Association</secondary-title><alt-title>Jnm</alt-title></titles><periodical><full-title>Jnma, Journal of the Nepal Medical Association</full-title><abbr-1>Jnm</abbr-1></periodical><alt-periodical><full-title>Jnma, Journal of the Nepal Medical Association</full-title><abbr-1>Jnm</abbr-1></alt-periodical><pages>210-213</pages><volume>53</volume><number>200</number><dates><year>2015</year><pub-dates><date>Oct-Dec</date></pub-dates></dates><isbn>0028-2715</isbn><accession-num>27746457</accession-num><work-type>Journal article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>20452Gabapentin (n = 26)Lower extremity orthopedic surgeryRegional anesthesia6002h before surgery--NoOpioid utilizationPostoperative painAdverse effect24hPlacebo (n = 26)0Same--Hassani et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXNzYW5pPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48

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ADDIN EN.CITE.DATA 20690Gabapentin (n = 30)Middle ear surgeryGeneral anesthesia3001h before surgery--Not mentionedPostoperative nausea or vomitingAdverse effects24hGranisetron (n = 30)32 min before surgery--Placebo (n = 30)0Not mentioned--Kumar et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Kumar</Author><Year>2015</Year><RecNum>15606</RecNum><DisplayText><style face="superscript">207</style></DisplayText><record><rec-number>15606</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067822">15606</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kumar, P. S.</author><author>Bhanuprakash, S.</author><author>Sahajananda, H.</author></authors></contributors><auth-address>[Kumar, Sudhir P.; Bhanuprakash, S.; Sahajananda, H.] Rajarajeshwari Med Coll &amp; Hosp, Dept Anaesthesia, Bangalore, Karnataka, India.; Bhanuprakash, S (reprint author), Door T-1,1st Main,1st Cross,Kanakapura Main Rd, Bangalore, Karnataka, India.; bhanushimoga@</auth-address><titles><title>The effect of single dose oral gabapentin as preemptive analgesia for postoperative pain for orthopedic surgeries done under spinal anaesthesia</title><secondary-title>Journal of Evolution of Medical and Dental Sciences-Jemds</secondary-title><alt-title>J. Evol. Med. Dent. Sci.-JEMDS</alt-title></titles><periodical><full-title>Journal of Evolution of Medical and Dental Sciences-Jemds</full-title></periodical><pages>16857-16864</pages><volume>4</volume><number>103</number><keywords><keyword>Pain</keyword><keyword>Gabapentin</keyword><keyword>Spinal Anesthesia</keyword><keyword>Orthopedic Surgeries</keyword><keyword>PREGABALIN</keyword><keyword>RATS</keyword></keywords><dates><year>2015</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>2278-4748</isbn><accession-num>WOS:000377973700013</accession-num><work-type>Article</work-type><urls></urls><electronic-resource-num>10.14260/jemds/2015/2535</electronic-resource-num><language>English</language></record></Cite></EndNote>20760Gabapentin (n = 30)Orthopedic surgeriesRegional anesthesia3002h before surgery--NoPostoperative painOpioid requirementChange in heart rate and blood pressurePostoperative nausea or vomitingAdverse effects24hPlacebo (n = 30)0Same--Lee et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 20841Pregabalin (n = 21)Total knee arthroplastyGeneral anesthesia1501h before surgery--NoPostoperative painAnalgesic utilizationFunctional recoveryAdverse effects48hPlacebo (n = 20)0Same--Lunn et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MdW5uPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 209300Gabapentin high dose(n = 91)Total knee arthroplastyGeneral anesthesia or Regional anesthesia9002h before surgery / 10PM after surgery13006NoPostoperative painSedationRescue analgesicSide effectsAnxiety/depressionGabapentin level in blood-sample7dGabapentin low dose(n = 92)600Same 9006Placebo (n = 91)0Same 06Mahran et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Mahran</Author><Year>2015</Year><RecNum>11066</RecNum><DisplayText><style face="superscript">210</style></DisplayText><record><rec-number>11066</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11066</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahran, Essam</author><author>Hassan, Mohamed Elsayed</author></authors></contributors><auth-address>Mahran,Essam. Department of Anesthesia, ICU, and Pain Therapy National Cancer Institute, Cairo University, Giza, Egypt.; Hassan,Mohamed Elsayed. Department of Anesthesia, ICU, and Pain Therapy National Cancer Institute, Cairo University, Giza, Egypt.</auth-address><titles><title>Comparison of pregabalin versus ketamine in postoperative pain management in breast cancer surgery</title><secondary-title>Saudi journal of anaesthesia</secondary-title><alt-title>Saudi J Anaesth</alt-title></titles><periodical><full-title>Saudi J Anaesth</full-title><abbr-1>Saudi journal of anaesthesia</abbr-1></periodical><alt-periodical><full-title>Saudi J Anaesth</full-title><abbr-1>Saudi journal of anaesthesia</abbr-1></alt-periodical><pages>253-257</pages><volume>9</volume><number>3</number><dates><year>2015</year><pub-dates><date>Jul-Sep</date></pub-dates></dates><isbn>1658-354X</isbn><accession-num>26240541</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">: NLM. PMC4478815</custom2><electronic-resource-num><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>21090Pregabalin (n = 30)Modified radical mastectomyGeneral anesthesia1501h before surgery--NoPostoperative painMorphine utilizationSedationPostoperative nausea or vomitingDizzinessVisual disturbancesNightmaresHallucinations24hKetamine (n = 30)0.5 mg/kgSame --Placebo (n = 30)0Same --Mansor et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Mansor</Author><Year>2015</Year><RecNum>14749</RecNum><DisplayText><style face="superscript">211</style></DisplayText><record><rec-number>14749</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067720">14749</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mansor, S. H.</author><author>Choy, C. Y.</author></authors></contributors><titles><title>Effect of preoperative oral pregabalin on postoperative pain after mastectomy</title><secondary-title>Middle East journal of anaesthesiology</secondary-title></titles><periodical><full-title>Middle East J Anaesthesiol</full-title><abbr-1>Middle East journal of anaesthesiology</abbr-1></periodical><pages>63-68</pages><volume>23</volume><number>1</number><keywords><keyword>Administration, Oral</keyword><keyword>Analgesics [therapeutic use]</keyword><keyword>Double-Blind Method</keyword><keyword>Mastectomy</keyword><keyword>Pain, Postoperative [drug therapy]</keyword><keyword>Pregabalin</keyword><keyword>gamma-Aminobutyric Acid [analogs &amp; derivatives] [therapeutic use]</keyword><keyword>Adult[checkword]</keyword><keyword>Female[checkword]</keyword><keyword>Humans[checkword]</keyword><keyword>Middle Aged[checkword]</keyword></keywords><dates><year>2015</year></dates><accession-num>CN-01108984</accession-num><work-type>Randomized Controlled Trial</work-type><urls><related-urls><url><style face="underline" font="default" size="100%"> 26121897</custom3></record></Cite></EndNote>21149Pregabalin (n = 25)Mastectomy with or without axillary lymph nodes dissectionGeneral anesthesia1501h before surgery--NoPostoperative painAnalgesic utilizationNauseaVomitingHeadacheSomnolenceDizzinessVisual disturbances24hPlacebo (n = 24)0Same--Matsutani et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXRzdXRhbmk8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy

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ADDIN EN.CITE.DATA 21268Pregabalin (n = 34)ThoracotomyRegional ou general anesthesia752h before surgery / 12h after surgery15014NoPostoperative painAdditional analgesic drug requirementNeuropathic painSleep interferenceAdverse effects12wLoxoprofen (n = 34)602h before surgery / 8h after surgery18014Memari et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZW1hcmk8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 214204Gabapentin (n = 100)Caesarean deliveryRegional anesthesia3001h before surgery / 8h after surgery6002NoPostoperative pain at rest and on movementSatisfaction scoreOpioid useSedationPostoperative nausea or vomitingDizzinessPruritusDifficulties balancingNeonatal Apgar scoreBreastfeeding issuesNeonatal ICU admissionAnxiety level6wPlacebo (n = 97)0Same02Ommid et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbW1pZDwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 21540Pregabalin (n = 20)Lower abdominal surgeriesGeneral anesthesia3001h before surgery--NoPostoperative painMorphine utilizationAdverse effects24hPlacebo (n = 20)0Same--Park et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 217102Gabapentin (n = 48)Primary total joint arthroplasty in a single hipRegional anesthesia6002h before surgery / 6 PM after surgery6002NoMorphine utilizationPostoperative painSide-effectsPatient satisfactionRange of motionLenght of stayHemodynamic/respiratory parameters72hPlacebo (n = 54)0Same02Ray et al.(2015) ADDIN EN.CITE <EndNote><Cite><Author>Ray</Author><Year>2015</Year><RecNum>16856</RecNum><DisplayText><style face="superscript">218</style></DisplayText><record><rec-number>16856</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524244493">16856</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ray, Debasis</author><author>Bhattacharjee, Samiksha</author></authors></contributors><titles><title>Effect of pre-operative gabapentin on early post operative pain, nausea, vomiting and analgesic consumption following hysterectomy in a tertiary care teaching hospital: A randomized controlled trial</title><secondary-title>Indian Journal of Pharmacy and Pharmacology</secondary-title></titles><periodical><full-title>Indian Journal of Pharmacy and Pharmacology</full-title></periodical><pages>113-118</pages><volume>2</volume><number>2</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>21860Gabapentin (n = 30)Abdominal hysterectomyRegional anesthesia3002h before surgery--NoPostoperative painAnalgesic utilizationPostoperative nausea or vomiting48hPlacebo (n = 30)0Same--Valadan et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYWxhZGFuPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48

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ADDIN EN.CITE.DATA 22052Pregabalin (n = 26)Oculofacial plastic surgery - Eyelid surgeryMonitored anesthesia care1500.25-1h before surgery--NoPostoperative painAcetaminophen utilizationSide effects48hPlacebo (n = 23)0Same--YaDeau et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYURlYXU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 221120Pregabalin 150 (n = 28)Total knee arthroplastyRegional anesthesia3000.5h before surgery / 12h after surgery300 (day 1-14)/ 150 (day 15-16)16YesPostoperative pain (2 weeks and acute)Opioid-related distress scoreSedationConfusionChronic pain (3 months)Neuropathic painOpioid usageSatisfaction3moPregabalin 100 (n = 29)200Same 200 (day 1-14)/ 100 (day 15-16)16Pregabalin 50 (n = 26)100Same 100 (day 1-14)/ 50 (day 15-16)16Placebo (n = 28)0Same 2Pl(day 1-14)/ 1Pl (day 15-16)16Ziyaeifard et al.(2015)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaXlhZWlmYXJkPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh

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ADDIN EN.CITE.DATA 22260Pregabalin (n = 30)Coronary artery bypass surgeryGeneral anesthesia1502h before surgery--NoHeart ratesBlood pressureRespiratory rateIntensive care unit (ICU) stay durationMorphine utilizationPostoperative pain24hPlacebo (n = 30)0Same--Ahiskalioglu et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaGlza2FsaW9nbHU8L0F1dGhvcj48WWVhcj4yMDE2PC9Z

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ADDIN EN.CITE.DATA 22447Pregabalin (n = 20)Double jaw surgeryGeneral anesthesia1501h before surgery--NoFentanyl utilizationPostoperative painAdverse effects24hPlacebo (n = 20)0Same--Ahn et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaG48L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 22560Pregabalin (n = 30)Arthroscopic shoulder surgeryGeneral anesthesia1501h before surgery--NoOpioid sparing effect (48h)Postoperative painNumber of rescue analgesic drugs administeredSide effectsIncidence of nausea48hPlacebo (n = 30)0Same--Akhan et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Akhan</Author><Year>2016</Year><RecNum>16857</RecNum><DisplayText><style face="superscript">226</style></DisplayText><record><rec-number>16857</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524245040">16857</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Akhan, Ayse</author><author>Subasi, Ferhunde Dilek</author><author>Bosna, Gulsen</author><author>Ekinci, Osman</author><author>Pamuk, Hakan</author><author>Batan, Siddika</author><author>Ateser, Rezzan Yagmur</author><author>Turan, Gulden</author></authors></contributors><titles><title>Comparison of mirtazapine, gabapentin and ondansetron to prevent intrathecal morphine-induced pruritus</title><secondary-title>North Clin Istanbul</secondary-title></titles><periodical><full-title>North Clin Istanbul</full-title></periodical><pages>53-59</pages><volume>3</volume><number>1</number><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>22680Gabapentin (n = 20)Inguinal hernia and sinus pilonidalRegional anesthesia12001h before surgery--NoPruritusAdverse effects24hMirtazapine (n = 20)30Same--Placebo (n = 20)0Same--Ondansetron (n = 20)8Same--Benton et al. ?(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW50b248L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 22980Pregabalin 300 (n = 20)Upper extremity bone surgeryRegional anesthesia3001h before surgery--YesPostoperative painVitals signsSedationSatisfactionTermination of sensorialMotor block1hPregabalin 150 (n = 20)150Same--Pregabalin 75 (n = 20)75Same--Placebo (n = 20)0Same--Damshenas et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Damshenas</Author><Year>2016</Year><RecNum>16812</RecNum><DisplayText><style face="superscript">230</style></DisplayText><record><rec-number>16812</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523366009">16812</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Damshenas, M. H.</author><author>Radmehr, M.</author><author>Rastegarian, A.</author></authors></contributors><titles><title>The effect of preoperative single dose of oral pregabalin on postoperative pain of orthopedic surgery of lower limbs</title><secondary-title>Iioab Journal</secondary-title></titles><periodical><full-title>Iioab Journal</full-title></periodical><pages>384-387</pages><volume>7</volume><number>1</number><keywords><keyword>Pregabalin</keyword><keyword>Pain</keyword><keyword>Orthopedics</keyword><keyword>Spinal Anesthesia</keyword><keyword>postsurgical pain</keyword><keyword>controlled-trial</keyword></keywords><dates><year>2016</year></dates><isbn>0976-3104</isbn><accession-num>WOS:000413556200052</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000413556200052</style></url></related-urls></urls></record></Cite></EndNote>23034Pregabalin (n = 20)Ortho lower limb surgeryRegional anesthesia1502h before surgery--Not mentionedPostoperative painHaemodynamic parameters10hPlacebo (n = 14)0Same--El Kenany et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>El Kenany</Author><Year>2016</Year><RecNum>11047</RecNum><DisplayText><style face="superscript">231</style></DisplayText><record><rec-number>11047</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11047</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>El Kenany, S.</author><author>El Tahan, M. R.</author></authors></contributors><auth-address>El Kenany,S. Department of Anaesthesia and Surgical Intensive Care, College of Medicine, Mansoura University, Mansoura, Egypt.; El Tahan,M R. Department of Anaesthesia and Surgical Intensive Care, College of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: mohamedrefaateltahan@.</auth-address><titles><title>Effect of preoperative pregabalin on post-caesarean delivery analgesia: A dose-response study</title><secondary-title>International Journal of Obstetric Anesthesia</secondary-title><alt-title>Int</alt-title></titles><periodical><full-title>Int J Obstet Anesth</full-title><abbr-1>International journal of obstetric anesthesia</abbr-1></periodical><pages>24-31</pages><volume>26</volume><dates><year>2016</year><pub-dates><date>May</date></pub-dates></dates><isbn>1532-3374</isbn><accession-num>26718698</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%"> face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>231135Pregabalin 300 (n = 45)Caesarean deliveryRegional anesthesia3001h before surgery--NoMorphine utilizationPostoperative painAPGAR scoreNeurologic scoresSedationPostoperative nausea or vomiting48hPregabalin 150 (n = 45)150Same--Placebo (n = 45)0Same--Fujita et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GdWppdGE8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 23297Pregabalin 150 (n = 30)Posterior lumbar interbody fusion (PLIF) surgeryGeneral anesthesia1502h before surgery--NoPostoperative painMorphine utilization48hPregabalin 75 (n = 30)75Same--Diazepam (n = 29)5Same--Gautam et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Gautam</Author><Year>2016</Year><RecNum>16814</RecNum><DisplayText><style face="superscript">233</style></DisplayText><record><rec-number>16814</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523366056">16814</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gautam, A.</author><author>Tandon, N.</author><author>Masar, R.</author><author>Kothari, D.</author><author>Goyal, P.</author><author>Yadav, S.</author><author>Gupta, S.</author><author>Chaudhary, B.</author></authors></contributors><titles><title>A comparative evaluation of pre-emptive doses of gabapentin and pregabalin for postoperative relief of pain in patients scheduled for surgery under general anaesthesia</title><secondary-title>Journal of Evolution of Medical and Dental Sciences-Jemds</secondary-title></titles><periodical><full-title>Journal of Evolution of Medical and Dental Sciences-Jemds</full-title></periodical><pages>5459-5462</pages><volume>5</volume><number>74</number><keywords><keyword>Gabapentin</keyword><keyword>Pregabalin</keyword><keyword>General Anaesthesia</keyword><keyword>laparoscopic cholecystectomy</keyword><keyword>attenuation</keyword></keywords><dates><year>2016</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>2278-4748</isbn><accession-num>WOS:000394672900007</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000394672900007</style></url></related-urls></urls><electronic-resource-num>10.14260/jemds/2016/1236</electronic-resource-num></record></Cite></EndNote>23390Gabapentin (n = 30)MultipleGeneral anesthesia6001.5h before surgery--NoPostoperative painTramadol utilizationAdverse effects8hPregabalin (n = 30)300Same--Placebo (n = 30)0Same--Hetta et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZXR0YTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 234120Pregabalin 300 (n = 26)Modified radical mastectomyGeneral anesthesia3002h before surgery--NoPostoperative pain24-hour postoperative morphine utilization Incidence and severity of pregabalin-related adverse effects24hPregabalin 150 (n = 27)150Same--Pregabalin 75 (n = 28)75Same--Placebo (n = 30)0Same--Kapse et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Kapse</Author><Year>2016</Year><RecNum>11052</RecNum><DisplayText><style face="superscript">235</style></DisplayText><record><rec-number>11052</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11052</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kapse, Upendra Kumar S.</author><author>Bhalerao, Pradnya Milind</author></authors></contributors><auth-address>Kapse,Upendra Kumar S. Department of Anaesthesiology and Critical Care, B.J. Government Medical College and Sassoon General Hospitals, Pune, Maharashtra, India.; Bhalerao,Pradnya Milind. Department of Anaesthesiology and Critical Care, B.J. Government Medical College and Sassoon General Hospitals, Pune, Maharashtra, India.</auth-address><titles><title>Oral clonidine and gabapentin suppress pressor response: A prospective, randomized, double blind study</title><secondary-title>Albang Maqalat Wa Abhat Fi Altahdir Waalinas</secondary-title><alt-title>Anesth Essays Res</alt-title></titles><alt-periodical><full-title>Anesth Essays Res</full-title><abbr-1>Anesthesia, essays and researches</abbr-1></alt-periodical><pages>17-22</pages><volume>10</volume><number>1</number><dates><year>2016</year><pub-dates><date>Jan-Apr</date></pub-dates></dates><isbn>0259-1162</isbn><accession-num>26957684</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">: NLM. PMC4767094</custom2><electronic-resource-num><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>23560Gabapentin (n = 30)Not mentionedGeneral anesthesia8001.5h before surgery--Not mentionedSedationHeart rateBlood pressure30 minClonidine (n = 30)5 mcg/kgSame--Khan et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Khan</Author><Year>2016</Year><RecNum>16858</RecNum><DisplayText><style face="superscript">236</style></DisplayText><record><rec-number>16858</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524245949">16858</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Khan, M.U.</author></authors></contributors><titles><title>Effect of preoperative oral administration of gabapentin on preoperative anxiety, postoperative pain and opioid consumption in patients schedule for laproscopic sleeve gastrectomy surgery</title></titles><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>23650Gabapentin (n = 25)Laparoscopic sleeve gastrectomyGeneral anesthesia12002h before surgery--NoPostoperative painMorphine requirement24hPlacebo (n = 25)0Same--Khetarpal et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGV0YXJwYWw8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

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ADDIN EN.CITE.DATA 23976Gabapentin (n = 37)Arthroscopic Bankart surgeryGeneral anesthesia6002h before surgery--NoPostoperative painPethidine utilizationNauseaVomitingDizzinessSedation24hPlacebo (n = 34)0Same--Mishra et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXNocmE8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 24090Pregabalin (n = 30)Laparoscopic cholecystectomyGeneral anesthesia1501h before surgery--NoPostoperative painTramadol utilizationSedationPostoperative nausea or vomitingRespiratory depressionHeadacheDizzinessVisual disturbancesSomnolence24hGabapentin (n = 30)900Same--Placebo (n = 30)0Same--Miyazaki et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXlhemFraTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+

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ADDIN EN.CITE.DATA 24172Pregabalin (n = 33)Surgery for NSMLCGeneral anesthesiaNot mentioned150Not mentionedYesAdditional usage of NSAIDPostoperative painFrequency of neuropathic pain3moPlacebo (n = 34)Not mentioned0Not mentionedMohamed et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb2hhbWVkPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA 24260Pregabalin300 (n = 15)Radical cystectomyGeneral anesthesia3002h before surgery00NoAnalgesic utilizationPostoperative painTime to first request rescue analgesia and Adverse effects24hPregabalin300b (n = 15)3002h before surgery+ 12 after fisrt dose3000Pregabalin600 (n = 15)6002h before surgery00Placebo (n = 15)02h before surgery00Nikhil et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Nikhil</Author><Year>2016</Year><RecNum>15545</RecNum><DisplayText><style face="superscript">243</style></DisplayText><record><rec-number>15545</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067822">15545</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nikhil, M. P.</author><author>Mallya, P.</author></authors></contributors><auth-address>[Nikhil, M. P.] KS Hegde Hosp, Dept Anaesthesiol, Mangalore 575018, India. [Mallya, Prashant] KVG Med Coll, Dept Anaesthesiol, Sullia, Karnataka, India.; Nikhil, MP (reprint author), KS Hegde Hosp, Dept Anaesthesiol, Mangalore 575018, India.; mpcas79@</auth-address><titles><title>The effect of preemptive gabapentin on postoperative pain and opioid requirement following surgeries in the anterior part of the neck</title><secondary-title>Journal of Evolution of Medical and Dental Sciences-Jemds</secondary-title><alt-title>J. Evol. Med. Dent. Sci.-JEMDS</alt-title></titles><periodical><full-title>Journal of Evolution of Medical and Dental Sciences-Jemds</full-title></periodical><pages>2142-2146</pages><volume>5</volume><number>36</number><keywords><keyword>Post-operative Pain</keyword><keyword>Pre-Emptive Analgesia</keyword><keyword>Gabapentin</keyword><keyword>Head and Neck</keyword><keyword>Surgeries</keyword><keyword>DOUBLE-BLIND</keyword><keyword>PLACEBO</keyword></keywords><dates><year>2016</year><pub-dates><date>May</date></pub-dates></dates><isbn>2278-4748</isbn><accession-num>WOS:000377963200013</accession-num><work-type>Article</work-type><urls></urls><electronic-resource-num>10.14260/jemds/2016/500</electronic-resource-num><language>English</language></record></Cite></EndNote>24360Gabapentin (n = 30)Surgical procedures in the anterior part of the neckGeneral anesthesia3002h before surgery--NoPostoperative painOpioid requirementChange in heart rateBlood pressurePostoperative nausea or vomiting24hPlacebo (n = 30)0Same--Olmedo-Gaya et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbG1lZG8tR2F5YTwvQXV0aG9yPjxZZWFyPjIwMTY8L1ll

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ADDIN EN.CITE.DATA 24460Pregabalin (n = 30)Surgical extraction of impacted lower third molarMonitored anesthesia care751h before surgery / 1h after surgery750NoTooth-related measurementPostoperative painIbuprofen utilizationNauseaVomitingDrowsinessMotion sicknessTremorsSweatingDyspepsiaDiarrheaBleedingDizzinessDisorientation24hPlacebo (n = 30)0Same00Park et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Park</Author><Year>2016</Year><RecNum>11006</RecNum><DisplayText><style face="superscript">245</style></DisplayText><record><rec-number>11006</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1480067014">11006</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Park, MiHye</author><author>Jeon, Younghoon</author></authors></contributors><auth-address>Park,MiHye. aDepartment of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine bDepartment of Anesthesiology and Pain Medicine, Kyungpook National University School of Dentistry, Daegu, Republic of Korea.</auth-address><titles><title>Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain: A double-blind, randomized clinical CONSORT study</title><secondary-title>Medicine</secondary-title><alt-title>Medicine (Baltimore)</alt-title></titles><periodical><full-title>Medicine (Baltimore)</full-title><abbr-1>Medicine</abbr-1></periodical><alt-periodical><full-title>Medicine (Baltimore)</full-title><abbr-1>Medicine</abbr-1></alt-periodical><pages>e4828</pages><volume>95</volume><number>36</number><dates><year>2016</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1536-5964</isbn><accession-num>27603398</accession-num><work-type>Journal Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">: NLM. PMC5023921</custom2><electronic-resource-num><style face="underline" font="default" size="100%"> Technologies</remote-database-provider><language>English</language></record></Cite></EndNote>24544Pregabalin (n = 21)Transurethral resection of the bladder (TUR-B) or transurethral resection of the prostate (TUR-P)Regional anesthesia1502h before surgery--NoMotor block durationPostoperative painOpioid utilizationDrowsinessDizzinessDry mouthPostoperative nausea or vomiting24hPlacebo (n = 22)0Same--Parveen et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJ2ZWVuPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA 24680Pregabalin (n = 40)Laparoscopic cholecystectomyGeneral anesthesia1501h before surgery--NoBlood pressureHRLevel of sedationPostoperative painPostoperative nausea or vomitingBradycardiaHypotensionSide effects24hClonidine (n = 40)0.3Same--Pourfakhr et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb3VyZmFraHI8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

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ADDIN EN.CITE.DATA 248135Pregabalin 150 (n = 45)Vaginal hysterectomyRegional anesthesia1501h before surgery--NoPostoperative painRescue analgesicsSleep qualityBlock optimizationSide effects24hPregabalin 75 (n = 45)75Same--Placebo (n = 45)0Same--Sadatsune et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYWRhdHN1bmU8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

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ADDIN EN.CITE.DATA 24940Gabapentin (n = 18)Open carpal tunnel release surgeryRegional anesthesia6001h before surgery--NoPostoperative painPreoperative and chronic painLidocaine utilizationMidazolam utilizationParacetamol and/or codeine utilizationDevelopment of neuropathic pain and/or complex regional pain syndrome6moPlacebo (n = 19)0Same--Saxena et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Saxena</Author><Year>2016</Year><RecNum>16815</RecNum><DisplayText><style face="superscript">250</style></DisplayText><record><rec-number>16815</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523366100">16815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Saxena, A.</author><author>Gupta, P.</author><author>Chaudhary, L.</author></authors></contributors><titles><title>Effect of pregabalin premedication on the laryngoscopic response and intra-operative hemodynamic variables in laparoscopic cholecystectomy: A randomized comparison of two doses</title><secondary-title>International Journal of Scientific Study</secondary-title></titles><periodical><full-title>International Journal of Scientific Study</full-title></periodical><pages>75-80</pages><volume>4</volume><number>5</number><keywords><keyword>Cardiovascular response to laryngoscopy</keyword><keyword>Intra-operative hemodynamic</keyword><keyword>variables</keyword><keyword>Pregabalin</keyword></keywords><dates><year>2016</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>2321-6379</isbn><accession-num>WOS:000408751700016</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000408751700016</style></url></related-urls></urls><electronic-resource-num>10.17354/ijss/2016/433</electronic-resource-num></record></Cite></EndNote>25090Pregabalin 150 (n = 30)Laparoscopic cholecystectomyGeneral anesthesia225At bedtime+1h before surgery--Not mentionedSedationHaemodynamic parametersSide effectsNot mentioned90Pregabalin 300 (n = 30)375Same--90Diazepam (n = 30)0Same--Sebastian et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWJhc3RpYW48L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

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ADDIN EN.CITE.DATA 25190Pregabalin (n = 45)Lower limb orthopedic surgeriesRegional anesthesia1501h before surgery--NoTime for regression of blockTime to rescue analgesicTotal dose of diclofenacSide effects24hPlacebo (n = 45)0Same--Shimony et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGltb255PC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

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ADDIN EN.CITE.DATA 25380Gabapentin (n = 40)Orthopedic surgeryRegional anesthesia600before surgery--NoPostoperative nausea or vomiting24hPlacebo (n = 40)0before surgery--Vasigh et al.(2016)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYXNpZ2g8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 255105Pregabalin 14 days (n = 35)bilateral foramenotomy and interlaminar discectomyGeneral anesthesia3008h before surgery / 12h after surgery30014NoPostoperative painRadiculopathyTreatment side effects (2 weeks post-operation)Low back pain12moPregabalin 1 day (n = 35)300Same3001Placebo (n = 35)0Same014Anand et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Anand</Author><Year>2017</Year><RecNum>16833</RecNum><DisplayText><style face="superscript">256</style></DisplayText><record><rec-number>16833</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974384">16833</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Anand, L. K.</author><author>Sandhu, M.</author><author>Singh, J.</author><author>Mitra, S.</author></authors></contributors><titles><title>Evaluation of analgesic efficacy of pregabalin for postoperative pain relief after laparoscopic cholecystectomy: A double blind study</title><secondary-title>Anaesthesia Pain &amp; Intensive Care</secondary-title></titles><periodical><full-title>Anaesthesia Pain &amp; Intensive Care</full-title></periodical><pages>174-180</pages><volume>21</volume><number>2</number><keywords><keyword>Pregabalin</keyword><keyword>Anxiety</keyword><keyword>Cholecystectomy</keyword><keyword>Pain,Postoperative</keyword><keyword>Analgesia</keyword><keyword>hysterectomy</keyword><keyword>attenuation</keyword><keyword>anxiety</keyword><keyword>trial</keyword></keywords><dates><year>2017</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1607-8322</isbn><accession-num>WOS:000410708800009</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000410708800009</style></url></related-urls></urls></record></Cite></EndNote>25660Pregabalin (n = 30)Laparoscopic cholecystectomyGeneral anesthesia1502h before surgery--NoPostoperative painAnalgesic utilizationAdverse effects24hAlprazolam (n = 30)0.5Same--Asgari et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc2dhcmk8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 25796Pregabalin75 (n = 20)Laparoscopic hysterectomyGeneral anesthesia150night + 30 mins before surgery + 6h after surgery751NoPostoperative painSurgical timeBlood lossAdverse effects24hPregabalin 150 (n = 20)300Same 1501Pregabalin 300 (n = 20)600Same 3001Placebo (n = 22)0Same 01Bhosale et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaG9zYWxlPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48

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ADDIN EN.CITE.DATA 25890Gabapentin (n = 30)Orthopedic / Obstetrics-Gynecology and surgeryRegional anesthesia3000.5h before surgery--NoPostoperative painAnalgesic utilizationPostoperative nausea or vomiting24hTobsramate (n = 30)200Same --Lamotrigine (n = 30)100Same --Borde et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Borde</Author><Year>2017</Year><RecNum>16860</RecNum><DisplayText><style face="superscript">259</style></DisplayText><record><rec-number>16860</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1524570827">16860</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Borde, Deepak Prakas</author><author>Futane, Savani Sameer</author><author>Asegaonkar, Balaji</author><author>Apsingekar, Pramod</author><author>Khade, Sujeet</author><author>Khodve, Bapu</author><author>Puranik, Manish</author><author>George, Antony</author><author>Joshi, Shreedhar</author></authors></contributors><titles><title>Effect of perioperative pregabalin on postoperative quality of recovery in patients undergoing off-pump coronary artery bypass grafting (OPCABG): A prospective, randomized, double-blind trial</title><secondary-title>Journal of Cardiothoracic and Vascular Anesthesia</secondary-title></titles><periodical><full-title>J Cardiothorac Vasc Anesth</full-title><abbr-1>Journal of cardiothoracic and vascular anesthesia</abbr-1></periodical><pages>1241-1245</pages><volume>31</volume><number>4</number><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>25980Pregabalin (n = 37)CABGGeneral anesthesia1501h before surgery / after extubation1502NoQuality of recovery score (QoR-40)HemodynamicSide effects48hPlacebo (n = 34)0Same02Bouzia et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Bouzia</Author><Year>2017</Year><RecNum>16828</RecNum><DisplayText><style face="superscript">260</style></DisplayText><record><rec-number>16828</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974242">16828</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bouzia, A.</author><author>Tassoudis, V.</author><author>Karanikolas, M.</author><author>Vretzakis, G.</author><author>Petsiti, A.</author><author>Tsilimingas, N.</author><author>Arnaoutoglou, E.</author></authors></contributors><titles><title>Pregabalin effect on acute and chronic pain after cardiac surgery</title><secondary-title>Anesthesiology Research and Practice</secondary-title></titles><periodical><full-title>Anesthesiology Research and Practice</full-title></periodical><pages>1-7</pages><volume>2017</volume><keywords><keyword>chronic postsurgical pain</keyword><keyword>acute postoperative pain</keyword><keyword>post-sternotomy</keyword><keyword>pain</keyword><keyword>preventive analgesia</keyword><keyword>controlled-trial</keyword><keyword>remifentanil</keyword><keyword>morphine</keyword><keyword>levobupivacaine</keyword><keyword>infiltration</keyword><keyword>metaanalysis</keyword></keywords><dates><year>2017</year></dates><isbn>1687-6962</isbn><accession-num>WOS:000400941700001</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000400941700001</style></url></related-urls></urls><custom7>2753962</custom7><electronic-resource-num>10.1155/2017/2753962</electronic-resource-num></record></Cite></EndNote>260102Pregabalin75 (n = 31)Primary cardiac surgery with median sternotomy and extracorporeal circulationGeneral anesthesia75Not mentioned--NoPostoperative painOpioid utilizationChronic painPostoperative nausea or vomiting3moPregabalin150 (n = 31)150Not mentioned--Placebo (n = 31)0Not mentioned--Eidy et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FaWR5PC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 261108Gabapentin (n = 36)Laparoscopic cholecystectomyGeneral anesthesia8001h before surgery--NoOpioid utilizationNumber of nausea and vomitingPostoperative pain24hPregabalin (n = 36)150Same --Placebo (n = 36)0Same --Gupta et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdXB0YTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 26290Pregabalin 150 (n = 30)Laparoscopic cholecystectomyGeneral anesthesia225At bedtime+1h before surgery--NoAnesthetic utilization Frequency of rescue analgesiaDizziness8hPregabalin 300 (n = 30)375Same --Diazepam (n = 30)15Same --Hafez et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWZlejwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 264422Gabapentin (n = 208)Mixed surgical cohortNot mentioned1200preoperation + postoperation18003NoPain resolutionOpioid cessationProportion of patients with continued pain or opioid at 6 months and 1 yearAdverse effects2yLorazepam (n = 202)0.5Same13Khalili et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Khalili</Author><Year>2017</Year><RecNum>16825</RecNum><DisplayText><style face="superscript">265</style></DisplayText><record><rec-number>16825</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974145">16825</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Khalili, M.</author><author>Modir, H.</author><author>Norouzi, A.</author><author>Mohammadbeigi, A.</author><author>Somesara, S. A. B.</author></authors></contributors><titles><title>Premedication with oral gabapentin versus intravenous paracetamol for post-operative analgesia after tibial fracture surgery</title><secondary-title>Advances in Human Biology</secondary-title></titles><periodical><full-title>Advances in Human Biology</full-title></periodical><pages>115-118</pages><volume>7</volume><number>3</number><keywords><keyword>Analgesia</keyword><keyword>gabapentin</keyword><keyword>intravenous paracetamol</keyword><keyword>tibial fracture</keyword><keyword>pain</keyword></keywords><dates><year>2017</year><pub-dates><date>Sep-Dec</date></pub-dates></dates><isbn>2321-8568</isbn><accession-num>WOS:000417267800005</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000417267800005</style></url></related-urls></urls><electronic-resource-num>10.4103/aihb.aihb_30_17</electronic-resource-num></record></Cite></EndNote>26596Gabapentin (n = 32)Tibial fractureGeneral anesthesia3001.5h before surgery--NoPostoperative painPethidine requirementAdverse effects6hParacetamol (n = 32)1000Same --Placebo (n = 32)0Same --Khan et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFuPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 26860Pregabalin (n = 30)Video-assisted thoracoscopic surgeryGeneral anesthesia1501h before surgery--NoPostoperative painAnalgesic utilizationAdverse effects48hPlacebo (n = 30)0Same--Kochhar et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Kochhar</Author><Year>2017</Year><RecNum>16827</RecNum><DisplayText><style face="superscript">269</style></DisplayText><record><rec-number>16827</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974195">16827</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kochhar, A</author><author>Banday, J</author><author>Ahmad, Z</author><author>Monga, S</author><author>Vajifdar, H</author></authors></contributors><titles><title>Pregabalin in monitored anesthesia care for ear-nose-throat surgery</title><secondary-title>Anesthesia, essays and researches</secondary-title></titles><periodical><full-title>Anesth Essays Res</full-title><abbr-1>Anesthesia, essays and researches</abbr-1></periodical><pages>350-353</pages><volume>11</volume><number>2</number><keywords><keyword>Sr-ent</keyword></keywords><dates><year>2017</year></dates><accession-num>CN-01383556</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> 28663620</custom3></record></Cite></EndNote>26950Pregabalin (n = 25)Myringoplasty septoplastyMonitored anesthesia care 1501h before surgery--NoPropofol requirementAnalgesic consumptionPostoperative painAdverse effects24hPlacebo (n = 25)0Same--Leung et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZXVuZzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 271170Gabapentin (n = 50)Percutaneous nephrolithotomyGeneral anesthesia6001h before surgery--NoPostoperative painAnalgesic utilizationVitals sign24hTolterodine (n = 50)2Same --Placebo (n = 70)0Same --Manorema et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Manorema</Author><Year>2017</Year><RecNum>16842</RecNum><DisplayText><style face="superscript">272</style></DisplayText><record><rec-number>16842</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="0">16842</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Manorema, V.</author><author>Balakrishna, R.</author><author>Anandan, H.</author></authors></contributors><titles><title>Comparison of pregabalin and tramadol for post-operative pain management in patients undergoing lumbar laminectomy</title><secondary-title>International Journal of Scientific Study</secondary-title></titles><periodical><full-title>International Journal of Scientific Study</full-title></periodical><pages>1-4</pages><volume>5</volume><number>3</number><keywords><keyword>Lumbar laminectomy</keyword><keyword>Post-operative pain</keyword><keyword>Pregabalin</keyword><keyword>Tramadol</keyword></keywords><dates><year>2017</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>2321-6379</isbn><accession-num>WOS:000414564500001</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000414564500001</style></url></related-urls></urls><electronic-resource-num>10.17354/ijss/2017/256</electronic-resource-num></record></Cite></EndNote>27275Pregabalin (n = 25)Lumbar decompressive laminectomyGeneral anesthesia1501h before surgery--NoAnalgesic and anxiolytic efficacyAdverse effects6hTramadol (n = 25)100Same --Placebo (n = 25)0Same --Myhre et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Myhre</Author><Year>2017</Year><RecNum>16826</RecNum><DisplayText><style face="superscript">273</style></DisplayText><record><rec-number>16826</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974176">16826</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Myhre, M.</author><author>Romundstad, L.</author><author>Stubhaug, A.</author></authors></contributors><titles><title>Pregabalin reduces opioid consumption and hyperalgesia but not pain intensity after laparoscopic donor nephrectomy</title><secondary-title>Acta Anaesthesiologica Scandinavica</secondary-title></titles><periodical><full-title>Acta Anaesthesiol Scand</full-title><abbr-1>Acta anaesthesiologica Scandinavica</abbr-1></periodical><pages>1314-1324</pages><volume>61</volume><number>10</number><keywords><keyword>postoperative pain</keyword><keyword>preoperative pregabalin</keyword><keyword>central sensitization</keyword><keyword>neuropathic pain</keyword><keyword>metaanalysis</keyword><keyword>surgery</keyword><keyword>arthroplasty</keyword><keyword>analgesia</keyword><keyword>ketamine</keyword><keyword>morphine</keyword></keywords><dates><year>2017</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0001-5172</isbn><accession-num>WOS:000412533500010</accession-num><work-type>Article</work-type><urls><related-urls><url>&lt;Go to ISI&gt;://WOS:000412533500010</url></related-urls></urls><electronic-resource-num>10.1111/aas.12963</electronic-resource-num></record></Cite></EndNote>27380Pregabalin (n = 39)Laparoscopic nephrectomyGeneral anesthesia751h before surgery--NoOpioid utilizationPostoperative painAdverse effect12moPlacebo (n = 40)0Same--Rezaeian(2017) ADDIN EN.CITE <EndNote><Cite><Author>Rezaeian</Author><Year>2017</Year><RecNum>16845</RecNum><DisplayText><style face="superscript">274</style></DisplayText><record><rec-number>16845</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="0">16845</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rezaeian, A</author></authors></contributors><titles><title>Administering of pregabalin and acetaminophen on management of postoperative pain in patients with nasal polyposis undergoing functional endoscopic sinus surgery</title><secondary-title>Acta Oto-Laryngologica</secondary-title></titles><periodical><full-title>Acta Oto-Laryngologica</full-title></periodical><pages>1249-1252</pages><volume>137</volume><number>12</number><dates><year>2017</year></dates><accession-num>CN-01402645</accession-num><urls><related-urls><url><style face="underline" font="default" size="100%"> 28784038</custom3></record></Cite></EndNote>27470Pregabalin (n = 35)Functional endoscopic sinus surgeryGeneral anesthesia0after surgery1503Not mentionedPostoperative pain Adverse effects72hAcetaminophen n = 35)0Same20003Rupniewska-Ladyko et al.(2017)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SdXBuaWV3c2thLUxhZHlrbzwvQXV0aG9yPjxZZWFyPjIw

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ADDIN EN.CITE.DATA 27660Pregabalin (n = 30)MultipleGeneral anesthesia1501h before surgery--Not mentionedHemodyn stability after laryngoscopyAdverse effects30minsDexmedetomidine (n = 30)0.001/kg10 min before surgery--Sanders et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Sanders</Author><Year>2017</Year><RecNum>16830</RecNum><DisplayText><style face="superscript">277</style></DisplayText><record><rec-number>16830</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="1523974316">16830</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sanders, J. G.</author><author>Cameron, C.</author><author>Dawes, P. J. D.</author></authors></contributors><titles><title>Gabapentin in the management of pain following tonsillectomy: A randomized double-blind placebo-controlled trial</title><secondary-title>Otolaryngology-Head and Neck Surgery</secondary-title></titles><periodical><full-title>Otolaryngology-Head and Neck Surgery</full-title></periodical><pages>781-790</pages><volume>157</volume><number>5</number><keywords><keyword>gabapentin</keyword><keyword>Neurontin</keyword><keyword>otolaryngology</keyword><keyword>tonsillectomy</keyword><keyword>perioperative</keyword><keyword>pain</keyword><keyword>postoperative pain</keyword><keyword>postoperative pain</keyword><keyword>abdominal hysterectomy</keyword><keyword>cold dissection</keyword><keyword>hemorrhage</keyword><keyword>surgery</keyword><keyword>combination</keyword><keyword>adults</keyword><keyword>dexamethasone</keyword><keyword>metaanalysis</keyword><keyword>difference</keyword></keywords><dates><year>2017</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0194-5998</isbn><accession-num>WOS:000414308000008</accession-num><work-type>Article; Proceedings Paper</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000414308000008</style></url></related-urls></urls><electronic-resource-num>10.1177/0194599817719883</electronic-resource-num></record></Cite></EndNote>27773Gabapentin (n = 27)TonsillectomyGeneral anesthesia6001-2h before surgery--NoPostoperative painAnalgesic utilizationPostoperative nausea or vomitingReturn to normal diet and activitiesAdverse effects14dPlacebo (n = 31)0Same--Sanie et al.(2017) ADDIN EN.CITE <EndNote><Cite><Author>Sanie</Author><Year>2017</Year><RecNum>16843</RecNum><DisplayText><style face="superscript">278</style></DisplayText><record><rec-number>16843</rec-number><foreign-keys><key app="EN" db-id="w90tzs52tz9ze4esfat5w5vhv5pxtepdtxsf" timestamp="0">16843</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sanie, M. S.</author><author>Damshenas, M. H.</author><author>Hosseini, Y.</author><author>Radmehr, M.</author><author>Mortezaie, M.</author><author>Behzadnia, A.</author></authors></contributors><titles><title>Comparison of analgesic effect of pregabalin and melatonin in patients undergoing shock wave lithotripsy: A randomized, double-blind, placebo-controlled study</title><secondary-title>Journal of Fundamental and Applied Sciences</secondary-title></titles><periodical><full-title>Journal of Fundamental and Applied Sciences</full-title></periodical><pages>1207-1213</pages><volume>9</volume><number>2</number><keywords><keyword>Melatonin</keyword><keyword>Pregabalin</keyword><keyword>lithotripsy</keyword><keyword>anxiety disorder</keyword><keyword>pain</keyword><keyword>multicenter</keyword></keywords><dates><year>2017</year></dates><isbn>1112-9867</isbn><accession-num>WOS:000404615800039</accession-num><work-type>Article</work-type><urls><related-urls><url><style face="underline" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000404615800039</style></url></related-urls></urls><electronic-resource-num>10.4314/jfas.v9i2.39</electronic-resource-num></record></Cite></EndNote>27845Pregabalin (n = 15)LithotripsyGeneral anesthesia1502h before surgery--Not mentionedPostoperative pain1hMelatonin (n = 15)3Same --Placebo (n = 15)0Same--Abdelfattah et al.(2018)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmRlbGZhdHRhaDwvQXV0aG9yPjxZZWFyPjIwMTg8L1ll

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ADDIN EN.CITE.DATA 27970Pregabalin (n = 35)Radiofrequency ablation of focal lesions in the liverMonitored anesthesia care 1501h before surgery--NoPostoperative painRescue analgesiaPostoperative nausea or vomiting24hPlacebo (n = 35)0Same --CABG Coronary artery bypass graft ; postanesthesia care unit; ICU intensive care unit; HD hemodynamic; ; h hours; mo months; d day; mg milligramReferences ADDIN EN.REFLIST 1.Yoon KJ, Kim CS, Ryu k H, Kim ES, Choi JH, Lee YK. Analgesic effects of gabapentin on post-hysterectomy pain - a double blind study. Korean journal of anesthesiology 2001; 41(6): S13-8.2.Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002; 97(3): 560-4.3.Fassoulaki A, Patris K, Sarantopoulos C, Hogan Q. The analgesic effect of gabapentin and mexiletine after breast surgery for cancer. 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