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Supplemental Table 1. Occurrence, Intensity, and Distress of Individual Symptom Identified in this Scoping ReviewSymptomFrequency (Occurrence)Intensity (Severity)Distress (Interference)Cognitive symptomsForgetfulness/memory loss14.1% (Caucasian)14.5% (African American)(Zhan et al., 2007)63.9% (Mortimer et al., 1999)Pre: 26.3%3M: 25.3%6M: 25.3%(Gallicchio, 2012)Difficulty concentratingPre: 25.3%3M: 24.2% 6M: 20.0% (Gallicchio, 2012)Easily distractedPre: 20.0%3M: 20.0%6M: 20.0% (Gallicchio, 2012)Musculoskeletal PainGeneral aches and pains44.5-59 out of 100(Kyvernitakis, 2014)70%(Mortimer et al., 1999)1.43 out of 4(Ochayon et al., 2014)Joint/muscle pains3.6%(Sagara, 2010)6%(Ohsako et al., 2006)8%(Zhou, 2011)27% (Horimoto, 2009)29.2%(Lu, 2011)31%(Waltman, 2009)32.6%(Dizdar, 2009)34%(Shi, 2013)36%(Laroche, 2014)44%(Hadji, 2014)46.3%(Brown, 2013)47%(Crew, 2007)(Mao, 2009)47.2%(Wang, 2013)48%(Menas, 2012)(Rosenberg et al., 2015)50.8%(Mao, 2011)54%(Singer, 2012)(Swenson, 2013)59.6%(Oberguggenberger, 2011)61%(Presant, 2007)61.3%(Napoli, 2010)64.7%(Olufade, 2015)65%(Boonstra, 2013)67.9%(Servitja, 2012)~80%(Boehm, 2009)83.6% (Kyvernitakis, 2014)85.1%(Gallicchio, 2012_1)62.1%/45.7% (AI/TAM)(Bowles et al., 2012)22%/12% (AI/TAM)(Garreau, 2006)15%/25% (AI/TAM)(Hu, 2016)Pre: 26.1%3M: 38.8%6M: 46.3%9M: 49.5%12M: 54.4%(Egawa, 2016)89%/65% (AI/TAM)(Litermans, 2014)72.9%/36.5% (AI/TAM)(Xu, 2014)Pre: 66%/50% (AI/TAM)(Litermans, 2014)Mean=4.9 out of 10(Boonstra, 2013)Mean=5.23 out of 10(Shi, 2013)Median=7.5 out of 101-4 out of 10: 14%5-7 out of 10: 16%8-10 out of 10: 30%(Presant, 2007)34.6% have 4 (out of 10) pain at worst(Chim, 2013)31.5% moderate to severe(Crew, 2007)54 out of 100(Kyvernitakis, 2014)31.5% moderate12.2% severe(Mao, 2009)Grade 1: 4%Grade 2: 0%Grade 3: 2%(by CTCAE 3.0) ADDIN EN.CITE <EndNote><Cite><Author>Ohsako</Author><Year>2006</Year><RecNum>2992</RecNum><DisplayText>(Ohsako et al., 2006)</DisplayText><record><rec-number>2992</rec-number><foreign-keys><key app="EN" db-id="tvva99a9dzsxfjeerpu5pfeywst2wst0efzv" timestamp="1487006422">2992</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ohsako, T.</author><author>Inoue, K.</author><author>Nagamoto, N.</author><author>Yoshida, Y.</author><author>Nakahara, O.</author><author>Sakamoto, N.</author></authors></contributors><auth-address>Department of Surgery, Japan Labour Health and Welfare Organization-Kumamoto Rosai Hospital, 167 Takehara-cho, Yatsushiro-city, Kumamoto 866-8533, Japan. geka-ohsako@kumamotoh.rofuku.go.jp</auth-address><titles><title>Joint symptoms: a practical problem of anastrozole</title><secondary-title>Breast Cancer</secondary-title><alt-title>Breast cancer (Tokyo, Japan)</alt-title></titles><periodical><full-title>Breast Cancer</full-title></periodical><pages>284-8</pages><volume>13</volume><number>3</number><edition>2006/08/25</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antineoplastic Agents, Hormonal/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Interviews as Topic</keyword><keyword>Joint Diseases/*chemically induced</keyword><keyword>Middle Aged</keyword><keyword>Nitriles/*adverse effects</keyword><keyword>Postmenopause</keyword><keyword>Triazoles/*adverse effects</keyword></keywords><dates><year>2006</year></dates><isbn>1340-6868 (Print)
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ADDIN EN.CITE.DATA (Mortimer et al., 1999)Mean=3.29 out of 10(Shi, 2013)Mild: 64%Moderate: 32.9%Severe: 3.1%(Egawa, 2016)1M: 0.274/0.272 (BCPT/BPI)6M: 0.62/0.282 (BCPT/BPI)(standardized mean difference to baseline)(Swenson, 2013)48%7% (interference only with athletic activity)31% (interference with function but not ADLs)10% (interference with ADLs)(Waltman, 2009)Joint/Muscle stiffness25%(Ohsako et al., 2006) ADDIN EN.CITE <EndNote><Cite><Author>Ohsako</Author><Year>2006</Year><RecNum>2992</RecNum><DisplayText>(Ohsako et al., 2006)</DisplayText><record><rec-number>2992</rec-number><foreign-keys><key app="EN" db-id="tvva99a9dzsxfjeerpu5pfeywst2wst0efzv" timestamp="1487006422">2992</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ohsako, T.</author><author>Inoue, K.</author><author>Nagamoto, N.</author><author>Yoshida, Y.</author><author>Nakahara, O.</author><author>Sakamoto, N.</author></authors></contributors><auth-address>Department of Surgery, Japan Labour Health and Welfare Organization-Kumamoto Rosai Hospital, 167 Takehara-cho, Yatsushiro-city, Kumamoto 866-8533, Japan. geka-ohsako@kumamotoh.rofuku.go.jp</auth-address><titles><title>Joint symptoms: a practical problem of anastrozole</title><secondary-title>Breast Cancer</secondary-title><alt-title>Breast cancer (Tokyo, Japan)</alt-title></titles><periodical><full-title>Breast Cancer</full-title></periodical><pages>284-8</pages><volume>13</volume><number>3</number><edition>2006/08/25</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antineoplastic Agents, Hormonal/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Interviews as Topic</keyword><keyword>Joint Diseases/*chemically induced</keyword><keyword>Middle Aged</keyword><keyword>Nitriles/*adverse effects</keyword><keyword>Postmenopause</keyword><keyword>Triazoles/*adverse effects</keyword></keywords><dates><year>2006</year></dates><isbn>1340-6868 (Print)
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ADDIN EN.CITE.DATA (Baxter et al., 2014)Mild: 22.6%Moderate: 22.6%Severe: 12.6%Very severe: 10.1%(Kyvernitakis, 2014)55.3%PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3J0aW1lcjwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+
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ADDIN EN.CITE.DATA (Mortimer et al., 1999)mean=1.51 out of 4PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PY2hheW9uPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48
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ADDIN EN.CITE.DATA (Ochayon et al., 2014)Pre: 37.9%3M: 43.2%6M: 30.5%(Gallicchio, 2012_2)Night sweats32.9%(Oberguggenberger, 2011)47%(Rosenberg et al., 2015)58%(Mortimer et al., 2008)39.4%/44.1% moderate (AI/TAM)(Baumgart, 2011)Pre: 29.5%3M: 30.5%6M: 23.2%(Gallicchio, 2012_2)Cold sweats20%(Oberguggenberger, 2011)39.4%/33.3% moderate (AI/TAM)(Baumgart, 2011)Hyperhidrosis2%(Hadji, 2014)Heart discomfort47.8%(Kyvernitakis, 2014)Mild: 23.9%Moderate: 19.5%Severe: 3.1%Very severe: 1.3%(Kyvernitakis, 2014)Gastrointestinal symptomsNausea5.3%(Oberguggenberger, 2011)7%(Lu, 2011)9.8%(Baxter et al., 2014)10%(Ribi et al., 2007, 2009)~30%(Boehm, 2009)9%/8% (AI/TAM)(Hu, 2016)10.7%/11.3%(Caucasian/African American)(Zhan et al., 2007)Vomiting2.4%(Oberguggenberger, 2011)~10%(Boehm, 2009)10%/6% (AI/TAM)(Hu, 2016)Diarrhea 6.6%(Lu, 2011)8.7%(Oberguggenberger, 2011)~35%(Boehm, 2009)Constipation 22.7%(Baxter et al., 2014)~40%(Boehm, 2009)Pre: 12.6%3M: 22.1%6M: 10.5%(Gallicchio, 2012_2)Urogenital SymptomsVaginal discharge5.5%(Oberguggenberger, 2011)10%(Ashraf et al., 2009)26%(Chin, 2009)49%(Frechette et al., 2013)73.9%/40% (AI/TAM)(Baumgart et al., 2013)29.3%/16.1% (Caucasian/African American)(Zhan et al., 2007)Mild: 10%(Ashraf et al., 2009)3.0%/17.6% moderate (AI/TAM)(Baumgart, 2011)Mild: 22% moderate: 4%(Chin, 2009)Genital itching/irritation7.4%(Oberguggenberger, 2011)27%(Chin, 2009)15.2%/8.8% moderate (AI/TAM)(Baumgart, 2011)Mild: 22% moderate: 5%(Chin, 2009)Vaginal bleeding or spotting0.4%(Ashraf et al., 2009) (Oberguggenberger, 2011)0.7%(Lu, 2011)2%(Ribi et al., 2007, 2009)~5%(Boehm, 2009)13%(Chin, 2009)5.4%/12.6% (AI/TAM)(Bowles et al., 2012)0%/5.9% moderate (AI/TAM)(Baumgart, 2011)Mild: 4% moderate: 0.8%(Chin, 2009)Irregular menstrual cyles11.9%(Ashraf et al., 2009)Difficulty with bladder32.7%(Kyvernitakis, 2014)Mild: 14.5%Moderate: 10.1%Severe: 7.5%Very severe: 0.6%(Kyvernitakis, 2014)Pre: 10.5%3M: 12.6%6M: 10.5%(Gallicchio, 2012_2)Frequent Urination63.2%/67.6% moderate (AI/TAM)(Baumgart, 2011)Incontinence~30%(Boehm, 2009)36%(Chin, 2009)23.8%/28.7% (AI/TAM)(Bowles et al., 2012)Urgency: 63.6%/55.9% moderate Stress: 69.7%/72.7% moderate (AI/TAM)(Baumgart, 2011)Mild: 30% moderate: 6%(Chin, 2009)Small amounts of leakage45.5%/47.1% moderate (AI/TAM)(Baumgart, 2011)Difficulties in emptying the bladder15.6%/17.6% moderate (AI/TAM)(Baumgart, 2011)Urinary urgency41%(Chin, 2009)Weight concernsWeight gain1%(Hadji, 2014)1.5%(Lu, 2011)33%(Oberguggenberger, 2011)45%(Ribi et al., 2007, 2009)32.8%/31.3% (AI/TAM)(Bowles et al., 2012)15%/14% (AI/TAM)(Garreau, 2006)Pre: 16.8%3M: 14.7%6M: 17.9%(Gallicchio, 2012_2)Decreased appetite6.1%(Baxter et al., 2014)30%(Boehm, 2009)10.6%/12.1% (AI/TAM)(Bowles et al., 2012)MoodUnhappy with the appearance of my body19%(Rosenberg et al., 2015)68.7%(Mortimer et al., 1999)mean=1.76 out of 4(Ochayon et al., 2014)Short temper53.4%(Mortimer et al., 1999)Nervousness26.5%(Baxter et al., 2014)Mood change/mood swing24.2%(Baxter et al., 2014)17.3%/27.6% (AI/TAM)(Bowles et al., 2012)36.2%(Oberguggenberger, 2011)Depression/depressive mood/blue1%(Hadji, 2014)17%(Rosenberg et al., 2015)58.2%(Kyvernitakis, 2014)42%/35% (AI/TAM)(Lintermans, 2014)13%/21.3% (Caucasian/African American)(Zhan et al., 2007)Mild: 23.4%Moderate: 22.2%Severe: 8.9%Extremely severe: 3.8%(Kyvernitakis, 2014)Pre: 14.7%3M: 20.0%6M: 21.1%(Gallicchio, 2012_2)Irritability10.3%(Lu, 2011)18%(Ribi et al., 2007, 2009)22%(Rosenberg et al., 2015)28.8%(Oberguggenberger, 2011)51.6 %(Kyvernitakis, 2014)21.3%/23.0%(Caucasian/African American)(Zhan et al., 2007)Mild: 27.0%Moderate: 17.6%Severe: 5.0%Extremely severe: 1.9%(Kyvernitakis, 2014)~60%(Boehm, 2009)Pre: 16.8%3M: 21.1%6M: 15.8%(Gallicchio, 2012_2)Anxiety44%(Kyvernitakis, 2014)Mild: 17.6%Moderate: 19.5%Severe: 6.3%Extremely severe: 0.6%(Kyvernitakis, 2014)SleepEarly awakening31.3%(Desai, 2013)Moderate: 18.2%Severe: 9.9%Very severe: 3.2%(Desai, 2013)51.6%(Mortimer et al., 1999)Pre: 27.4%3M: 27.4%6M: 24.2%(Gallicchio, 2012_2)Trouble sleeping/sleeping difficulty/Sleep disorder/Insomnia2%(Hadji, 2014)16.4%(Oberguggenberger, 2011)56.8%(Baxter et al., 2014)74.8%(Kyvernitakis, 2014)~80%(Boehm, 2009)44.2%/39.1% (AI/TAM)(Bowles et al., 2012)18%/17% (AI/TAM)(Garreau, 2006)36.1%/25.8%(Caucasian/African American)(Zhan et al., 2007)Mild: 17.0%Moderate: 32.7%Severe: 18.9%Extremely severe: 6.3%(Kyvernitakis, 2014)Sleepiness31.8%(Baxter et al., 2014)Difficulties falling asleep30.3%(Desai, 2013)Moderate: 20.3%Severe: 7.8%Very severe: 2.2%(Desai, 2013)Pre: 25.3%3M: 26.3%6M: 30.5%(Gallicchio, 2012_2)Having trouble staying asleep at night/interrupted sleep41.6%(Desai, 2013)Moderate: 28.3%Severe: 10.9%Very severe: 2.4%(Desai, 2013)Pre: 36.8%3M: 41.1%6M: 34.7%(Gallicchio, 2012_2)Tendency to take nap; 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ADDIN EN.CITE.DATA Pre: 12.6%3M: 18.9%6M: 15.8%(Gallicchio, 2012_2)Low sexual interest/sexual desire problem/lost interest in sex/decreased sex drive29%(Ribi et al., 2007, 2009)51.4%(Oberguggenberger, 2011)73%(Frechette et al., 2013)50.0%/28.6% (AI/TAM)(Baumgart et al., 2013)36.0%/30.5% (AI/TAM)(Bowles et al., 2012)21.2%/10.3% (AI/TAM)(Baumgart et al., 2013)Dyspareunia56.5%/31.3% (AI/TAM)(Baumgart et al., 2013)57.1%/31.0% (AI/TAM)(Baumgart et al., 2013)Orgasmic dysfunction/ Sexual arousal problem46%(Frechette et al., 2013)50.0%/41.9% (AI/TAM)(Baumgart et al., 2013)29.6%/27.3% (AI/TAM)(Baumgart et al., 2013)Sexual problem47.5%(Kyvernitakis, 2014)71%(Schover, 2014)Mild: 13.3%Moderate: 21.5%Severe: 8.2%Extremely severe: 4.4%(Kyvernitakis, 2014)Others Difficulty breathing/Short of breath/Dyspnea/Breathlessness/Feeling of suffocation1%(Hadji, 2014)~15%(Boehm, 2009)17%(Ribi et al., 2007, 2009)19.5%/12.4% (AI/TAM)(Bowles et al., 2012)cough1%(Hadji, 2014)Dry mouth1%(Hadji, 2014)28.8%(Baxter et al., 2014)~50%(Boehm, 2009)Pre: 18.9%3M: 13.7%6M: 11.6%(Gallicchio, 2012_2)Oral/pharyngeal mucositis0.2%(Sagara, 2010)Visual problem15.3%/16.1%(Caucasian/African American)(Zhan et al., 2007)Blind spots, fuzzy vision/changes in eyesight26.8%/23.3% (AI/TAM)(Bowles et al., 2012)Eye irritation~50%(Boehm, 2009)Dry eye syndrome35%(Inglis et al., 2015)Mild: 14.0%Moderate: 11.8%Severe: 9.7%(Inglis et al., 2015)Dizziness, faintness18.9%(Baxter et al., 2014)20%(Oberguggenberger, 2011)~70%(Boehm, 2009)19.0%/17.8% (AI/TAM)(Bowles et al., 2012)Headaches/migraines0.3%(Sagara, 2010)2%(Hadji, 2014)~60%(Boehm, 2009)19%(Oberguggenberger, 2011)16.8%/15.8% (AI/TAM)(Bowles et al., 2012)6.5%/4.0% (Caucasian/African American)(Zhan et al., 2007)59.3%(Mortimer et al., 1999)Pre: 10.5%3M: 12.6%6M: 9.5%(Gallicchio, 2012_2)Cramps 61%/67% (AI/TAM)(Lintermans, 2014_2)Pre: 12.6%3M: 17.9%6M: 22.18%(Gallicchio, 2012_2)Breast sensitivity/tenderness26.4%(Oberguggenberger, 2011)21.7%/23.9% (AI/TAM)(Bowles et al., 2012)51.1%(Mortimer et al., 1999)Fatigue/Feeling tired/physical and mental exhaustion/lack of energy/low energy4%(Hadji, 2014)6.6%(Lu, 2011)40.3%(Oberguggenberger, 2011)46%(Ribi e al., 2007, 2009)57.6%(Baxter et al., 2014)53.1%/50.3% (AI/TAM)(Bowles et al., 2012)60%(Huang et al., 2010)71.1%(Kyvernitakis, 2014)Mild: 44.8%Moderate: 9.8%Severe: 5.4%(Huang et al., 2010)Mild: 23.9%Moderate: 30.2%Severe: 12.6%Extremely severe: 4.4%(Kyvernitakis, 2014)Pre: 50.5%3M: 36.8%6M: 35.8%(Gallicchio, 2012_2)lymphedema1%(Hadji, 2014)Retaining water/feeling bloated/fluid retention15.4%(Oberguggenberger,2011)20%(Ribi et al., 2007, 2009)19.5%/72.7% (AI/TAM)(Bowles et al., 2012)Loss of hair/hair thinning/Alopecia2%(Hadji, 2014)~30%(Boehm, 2009)34.7%/28.4% (AI/TAM)(Bowles et al., 2012)Pre: 12.6%3M: 5.3%6M: 11.6%(Gallicchio, 2012_2)Hair loss: 27.0%/26.6%Hair thinning: 39.6%/33.5% (AI/TAM)(Gallicchio, 2013)Hair and scalp sensations (trichodrynia/pruritus)31%(Kanti et al., 2016)Peripheral sensory neuropathy2%(Hadji, 2014)Nail Disorder1%(Hadji, 2014)Skin rash0.3%(Sagara, 2010)10%(Ribi et al., 2007, 2009)Abdominal pain or discomfort24.2%/17.6% moderate (AI/TAM)(Baumgart, 2011)Abbreviations: AI, aromatase inhibitor; M, month; TAM, tamoxifen. ................
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