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Undergraduate Toxicology Course syllabus from the United States Coast Guard Academy. Submitted to the Society of Toxicology Education Resource on 7/16/13 by Joshua Gray. TOXICOLOGY (5417) - Spring 2013United States Coast Guard AcademyCourse Information SheetInstructor Office # Phone Ext. E-Mail AddressPROF Joshua Gray Smith 308 joshua.p.gray@uscga.eduCDR Gregory Hall Smith 301 gregory.hall@uscga.eduTEXTS:Basics of Toxicology, C. KentThe Physiology Coloring Book (2nd edition), W. Kapit, R. I. Macey, E. Meisami (listed as “P” in the syllabus)The Anatomy Coloring Book (3rd edition), W. Kapit, L. M. Elson (listed as “A” in the syllabus)WEBSITES: For General Information: Toxicology Tutorials: (listed as “tox tutor” in the syllabus)COURSE DESCRIPTION: This course will survey the most important concepts in toxicology. Effects of xenobiotic substances on living systems will be studied with examples relevant to the Coast Guard and the Department of Homeland Security. Subject matter will include a review of physiology as it pertains to adsorption, distribution, and metabolism. Substances of interest include: chemical warfare agents, industrial chemicals, pesticides and heavy metals. Exposure assessment, aerosol bio-dynamics, and dose-response concepts will also be covered. This course is designed to be a 3 credit-hour elective. Chemistry II and Physics I are prerequisites.COURSE OBJECTIVES:Knowledge and Competency:Review the fundamentals of human physiology and cell biology.Apply the tenets of chemistry, physics, biology, and statistics to grasp the main concepts of descriptive and applied toxicology including:the relationship between dose and response;the application of toxicological and epidemiological studies;and the application of risk and exposure assessments;Apply the tenets of chemistry, physics, biology, and statistics to grasp the main concepts of mechanistic toxicology including:the uptake and distribution of xenobiotics;phase I and phase II biotransformations;the basic mechanisms of target organ toxicity in the liver, kidney, lung, skin, eye, andin the nervous and reproductive systems;the basic mechanisms of nonorgan-directed toxicity, including mutagenesis, teratagenesis, and carcinogenesis;Reference academic and governmental databases and journals in order to find salient information on specific xenobiotic substances of interest to the Coast Guard.Understand the mechanism of action for agents of interest in terrorism planning and prevention including nerve gases, botulinum toxin, anthrax, mustard gas, and capsicum.Understand the mechanism of action of agents important in environmental pollution including mercury, lead, asbestos, and organophosphate pesticides.Understand the mechanism of action of specific medications and drugs of abuse such as acetaminophen, cocaine, ethanol, and methanol.Interpret multi-conceptual journal article drawing conclusions about new information using previous knowledge and munication:Review toxicological ideas and data by reading the text and any assigned journal articles and by completing the assigned toxicology tutorials.Search the primary literature for a study of interest.Present toxicological ideas and data through the written word in professionally completed assignments and exams.Thinking and Awareness:Use toxicological ideas and data to solve a variety of quantitative and qualitative questions.Evaluate scientific theories and practices within the field of toxicology.Reflect on the science of toxicology and its relevance to you as a scientist, as a Coast Guard Officer, and as a proactive member of society.Leadership:Demonstrate core values and fundamental leadership traits by thoroughly and professionally completing all assignments and exams and by showing interest through class participation.Learn about global leaders in the field of toxicology.Meet a global leader in the field of toxicology.COURSE ASSESSMENTSGrade Distribution:3 Homework Assignments……………. 30%2 Hourly exams……………. 40%1 Literature Review…………… 10%Final Exam…………………. 20%Homework Assignments: Homework assignments are designed to help you prepare for your two hourly exams and for the final. You are encouraged to collaborate on these three assignments.Hourly and Final Exams: Due to the nature of toxicology, the topics covered will build on one another throughout the semester. Therefore, each exam will be cumulative. Only individual effort will be allowed on these exams. The final exam will cover the material since Exam 2 and will also cover cumulative material. Students with better than a 90% average prior to the final will be offered validation of the final exam.Article Review: Prior to the final, you will be asked to find a review article in the primary literature. You will be asked to research a topic in the review article a bit deeper by reading some of the cited literature and write a summary of the knowledge in that area.DayDateLecture TopicReading AssignmentAnatomy/Physiology Coloring BookM1/14/2013Introduction to Toxicology1; TTI: IntroductionA Intro; P IntroT1/15/2013W1/16/2013Basic PhysiologyTTIII: Basic PhysiologyA3-4Th1/17/2013F1/18/2013Cell Biology/Toxicity3.1-3.2; TTIII: ToxicityA8; P1??????M1/21/2013No Class - MLK DayT1/22/2013ADME5.1; TTII: IntroductionW1/23/2013ADME5.2-5.3, 5.5 TTII: Absorption, Distrib. & EliminationA 3-4Th1/24/2013F1/25/2013Circulation and InflammationA 102-103,106 P 31-32??????M1/28/2013Biotransformation: Phase I5.4; TTII: BiotransformationT1/29/2013W1/30/2013Biotransformation: Phase IITh1/31/2013F2/1/2013Biotransformation: Acetominophen??????M2/4/2013Dose-Response4.1 -4.3; TTI: Dose & Dose ResponseT2/5/2013W2/6/2013Dose-Response4.4Th2/7/2013F2/8/2013Risk Assessment - Basics10.1; TTI: Risk Assessment ??????M2/11/2013Risk Assessment - Applied10.2 - 10.4T2/12/2013W2/13/2013ReviewTh2/14/2013F2/15/2013Exam 1??????M2/18/2013Hepatic Physiology5.3A 144-145,119; P 77T2/19/2013W2/20/2013Hepatotoxicity: Acetominophen and EthanolTh2/21/2013F2/22/2013Kidney Physiology5.3A 148-150; P 58-60??????M2/25/2013President's Day holiday??T2/26/2013W2/27/2013Nephrotoxicity6.8Th2/28/2013F3/1/2013Pulmonary Physiology3.3A 129,132,134; P 48-50, 53-54??????M3/4/2013Pulmonary Toxicity6.6T3/5/2013W3/6/2013Pulmonary Toxicity: Asbestos and AnthraxTh3/7/2013F3/8/2013History of Chemical Warfare8.3??????M3/11/2013No Class - Spring BreakT3/12/2013No Class - Spring BreakW3/13/2013No Class - Spring BreakTh3/14/2013No Class - Spring BreakF3/15/2013No Class - Spring Break??????M3/18/2013Dermal Physiology6.2A 70-72,92-94; P 15-20T3/19/2013W3/20/2013Dermal Toxicity: Mustard GasesTh3/21/2013F3/22/2013No Class - Ethics Forum??????M3/25/2013Dermal Toxicity and DermititsT3/26/2013(F)3/27/2013Neural Physiology6.2A 70-72,92-94; P 15-20Th3/28/2013F3/29/2013Neurotoxicity??????M4/1/2013Neurotoxicity: Nerve Gases, Botulinum Toxin, Pepper SprayT4/2/2013W4/3/2013Neurotoxicity: Mercury and LeadTh4/4/2013F 4/5/2013Review??????M4/8/2013Exam 2T4/9/2013W4/10/2013Ocular Toxicity: MethanolA 18-19Th4/11/2013F4/12/2013Developmental Toxicology9.1 - 9.4??????M4/15/2013Reproductive Toxicology9.5A 95-96; P 98-99T4/16/2013W4/17/2013Genetic ToxicologyTh4/18/2013F4/19/2013Cardiac Toxicology6.5??????M4/22/2013Chemical Carcinogenesis6.9A 158,161; P 150,155T4/23/2013W4/24/2013Chemical Carcinogenesis9.4A 165-167; P157Th4/25/2013F4/26/2013Techniques in Toxicology??????M4/29/2013Guest SpeakerT4/30/2013W5/1/2013Final Prep/CritiquesTh5/2/2013Senior Research SymposiumF5/3/2013Study & Conference Day??????TBDFinal Exam ................
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