Imperial College London
A Propensity-Score Adjusted Analysis of Clinical Outcomes after Pulmonary Valve Replacement in Tetralogy of Fallot
Jouke P. Bokma MD1,2; Tal Geva MD3; Lynn A. Sleeper ScD3; Sonya V. Babu-Narayan MB BS BSc FRCP PhD4; Rachel M. Wald MD5; Kelsey Hickey3; Katrijn Jansen MD5; Rebecca E. Wassall MSc4; Minmin Lu MS3; Michael A. Gatzoulis MD PhD4; Barbara J.M. Mulder MD PhD1,2; Anne Marie Valente MD3
1 Department of Cardiology, Academic Medical Center Amsterdam, the Netherlands
2 Netherlands Heart Institute, Utrecht, the Netherlands
3 Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
4 Department of Adult Congenital Heart Disease, Royal Brompton Hospital, London, UK
5 Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto, Ontario, Canada
Word count: 2953 (excluding references, figure legends and tables)
Corresponding author:
Anne Marie Valente, MD
Boston Children’s Hospital, Department of Cardiology
Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115
E-mail: anne.valente@cardio.
Abstract
Objective: To determine the association of pulmonary valve replacement (PVR) with death and sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF).
Methods: Subjects with rTOF and cardiac magnetic resonance (CMR) from an international registry were included. A PVR propensity score was created to adjust for baseline differences. PVR consensus criteria were pre-defined as pulmonary regurgitation >25% and ≥2 of the following criteria: right ventricular (RV) end-diastolic volume >160 mL/m2, RV end-systolic volume >80 mL/m2, RV ejection fraction (EF) ................
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