Dr C Jackson



A feasibility study:Improving management of comorbidity in patients with colorectal cancerDr C JacksonA/Prof Diana SarfatiProtocol version 1.124/08/2015Project Title:Improving management of comorbidity in patients with colorectal cancer – a feasibility study Short title: C3 Comorbidity CRC Pilot StudyInvestigatorsDr Christopher JacksonAssociate Professor Diana SarfatiProfessor John McCallAssociate Professor Katrina SharplesDr Stephen ChalcroftDr Marie McLaughlinDr Stephanie FarrandMs Tracy SteinerTable of Contents TOC \o "1-3" \h \z \u Investigators PAGEREF _Toc300699444 \h 21.Lay summary PAGEREF _Toc300699445 \h 42.Background PAGEREF _Toc300699446 \h 43.Purpose of the current proposal PAGEREF _Toc300699447 \h 74.Participants PAGEREF _Toc300699448 \h 74.1Inclusion criteria PAGEREF _Toc300699449 \h 74.2Exclusion criteria PAGEREF _Toc300699450 \h 75.Study procedures PAGEREF _Toc300699451 \h 85.1Patient identification PAGEREF _Toc300699452 \h 85.2Screening tool PAGEREF _Toc300699453 \h 85.3Medicines reconciliation: PAGEREF _Toc300699454 \h 85.4Interaction check: PAGEREF _Toc300699455 \h 85.5Comprehensive Medical Assessment PAGEREF _Toc300699456 \h 86Outcome Measures PAGEREF _Toc300699457 \h 97Statistical Analyses PAGEREF _Toc300699458 \h 98Risks/Harms to participants: PAGEREF _Toc300699459 \h 99Funding PAGEREF _Toc300699460 \h 1010Screening tool PAGEREF _Toc300699463 \h 1011Quality of life assessment PAGEREF _Toc300699464 \h 1412Eligibility check list PAGEREF _Toc300699466 \h 15Lay summaryPatients who are diagnosed with colorectal cancer often have other health problems as well as their cancer. These concurrent medical conditions (comorbidity) can impact on the treatment that is recommended for them, and on their recovery from their cancer. In addition, people with a lot of additional health problems may find cancer treatment more difficult to tolerate. International research has examined the impact of Comprehensive Geriatric Assessment on patients who are receiving chemotherapy. Studies have shown that people undergoing this assessment have fewer serious side effects from the chemotherapy. We are proposing a large, multi-centre study looking at the impact of a slightly broader intervention aimed at managing comorbidity in patients with colorectal cancer who are undergoing surgery, chemotherapy, or both. Prior to embarking on such a large study we need to test the appropriateness and acceptability of our screening tools and “road test” our comprehensive medical (geriatric) assessment. This current application is a pilot study where we aim to test these tools. BackgroundComorbidity among cancer patients is common. Data from New Zealand indicate that approximately half of all cancer patients have at least one other chronic condition recorded, and a third have two or more. The most common chronic conditions recorded are cardiovascular illness, metabolic illness, diabetes and chronic respiratory disease. ADDIN EN.CITE <EndNote><Cite><Author>Sarfati</Author><Year>2013</Year><RecNum>1737</RecNum><DisplayText>(1, 2)</DisplayText><record><rec-number>1737</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1372295267">1737</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sarfati, D</author><author>Gurney, J</author><author>Lim, BT</author><author>Bagheri, N</author><author>Simpson, A.</author><author>Koea, Jonathan</author><author>Dennett, E</author></authors></contributors><titles><title>Identifying important comorbidity among cancer populations using administrative data: prevalence and impact on survival</title><secondary-title>Asia-Pacific Journal of Clinical Oncology</secondary-title></titles><periodical><full-title>Asia-Pacific Journal of Clinical Oncology</full-title></periodical><volume>doi: 10.1111/ajco.12130</volume><dates><year>2013</year></dates><urls></urls></record></Cite><Cite><Author>Sarfati</Author><Year>2014</Year><RecNum>1736</RecNum><record><rec-number>1736</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1372294941">1736</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sarfati, D</author><author>Gurney, J</author><author>Stanley, J</author><author>salmond, C.</author><author>Crampton, P.</author><author>Dennett, E</author><author>Koea, Jonathan</author><author>Pearce, N</author></authors></contributors><titles><title>Cancer-specific administrative data-based comorbidity indices provided valid alternative to Charlson and NHI indices</title><secondary-title>Journal of Clinical Oncology</secondary-title></titles><periodical><full-title>Journal of Clinical Oncology</full-title><abbr-1>J Clin Oncol</abbr-1></periodical><pages>586-95</pages><volume>67</volume><number>5</number><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>(1, 2)Comorbidity is even more common for Māori and Pacific patients. For example, while 10% of European patients with colon cancer had a Charlson score of 3+ (indicating a high level of comorbidity), 17% of Māori and Pacific patients were in this category. ADDIN EN.CITE <EndNote><Cite><Author>Sarfati</Author><Year>2011</Year><RecNum>1656</RecNum><DisplayText>(3)</DisplayText><record><rec-number>1656</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1365712730">1656</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sarfati, Diana</author><author>Tan, Lavinia</author><author>Blakely, Tony</author><author>Pearce, Neil</author></authors></contributors><titles><title>Comorbidity among patients with colon cancer in New Zealand</title><secondary-title>New Zealand Medical Journal</secondary-title></titles><periodical><full-title>New Zealand Medical Journal</full-title><abbr-1>N Z Med J</abbr-1></periodical><pages>76-88</pages><volume>124</volume><number>1338</number><dates><year>2011</year></dates><accession-num>21946965</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>;(3)The coexistence of cancer and other chronic conditions has substantial implications on treatment decisions and treatment outcomes for both cancer and chronic disease. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FeHRlcm1hbm48L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy

PjxSZWNOdW0+MTAxMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNC0xMCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTAxMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0

YW1wPSIwIj4xMDEzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5FeHRl

cm1hbm4sIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciBhdCB0aGUgVW5pdmVyc2l0eSBvZiBTb3V0aCBG

bG9yaWRhLCAxMjkwMiBNYWdub2xpYSBEcml2ZSwgVGFtcGEsIEZMIDMzNjEyLCBVU0EuIGV4dGVy

bWFubkBtb2ZmaXR0LnVzZi5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5NZWFzdXJl

bWVudCBhbmQgaW1wYWN0IG9mIGNvbW9yYmlkaXR5IGluIG9sZGVyIGNhbmNlciBwYXRpZW50czwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5Dcml0aWNhbCBSZXZpZXdzIGluIE9uY29sb2d5LUhlbWF0

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNyaXQgUmV2IE9uY29sIEhlbWF0b2w8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0aWNhbCBSZXZp

ZXdzIGluIE9uY29sb2d5LUhlbWF0b2xvZ3k8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1hdG9sPC9mdWxsLXRpdGxl

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE4MS0yMDA8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVt

ZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5

d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD4qQ29tb3JiaWRpdHk8L2tl

eXdvcmQ+PGtleXdvcmQ+KkVwaWRlbWlvbG9naWMgTWVhc3VyZW1lbnRzPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvY28gW0NvbXBsaWNhdGlvbnNd

PC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5

d29yZD4qTmVvcGxhc21zL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb2du

b3Npczwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAm

I3hEO1NlcDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNDAtODQyODwvaXNibj48

YWNjZXNzaW9uLW51bT4xMDk2MDgwMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RXh0ZXJtYW5uPC9BdXRob3I+PFllYXI+MjAwMDwvWWVh

cj48UmVjTnVtPjEwMTQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwMTQ8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXpl

cHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMCI+MTAxNDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlbmlvciBBZHVsdCBPbmNvbG9neSBQcm9ncmFtLCBI

LiBMZWUgTW9mZml0dCBDYW5jZXIgQ2VudGVyIGF0IHRoZSBVbml2ZXJzaXR5IG9mIFNvdXRoIEZs

b3JpZGEsIDEyOTAyIE1hZ25vbGlhIERyaXZlLCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJt

YW5uQG1pZmZpdHQudXNmLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1lYXN1cmlu

ZyBjb21vcmJpZGl0eSBpbiBvbGRlciBjYW5jZXIgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDYW5jZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp

dGxlPkV1ciBKIENhbmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEog

Q2FuY2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5F

dXJvcGVhbiBKb3VybmFsIG9mIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkV1ciBKIENhbmNl

cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ1My03MTwvcGFnZXM+PHZvbHVtZT4z

Njwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlk

aXR5PC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBTdGF0dXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9w

bGFzbXMvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lzPC9rZXl3

b3JkPjxrZXl3b3JkPlJpc2sgQXNzZXNzbWVudDwva2V5d29yZD48a2V5d29yZD4qU2V2ZXJpdHkg

b2YgSWxsbmVzcyBJbmRleDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyJiN4RDtNYXI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl

cz48aXNibj4wOTU5LTgwNDk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA3MTc1MjE8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNhdGFyaWFu

bzwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT4xMDEwPC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj4xMDEwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAi

PjEwMTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhdGFyaWFubywg

V2lsbGlhbSBBLjwvYXV0aG9yPjxhdXRob3I+U2lsbGltYW4sIFJlYmVjY2EgQS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBFcGlkZW1p

b2xvZ3ksIFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEt

QmVya2VsZXksIDE0MCBXYXJyZW4gSGFsbCwgQmVya2VsZXksIENBIDk0NzIwLCBVU0EuIGJpbGxz

QHVjbGluazQuYmVya2VsZXkuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tb3Ji

aWRpdHk6IGltcGxpY2F0aW9ucyBmb3IgcmVzZWFyY2ggYW5kIHByYWN0aWNlIGluIGdlcmlhdHJp

YyBvbmNvbG9neTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Dcml0aWNhbCBSZXZpZXdzIGluIE9u

Y29sb2d5LUhlbWF0b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNyaXQgUmV2IE9u

Y29sIEhlbWF0b2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5D

cml0aWNhbCBSZXZpZXdzIGluIE9uY29sb2d5LUhlbWF0b2xvZ3k8L2Z1bGwtdGl0bGU+PC9wZXJp

b2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1hdG9s

PC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzOS00ODwvcGFnZXM+PHZvbHVt

ZT40ODwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPipDb21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1h

bmFnZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpY3MvbXQgW01ldGhvZHNdPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NZWRpY2FsIE9uY29sb2d5L210

IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2VwIFtFcGlkZW1pb2xvZ3ld

PC9rZXl3b3JkPjxrZXl3b3JkPlByYWN0aWNlIEd1aWRlbGluZXMgYXMgVG9waWM8L2tleXdvcmQ+

PGtleXdvcmQ+UmVzZWFyY2g8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMzwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiYjeEQ7Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0

ZXM+PGlzYm4+MTA0MC04NDI4PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0NjA3Mzg2PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Tb2dhYXJk

PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjE5OTg8L1JlY051bT48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE5OTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQy

MTcwNDA4OCI+MTk5ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U29n

YWFyZCwgTTwvYXV0aG9yPjxhdXRob3I+VGhvbXNlbiwgUlc8L2F1dGhvcj48YXV0aG9yPkJvc3Nl

biwgS1M8L2F1dGhvcj48YXV0aG9yPlNvcmVuc2VuLCBILiBULjwvYXV0aG9yPjxhdXRob3I+SG9y

Z2FhcmQsIE08L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

VGhlIGltcGFjdCBvZiBjb21vcmJpZGl0eSBvbiBjYW5jZXIgc3Vydml2YWw6IGEgcmV2aWV3PC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5pY2FsIEVwaWRlbWlvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEVwaWRlbWlvbG9n

eTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjMtMjk8L3BhZ2VzPjx2b2x1bWU+NTwv

dm9sdW1lPjxudW1iZXI+U3VwcGwgMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwv

ZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkluc3RpdHV0

ZSBvZiBNZWRpY2luZTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4yMDAwPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDAwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0

aW1lc3RhbXA9IjE0MjE3ODAxOTIiPjIwMDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iQm9vayI+NjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPklu

c3RpdHV0ZSBvZiBNZWRpY2luZSw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRp

dGxlcz48dGl0bGU+RGVsaXZlcmluZyBoaWdoLXF1YWxpdHkgY2FuY2VyIGNhcmU6IENoYXJ0aW5n

IGEgbmV3IGNvdXJzZSBmb3IgYSBzeXN0ZW0gaW4gY3Jpc2lzPC90aXRsZT48L3RpdGxlcz48ZGF0

ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxwdWItbG9jYXRpb24+V2FzaGluZ3RvbiwgREM8

L3B1Yi1sb2NhdGlvbj48cHVibGlzaGVyPlRoZSBOYXRpb25hbCBBY2FkZW1pZXMgUHJlc3MuPC9w

dWJsaXNoZXI+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNhcmZh

dGk8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MTk5NjwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTk5NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDIwNzY3MTY1Ij4xOTk2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

YXJmYXRpLCBEPC9hdXRob3I+PGF1dGhvcj5HdXJuZXksIEo8L2F1dGhvcj48YXV0aG9yPlN0YW5s

ZXksIEo8L2F1dGhvcj48YXV0aG9yPktvZWEsIEo8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PHRpdGxlcz48dGl0bGU+QSByZXRyb3NwZWN0aXZlIGNvaG9ydCBzdHVkeSBvZiBwYXRp

ZW50cyB3aXRoIHN0b21hY2ggYW5kIGxpdmVyIGNhbmNlcnM6IHRoZSBpbXBhY3Qgb2YgY29tb3Ji

aWRpdHkgYW5kIGV0aG5pY2l0eSBvbiBjYW5jZXIgY2FyZSBhbmQgb3V0Y29tZXM8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Qk1DIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJNQyBDYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgQ2Fu

Y2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz44MjE8L3BhZ2VzPjx2b2x1bWU+MTQ8L3Zv

bHVtZT48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TYXJmYXRpPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjkyNDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTI0PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2

d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAiPjkyNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+U2FyZmF0aSwgRGlhbmE8L2F1dGhvcj48YXV0aG9yPkhpbGwsIFNhcmFo

PC9hdXRob3I+PGF1dGhvcj5CbGFrZWx5LCBUb255PC9hdXRob3I+PGF1dGhvcj5Sb2Jzb24sIEJy

aWRnZXQ8L2F1dGhvcj48YXV0aG9yPlB1cmRpZSwgR29yZG9uPC9hdXRob3I+PGF1dGhvcj5EZW5u

ZXR0LCBFbGl6YWJldGg8L2F1dGhvcj48YXV0aG9yPkNvcm1hY2ssIERvbm5hPC9hdXRob3I+PGF1

dGhvcj5EZXcsIEtldmluPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk

ZHJlc3M+RGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIE90YWdvIFdl

bGxpbmd0b24sIFBPIEJveCA3MzQzLCBXZWxsaW5ndG9uIDYyNDIsIE5ldyBaZWFsYW5kLiBkaWFu

YS5zYXJmYXRpQG90YWdvLmFjLm56PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVm

ZmVjdCBvZiBjb21vcmJpZGl0eSBvbiB0aGUgdXNlIG9mIGFkanV2YW50IGNoZW1vdGhlcmFweSBh

bmQgc3Vydml2YWwgZnJvbSBjb2xvbiBjYW5jZXI6IGEgcmV0cm9zcGVjdGl2ZSBjb2hvcnQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+Qk1DIENhbmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkJNQyBDYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgQ2FuY2VyPC9hYmJyLTE+

PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CTUMgQ2FuY2VyPC9mdWxs

LXRpdGxlPjxhYmJyLTE+Qk1DIENhbmNlcjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjExNjwvcGFnZXM+PHZvbHVtZT45PC92b2x1bWU+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9r

ZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2hlbW90aGVyYXB5LCBBZGp1dmFudDwva2V5d29yZD48a2V5d29yZD5D

b2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD4qQ29sb25pYyBOZW9wbGFzbXMvZHQgW0Ry

dWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkNvbG9uaWMgTmVvcGxhc21zL2VwIFtFcGlk

ZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9uaWMgTmVvcGxhc21zL21vIFtNb3J0YWxp

dHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs

ZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2lkbmV5IERpc2Vhc2VzL2Vw

IFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtIFN0YWdpbmc8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2VwIFtF

cGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPk5ldyBaZWFsYW5kL2VwIFtFcGlkZW1pb2xv

Z3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3BvcnRpb25hbCBIYXphcmRzIE1vZGVsczwva2V5d29y

ZD48a2V5d29yZD5SZWdpc3RyaWVzL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVyaWNhbCBEYXRh

XTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+U3Vydml2YWwgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0ZTwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjwvZGF0ZXM+PGFjY2Vzc2lv

bi1udW0+MTkzNzk1MjA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FeHRlcm1hbm48L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy

PjxSZWNOdW0+MTAxMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNC0xMCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTAxMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0

YW1wPSIwIj4xMDEzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5FeHRl

cm1hbm4sIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

SC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciBhdCB0aGUgVW5pdmVyc2l0eSBvZiBTb3V0aCBG

bG9yaWRhLCAxMjkwMiBNYWdub2xpYSBEcml2ZSwgVGFtcGEsIEZMIDMzNjEyLCBVU0EuIGV4dGVy

bWFubkBtb2ZmaXR0LnVzZi5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5NZWFzdXJl

bWVudCBhbmQgaW1wYWN0IG9mIGNvbW9yYmlkaXR5IGluIG9sZGVyIGNhbmNlciBwYXRpZW50czwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5Dcml0aWNhbCBSZXZpZXdzIGluIE9uY29sb2d5LUhlbWF0

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNyaXQgUmV2IE9uY29sIEhlbWF0b2w8

L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0aWNhbCBSZXZp

ZXdzIGluIE9uY29sb2d5LUhlbWF0b2xvZ3k8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1hdG9sPC9mdWxsLXRpdGxl

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE4MS0yMDA8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVt

ZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5

d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD4qQ29tb3JiaWRpdHk8L2tl

eXdvcmQ+PGtleXdvcmQ+KkVwaWRlbWlvbG9naWMgTWVhc3VyZW1lbnRzPC9rZXl3b3JkPjxrZXl3

b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvY28gW0NvbXBsaWNhdGlvbnNd

PC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5

d29yZD4qTmVvcGxhc21zL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb2du

b3Npczwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAm

I3hEO1NlcDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNDAtODQyODwvaXNibj48

YWNjZXNzaW9uLW51bT4xMDk2MDgwMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PC9yZWNv

cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RXh0ZXJtYW5uPC9BdXRob3I+PFllYXI+MjAwMDwvWWVh

cj48UmVjTnVtPjEwMTQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEwMTQ8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXpl

cHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMCI+MTAxNDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNlbmlvciBBZHVsdCBPbmNvbG9neSBQcm9ncmFtLCBI

LiBMZWUgTW9mZml0dCBDYW5jZXIgQ2VudGVyIGF0IHRoZSBVbml2ZXJzaXR5IG9mIFNvdXRoIEZs

b3JpZGEsIDEyOTAyIE1hZ25vbGlhIERyaXZlLCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJt

YW5uQG1pZmZpdHQudXNmLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1lYXN1cmlu

ZyBjb21vcmJpZGl0eSBpbiBvbGRlciBjYW5jZXIgcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDYW5jZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp

dGxlPkV1ciBKIENhbmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEog

Q2FuY2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5F

dXJvcGVhbiBKb3VybmFsIG9mIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkV1ciBKIENhbmNl

cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ1My03MTwvcGFnZXM+PHZvbHVtZT4z

Njwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlk

aXR5PC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBTdGF0dXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9w

bGFzbXMvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lzPC9rZXl3

b3JkPjxrZXl3b3JkPlJpc2sgQXNzZXNzbWVudDwva2V5d29yZD48a2V5d29yZD4qU2V2ZXJpdHkg

b2YgSWxsbmVzcyBJbmRleDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyJiN4RDtNYXI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl

cz48aXNibj4wOTU5LTgwNDk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTA3MTc1MjE8L2FjY2Vzc2lv

bi1udW0+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNhdGFyaWFu

bzwvQXV0aG9yPjxZZWFyPjIwMDM8L1llYXI+PFJlY051bT4xMDEwPC9SZWNOdW0+PHJlY29yZD48

cmVjLW51bWJlcj4xMDEwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAi

PjEwMTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhdGFyaWFubywg

V2lsbGlhbSBBLjwvYXV0aG9yPjxhdXRob3I+U2lsbGltYW4sIFJlYmVjY2EgQS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBFcGlkZW1p

b2xvZ3ksIFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEt

QmVya2VsZXksIDE0MCBXYXJyZW4gSGFsbCwgQmVya2VsZXksIENBIDk0NzIwLCBVU0EuIGJpbGxz

QHVjbGluazQuYmVya2VsZXkuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tb3Ji

aWRpdHk6IGltcGxpY2F0aW9ucyBmb3IgcmVzZWFyY2ggYW5kIHByYWN0aWNlIGluIGdlcmlhdHJp

YyBvbmNvbG9neTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Dcml0aWNhbCBSZXZpZXdzIGluIE9u

Y29sb2d5LUhlbWF0b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNyaXQgUmV2IE9u

Y29sIEhlbWF0b2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5D

cml0aWNhbCBSZXZpZXdzIGluIE9uY29sb2d5LUhlbWF0b2xvZ3k8L2Z1bGwtdGl0bGU+PC9wZXJp

b2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1hdG9s

PC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIzOS00ODwvcGFnZXM+PHZvbHVt

ZT40ODwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9r

ZXl3b3JkPjxrZXl3b3JkPipDb21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1h

bmFnZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpY3MvbXQgW01ldGhvZHNdPC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NZWRpY2FsIE9uY29sb2d5L210

IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2VwIFtFcGlkZW1pb2xvZ3ld

PC9rZXl3b3JkPjxrZXl3b3JkPlByYWN0aWNlIEd1aWRlbGluZXMgYXMgVG9waWM8L2tleXdvcmQ+

PGtleXdvcmQ+UmVzZWFyY2g8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMzwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdiYjeEQ7Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0

ZXM+PGlzYm4+MTA0MC04NDI4PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0NjA3Mzg2PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Tb2dhYXJk

PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjE5OTg8L1JlY051bT48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE5OTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQy

MTcwNDA4OCI+MTk5ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U29n

YWFyZCwgTTwvYXV0aG9yPjxhdXRob3I+VGhvbXNlbiwgUlc8L2F1dGhvcj48YXV0aG9yPkJvc3Nl

biwgS1M8L2F1dGhvcj48YXV0aG9yPlNvcmVuc2VuLCBILiBULjwvYXV0aG9yPjxhdXRob3I+SG9y

Z2FhcmQsIE08L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

VGhlIGltcGFjdCBvZiBjb21vcmJpZGl0eSBvbiBjYW5jZXIgc3Vydml2YWw6IGEgcmV2aWV3PC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNsaW5pY2FsIEVwaWRlbWlvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW5pY2FsIEVwaWRlbWlvbG9n

eTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjMtMjk8L3BhZ2VzPjx2b2x1bWU+NTwv

dm9sdW1lPjxudW1iZXI+U3VwcGwgMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwv

ZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkluc3RpdHV0

ZSBvZiBNZWRpY2luZTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4yMDAwPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDAwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0

aW1lc3RhbXA9IjE0MjE3ODAxOTIiPjIwMDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iQm9vayI+NjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPklu

c3RpdHV0ZSBvZiBNZWRpY2luZSw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRp

dGxlcz48dGl0bGU+RGVsaXZlcmluZyBoaWdoLXF1YWxpdHkgY2FuY2VyIGNhcmU6IENoYXJ0aW5n

IGEgbmV3IGNvdXJzZSBmb3IgYSBzeXN0ZW0gaW4gY3Jpc2lzPC90aXRsZT48L3RpdGxlcz48ZGF0

ZXM+PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxwdWItbG9jYXRpb24+V2FzaGluZ3RvbiwgREM8

L3B1Yi1sb2NhdGlvbj48cHVibGlzaGVyPlRoZSBOYXRpb25hbCBBY2FkZW1pZXMgUHJlc3MuPC9w

dWJsaXNoZXI+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNhcmZh

dGk8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MTk5NjwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTk5NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDIwNzY3MTY1Ij4xOTk2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

YXJmYXRpLCBEPC9hdXRob3I+PGF1dGhvcj5HdXJuZXksIEo8L2F1dGhvcj48YXV0aG9yPlN0YW5s

ZXksIEo8L2F1dGhvcj48YXV0aG9yPktvZWEsIEo8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PHRpdGxlcz48dGl0bGU+QSByZXRyb3NwZWN0aXZlIGNvaG9ydCBzdHVkeSBvZiBwYXRp

ZW50cyB3aXRoIHN0b21hY2ggYW5kIGxpdmVyIGNhbmNlcnM6IHRoZSBpbXBhY3Qgb2YgY29tb3Ji

aWRpdHkgYW5kIGV0aG5pY2l0eSBvbiBjYW5jZXIgY2FyZSBhbmQgb3V0Y29tZXM8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Qk1DIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJNQyBDYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgQ2Fu

Y2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz44MjE8L3BhZ2VzPjx2b2x1bWU+MTQ8L3Zv

bHVtZT48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TYXJmYXRpPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48

UmVjTnVtPjkyNDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTI0PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2

d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAiPjkyNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+U2FyZmF0aSwgRGlhbmE8L2F1dGhvcj48YXV0aG9yPkhpbGwsIFNhcmFo

PC9hdXRob3I+PGF1dGhvcj5CbGFrZWx5LCBUb255PC9hdXRob3I+PGF1dGhvcj5Sb2Jzb24sIEJy

aWRnZXQ8L2F1dGhvcj48YXV0aG9yPlB1cmRpZSwgR29yZG9uPC9hdXRob3I+PGF1dGhvcj5EZW5u

ZXR0LCBFbGl6YWJldGg8L2F1dGhvcj48YXV0aG9yPkNvcm1hY2ssIERvbm5hPC9hdXRob3I+PGF1

dGhvcj5EZXcsIEtldmluPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk

ZHJlc3M+RGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIE90YWdvIFdl

bGxpbmd0b24sIFBPIEJveCA3MzQzLCBXZWxsaW5ndG9uIDYyNDIsIE5ldyBaZWFsYW5kLiBkaWFu

YS5zYXJmYXRpQG90YWdvLmFjLm56PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVm

ZmVjdCBvZiBjb21vcmJpZGl0eSBvbiB0aGUgdXNlIG9mIGFkanV2YW50IGNoZW1vdGhlcmFweSBh

bmQgc3Vydml2YWwgZnJvbSBjb2xvbiBjYW5jZXI6IGEgcmV0cm9zcGVjdGl2ZSBjb2hvcnQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+Qk1DIENhbmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkJNQyBDYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgQ2FuY2VyPC9hYmJyLTE+

PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CTUMgQ2FuY2VyPC9mdWxs

LXRpdGxlPjxhYmJyLTE+Qk1DIENhbmNlcjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjExNjwvcGFnZXM+PHZvbHVtZT45PC92b2x1bWU+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9r

ZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2hlbW90aGVyYXB5LCBBZGp1dmFudDwva2V5d29yZD48a2V5d29yZD5D

b2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD4qQ29sb25pYyBOZW9wbGFzbXMvZHQgW0Ry

dWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkNvbG9uaWMgTmVvcGxhc21zL2VwIFtFcGlk

ZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9uaWMgTmVvcGxhc21zL21vIFtNb3J0YWxp

dHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs

ZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2lkbmV5IERpc2Vhc2VzL2Vw

IFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkxvZ2lzdGljIE1vZGVsczwva2V5d29y

ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtIFN0YWdpbmc8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2VwIFtF

cGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPk5ldyBaZWFsYW5kL2VwIFtFcGlkZW1pb2xv

Z3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3BvcnRpb25hbCBIYXphcmRzIE1vZGVsczwva2V5d29y

ZD48a2V5d29yZD5SZWdpc3RyaWVzL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVyaWNhbCBEYXRh

XTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdv

cmQ+U3Vydml2YWwgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0ZTwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjwvZGF0ZXM+PGFjY2Vzc2lv

bi1udW0+MTkzNzk1MjA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (4-10) However most studies of cancer therapies and treatment guidelines ignore the complex interrelationships between cancer and comorbidity in favour of a “single disease” approach to management. ADDIN EN.CITE <EndNote><Cite><Author>Institute of Medicine</Author><Year>2013</Year><RecNum>2000</RecNum><DisplayText>(8)</DisplayText><record><rec-number>2000</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1421780192">2000</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Institute of Medicine,</author></authors></contributors><titles><title>Delivering high-quality cancer care: Charting a new course for a system in crisis</title></titles><dates><year>2013</year></dates><pub-location>Washington, DC</pub-location><publisher>The National Academies Press.</publisher><urls></urls></record></Cite></EndNote>(8)Previous work led by Sarfati has shown that 70% of patients presenting with colon cancer in New Zealand have at least one comorbid condition identified from their hospital notes and a quarter have three or more. Work from this team in New Zealand and others internationally has consistently found that comorbidity has an adverse impact on cancer outcomes, and that comorbidity substantially reduces the likelihood that an individual will receive treatment despite evidence that the treatment would have been beneficial for at least some of these patients.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FeHRlcm1hbm48L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy

PjxSZWNOdW0+MTAxMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNCwgNywgMTEpPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwMTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRp

bWVzdGFtcD0iMCI+MTAxMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkguIExlZSBNb2ZmaXR0IENhbmNlciBDZW50ZXIgYXQgdGhlIFVuaXZlcnNpdHkgb2YgU291

dGggRmxvcmlkYSwgMTI5MDIgTWFnbm9saWEgRHJpdmUsIFRhbXBhLCBGTCAzMzYxMiwgVVNBLiBl

eHRlcm1hbm5AbW9mZml0dC51c2YuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TWVh

c3VyZW1lbnQgYW5kIGltcGFjdCBvZiBjb21vcmJpZGl0eSBpbiBvbGRlciBjYW5jZXIgcGF0aWVu

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBPbmNvbG9neS1I

ZW1hdG9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1h

dG9sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwg

UmV2aWV3cyBpbiBPbmNvbG9neS1IZW1hdG9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdCBSZXYgT25jb2wgSGVtYXRvbDwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODEtMjAwPC9wYWdlcz48dm9sdW1lPjM1PC92

b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPipFcGlkZW1pb2xvZ2ljIE1lYXN1cmVtZW50czwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2NvIFtDb21wbGljYXRp

b25zXTwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvZGkgW0RpYWdub3Npc108L2tleXdvcmQ+

PGtleXdvcmQ+Kk5lb3BsYXNtcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Q

cm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+U2V2ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

U2VwJiN4RDtTZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDQwLTg0Mjg8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTA5NjA4MDA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

PFJlY051bT4xNTU5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNTU5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4

ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjEzMjEzMjgxNzMiPjE1NTk8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlZSwgTGluZGE8L2F1dGhvcj48YXV0aG9yPkNo

ZXVuZywgV2luc29uIFkuPC9hdXRob3I+PGF1dGhvcj5BdGtpbnNvbiwgRXN0aGVyPC9hdXRob3I+

PGF1dGhvcj5Lcnp5emFub3dza2EsIE1vbmlrYSBLLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByaW5jZXNzIE1hcmdhcmV0IEhvc3BpdGFsLCBVbml2ZXJz

aXR5IG9mIFRvcm9udG8sIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5JbXBhY3Qgb2YgY29tb3JiaWRpdHkgb24gY2hlbW90aGVyYXB5IHVzZSBh

bmQgb3V0Y29tZXMgaW4gc29saWQgdHVtb3JzOiBhIHN5c3RlbWF0aWMgcmV2aWV3PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDYtMTc8

L3BhZ2VzPjx2b2x1bWU+Mjk8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD4qQW50aW5lb3BsYXN0aWMgQWdlbnRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvY28gW0Nv

bXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvZHQgW0RydWcgVGhlcmFw

eV08L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+

VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+MCAoQW50aW5lb3BsYXN0aWMgQWdl

bnRzKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SmFuIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI3LTc3NTU8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEwOTgzMTQ8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5S

ZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5v

dmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1

bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIxMDk4MzE0PC91cmw+PHVybD5odHRwOi8vcmI2ZmM3

dHY2cy5zZWFyY2guc2VyaWFsc3NvbHV0aW9ucy5jb20/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4

UiUyOSZhbXA7aWQ9cG1pZDoyMTA5ODMxNCZhbXA7aWQ9JmFtcDtpc3NuPTA3MzItMTgzWCZhbXA7

aXNibj0mYW1wO3ZvbHVtZT0yOSZhbXA7aXNzdWU9MSZhbXA7c3BhZ2U9MTA2JmFtcDtwYWdlcz0x

MDYtMTcmYW1wO2RhdGU9MjAxMSZhbXA7dGl0bGU9Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9n

eSZhbXA7YXRpdGxlPUltcGFjdCtvZitjb21vcmJpZGl0eStvbitjaGVtb3RoZXJhcHkrdXNlK2Fu

ZCtvdXRjb21lcytpbitzb2xpZCt0dW1vcnMlM0ErYStzeXN0ZW1hdGljK3Jldmlldy4mYW1wO2F1

bGFzdD1MZWUmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0O0xlZStMJTNCQ2hldW5nK1dZJTNCQXRraW5z

b24rRSUzQktyenl6YW5vd3NrYStNSyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OzIxMDk4

MzE0Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPkVuZ2xp

c2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNvZ2FhcmQ8L0F1dGhv

cj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MTk5ODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i

ZXI+MTk5ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIy

c3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDIxNzA0MDg4

Ij4xOTk4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Tb2dhYXJkLCBN

PC9hdXRob3I+PGF1dGhvcj5UaG9tc2VuLCBSVzwvYXV0aG9yPjxhdXRob3I+Qm9zc2VuLCBLUzwv

YXV0aG9yPjxhdXRob3I+U29yZW5zZW4sIEguIFQuPC9hdXRob3I+PGF1dGhvcj5Ib3JnYWFyZCwg

TTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5UaGUgaW1w

YWN0IG9mIGNvbW9yYmlkaXR5IG9uIGNhbmNlciBzdXJ2aXZhbDogYSByZXZpZXc8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgRXBpZGVtaW9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgRXBpZGVtaW9sb2d5PC9mdWxs

LXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+My0yOTwvcGFnZXM+PHZvbHVtZT41PC92b2x1bWU+

PG51bWJlcj5TdXBwbCAxPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48

dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FeHRlcm1hbm48L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFy

PjxSZWNOdW0+MTAxMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNCwgNywgMTEpPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjEwMTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRp

bWVzdGFtcD0iMCI+MTAxMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkguIExlZSBNb2ZmaXR0IENhbmNlciBDZW50ZXIgYXQgdGhlIFVuaXZlcnNpdHkgb2YgU291

dGggRmxvcmlkYSwgMTI5MDIgTWFnbm9saWEgRHJpdmUsIFRhbXBhLCBGTCAzMzYxMiwgVVNBLiBl

eHRlcm1hbm5AbW9mZml0dC51c2YuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TWVh

c3VyZW1lbnQgYW5kIGltcGFjdCBvZiBjb21vcmJpZGl0eSBpbiBvbGRlciBjYW5jZXIgcGF0aWVu

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q3JpdGljYWwgUmV2aWV3cyBpbiBPbmNvbG9neS1I

ZW1hdG9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Dcml0IFJldiBPbmNvbCBIZW1h

dG9sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdGljYWwg

UmV2aWV3cyBpbiBPbmNvbG9neS1IZW1hdG9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3JpdCBSZXYgT25jb2wgSGVtYXRvbDwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODEtMjAwPC9wYWdlcz48dm9sdW1lPjM1PC92

b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPipFcGlkZW1pb2xvZ2ljIE1lYXN1cmVtZW50czwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2NvIFtDb21wbGljYXRp

b25zXTwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvZGkgW0RpYWdub3Npc108L2tleXdvcmQ+

PGtleXdvcmQ+Kk5lb3BsYXNtcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Q

cm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+U2V2ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

U2VwJiN4RDtTZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDQwLTg0Mjg8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTA5NjA4MDA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

PFJlY051bT4xNTU5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNTU5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4

ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjEzMjEzMjgxNzMiPjE1NTk8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlZSwgTGluZGE8L2F1dGhvcj48YXV0aG9yPkNo

ZXVuZywgV2luc29uIFkuPC9hdXRob3I+PGF1dGhvcj5BdGtpbnNvbiwgRXN0aGVyPC9hdXRob3I+

PGF1dGhvcj5Lcnp5emFub3dza2EsIE1vbmlrYSBLLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByaW5jZXNzIE1hcmdhcmV0IEhvc3BpdGFsLCBVbml2ZXJz

aXR5IG9mIFRvcm9udG8sIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5JbXBhY3Qgb2YgY29tb3JiaWRpdHkgb24gY2hlbW90aGVyYXB5IHVzZSBh

bmQgb3V0Y29tZXMgaW4gc29saWQgdHVtb3JzOiBhIHN5c3RlbWF0aWMgcmV2aWV3PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDYtMTc8

L3BhZ2VzPjx2b2x1bWU+Mjk8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD4qQW50aW5lb3BsYXN0aWMgQWdlbnRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvY28gW0Nv

bXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvZHQgW0RydWcgVGhlcmFw

eV08L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+

VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+MCAoQW50aW5lb3BsYXN0aWMgQWdl

bnRzKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SmFuIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI3LTc3NTU8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEwOTgzMTQ8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5S

ZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5v

dmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1

bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIxMDk4MzE0PC91cmw+PHVybD5odHRwOi8vcmI2ZmM3

dHY2cy5zZWFyY2guc2VyaWFsc3NvbHV0aW9ucy5jb20/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4

UiUyOSZhbXA7aWQ9cG1pZDoyMTA5ODMxNCZhbXA7aWQ9JmFtcDtpc3NuPTA3MzItMTgzWCZhbXA7

aXNibj0mYW1wO3ZvbHVtZT0yOSZhbXA7aXNzdWU9MSZhbXA7c3BhZ2U9MTA2JmFtcDtwYWdlcz0x

MDYtMTcmYW1wO2RhdGU9MjAxMSZhbXA7dGl0bGU9Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9n

eSZhbXA7YXRpdGxlPUltcGFjdCtvZitjb21vcmJpZGl0eStvbitjaGVtb3RoZXJhcHkrdXNlK2Fu

ZCtvdXRjb21lcytpbitzb2xpZCt0dW1vcnMlM0ErYStzeXN0ZW1hdGljK3Jldmlldy4mYW1wO2F1

bGFzdD1MZWUmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0O0xlZStMJTNCQ2hldW5nK1dZJTNCQXRraW5z

b24rRSUzQktyenl6YW5vd3NrYStNSyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OzIxMDk4

MzE0Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPkVuZ2xp

c2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNvZ2FhcmQ8L0F1dGhv

cj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MTk5ODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i

ZXI+MTk5ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIy

c3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDIxNzA0MDg4

Ij4xOTk4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Tb2dhYXJkLCBN

PC9hdXRob3I+PGF1dGhvcj5UaG9tc2VuLCBSVzwvYXV0aG9yPjxhdXRob3I+Qm9zc2VuLCBLUzwv

YXV0aG9yPjxhdXRob3I+U29yZW5zZW4sIEguIFQuPC9hdXRob3I+PGF1dGhvcj5Ib3JnYWFyZCwg

TTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5UaGUgaW1w

YWN0IG9mIGNvbW9yYmlkaXR5IG9uIGNhbmNlciBzdXJ2aXZhbDogYSByZXZpZXc8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Q2xpbmljYWwgRXBpZGVtaW9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2xpbmljYWwgRXBpZGVtaW9sb2d5PC9mdWxs

LXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+My0yOTwvcGFnZXM+PHZvbHVtZT41PC92b2x1bWU+

PG51bWJlcj5TdXBwbCAxPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48

dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (4, 7, 11) For example, Sarfati et al found that among patients with colon cancer, those with comorbidity had substantially poorer survival than those without comorbidity. Only 19% of these patients with comorbidity (defined as a Charlson score of 3+) were offered adjuvant chemotherapy compared with 84% of patients without comorbidity. This is despite the fact that within the group who had comorbidity, those who received chemotherapy had 60% lower mortality than those who did not. More recent work from the PIPER study (led by Findlay and Jackson) shows that a substantial proportion of patients with colorectal cancer who are potentially eligible for adjuvant or palliative chemotherapy are still not receiving it. Comorbidity is likely to be an important driver for this.A number of international studies have confirmed both that cancer patients with comorbidity are less likely to receive definitive treatment and that where such treatment is given, outcomes are significantly better.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmRvbGxhaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

PFJlY051bT4xOTkzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig5LCAxMi0xNyk8L0Rpc3BsYXlUZXh0

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk5MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGlt

ZXN0YW1wPSIxNDIwNzUyODczIj4xOTkzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5BYmRvbGxhaCwgRi48L2F1dGhvcj48YXV0aG9yPlN1biwgTS48L2F1dGhvcj48YXV0

aG9yPlNjaG1pdGdlcywgSi48L2F1dGhvcj48YXV0aG9yPlRodXJldCwgUi48L2F1dGhvcj48YXV0

aG9yPkJpYW5jaGksIE0uPC9hdXRob3I+PGF1dGhvcj5TaGFyaWF0LCBTLiBGLjwvYXV0aG9yPjxh

dXRob3I+QnJpZ2FudGksIEEuPC9hdXRob3I+PGF1dGhvcj5KZWxkcmVzLCBDLjwvYXV0aG9yPjxh

dXRob3I+UGVycm90dGUsIFAuPC9hdXRob3I+PGF1dGhvcj5Nb250b3JzaSwgRi48L2F1dGhvcj48

YXV0aG9yPkthcmFraWV3aWN6LCBQLiBJLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkNhbmNlciBQcm9nbm9zdGljcyBhbmQgSGVhbHRoIE91dGNvbWVzIFVu

aXQsIFVuaXZlcnNpdHkgb2YgTW9udHJlYWwgSGVhbHRoIENlbnRyZSwgTW9udHJlYWwsIFF1ZWJl

YywgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlN1cnZpdmFsIGJlbmVmaXQg

b2YgcmFkaWNhbCBwcm9zdGF0ZWN0b215IGluIHBhdGllbnRzIHdpdGggbG9jYWxpemVkIHByb3N0

YXRlIGNhbmNlcjogZXN0aW1hdGlvbnMgb2YgdGhlIG51bWJlciBuZWVkZWQgdG8gdHJlYXQgYWNj

b3JkaW5nIHRvIHR1bW9yIGFuZCBwYXRpZW50IGNoYXJhY3RlcmlzdGljczwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIFVyb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkogVXJvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgVXJvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgVXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogVXJvbDwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjczLTgzPC9wYWdlcz48dm9sdW1lPjE4ODwv

dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwv

a2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVy

PC9rZXl3b3JkPjxrZXl3b3JkPkNhbmFkYS9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5

d29yZD5FdXJvcGUvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+KkhlYWx0aCBT

ZXJ2aWNlcyBOZWVkcyBhbmQgRGVtYW5kL3V0IFtVdGlsaXphdGlvbl08L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3BlbnNpdHkgU2NvcmU8L2tleXdvcmQ+PGtleXdvcmQ+

KlByb3N0YXRlL3BhIFtQYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0YXRlL3N1IFtT

dXJnZXJ5XTwva2V5d29yZD48a2V5d29yZD4qUHJvc3RhdGVjdG9teS9tdCBbTWV0aG9kc108L2tl

eXdvcmQ+PGtleXdvcmQ+UHJvc3RhdGVjdG9teS9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5

d29yZD5Qcm9zdGF0aWMgTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipQcm9zdGF0aWMgTmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPlBy

b3N0YXRpYyBOZW9wbGFzbXMvc3UgW1N1cmdlcnldPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD4qUmlzayBBc3Nlc3NtZW50L210IFtNZXRo

b2RzXTwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+KlNF

RVIgUHJvZ3JhbTwva2V5d29yZD48a2V5d29yZD5Tb2Npb2Vjb25vbWljIEZhY3RvcnM8L2tleXdv

cmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0ZS90ZCBbVHJlbmRzXTwva2V5d29yZD48a2V5d29yZD5U

aW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcCBbRXBpZGVtaW9s

b2d5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy0zNzkyPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjIyNTc4NzMyPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29t

cGFyYXRpdmUgU3R1ZHkmI3hEO011bHRpY2VudGVyIFN0dWR5JiN4RDtSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjU3ODczMjwvdXJsPjx1

cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdU

T04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92

YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9P

dmlkOm1lZGwmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTAx

NiUyRmouanVyby4yMDEyLjAzLjAwNSZhbXA7cmZ0X2lkPWluZm86cG1pZC8yMjU3ODczMiZhbXA7

cmZ0Lmlzc249MDAyMi01MzQ3JmFtcDtyZnQudm9sdW1lPTE4OCZhbXA7cmZ0Lmlzc3VlPTEmYW1w

O3JmdC5zcGFnZT03MyZhbXA7cmZ0LnBhZ2VzPTczLTgzJmFtcDtyZnQuZGF0ZT0yMDEyJmFtcDty

ZnQuanRpdGxlPUpvdXJuYWwrb2YrVXJvbG9neSZhbXA7cmZ0LmF0aXRsZT1TdXJ2aXZhbCtiZW5l

Zml0K29mK3JhZGljYWwrcHJvc3RhdGVjdG9teStpbitwYXRpZW50cyt3aXRoK2xvY2FsaXplZCtw

cm9zdGF0ZStjYW5jZXIlM0ErZXN0aW1hdGlvbnMrb2YrdGhlK251bWJlcituZWVkZWQrdG8rdHJl

YXQrYWNjb3JkaW5nK3RvK3R1bW9yK2FuZCtwYXRpZW50K2NoYXJhY3RlcmlzdGljcy4mYW1wO3Jm

dC5hdWxhc3Q9QWJkb2xsYWg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qdXJvLjIwMTIuMDMuMDA1

PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwv

cmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hu

b2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CcmFkbGV5PC9BdXRob3I+PFllYXI+

MjAxNDwvWWVhcj48UmVjTnVtPjE4ODM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE4ODM8

L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25k

YXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQwNDY5MDE0OSI+MTg4Mzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJhZGxleSwgQy4gSi48L2F1

dGhvcj48YXV0aG9yPkRhaG1hbiwgQi48L2F1dGhvcj48YXV0aG9yPkFuc2NoZXIsIE0uPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudHMgb2Yg

KkhlYWx0aGNhcmUgUG9saWN5IGFuZCBSZXNlYXJjaCArUmFkaWF0aW9uIE9uY29sb2d5LCBWaXJn

aW5pYSBDb21tb253ZWFsdGggVW5pdmVyc2l0eSwgUmljaG1vbmQsIFZBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPlByb3N0YXRlIGNhbmNlciB0cmVhdG1lbnQgYW5kIHN1cnZpdmFsOiBl

dmlkZW5jZSBmb3IgbWVuIHdpdGggcHJldmFsZW50IGNvbW9yYmlkIGNvbmRpdGlvbnM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TWVkaWNhbCBDYXJlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5NZWQgQ2FyZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk1l

ZGljYWwgQ2FyZTwvZnVsbC10aXRsZT48YWJici0xPk1lZCBDYXJlPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NZWRpY2FsIENhcmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5NZWQgQ2FyZTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ4Mi05PC9w

YWdlcz48dm9sdW1lPjUyPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdv

cmQ+Q2VyZWJyb3Zhc2N1bGFyIERpc29yZGVycy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5

d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaWFiZXRlcyBNZWxsaXR1cywgVHlw

ZSAyL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPkV2aWRlbmNlLUJhc2VkIE1lZGlj

aW5lPC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBTdGF0dXMgSW5kaWNhdG9yczwva2V5d29yZD48

a2V5d29yZD5IZWFydCBGYWlsdXJlL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5MaWtlbGlob29kIEZ1bmN0aW9uczwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtIFN0YWdpbmc8L2tleXdvcmQ+PGtl

eXdvcmQ+KlByb3N0YXRpYyBOZW9wbGFzbXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdv

cmQ+UHJvc3RhdGljIE5lb3BsYXNtcy9wYSBbUGF0aG9sb2d5XTwva2V5d29yZD48a2V5d29yZD4q

UHJvc3RhdGljIE5lb3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9u

YXJ5IERpc2Vhc2UsIENocm9uaWMgT2JzdHJ1Y3RpdmUvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+

PGtleXdvcmQ+U0VFUiBQcm9ncmFtPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIFJhdGU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctMTk0ODwvaXNibj48YWNj

ZXNzaW9uLW51bT4yNDgyNDUzNTwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZl

IFN0dWR5JiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0ODI0

NTM1PC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51

cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAw

NCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lk

PWluZm86c2lkL092aWQ6bWVkbCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZv

OmRvaS8xMC4xMDk3JTJGTUxSLjAwMDAwMDAwMDAwMDAxMTMmYW1wO3JmdF9pZD1pbmZvOnBtaWQv

MjQ4MjQ1MzUmYW1wO3JmdC5pc3NuPTAwMjUtNzA3OSZhbXA7cmZ0LnZvbHVtZT01MiZhbXA7cmZ0

Lmlzc3VlPTYmYW1wO3JmdC5zcGFnZT00ODImYW1wO3JmdC5wYWdlcz00ODItOSZhbXA7cmZ0LmRh

dGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1NZWRpY2FsK0NhcmUmYW1wO3JmdC5hdGl0bGU9UHJvc3Rh

dGUrY2FuY2VyK3RyZWF0bWVudCthbmQrc3Vydml2YWwlM0ErZXZpZGVuY2UrZm9yK21lbit3aXRo

K3ByZXZhbGVudCtjb21vcmJpZCtjb25kaXRpb25zLiZhbXA7cmZ0LmF1bGFzdD1CcmFkbGV5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4xMDk3L01MUi4wMDAwMDAwMDAwMDAwMTEzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5h

bWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PENpdGU+PEF1dGhvcj5FYXJsZTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4x

OTk1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xOTk1PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2Fm

ZWU5enBwIiB0aW1lc3RhbXA9IjE0MjA3NTI4NzMiPjE5OTU8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPkVhcmxlLCBDLiBDLjwvYXV0aG9yPjxhdXRob3I+VHNhaSwgSi4g

Uy48L2F1dGhvcj48YXV0aG9yPkdlbGJlciwgUi4gRC48L2F1dGhvcj48YXV0aG9yPldlaW5zdGVp

biwgTS4gQy48L2F1dGhvcj48YXV0aG9yPk5ldW1hbm4sIFAuIEouPC9hdXRob3I+PGF1dGhvcj5X

ZWVrcywgSi4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5DZW50ZXIgZm9yIE91dGNvbWVzIGFuZCBQb2xpY3kgUmVzZWFyY2gsIERhbmEtRmFyYmVyIENh

bmNlciBJbnN0aXR1dGUsIEJvc3RvbiwgTUEgMDIxMTUsIFVTQS4gY3JhaWdfZWFybGVAZGZjaS5o

YXJ2YXJkLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdGl2ZW5lc3Mgb2Yg

Y2hlbW90aGVyYXB5IGZvciBhZHZhbmNlZCBsdW5nIGNhbmNlciBpbiB0aGUgZWxkZXJseTogaW5z

dHJ1bWVudGFsIHZhcmlhYmxlIGFuZCBwcm9wZW5zaXR5IGFuYWx5c2lzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5K

IENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDY0LTcwPC9wYWdl

cz48dm9sdW1lPjE5PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9wbGFzdGljIEFnZW50cy90dSBbVGhlcmFw

ZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD4qQ2FyY2lub21hLCBOb24tU21hbGwtQ2VsbCBM

dW5nL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3

b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+Kkx1bmcgTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvYmFiaWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

cG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Tb2Npb2Vjb25vbWljIEZhY3RvcnM8L2tleXdvcmQ+

PGtleXdvcmQ+MCAoQW50aW5lb3BsYXN0aWMgQWdlbnRzKTwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDAxPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViIDE1PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDczMi0xODNYPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjExMTgx

NjcwPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29tcGFyYXRpdmUgU3R1ZHkmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ0JmFtcDtBTj0x

MTE4MTY3MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9v

cGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4

LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jm

cl9pZD1pbmZvOnNpZC9PdmlkOm1lZDQmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9

aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzExMTgxNjcwJmFtcDtyZnQuaXNzbj0wNzMy

LTE4M1gmYW1wO3JmdC52b2x1bWU9MTkmYW1wO3JmdC5pc3N1ZT00JmFtcDtyZnQuc3BhZ2U9MTA2

NCZhbXA7cmZ0LnBhZ2VzPTEwNjQtNzAmYW1wO3JmdC5kYXRlPTIwMDEmYW1wO3JmdC5qdGl0bGU9

Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1FZmZlY3RpdmVuZXNz

K29mK2NoZW1vdGhlcmFweStmb3IrYWR2YW5jZWQrbHVuZytjYW5jZXIraW4rdGhlK2VsZGVybHkl

M0EraW5zdHJ1bWVudGFsK3ZhcmlhYmxlK2FuZCtwcm9wZW5zaXR5K2FuYWx5c2lzLiZhbXA7cmZ0

LmF1bGFzdD1FYXJsZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNl

LW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFn

ZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HcmFubjwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4xNzg0PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj4xNzg0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjEzNzU4

Mjc4ODIiPjE3ODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdyYW5u

LCBBRjwvYXV0aG9yPjxhdXRob3I+RnJvc2xldiwgVDwvYXV0aG9yPjxhdXRob3I+T2xlc2VuLCBB

QjwvYXV0aG9yPjxhdXRob3I+U2NobWlkdCwgSDwvYXV0aG9yPjxhdXRob3I+TGFzaCwgVC4gTC48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+VGhlIGltcGFj

dCBvZiBjb21vcmJpZGl0eSBhbmQgc3RhZ2Ugb24gcHJvZ25vc2lzIG9mIERhbmlzaCBtZWxhbm9t

YSBwYXRpZW50cywgMTk4Ny0yMDA5OiBhIHJlZ2lzdHJ5LWJhc2VkIGNvaG9ydCBzdHVkeTwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CciBKIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBDYW5jZXI8L2Z1bGwt

dGl0bGU+PGFiYnItMT5CciBKIENhbmNlcjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MjY1

LTcxPC9wYWdlcz48dm9sdW1lPjEwOTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwv

ZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkdyb3NzPC9B

dXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjQwNTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

MjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAiPjQwNTwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3Jvc3MsIEMuIFAuPC9hdXRo

b3I+PGF1dGhvcj5NY0F2YXksIEcuIEouPC9hdXRob3I+PGF1dGhvcj5HdW8sIFouPC9hdXRob3I+

PGF1dGhvcj5UaW5ldHRpLCBNLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5UaGUgaW1wYWN0IG9mIGNocm9uaWMgaWxsbmVzc2VzIG9uIHRoZSB1c2Ug

YW5kIGVmZmVjdGl2ZW5lc3Mgb2YgYWRqdXZhbnQgY2hlbW90aGVyYXB5IGZvciBjb2xvbiBjYW5j

ZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2FuY2VyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2Fu

Y2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNDEwLTk8L3BhZ2VzPjx2b2x1bWU+MTA5

PC92b2x1bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjwvZGF0

ZXM+PGFjY2Vzc2lvbi1udW0+MTc1MTA5NzM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkplaG48L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+MTkwNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTkwNzwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVw

eGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDA1NTYxMzA3Ij4xOTA3PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KZWhuLCBDLiBGLjwvYXV0aG9yPjxhdXRob3I+

Qm9uaW5nLCBMLjwvYXV0aG9yPjxhdXRob3I+S3JvbmluZywgSC48L2F1dGhvcj48YXV0aG9yPlBl

enp1dHRvLCBBLjwvYXV0aG9yPjxhdXRob3I+THVmdG5lciwgRC48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpemluaXNjaGUgS2xpbmlrIG0uIFMuIEhh

bWF0b2xvZ2llLCBPbmtvbG9naWUgdW5kIFR1bW9yaW1tdW5vbG9naWUsIENoYXJpdGUgQ2FtcHVz

IFZpcmNob3ctS2xpbmlrdW0sIFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55LiBF

bGVjdHJvbmljIGFkZHJlc3M6IGNocmlzdGlhbi5qZWhuQGNoYXJpdGUuZGUuJiN4RDtPbmtvbG9n

aXNjaGUgUHJheGlzIEVsaXNlbmhvZiwgTXVuY2hlbiwgR2VybWFueS4mI3hEO0dlbWVpbnNjaGFm

dHNwcmF4aXMgZnVyIEhhbWF0b2xvZ2llIHVuZCBPbmtvbG9naWUsIE1hZ2RlYnVyZywgR2VybWFu

eS4mI3hEO01lZGl6aW5pc2NoZSBLbGluaWsgbS4gUy4gSGFtYXRvbG9naWUsIE9ua29sb2dpZSB1

bmQgVHVtb3JpbW11bm9sb2dpZSwgQ2hhcml0ZSBDYW1wdXMgQmVuamFtaW4gRnJhbmtsaW4sIFVu

aXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkluZmx1ZW5jZSBvZiBjb21vcmJpZGl0eSwgYWdlIGFuZCBwZXJmb3JtYW5jZSBzdGF0

dXMgb24gdHJlYXRtZW50IGVmZmljYWN5IGFuZCBzYWZldHkgb2YgY2V0dXhpbWFiIHBsdXMgaXJp

bm90ZWNhbiBpbiBpcmlub3RlY2FuLXJlZnJhY3RvcnkgZWxkZXJseSBwYXRpZW50cyB3aXRoIG1l

dGFzdGF0aWMgY29sb3JlY3RhbCBjYW5jZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3Bl

YW4gSm91cm5hbCBvZiBDYW5jZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1ciBKIENh

bmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFu

IEpvdXJuYWwgb2YgQ2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEogQ2FuY2VyPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBKb3Vy

bmFsIG9mIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkV1ciBKIENhbmNlcjwvYWJici0xPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEyNjktNzU8L3BhZ2VzPjx2b2x1bWU+NTA8L3ZvbHVtZT48

bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5B

Z2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFs

LCBIdW1hbml6ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtl

eXdvcmQ+KkFudGluZW9wbGFzdGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUg

W1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FtcHRvdGhlY2luL2FkIFtBZG1p

bmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNhbXB0b3RoZWNpbi9h

YSBbQW5hbG9ncyAmYW1wOyBEZXJpdmF0aXZlc108L2tleXdvcmQ+PGtleXdvcmQ+KkNvbG9yZWN0

YWwgTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9yZWN0

YWwgTmVvcGxhc21zL3BhIFtQYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UtRnJlZSBTdXJ2aXZhbDwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFN0YXR1czwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD4wIChBbnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1hbml6

ZWQpPC9rZXl3b3JkPjxrZXl3b3JkPjc2NzMzMjYwNDIgKGlyaW5vdGVjYW4pPC9rZXl3b3JkPjxr

ZXl3b3JkPlBRWDBEOEoyMUogKGNldHV4aW1hYik8L2tleXdvcmQ+PGtleXdvcmQ+WFQzWjU0WjI4

QSAoQ2FtcHRvdGhlY2luKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTg3OS0wODUyPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTAzMDI3PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0NTAzMDI3PC91cmw+PHVybD5odHRwOi8v

b3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5H

VE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5m

bzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkbCZh

bXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDE2JTJGai5lamNh

LjIwMTQuMDEuMDA1JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0NTAzMDI3JmFtcDtyZnQuaXNzbj0w

OTU5LTgwNDkmYW1wO3JmdC52b2x1bWU9NTAmYW1wO3JmdC5pc3N1ZT03JmFtcDtyZnQuc3BhZ2U9

MTI2OSZhbXA7cmZ0LnBhZ2VzPTEyNjktNzUmYW1wO3JmdC5kYXRlPTIwMTQmYW1wO3JmdC5qdGl0

bGU9RXVyb3BlYW4rSm91cm5hbCtvZitDYW5jZXImYW1wO3JmdC5hdGl0bGU9SW5mbHVlbmNlK29m

K2NvbW9yYmlkaXR5JTJDK2FnZSthbmQrcGVyZm9ybWFuY2Urc3RhdHVzK29uK3RyZWF0bWVudCtl

ZmZpY2FjeSthbmQrc2FmZXR5K29mK2NldHV4aW1hYitwbHVzK2lyaW5vdGVjYW4raW4raXJpbm90

ZWNhbi1yZWZyYWN0b3J5K2VsZGVybHkrcGF0aWVudHMrd2l0aCttZXRhc3RhdGljK2NvbG9yZWN0

YWwrY2FuY2VyLiZhbXA7cmZ0LmF1bGFzdD1KZWhuPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouZWpj

YS4yMDE0LjAxLjAwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1u

YW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2FyZmF0aTwv

QXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xOTk2PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj4xOTk2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MjA3

NjcxNjUiPjE5OTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhcmZh

dGksIEQ8L2F1dGhvcj48YXV0aG9yPkd1cm5leSwgSjwvYXV0aG9yPjxhdXRob3I+U3RhbmxleSwg

SjwvYXV0aG9yPjxhdXRob3I+S29lYSwgSjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48dGl0bGVzPjx0aXRsZT5BIHJldHJvc3BlY3RpdmUgY29ob3J0IHN0dWR5IG9mIHBhdGllbnRz

IHdpdGggc3RvbWFjaCBhbmQgbGl2ZXIgY2FuY2VyczogdGhlIGltcGFjdCBvZiBjb21vcmJpZGl0

eSBhbmQgZXRobmljaXR5IG9uIGNhbmNlciBjYXJlIGFuZCBvdXRjb21lczwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5CTUMgQ2FuY2VyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Qk1DIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkJNQyBDYW5jZXI8

L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjgyMTwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1l

PjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwv

Q2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmRvbGxhaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

PFJlY051bT4xOTkzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig5LCAxMi0xNyk8L0Rpc3BsYXlUZXh0

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk5MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGlt

ZXN0YW1wPSIxNDIwNzUyODczIj4xOTkzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5BYmRvbGxhaCwgRi48L2F1dGhvcj48YXV0aG9yPlN1biwgTS48L2F1dGhvcj48YXV0

aG9yPlNjaG1pdGdlcywgSi48L2F1dGhvcj48YXV0aG9yPlRodXJldCwgUi48L2F1dGhvcj48YXV0

aG9yPkJpYW5jaGksIE0uPC9hdXRob3I+PGF1dGhvcj5TaGFyaWF0LCBTLiBGLjwvYXV0aG9yPjxh

dXRob3I+QnJpZ2FudGksIEEuPC9hdXRob3I+PGF1dGhvcj5KZWxkcmVzLCBDLjwvYXV0aG9yPjxh

dXRob3I+UGVycm90dGUsIFAuPC9hdXRob3I+PGF1dGhvcj5Nb250b3JzaSwgRi48L2F1dGhvcj48

YXV0aG9yPkthcmFraWV3aWN6LCBQLiBJLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkNhbmNlciBQcm9nbm9zdGljcyBhbmQgSGVhbHRoIE91dGNvbWVzIFVu

aXQsIFVuaXZlcnNpdHkgb2YgTW9udHJlYWwgSGVhbHRoIENlbnRyZSwgTW9udHJlYWwsIFF1ZWJl

YywgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlN1cnZpdmFsIGJlbmVmaXQg

b2YgcmFkaWNhbCBwcm9zdGF0ZWN0b215IGluIHBhdGllbnRzIHdpdGggbG9jYWxpemVkIHByb3N0

YXRlIGNhbmNlcjogZXN0aW1hdGlvbnMgb2YgdGhlIG51bWJlciBuZWVkZWQgdG8gdHJlYXQgYWNj

b3JkaW5nIHRvIHR1bW9yIGFuZCBwYXRpZW50IGNoYXJhY3RlcmlzdGljczwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIFVyb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkogVXJvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgVXJvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgVXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkogVXJvbDwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjczLTgzPC9wYWdlcz48dm9sdW1lPjE4ODwv

dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwv

a2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVy

PC9rZXl3b3JkPjxrZXl3b3JkPkNhbmFkYS9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5

d29yZD5FdXJvcGUvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+KkhlYWx0aCBT

ZXJ2aWNlcyBOZWVkcyBhbmQgRGVtYW5kL3V0IFtVdGlsaXphdGlvbl08L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25v

c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3BlbnNpdHkgU2NvcmU8L2tleXdvcmQ+PGtleXdvcmQ+

KlByb3N0YXRlL3BhIFtQYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0YXRlL3N1IFtT

dXJnZXJ5XTwva2V5d29yZD48a2V5d29yZD4qUHJvc3RhdGVjdG9teS9tdCBbTWV0aG9kc108L2tl

eXdvcmQ+PGtleXdvcmQ+UHJvc3RhdGVjdG9teS9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5

d29yZD5Qcm9zdGF0aWMgTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipQcm9zdGF0aWMgTmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPlBy

b3N0YXRpYyBOZW9wbGFzbXMvc3UgW1N1cmdlcnldPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD4qUmlzayBBc3Nlc3NtZW50L210IFtNZXRo

b2RzXTwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+KlNF

RVIgUHJvZ3JhbTwva2V5d29yZD48a2V5d29yZD5Tb2Npb2Vjb25vbWljIEZhY3RvcnM8L2tleXdv

cmQ+PGtleXdvcmQ+U3Vydml2YWwgUmF0ZS90ZCBbVHJlbmRzXTwva2V5d29yZD48a2V5d29yZD5U

aW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcCBbRXBpZGVtaW9s

b2d5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0

ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy0zNzkyPC9p

c2JuPjxhY2Nlc3Npb24tbnVtPjIyNTc4NzMyPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29t

cGFyYXRpdmUgU3R1ZHkmI3hEO011bHRpY2VudGVyIFN0dWR5JiN4RDtSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjU3ODczMjwvdXJsPjx1

cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdU

T04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92

YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9P

dmlkOm1lZGwmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTAx

NiUyRmouanVyby4yMDEyLjAzLjAwNSZhbXA7cmZ0X2lkPWluZm86cG1pZC8yMjU3ODczMiZhbXA7

cmZ0Lmlzc249MDAyMi01MzQ3JmFtcDtyZnQudm9sdW1lPTE4OCZhbXA7cmZ0Lmlzc3VlPTEmYW1w

O3JmdC5zcGFnZT03MyZhbXA7cmZ0LnBhZ2VzPTczLTgzJmFtcDtyZnQuZGF0ZT0yMDEyJmFtcDty

ZnQuanRpdGxlPUpvdXJuYWwrb2YrVXJvbG9neSZhbXA7cmZ0LmF0aXRsZT1TdXJ2aXZhbCtiZW5l

Zml0K29mK3JhZGljYWwrcHJvc3RhdGVjdG9teStpbitwYXRpZW50cyt3aXRoK2xvY2FsaXplZCtw

cm9zdGF0ZStjYW5jZXIlM0ErZXN0aW1hdGlvbnMrb2YrdGhlK251bWJlcituZWVkZWQrdG8rdHJl

YXQrYWNjb3JkaW5nK3RvK3R1bW9yK2FuZCtwYXRpZW50K2NoYXJhY3RlcmlzdGljcy4mYW1wO3Jm

dC5hdWxhc3Q9QWJkb2xsYWg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qdXJvLjIwMTIuMDMuMDA1

PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwv

cmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hu

b2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CcmFkbGV5PC9BdXRob3I+PFllYXI+

MjAxNDwvWWVhcj48UmVjTnVtPjE4ODM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE4ODM8

L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25k

YXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQwNDY5MDE0OSI+MTg4Mzwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJhZGxleSwgQy4gSi48L2F1

dGhvcj48YXV0aG9yPkRhaG1hbiwgQi48L2F1dGhvcj48YXV0aG9yPkFuc2NoZXIsIE0uPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudHMgb2Yg

KkhlYWx0aGNhcmUgUG9saWN5IGFuZCBSZXNlYXJjaCArUmFkaWF0aW9uIE9uY29sb2d5LCBWaXJn

aW5pYSBDb21tb253ZWFsdGggVW5pdmVyc2l0eSwgUmljaG1vbmQsIFZBLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPlByb3N0YXRlIGNhbmNlciB0cmVhdG1lbnQgYW5kIHN1cnZpdmFsOiBl

dmlkZW5jZSBmb3IgbWVuIHdpdGggcHJldmFsZW50IGNvbW9yYmlkIGNvbmRpdGlvbnM8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TWVkaWNhbCBDYXJlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5NZWQgQ2FyZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk1l

ZGljYWwgQ2FyZTwvZnVsbC10aXRsZT48YWJici0xPk1lZCBDYXJlPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5NZWRpY2FsIENhcmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5NZWQgQ2FyZTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ4Mi05PC9w

YWdlcz48dm9sdW1lPjUyPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2F1c2Ugb2YgRGVhdGg8L2tleXdvcmQ+PGtleXdv

cmQ+Q2VyZWJyb3Zhc2N1bGFyIERpc29yZGVycy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5

d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaWFiZXRlcyBNZWxsaXR1cywgVHlw

ZSAyL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPkV2aWRlbmNlLUJhc2VkIE1lZGlj

aW5lPC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBTdGF0dXMgSW5kaWNhdG9yczwva2V5d29yZD48

a2V5d29yZD5IZWFydCBGYWlsdXJlL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD5MaWtlbGlob29kIEZ1bmN0aW9uczwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtIFN0YWdpbmc8L2tleXdvcmQ+PGtl

eXdvcmQ+KlByb3N0YXRpYyBOZW9wbGFzbXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdv

cmQ+UHJvc3RhdGljIE5lb3BsYXNtcy9wYSBbUGF0aG9sb2d5XTwva2V5d29yZD48a2V5d29yZD4q

UHJvc3RhdGljIE5lb3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+UHVsbW9u

YXJ5IERpc2Vhc2UsIENocm9uaWMgT2JzdHJ1Y3RpdmUvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+

PGtleXdvcmQ+U0VFUiBQcm9ncmFtPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIFJhdGU8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRl

Pkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzctMTk0ODwvaXNibj48YWNj

ZXNzaW9uLW51bT4yNDgyNDUzNTwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZl

IFN0dWR5JiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0ODI0

NTM1PC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51

cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAw

NCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lk

PWluZm86c2lkL092aWQ6bWVkbCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZv

OmRvaS8xMC4xMDk3JTJGTUxSLjAwMDAwMDAwMDAwMDAxMTMmYW1wO3JmdF9pZD1pbmZvOnBtaWQv

MjQ4MjQ1MzUmYW1wO3JmdC5pc3NuPTAwMjUtNzA3OSZhbXA7cmZ0LnZvbHVtZT01MiZhbXA7cmZ0

Lmlzc3VlPTYmYW1wO3JmdC5zcGFnZT00ODImYW1wO3JmdC5wYWdlcz00ODItOSZhbXA7cmZ0LmRh

dGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1NZWRpY2FsK0NhcmUmYW1wO3JmdC5hdGl0bGU9UHJvc3Rh

dGUrY2FuY2VyK3RyZWF0bWVudCthbmQrc3Vydml2YWwlM0ErZXZpZGVuY2UrZm9yK21lbit3aXRo

K3ByZXZhbGVudCtjb21vcmJpZCtjb25kaXRpb25zLiZhbXA7cmZ0LmF1bGFzdD1CcmFkbGV5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4xMDk3L01MUi4wMDAwMDAwMDAwMDAwMTEzPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5h

bWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PENpdGU+PEF1dGhvcj5FYXJsZTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4x

OTk1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xOTk1PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2Fm

ZWU5enBwIiB0aW1lc3RhbXA9IjE0MjA3NTI4NzMiPjE5OTU8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPkVhcmxlLCBDLiBDLjwvYXV0aG9yPjxhdXRob3I+VHNhaSwgSi4g

Uy48L2F1dGhvcj48YXV0aG9yPkdlbGJlciwgUi4gRC48L2F1dGhvcj48YXV0aG9yPldlaW5zdGVp

biwgTS4gQy48L2F1dGhvcj48YXV0aG9yPk5ldW1hbm4sIFAuIEouPC9hdXRob3I+PGF1dGhvcj5X

ZWVrcywgSi4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5DZW50ZXIgZm9yIE91dGNvbWVzIGFuZCBQb2xpY3kgUmVzZWFyY2gsIERhbmEtRmFyYmVyIENh

bmNlciBJbnN0aXR1dGUsIEJvc3RvbiwgTUEgMDIxMTUsIFVTQS4gY3JhaWdfZWFybGVAZGZjaS5o

YXJ2YXJkLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdGl2ZW5lc3Mgb2Yg

Y2hlbW90aGVyYXB5IGZvciBhZHZhbmNlZCBsdW5nIGNhbmNlciBpbiB0aGUgZWxkZXJseTogaW5z

dHJ1bWVudGFsIHZhcmlhYmxlIGFuZCBwcm9wZW5zaXR5IGFuYWx5c2lzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48

YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5K

IENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDY0LTcwPC9wYWdl

cz48dm9sdW1lPjE5PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9wbGFzdGljIEFnZW50cy90dSBbVGhlcmFw

ZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD4qQ2FyY2lub21hLCBOb24tU21hbGwtQ2VsbCBM

dW5nL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3

b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+Kkx1bmcgTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvYmFiaWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

cG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Tb2Npb2Vjb25vbWljIEZhY3RvcnM8L2tleXdvcmQ+

PGtleXdvcmQ+MCAoQW50aW5lb3BsYXN0aWMgQWdlbnRzKTwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDAxPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViIDE1PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDczMi0xODNYPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjExMTgx

NjcwPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29tcGFyYXRpdmUgU3R1ZHkmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ0JmFtcDtBTj0x

MTE4MTY3MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9v

cGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4

LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jm

cl9pZD1pbmZvOnNpZC9PdmlkOm1lZDQmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9

aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzExMTgxNjcwJmFtcDtyZnQuaXNzbj0wNzMy

LTE4M1gmYW1wO3JmdC52b2x1bWU9MTkmYW1wO3JmdC5pc3N1ZT00JmFtcDtyZnQuc3BhZ2U9MTA2

NCZhbXA7cmZ0LnBhZ2VzPTEwNjQtNzAmYW1wO3JmdC5kYXRlPTIwMDEmYW1wO3JmdC5qdGl0bGU9

Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1FZmZlY3RpdmVuZXNz

K29mK2NoZW1vdGhlcmFweStmb3IrYWR2YW5jZWQrbHVuZytjYW5jZXIraW4rdGhlK2VsZGVybHkl

M0EraW5zdHJ1bWVudGFsK3ZhcmlhYmxlK2FuZCtwcm9wZW5zaXR5K2FuYWx5c2lzLiZhbXA7cmZ0

LmF1bGFzdD1FYXJsZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNl

LW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFn

ZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HcmFubjwv

QXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4xNzg0PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj4xNzg0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjEzNzU4

Mjc4ODIiPjE3ODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdyYW5u

LCBBRjwvYXV0aG9yPjxhdXRob3I+RnJvc2xldiwgVDwvYXV0aG9yPjxhdXRob3I+T2xlc2VuLCBB

QjwvYXV0aG9yPjxhdXRob3I+U2NobWlkdCwgSDwvYXV0aG9yPjxhdXRob3I+TGFzaCwgVC4gTC48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+VGhlIGltcGFj

dCBvZiBjb21vcmJpZGl0eSBhbmQgc3RhZ2Ugb24gcHJvZ25vc2lzIG9mIERhbmlzaCBtZWxhbm9t

YSBwYXRpZW50cywgMTk4Ny0yMDA5OiBhIHJlZ2lzdHJ5LWJhc2VkIGNvaG9ydCBzdHVkeTwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CciBKIENhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz

PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBDYW5jZXI8L2Z1bGwt

dGl0bGU+PGFiYnItMT5CciBKIENhbmNlcjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MjY1

LTcxPC9wYWdlcz48dm9sdW1lPjEwOTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwv

ZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkdyb3NzPC9B

dXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjQwNTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+NDA1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

MjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjAiPjQwNTwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3Jvc3MsIEMuIFAuPC9hdXRo

b3I+PGF1dGhvcj5NY0F2YXksIEcuIEouPC9hdXRob3I+PGF1dGhvcj5HdW8sIFouPC9hdXRob3I+

PGF1dGhvcj5UaW5ldHRpLCBNLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5UaGUgaW1wYWN0IG9mIGNocm9uaWMgaWxsbmVzc2VzIG9uIHRoZSB1c2Ug

YW5kIGVmZmVjdGl2ZW5lc3Mgb2YgYWRqdXZhbnQgY2hlbW90aGVyYXB5IGZvciBjb2xvbiBjYW5j

ZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2FuY2VyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2Fu

Y2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNDEwLTk8L3BhZ2VzPjx2b2x1bWU+MTA5

PC92b2x1bWU+PG51bWJlcj4xMjwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjwvZGF0

ZXM+PGFjY2Vzc2lvbi1udW0+MTc1MTA5NzM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkplaG48L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+MTkwNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTkwNzwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVw

eGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDA1NTYxMzA3Ij4xOTA3PC9rZXk+PC9mb3Jl

aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj

b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KZWhuLCBDLiBGLjwvYXV0aG9yPjxhdXRob3I+

Qm9uaW5nLCBMLjwvYXV0aG9yPjxhdXRob3I+S3JvbmluZywgSC48L2F1dGhvcj48YXV0aG9yPlBl

enp1dHRvLCBBLjwvYXV0aG9yPjxhdXRob3I+THVmdG5lciwgRC48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NZWRpemluaXNjaGUgS2xpbmlrIG0uIFMuIEhh

bWF0b2xvZ2llLCBPbmtvbG9naWUgdW5kIFR1bW9yaW1tdW5vbG9naWUsIENoYXJpdGUgQ2FtcHVz

IFZpcmNob3ctS2xpbmlrdW0sIFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55LiBF

bGVjdHJvbmljIGFkZHJlc3M6IGNocmlzdGlhbi5qZWhuQGNoYXJpdGUuZGUuJiN4RDtPbmtvbG9n

aXNjaGUgUHJheGlzIEVsaXNlbmhvZiwgTXVuY2hlbiwgR2VybWFueS4mI3hEO0dlbWVpbnNjaGFm

dHNwcmF4aXMgZnVyIEhhbWF0b2xvZ2llIHVuZCBPbmtvbG9naWUsIE1hZ2RlYnVyZywgR2VybWFu

eS4mI3hEO01lZGl6aW5pc2NoZSBLbGluaWsgbS4gUy4gSGFtYXRvbG9naWUsIE9ua29sb2dpZSB1

bmQgVHVtb3JpbW11bm9sb2dpZSwgQ2hhcml0ZSBDYW1wdXMgQmVuamFtaW4gRnJhbmtsaW4sIFVu

aXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPkluZmx1ZW5jZSBvZiBjb21vcmJpZGl0eSwgYWdlIGFuZCBwZXJmb3JtYW5jZSBzdGF0

dXMgb24gdHJlYXRtZW50IGVmZmljYWN5IGFuZCBzYWZldHkgb2YgY2V0dXhpbWFiIHBsdXMgaXJp

bm90ZWNhbiBpbiBpcmlub3RlY2FuLXJlZnJhY3RvcnkgZWxkZXJseSBwYXRpZW50cyB3aXRoIG1l

dGFzdGF0aWMgY29sb3JlY3RhbCBjYW5jZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3Bl

YW4gSm91cm5hbCBvZiBDYW5jZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1ciBKIENh

bmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFu

IEpvdXJuYWwgb2YgQ2FuY2VyPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEogQ2FuY2VyPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBKb3Vy

bmFsIG9mIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkV1ciBKIENhbmNlcjwvYWJici0xPjwv

YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEyNjktNzU8L3BhZ2VzPjx2b2x1bWU+NTA8L3ZvbHVtZT48

bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdv

cmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5B

Z2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5BbnRpYm9kaWVzLCBNb25vY2xvbmFs

LCBIdW1hbml6ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtl

eXdvcmQ+KkFudGluZW9wbGFzdGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUg

W1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FtcHRvdGhlY2luL2FkIFtBZG1p

bmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNhbXB0b3RoZWNpbi9h

YSBbQW5hbG9ncyAmYW1wOyBEZXJpdmF0aXZlc108L2tleXdvcmQ+PGtleXdvcmQ+KkNvbG9yZWN0

YWwgTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbG9yZWN0

YWwgTmVvcGxhc21zL3BhIFtQYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UtRnJlZSBTdXJ2aXZhbDwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFN0YXR1czwva2V5d29yZD48a2V5d29y

ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUg

QWdlZDwva2V5d29yZD48a2V5d29yZD4wIChBbnRpYm9kaWVzLCBNb25vY2xvbmFsLCBIdW1hbml6

ZWQpPC9rZXl3b3JkPjxrZXl3b3JkPjc2NzMzMjYwNDIgKGlyaW5vdGVjYW4pPC9rZXl3b3JkPjxr

ZXl3b3JkPlBRWDBEOEoyMUogKGNldHV4aW1hYik8L2tleXdvcmQ+PGtleXdvcmQ+WFQzWjU0WjI4

QSAoQ2FtcHRvdGhlY2luKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTg3OS0wODUyPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTAzMDI3PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0NTAzMDI3PC91cmw+PHVybD5odHRwOi8v

b3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5H

VE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5m

bzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkbCZh

bXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDE2JTJGai5lamNh

LjIwMTQuMDEuMDA1JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0NTAzMDI3JmFtcDtyZnQuaXNzbj0w

OTU5LTgwNDkmYW1wO3JmdC52b2x1bWU9NTAmYW1wO3JmdC5pc3N1ZT03JmFtcDtyZnQuc3BhZ2U9

MTI2OSZhbXA7cmZ0LnBhZ2VzPTEyNjktNzUmYW1wO3JmdC5kYXRlPTIwMTQmYW1wO3JmdC5qdGl0

bGU9RXVyb3BlYW4rSm91cm5hbCtvZitDYW5jZXImYW1wO3JmdC5hdGl0bGU9SW5mbHVlbmNlK29m

K2NvbW9yYmlkaXR5JTJDK2FnZSthbmQrcGVyZm9ybWFuY2Urc3RhdHVzK29uK3RyZWF0bWVudCtl

ZmZpY2FjeSthbmQrc2FmZXR5K29mK2NldHV4aW1hYitwbHVzK2lyaW5vdGVjYW4raW4raXJpbm90

ZWNhbi1yZWZyYWN0b3J5K2VsZGVybHkrcGF0aWVudHMrd2l0aCttZXRhc3RhdGljK2NvbG9yZWN0

YWwrY2FuY2VyLiZhbXA7cmZ0LmF1bGFzdD1KZWhuPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouZWpj

YS4yMDE0LjAxLjAwNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1u

YW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2FyZmF0aTwv

QXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xOTk2PC9SZWNOdW0+PHJlY29yZD48cmVj

LW51bWJlcj4xOTk2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MjA3

NjcxNjUiPjE5OTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhcmZh

dGksIEQ8L2F1dGhvcj48YXV0aG9yPkd1cm5leSwgSjwvYXV0aG9yPjxhdXRob3I+U3RhbmxleSwg

SjwvYXV0aG9yPjxhdXRob3I+S29lYSwgSjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48dGl0bGVzPjx0aXRsZT5BIHJldHJvc3BlY3RpdmUgY29ob3J0IHN0dWR5IG9mIHBhdGllbnRz

IHdpdGggc3RvbWFjaCBhbmQgbGl2ZXIgY2FuY2VyczogdGhlIGltcGFjdCBvZiBjb21vcmJpZGl0

eSBhbmQgZXRobmljaXR5IG9uIGNhbmNlciBjYXJlIGFuZCBvdXRjb21lczwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5CTUMgQ2FuY2VyPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Qk1DIENhbmNlcjwvZnVsbC10aXRsZT48YWJici0xPkJNQyBDYW5jZXI8

L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjgyMTwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1l

PjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwv

Q2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (9, 12-17) For example, Gross et al used propensity scores to adjust for background likelihood of receiving adjuvant chemotherapy for 5330 older patients with stage III colorectal cancer. ADDIN EN.CITE <EndNote><Cite><Author>Gross</Author><Year>2007</Year><RecNum>405</RecNum><DisplayText>(16)</DisplayText><record><rec-number>405</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="0">405</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gross, C. P.</author><author>McAvay, G. J.</author><author>Guo, Z.</author><author>Tinetti, M. E.</author></authors></contributors><titles><title>The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer</title><secondary-title>Cancer</secondary-title></titles><periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></periodical><pages>2410-9</pages><volume>109</volume><number>12</number><dates><year>2007</year></dates><accession-num>17510973</accession-num><urls></urls></record></Cite></EndNote>(16) They found lower likelihood of receipt of chemotherapy among patients with comorbidity, but clear and consistent survival advantages for those who were treated compared with those who were not. The risk of hospitalisation after treatment was not altered by receipt of adjuvant chemotherapy regardless of comorbidity. Both physical and mental comorbidity appear to be important. Depression at the time of cancer diagnosis, in particular, has been found to be associated with lower likelihood of treatment and poorer survival in a number of studies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb29kd2luPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48

UmVjTnVtPjIwNTQ8L1JlY051bT48RGlzcGxheVRleHQ+KDE4LTIxKTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yMDU0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3Rh

bXA9IjE0MzU0MzQ0MDIiPjIwNTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkdvb2R3aW4sIEouIFMuPC9hdXRob3I+PGF1dGhvcj5aaGFuZywgRC4gRC48L2F1dGhvcj48

YXV0aG9yPk9zdGlyLCBHLiBWLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkdvb2R3aW4sSmFtZXMgUy4gRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2lu

ZSBhbmQgU2VhbHkgQ2VudGVyIG9uIEFnaW5nLCBVbml2ZXJzaXR5IG9mIFRleGFzIE1lZGljYWwg

QnJhbmNoLCBHYWx2ZXN0b24sIFRleGFzLCBVU0EuIGpzZ29vZHdpQHV0bWIuZWR1PC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGRlcHJlc3Npb24gb24gZGlhZ25vc2lzLCB0

cmVhdG1lbnQsIGFuZCBzdXJ2aXZhbCBvZiBvbGRlciB3b21lbiB3aXRoIGJyZWFzdCBjYW5jZXI8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiB0aGUgQW1lcmljYW4gR2VyaWF0cmlj

cyBTb2NpZXR5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIEFtIEdlcmlhdHIgU29jPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUg

QW1lcmljYW4gR2VyaWF0cmljcyBTb2NpZXR5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xMDYtMTE8L3BhZ2VzPjx2b2x1bWU+NTI8L3ZvbHVtZT48bnVt

YmVyPjE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD4q

QnJlYXN0IE5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD4qQnJlYXN0

IE5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD4qQnJlYXN0IE5lb3Bs

YXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkRlcHJlc3Npb24vZXAgW0VwaWRl

bWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

cG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+

U0VFUiBQcm9ncmFtPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3Jk

PjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDItODYxNDwvaXNibj48YWNjZXNzaW9uLW51bT4x

NDY4NzMyMzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIFUuUy4g

R292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNDY4NzMyMzwvdXJsPjx1cmw+

aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04v

V0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxf

Zm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9Pdmlk

Om1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRf

aWQ9aW5mbzpwbWlkLzE0Njg3MzIzJmFtcDtyZnQuaXNzbj0wMDAyLTg2MTQmYW1wO3JmdC52b2x1

bWU9NTImYW1wO3JmdC5pc3N1ZT0xJmFtcDtyZnQuc3BhZ2U9MTA2JmFtcDtyZnQucGFnZXM9MTA2

LTExJmFtcDtyZnQuZGF0ZT0yMDA0JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrdGhlK0FtZXJp

Y2FuK0dlcmlhdHJpY3MrU29jaWV0eSZhbXA7cmZ0LmF0aXRsZT1FZmZlY3Qrb2YrZGVwcmVzc2lv

bitvbitkaWFnbm9zaXMlMkMrdHJlYXRtZW50JTJDK2FuZCtzdXJ2aXZhbCtvZitvbGRlcit3b21l

bit3aXRoK2JyZWFzdCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PUdvb2R3aW48L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+TklITVMyMDA0OCYjeEQ7UE1DMTg1MzI1MTwvY3VzdG9t

Mj48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENp

dGU+PEF1dGhvcj5QcmFzYWQ8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjA1Mzwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjA1MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpw

cCIgdGltZXN0YW1wPSIxNDM1NDM0NDAyIj4yMDUzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5QcmFzYWQsIFMuIE0uPC9hdXRob3I+PGF1dGhvcj5FZ2dlbmVyLCBTLiBF

LjwvYXV0aG9yPjxhdXRob3I+TGlwc2l0eiwgUy4gUi48L2F1dGhvcj48YXV0aG9yPklyd2luLCBN

LiBSLjwvYXV0aG9yPjxhdXRob3I+R2FueiwgUC4gQS48L2F1dGhvcj48YXV0aG9yPkh1LCBKLiBD

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByYXNhZCxT

YW5kaXAgTS4gU2FuZGlwIE0uIFByYXNhZCwgTWVkaWNhbCBVbml2ZXJzaXR5IG9mIFNvdXRoIENh

cm9saW5hLCBDaGFybGVzdG9uLCBTQzsgU2NvdHQgRS4gRWdnZW5lciwgVW5pdmVyc2l0eSBvZiBD

aGljYWdvIE1lZGljYWwgQ2VudGVyLCBDaGljYWdvLCBJTDsgU3R1YXJ0IFIuIExpcHNpdHosIEJy

aWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCwgQm9zdG9uLCBNQTsgTWljaGFlbCBSLiBJ

cndpbiBhbmQgUGF0cmljaWEgQS4gR2FueiwgRGF2aWQgR2VmZmVuIFNjaG9vbCBvZiBNZWRpY2lu

ZSBhdCB0aGUgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBMb3MgQW5nZWxlczsgYW5kIEppbSBD

LiBIdSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBMb3MgQW5nZWxlcywgTG9zIEFuZ2VsZXMs

IENBLiBFZ2dlbmVyLFNjb3R0IEUuIFNhbmRpcCBNLiBQcmFzYWQsIE1lZGljYWwgVW5pdmVyc2l0

eSBvZiBTb3V0aCBDYXJvbGluYSwgQ2hhcmxlc3RvbiwgU0M7IFNjb3R0IEUuIEVnZ2VuZXIsIFVu

aXZlcnNpdHkgb2YgQ2hpY2FnbyBNZWRpY2FsIENlbnRlciwgQ2hpY2FnbywgSUw7IFN0dWFydCBS

LiBMaXBzaXR6LCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEJvc3RvbiwgTUE7

IE1pY2hhZWwgUi4gSXJ3aW4gYW5kIFBhdHJpY2lhIEEuIEdhbnosIERhdmlkIEdlZmZlbiBTY2hv

b2wgb2YgTWVkaWNpbmUgYXQgdGhlIFVuaXZlcnNpdHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2Vs

ZXM7IGFuZCBKaW0gQy4gSHUsIFVuaXZlcnNpdHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXMs

IExvcyBBbmdlbGVzLCBDQS4gTGlwc2l0eixTdHVhcnQgUi4gU2FuZGlwIE0uIFByYXNhZCwgTWVk

aWNhbCBVbml2ZXJzaXR5IG9mIFNvdXRoIENhcm9saW5hLCBDaGFybGVzdG9uLCBTQzsgU2NvdHQg

RS4gRWdnZW5lciwgVW5pdmVyc2l0eSBvZiBDaGljYWdvIE1lZGljYWwgQ2VudGVyLCBDaGljYWdv

LCBJTDsgU3R1YXJ0IFIuIExpcHNpdHosIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRh

bCwgQm9zdG9uLCBNQTsgTWljaGFlbCBSLiBJcndpbiBhbmQgUGF0cmljaWEgQS4gR2FueiwgRGF2

aWQgR2VmZmVuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCB0aGUgVW5pdmVyc2l0eSBvZiBDYWxpZm9y

bmlhLCBMb3MgQW5nZWxlczsgYW5kIEppbSBDLiBIdSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlh

LCBMb3MgQW5nZWxlcywgTG9zIEFuZ2VsZXMsIENBLiBJcndpbixNaWNoYWVsIFIuIFNhbmRpcCBN

LiBQcmFzYWQsIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBTb3V0aCBDYXJvbGluYSwgQ2hhcmxlc3Rv

biwgU0M7IFNjb3R0IEUuIEVnZ2VuZXIsIFVuaXZlcnNpdHkgb2YgQ2hpY2FnbyBNZWRpY2FsIENl

bnRlciwgQ2hpY2FnbywgSUw7IFN0dWFydCBSLiBMaXBzaXR6LCBCcmlnaGFtIGFuZCBXb21lbiZh

cG9zO3MgSG9zcGl0YWwsIEJvc3RvbiwgTUE7IE1pY2hhZWwgUi4gSXJ3aW4gYW5kIFBhdHJpY2lh

IEEuIEdhbnosIERhdmlkIEdlZmZlbiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQgdGhlIFVuaXZlcnNp

dHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXM7IGFuZCBKaW0gQy4gSHUsIFVuaXZlcnNpdHkg

b2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXMsIExvcyBBbmdlbGVzLCBDQS4gR2FueixQYXRyaWNp

YSBBLiBTYW5kaXAgTS4gUHJhc2FkLCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgU291dGggQ2Fyb2xp

bmEsIENoYXJsZXN0b24sIFNDOyBTY290dCBFLiBFZ2dlbmVyLCBVbml2ZXJzaXR5IG9mIENoaWNh

Z28gTWVkaWNhbCBDZW50ZXIsIENoaWNhZ28sIElMOyBTdHVhcnQgUi4gTGlwc2l0eiwgQnJpZ2hh

bSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1BOyBNaWNoYWVsIFIuIElyd2lu

IGFuZCBQYXRyaWNpYSBBLiBHYW56LCBEYXZpZCBHZWZmZW4gU2Nob29sIG9mIE1lZGljaW5lIGF0

IHRoZSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzOyBhbmQgSmltIEMuIEh1

LCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzLCBMb3MgQW5nZWxlcywgQ0Eu

IEh1LEppbSBDLiBTYW5kaXAgTS4gUHJhc2FkLCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgU291dGgg

Q2Fyb2xpbmEsIENoYXJsZXN0b24sIFNDOyBTY290dCBFLiBFZ2dlbmVyLCBVbml2ZXJzaXR5IG9m

IENoaWNhZ28gTWVkaWNhbCBDZW50ZXIsIENoaWNhZ28sIElMOyBTdHVhcnQgUi4gTGlwc2l0eiwg

QnJpZ2hhbSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1BOyBNaWNoYWVsIFIu

IElyd2luIGFuZCBQYXRyaWNpYSBBLiBHYW56LCBEYXZpZCBHZWZmZW4gU2Nob29sIG9mIE1lZGlj

aW5lIGF0IHRoZSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzOyBhbmQgSmlt

IEMuIEh1LCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzLCBMb3MgQW5nZWxl

cywgQ0EuIGpjaHVAbWVkbmV0LnVjbGEuZWR1LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkVmZmVjdCBvZiBkZXByZXNzaW9uIG9uIGRpYWdub3NpcywgdHJlYXRtZW50LCBhbmQgbW9ydGFs

aXR5IG9mIG1lbiB3aXRoIGNsaW5pY2FsbHkgbG9jYWxpemVkIHByb3N0YXRlIGNhbmNlcjwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5KIENsaW4gT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRp

dGxlPjxhYmJyLTE+SiBDbGluIE9uY29sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxl

PjxhYmJyLTE+SiBDbGluIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjQ3

MS04PC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4yMzwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3

b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRlcHJlc3Npb24v

ZGkgW0RpYWdub3Npc108L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2lvbi9lcCBbRXBpZGVtaW9s

b2d5XTwva2V5d29yZD48a2V5d29yZD4qRGVwcmVzc2lvbi9weCBbUHN5Y2hvbG9neV08L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+UHJvc3RhdGljIE5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD5Q

cm9zdGF0aWMgTmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPipQcm9z

dGF0aWMgTmVvcGxhc21zL3B4IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9zdGF0

aWMgTmVvcGxhc21zL3RoIFtUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5TRUVSIFByb2dyYW08

L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVn

IDEwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjI1MDAyNzI4PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+T2JzZXJ2YXRpb25h

bCBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3YmYXBvczt0LCBOb24tUC5ILlMu

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRsJmFtcDtBTj0yNTAwMjcyODwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3Rl

ZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNF

U19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDpr

ZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1wO3JmdC5nZW5y

ZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTIwMCUyRkpDTy4yMDEzLjUxLjEwNDgm

YW1wO3JmdF9pZD1pbmZvOnBtaWQvMjUwMDI3MjgmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7

cmZ0LnZvbHVtZT0zMiZhbXA7cmZ0Lmlzc3VlPTIzJmFtcDtyZnQuc3BhZ2U9MjQ3MSZhbXA7cmZ0

LnBhZ2VzPTI0NzEtOCZhbXA7cmZ0LmRhdGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29m

K0NsaW5pY2FsK09uY29sb2d5JmFtcDtyZnQuYXRpdGxlPUVmZmVjdCtvZitkZXByZXNzaW9uK29u

K2RpYWdub3NpcyUyQyt0cmVhdG1lbnQlMkMrYW5kK21vcnRhbGl0eStvZittZW4rd2l0aCtjbGlu

aWNhbGx5K2xvY2FsaXplZCtwcm9zdGF0ZStjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PVByYXNhZDwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM0MTIxNTA1IFtBdmFpbGFibGUg

b24gMDgvMTAvMTVdPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHgu

ZG9pLm9yZy8xMC4xMjAwL0pDTy4yMDEzLjUxLjEwNDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0

ZT48QXV0aG9yPkZyZXllcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4yMDQ4PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBw

IiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkZyZXllciwgRy48L2F1dGhvcj48YXV0aG9yPkdlYXksIEouIEYuPC9hdXRo

b3I+PGF1dGhvcj5Ub3V6ZXQsIFMuPC9hdXRob3I+PGF1dGhvcj5Qcm92ZW5jYWwsIEouPC9hdXRo

b3I+PGF1dGhvcj5XZWJlciwgQi48L2F1dGhvcj48YXV0aG9yPkphY3F1aW4sIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5HYW5lbSwgRy48L2F1dGhvcj48YXV0aG9yPlR1YmlhbmEtTWF0aGlldSwgTi48

L2F1dGhvcj48YXV0aG9yPkdpc3Nlcm90LCBPLjwvYXV0aG9yPjxhdXRob3I+UHVqYWRlLUxhdXJh

aW5lLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZy

ZXllcixHLiBTZXJ2aWNlIGQmYXBvcztvbmNvbG9naWUgbWVkaWNhbGUsIENlbnRyZSBIb3NwaXRh

bGllciBMeW9uIFN1ZCwgUGllcnJlLUJlbml0ZS4gZ2lsbGVzLmZyZXllckBjaHUtbHlvbi5mcjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2VyaWF0cmljIGFzc2Vz

c21lbnQgcHJlZGljdHMgdG9sZXJhbmNlIHRvIGNoZW1vdGhlcmFweSBhbmQgc3Vydml2YWwgaW4g

ZWxkZXJseSBwYXRpZW50cyB3aXRoIGFkdmFuY2VkIG92YXJpYW4gY2FyY2lub21hOiBhIEdJTkVD

TyBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2YgT25jb2xvZ3k8L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVy

aW9kaWNhbD48cGFnZXM+MTc5NS04MDA8L3BhZ2VzPjx2b2x1bWU+MTY8L3ZvbHVtZT48bnVtYmVy

PjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdl

ZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9wbGFzdGljIENvbWJpbmVk

IENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtl

eXdvcmQ+Q2FyYm9wbGF0aW4vYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvZHQgW0RydWcgVGhlcmFweV08L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+

PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvc2MgW1NlY29uZGFyeV08L2tleXdvcmQ+PGtl

eXdvcmQ+Q3ljbG9waG9zcGhhbWlkZS9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwv

a2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9kdCBbRHJ1ZyBUaGVy

YXB5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9tbyBbTW9y

dGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9zYyBb

U2Vjb25kYXJ5XTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIFByb2dyZXNzaW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1heGltdW0gVG9sZXJh

dGVkIERvc2U8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJyZW5jZSwgTG9jYWwvZHQg

W0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJyZW5jZSwgTG9j

YWwvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk92YXJpYW4gTmVvcGxhc21zL2R0

IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipPdmFyaWFuIE5lb3BsYXNtcy9tbyBb

TW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5PdmFyaWFuIE5lb3BsYXNtcy9wYSBbUGF0aG9s

b2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZhbCBSYXRlPC9rZXl3b3JkPjxr

ZXl3b3JkPjhOM0RXNzI3MlAgKEN5Y2xvcGhvc3BoYW1pZGUpPC9rZXl3b3JkPjxrZXl3b3JkPkJH

M0Y2Mk9ORDUgKENhcmJvcGxhdGluKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDkyMy03NTM0PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDkzMjc1PC9hY2Nlc3Npb24t

bnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5v

bi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE2MDkzMjc1PC91cmw+PHVybD5o

dHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9X

RUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9m

bXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6

bWVkNSZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9p

ZD1pbmZvOnBtaWQvMTYwOTMyNzUmYW1wO3JmdC5pc3NuPTA5MjMtNzUzNCZhbXA7cmZ0LnZvbHVt

ZT0xNiZhbXA7cmZ0Lmlzc3VlPTExJmFtcDtyZnQuc3BhZ2U9MTc5NSZhbXA7cmZ0LnBhZ2VzPTE3

OTUtODAwJmFtcDtyZnQuZGF0ZT0yMDA1JmFtcDtyZnQuanRpdGxlPUFubmFscytvZitPbmNvbG9n

eSZhbXA7cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50K3ByZWRp

Y3RzK3RvbGVyYW5jZSt0bytjaGVtb3RoZXJhcHkrYW5kK3N1cnZpdmFsK2luK2VsZGVybHkrcGF0

aWVudHMrd2l0aCthZHZhbmNlZCtvdmFyaWFuK2NhcmNpbm9tYSUzQSthK0dJTkVDTytzdHVkeS4m

YW1wO3JmdC5hdWxhc3Q9RnJleWVyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUt

ZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFi

YXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PkV4dGVybWFubjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4yMDQ3PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yMDQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1l

c3RhbXA9IjE0MzUyOTM1NDciPjIwNDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkV4dGVybWFubiwgTS48L2F1dGhvcj48YXV0aG9yPkh1cnJpYSwgQS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5FeHRlcm1hbm4sTWFydGluZS4g

SC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciwgVW5pdmVyc2l0eSBvZiBTb3V0aCBGbG9yaWRh

LCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJtYW5uQG1vZmZpdHQudXNmLmVkdTwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2VyaWF0cmljIGFzc2Vzc21lbnQg

Zm9yIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkog

Q2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25j

b2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25jb2w8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODI0LTMxPC9wYWdlcz48dm9sdW1lPjI1

PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNvZ25pdGlvbjwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5

d29yZD48a2V5d29yZD5EaXNlYXNlIE1hbmFnZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+Kkdlcmlh

dHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtcy9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+TmVv

cGxhc21zL3BwIFtQaHlzaW9wYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9w

eCBbUHN5Y2hvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3RoIFtUaGVyYXB5XTwv

a2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zPC9rZXl3b3JkPjxrZXl3b3JkPk51dHJpdGlvbmFs

IFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb2x5cGhhcm1hY3k8L2tleXdvcmQ+PGtleXdvcmQ+

U29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVh

cj48cHViLWRhdGVzPjxkYXRlPk1heSAxMDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjE1MjctNzc1NTwvaXNibj48YWNjZXNzaW9uLW51bT4xNzQ4ODk4MDwvYWNjZXNzaW9uLW51bT48

d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCYjeEQ7UmVzZWFy

Y2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/

VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFt

cDtBTj0xNzQ4ODk4MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3Vw

LmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9

WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwm

YW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDty

ZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE3NDg4OTgwJmFtcDtyZnQuaXNz

bj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5pc3N1ZT0xNCZhbXA7cmZ0LnNw

YWdlPTE4MjQmYW1wO3JmdC5wYWdlcz0xODI0LTMxJmFtcDtyZnQuZGF0ZT0yMDA3JmFtcDtyZnQu

anRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9Q29tcHJl

aGVuc2l2ZStnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIrcGF0aWVudHMrd2l0aCtjYW5j

ZXIuJmFtcDtyZnQuYXVsYXN0PUV4dGVybWFubjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb29kd2luPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48

UmVjTnVtPjIwNTQ8L1JlY051bT48RGlzcGxheVRleHQ+KDE4LTIxKTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yMDU0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3Rh

bXA9IjE0MzU0MzQ0MDIiPjIwNTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkdvb2R3aW4sIEouIFMuPC9hdXRob3I+PGF1dGhvcj5aaGFuZywgRC4gRC48L2F1dGhvcj48

YXV0aG9yPk9zdGlyLCBHLiBWLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkdvb2R3aW4sSmFtZXMgUy4gRGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2lu

ZSBhbmQgU2VhbHkgQ2VudGVyIG9uIEFnaW5nLCBVbml2ZXJzaXR5IG9mIFRleGFzIE1lZGljYWwg

QnJhbmNoLCBHYWx2ZXN0b24sIFRleGFzLCBVU0EuIGpzZ29vZHdpQHV0bWIuZWR1PC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGRlcHJlc3Npb24gb24gZGlhZ25vc2lzLCB0

cmVhdG1lbnQsIGFuZCBzdXJ2aXZhbCBvZiBvbGRlciB3b21lbiB3aXRoIGJyZWFzdCBjYW5jZXI8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiB0aGUgQW1lcmljYW4gR2VyaWF0cmlj

cyBTb2NpZXR5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIEFtIEdlcmlhdHIgU29jPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUg

QW1lcmljYW4gR2VyaWF0cmljcyBTb2NpZXR5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xMDYtMTE8L3BhZ2VzPjx2b2x1bWU+NTI8L3ZvbHVtZT48bnVt

YmVyPjE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD4q

QnJlYXN0IE5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD4qQnJlYXN0

IE5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD4qQnJlYXN0IE5lb3Bs

YXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkRlcHJlc3Npb24vZXAgW0VwaWRl

bWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu

czwva2V5d29yZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv

cG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+

U0VFUiBQcm9ncmFtPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3Jk

PjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDItODYxNDwvaXNibj48YWNjZXNzaW9uLW51bT4x

NDY4NzMyMzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIFUuUy4g

R292JmFwb3M7dCwgUC5ILlMuPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNDY4NzMyMzwvdXJsPjx1cmw+

aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04v

V0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxf

Zm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9Pdmlk

Om1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRf

aWQ9aW5mbzpwbWlkLzE0Njg3MzIzJmFtcDtyZnQuaXNzbj0wMDAyLTg2MTQmYW1wO3JmdC52b2x1

bWU9NTImYW1wO3JmdC5pc3N1ZT0xJmFtcDtyZnQuc3BhZ2U9MTA2JmFtcDtyZnQucGFnZXM9MTA2

LTExJmFtcDtyZnQuZGF0ZT0yMDA0JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrdGhlK0FtZXJp

Y2FuK0dlcmlhdHJpY3MrU29jaWV0eSZhbXA7cmZ0LmF0aXRsZT1FZmZlY3Qrb2YrZGVwcmVzc2lv

bitvbitkaWFnbm9zaXMlMkMrdHJlYXRtZW50JTJDK2FuZCtzdXJ2aXZhbCtvZitvbGRlcit3b21l

bit3aXRoK2JyZWFzdCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PUdvb2R3aW48L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+TklITVMyMDA0OCYjeEQ7UE1DMTg1MzI1MTwvY3VzdG9t

Mj48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENp

dGU+PEF1dGhvcj5QcmFzYWQ8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjA1Mzwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjA1MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpw

cCIgdGltZXN0YW1wPSIxNDM1NDM0NDAyIj4yMDUzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10

eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1

dGhvcnM+PGF1dGhvcj5QcmFzYWQsIFMuIE0uPC9hdXRob3I+PGF1dGhvcj5FZ2dlbmVyLCBTLiBF

LjwvYXV0aG9yPjxhdXRob3I+TGlwc2l0eiwgUy4gUi48L2F1dGhvcj48YXV0aG9yPklyd2luLCBN

LiBSLjwvYXV0aG9yPjxhdXRob3I+R2FueiwgUC4gQS48L2F1dGhvcj48YXV0aG9yPkh1LCBKLiBD

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByYXNhZCxT

YW5kaXAgTS4gU2FuZGlwIE0uIFByYXNhZCwgTWVkaWNhbCBVbml2ZXJzaXR5IG9mIFNvdXRoIENh

cm9saW5hLCBDaGFybGVzdG9uLCBTQzsgU2NvdHQgRS4gRWdnZW5lciwgVW5pdmVyc2l0eSBvZiBD

aGljYWdvIE1lZGljYWwgQ2VudGVyLCBDaGljYWdvLCBJTDsgU3R1YXJ0IFIuIExpcHNpdHosIEJy

aWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCwgQm9zdG9uLCBNQTsgTWljaGFlbCBSLiBJ

cndpbiBhbmQgUGF0cmljaWEgQS4gR2FueiwgRGF2aWQgR2VmZmVuIFNjaG9vbCBvZiBNZWRpY2lu

ZSBhdCB0aGUgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBMb3MgQW5nZWxlczsgYW5kIEppbSBD

LiBIdSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBMb3MgQW5nZWxlcywgTG9zIEFuZ2VsZXMs

IENBLiBFZ2dlbmVyLFNjb3R0IEUuIFNhbmRpcCBNLiBQcmFzYWQsIE1lZGljYWwgVW5pdmVyc2l0

eSBvZiBTb3V0aCBDYXJvbGluYSwgQ2hhcmxlc3RvbiwgU0M7IFNjb3R0IEUuIEVnZ2VuZXIsIFVu

aXZlcnNpdHkgb2YgQ2hpY2FnbyBNZWRpY2FsIENlbnRlciwgQ2hpY2FnbywgSUw7IFN0dWFydCBS

LiBMaXBzaXR6LCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEJvc3RvbiwgTUE7

IE1pY2hhZWwgUi4gSXJ3aW4gYW5kIFBhdHJpY2lhIEEuIEdhbnosIERhdmlkIEdlZmZlbiBTY2hv

b2wgb2YgTWVkaWNpbmUgYXQgdGhlIFVuaXZlcnNpdHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2Vs

ZXM7IGFuZCBKaW0gQy4gSHUsIFVuaXZlcnNpdHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXMs

IExvcyBBbmdlbGVzLCBDQS4gTGlwc2l0eixTdHVhcnQgUi4gU2FuZGlwIE0uIFByYXNhZCwgTWVk

aWNhbCBVbml2ZXJzaXR5IG9mIFNvdXRoIENhcm9saW5hLCBDaGFybGVzdG9uLCBTQzsgU2NvdHQg

RS4gRWdnZW5lciwgVW5pdmVyc2l0eSBvZiBDaGljYWdvIE1lZGljYWwgQ2VudGVyLCBDaGljYWdv

LCBJTDsgU3R1YXJ0IFIuIExpcHNpdHosIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRh

bCwgQm9zdG9uLCBNQTsgTWljaGFlbCBSLiBJcndpbiBhbmQgUGF0cmljaWEgQS4gR2FueiwgRGF2

aWQgR2VmZmVuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCB0aGUgVW5pdmVyc2l0eSBvZiBDYWxpZm9y

bmlhLCBMb3MgQW5nZWxlczsgYW5kIEppbSBDLiBIdSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlh

LCBMb3MgQW5nZWxlcywgTG9zIEFuZ2VsZXMsIENBLiBJcndpbixNaWNoYWVsIFIuIFNhbmRpcCBN

LiBQcmFzYWQsIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBTb3V0aCBDYXJvbGluYSwgQ2hhcmxlc3Rv

biwgU0M7IFNjb3R0IEUuIEVnZ2VuZXIsIFVuaXZlcnNpdHkgb2YgQ2hpY2FnbyBNZWRpY2FsIENl

bnRlciwgQ2hpY2FnbywgSUw7IFN0dWFydCBSLiBMaXBzaXR6LCBCcmlnaGFtIGFuZCBXb21lbiZh

cG9zO3MgSG9zcGl0YWwsIEJvc3RvbiwgTUE7IE1pY2hhZWwgUi4gSXJ3aW4gYW5kIFBhdHJpY2lh

IEEuIEdhbnosIERhdmlkIEdlZmZlbiBTY2hvb2wgb2YgTWVkaWNpbmUgYXQgdGhlIFVuaXZlcnNp

dHkgb2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXM7IGFuZCBKaW0gQy4gSHUsIFVuaXZlcnNpdHkg

b2YgQ2FsaWZvcm5pYSwgTG9zIEFuZ2VsZXMsIExvcyBBbmdlbGVzLCBDQS4gR2FueixQYXRyaWNp

YSBBLiBTYW5kaXAgTS4gUHJhc2FkLCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgU291dGggQ2Fyb2xp

bmEsIENoYXJsZXN0b24sIFNDOyBTY290dCBFLiBFZ2dlbmVyLCBVbml2ZXJzaXR5IG9mIENoaWNh

Z28gTWVkaWNhbCBDZW50ZXIsIENoaWNhZ28sIElMOyBTdHVhcnQgUi4gTGlwc2l0eiwgQnJpZ2hh

bSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1BOyBNaWNoYWVsIFIuIElyd2lu

IGFuZCBQYXRyaWNpYSBBLiBHYW56LCBEYXZpZCBHZWZmZW4gU2Nob29sIG9mIE1lZGljaW5lIGF0

IHRoZSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzOyBhbmQgSmltIEMuIEh1

LCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzLCBMb3MgQW5nZWxlcywgQ0Eu

IEh1LEppbSBDLiBTYW5kaXAgTS4gUHJhc2FkLCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgU291dGgg

Q2Fyb2xpbmEsIENoYXJsZXN0b24sIFNDOyBTY290dCBFLiBFZ2dlbmVyLCBVbml2ZXJzaXR5IG9m

IENoaWNhZ28gTWVkaWNhbCBDZW50ZXIsIENoaWNhZ28sIElMOyBTdHVhcnQgUi4gTGlwc2l0eiwg

QnJpZ2hhbSBhbmQgV29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1BOyBNaWNoYWVsIFIu

IElyd2luIGFuZCBQYXRyaWNpYSBBLiBHYW56LCBEYXZpZCBHZWZmZW4gU2Nob29sIG9mIE1lZGlj

aW5lIGF0IHRoZSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzOyBhbmQgSmlt

IEMuIEh1LCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzLCBMb3MgQW5nZWxl

cywgQ0EuIGpjaHVAbWVkbmV0LnVjbGEuZWR1LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkVmZmVjdCBvZiBkZXByZXNzaW9uIG9uIGRpYWdub3NpcywgdHJlYXRtZW50LCBhbmQgbW9ydGFs

aXR5IG9mIG1lbiB3aXRoIGNsaW5pY2FsbHkgbG9jYWxpemVkIHByb3N0YXRlIGNhbmNlcjwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5KIENsaW4gT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRp

dGxlPjxhYmJyLTE+SiBDbGluIE9uY29sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxl

PjxhYmJyLTE+SiBDbGluIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjQ3

MS04PC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4yMzwvbnVtYmVyPjxrZXl3b3Jk

cz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3

b3JkPjxrZXl3b3JkPkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRlcHJlc3Npb24v

ZGkgW0RpYWdub3Npc108L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2lvbi9lcCBbRXBpZGVtaW9s

b2d5XTwva2V5d29yZD48a2V5d29yZD4qRGVwcmVzc2lvbi9weCBbUHN5Y2hvbG9neV08L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+UHJvc3RhdGljIE5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD5Q

cm9zdGF0aWMgTmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPipQcm9z

dGF0aWMgTmVvcGxhc21zL3B4IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9zdGF0

aWMgTmVvcGxhc21zL3RoIFtUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5TRUVSIFByb2dyYW08

L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVn

IDEwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjI1MDAyNzI4PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+T2JzZXJ2YXRpb25h

bCBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgVS5TLiBHb3YmYXBvczt0LCBOb24tUC5ILlMu

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRsJmFtcDtBTj0yNTAwMjcyODwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3Rl

ZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNF

U19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDpr

ZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1wO3JmdC5nZW5y

ZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTIwMCUyRkpDTy4yMDEzLjUxLjEwNDgm

YW1wO3JmdF9pZD1pbmZvOnBtaWQvMjUwMDI3MjgmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7

cmZ0LnZvbHVtZT0zMiZhbXA7cmZ0Lmlzc3VlPTIzJmFtcDtyZnQuc3BhZ2U9MjQ3MSZhbXA7cmZ0

LnBhZ2VzPTI0NzEtOCZhbXA7cmZ0LmRhdGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29m

K0NsaW5pY2FsK09uY29sb2d5JmFtcDtyZnQuYXRpdGxlPUVmZmVjdCtvZitkZXByZXNzaW9uK29u

K2RpYWdub3NpcyUyQyt0cmVhdG1lbnQlMkMrYW5kK21vcnRhbGl0eStvZittZW4rd2l0aCtjbGlu

aWNhbGx5K2xvY2FsaXplZCtwcm9zdGF0ZStjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PVByYXNhZDwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM0MTIxNTA1IFtBdmFpbGFibGUg

b24gMDgvMTAvMTVdPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHgu

ZG9pLm9yZy8xMC4xMjAwL0pDTy4yMDEzLjUxLjEwNDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0

ZT48QXV0aG9yPkZyZXllcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4yMDQ4PC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBw

IiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkZyZXllciwgRy48L2F1dGhvcj48YXV0aG9yPkdlYXksIEouIEYuPC9hdXRo

b3I+PGF1dGhvcj5Ub3V6ZXQsIFMuPC9hdXRob3I+PGF1dGhvcj5Qcm92ZW5jYWwsIEouPC9hdXRo

b3I+PGF1dGhvcj5XZWJlciwgQi48L2F1dGhvcj48YXV0aG9yPkphY3F1aW4sIEouIFAuPC9hdXRo

b3I+PGF1dGhvcj5HYW5lbSwgRy48L2F1dGhvcj48YXV0aG9yPlR1YmlhbmEtTWF0aGlldSwgTi48

L2F1dGhvcj48YXV0aG9yPkdpc3Nlcm90LCBPLjwvYXV0aG9yPjxhdXRob3I+UHVqYWRlLUxhdXJh

aW5lLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZy

ZXllcixHLiBTZXJ2aWNlIGQmYXBvcztvbmNvbG9naWUgbWVkaWNhbGUsIENlbnRyZSBIb3NwaXRh

bGllciBMeW9uIFN1ZCwgUGllcnJlLUJlbml0ZS4gZ2lsbGVzLmZyZXllckBjaHUtbHlvbi5mcjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2VyaWF0cmljIGFzc2Vz

c21lbnQgcHJlZGljdHMgdG9sZXJhbmNlIHRvIGNoZW1vdGhlcmFweSBhbmQgc3Vydml2YWwgaW4g

ZWxkZXJseSBwYXRpZW50cyB3aXRoIGFkdmFuY2VkIG92YXJpYW4gY2FyY2lub21hOiBhIEdJTkVD

TyBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2YgT25jb2xvZ3k8L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVy

aW9kaWNhbD48cGFnZXM+MTc5NS04MDA8L3BhZ2VzPjx2b2x1bWU+MTY8L3ZvbHVtZT48bnVtYmVy

PjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdl

ZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9wbGFzdGljIENvbWJpbmVk

IENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtl

eXdvcmQ+Q2FyYm9wbGF0aW4vYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvZHQgW0RydWcgVGhlcmFweV08L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+

PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvc2MgW1NlY29uZGFyeV08L2tleXdvcmQ+PGtl

eXdvcmQ+Q3ljbG9waG9zcGhhbWlkZS9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwv

a2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9kdCBbRHJ1ZyBUaGVy

YXB5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9tbyBbTW9y

dGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91cy9zYyBb

U2Vjb25kYXJ5XTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIFByb2dyZXNzaW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1heGltdW0gVG9sZXJh

dGVkIERvc2U8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJyZW5jZSwgTG9jYWwvZHQg

W0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJyZW5jZSwgTG9j

YWwvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk92YXJpYW4gTmVvcGxhc21zL2R0

IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipPdmFyaWFuIE5lb3BsYXNtcy9tbyBb

TW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5PdmFyaWFuIE5lb3BsYXNtcy9wYSBbUGF0aG9s

b2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3Bl

Y3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZhbCBSYXRlPC9rZXl3b3JkPjxr

ZXl3b3JkPjhOM0RXNzI3MlAgKEN5Y2xvcGhvc3BoYW1pZGUpPC9rZXl3b3JkPjxrZXl3b3JkPkJH

M0Y2Mk9ORDUgKENhcmJvcGxhdGluKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDkyMy03NTM0PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDkzMjc1PC9hY2Nlc3Npb24t

bnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5v

bi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE2MDkzMjc1PC91cmw+PHVybD5o

dHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9X

RUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9m

bXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6

bWVkNSZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9p

ZD1pbmZvOnBtaWQvMTYwOTMyNzUmYW1wO3JmdC5pc3NuPTA5MjMtNzUzNCZhbXA7cmZ0LnZvbHVt

ZT0xNiZhbXA7cmZ0Lmlzc3VlPTExJmFtcDtyZnQuc3BhZ2U9MTc5NSZhbXA7cmZ0LnBhZ2VzPTE3

OTUtODAwJmFtcDtyZnQuZGF0ZT0yMDA1JmFtcDtyZnQuanRpdGxlPUFubmFscytvZitPbmNvbG9n

eSZhbXA7cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50K3ByZWRp

Y3RzK3RvbGVyYW5jZSt0bytjaGVtb3RoZXJhcHkrYW5kK3N1cnZpdmFsK2luK2VsZGVybHkrcGF0

aWVudHMrd2l0aCthZHZhbmNlZCtvdmFyaWFuK2NhcmNpbm9tYSUzQSthK0dJTkVDTytzdHVkeS4m

YW1wO3JmdC5hdWxhc3Q9RnJleWVyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUt

ZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFi

YXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PkV4dGVybWFubjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4yMDQ3PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yMDQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1l

c3RhbXA9IjE0MzUyOTM1NDciPjIwNDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkV4dGVybWFubiwgTS48L2F1dGhvcj48YXV0aG9yPkh1cnJpYSwgQS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5FeHRlcm1hbm4sTWFydGluZS4g

SC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciwgVW5pdmVyc2l0eSBvZiBTb3V0aCBGbG9yaWRh

LCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJtYW5uQG1vZmZpdHQudXNmLmVkdTwvYXV0aC1h

ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2VyaWF0cmljIGFzc2Vzc21lbnQg

Zm9yIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkog

Q2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25j

b2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJu

YWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIENsaW4gT25jb2w8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODI0LTMxPC9wYWdlcz48dm9sdW1lPjI1

PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNvZ25pdGlvbjwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5

d29yZD48a2V5d29yZD5EaXNlYXNlIE1hbmFnZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+Kkdlcmlh

dHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtcy9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+TmVv

cGxhc21zL3BwIFtQaHlzaW9wYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9w

eCBbUHN5Y2hvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3RoIFtUaGVyYXB5XTwv

a2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zPC9rZXl3b3JkPjxrZXl3b3JkPk51dHJpdGlvbmFs

IFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb2x5cGhhcm1hY3k8L2tleXdvcmQ+PGtleXdvcmQ+

U29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVh

cj48cHViLWRhdGVzPjxkYXRlPk1heSAxMDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjE1MjctNzc1NTwvaXNibj48YWNjZXNzaW9uLW51bT4xNzQ4ODk4MDwvYWNjZXNzaW9uLW51bT48

d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCYjeEQ7UmVzZWFy

Y2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/

VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFt

cDtBTj0xNzQ4ODk4MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3Vw

LmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9

WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwm

YW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDty

ZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE3NDg4OTgwJmFtcDtyZnQuaXNz

bj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5pc3N1ZT0xNCZhbXA7cmZ0LnNw

YWdlPTE4MjQmYW1wO3JmdC5wYWdlcz0xODI0LTMxJmFtcDtyZnQuZGF0ZT0yMDA3JmFtcDtyZnQu

anRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9Q29tcHJl

aGVuc2l2ZStnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIrcGF0aWVudHMrd2l0aCtjYW5j

ZXIuJmFtcDtyZnQuYXVsYXN0PUV4dGVybWFubjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPgB=

ADDIN EN.CITE.DATA (18-21)Comprehensive geriatric assessments (CGA) are used increasingly in geriatric oncology to provide data on patient functional status, comorbidity, polypharmacy, existence of geriatric syndromes, nutritional status, social support and psychological status.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QdXRzPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjIwNDM8L1JlY051bT48RGlzcGxheVRleHQ+KDIxLTI1KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4yMDQzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9

IjE0MzUyOTM1NDciPjIwNDM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlB1dHMsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5IYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPk1v

bmV0dGUsIEouPC9hdXRob3I+PGF1dGhvcj5HaXJyZSwgVi48L2F1dGhvcj48YXV0aG9yPlNwcmlu

Z2FsbCwgRS48L2F1dGhvcj48YXV0aG9yPkFsaWJoYWksIFMuIE0uPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UHV0cyxNIFQgRS4gTGF3cmVuY2UgUy4gQmxv

b21iZXJnIEZhY3VsdHkgb2YgTnVyc2luZywgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRv

LCBPTiwgQ2FuYWRhLiBtYXJ0aW5lLnB1dHNAdXRvcm9udG8uY2E8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5Vc2Ugb2YgZ2VyaWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIGFkdWx0cyBp

biB0aGUgb25jb2xvZ3kgc2V0dGluZzogYSBzeXN0ZW1hdGljIHJldmlldzwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIHRoZSBOYXRpb25hbCBDYW5jZXIgSW5zdGl0dXRlPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIE5hdGwgQ2FuY2VyIEluc3Q8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIHRoZSBOYXRpb25hbCBDYW5j

ZXIgSW5zdGl0dXRlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBOYXRsIENhbmNlciBJbnN0PC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIHRo

ZSBOYXRpb25hbCBDYW5jZXIgSW5zdGl0dXRlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBOYXRsIENh

bmNlciBJbnN0PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTEzMy02MzwvcGFnZXM+

PHZvbHVtZT4xMDQ8L3ZvbHVtZT48bnVtYmVyPjE1PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdv

cmQ+Q2FuYWRhPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3Jk

PkV1cm9wZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1lZGljYWwgT25jb2xvZ3kvc3QgW1N0

YW5kYXJkc108L2tleXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvdGQgW1RyZW5kc108

L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtczwva2V5d29yZD48a2V5d29yZD5OdXRyaXRpb24g

QXNzZXNzbWVudDwva2V5d29yZD48a2V5d29yZD5Qc3ljaG9tZXRyaWNzPC9rZXl3b3JkPjxrZXl3

b3JkPlF1ZXN0aW9ubmFpcmVzL3N0IFtTdGFuZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPipRdWVz

dGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8

L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDg8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDYwLTIxMDU8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjI4NTEyNjk8

L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym

YXBvczt0JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIyODUxMjY5PC91cmw+PHVybD5o

dHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9X

RUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9m

bXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6

bWVkbCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDkzJTJG

am5jaSUyRmRqczI4NSZhbXA7cmZ0X2lkPWluZm86cG1pZC8yMjg1MTI2OSZhbXA7cmZ0Lmlzc249

MDAyNy04ODc0JmFtcDtyZnQudm9sdW1lPTEwNCZhbXA7cmZ0Lmlzc3VlPTE1JmFtcDtyZnQuc3Bh

Z2U9MTEzMyZhbXA7cmZ0LnBhZ2VzPTExMzMtNjMmYW1wO3JmdC5kYXRlPTIwMTImYW1wO3JmdC5q

dGl0bGU9Sm91cm5hbCtvZit0aGUrTmF0aW9uYWwrQ2FuY2VyK0luc3RpdHV0ZSZhbXA7cmZ0LmF0

aXRsZT1Vc2Urb2YrZ2VyaWF0cmljK2Fzc2Vzc21lbnQrZm9yK29sZGVyK2FkdWx0cytpbit0aGUr

b25jb2xvZ3krc2V0dGluZyUzQSthK3N5c3RlbWF0aWMrcmV2aWV3LiZhbXA7cmZ0LmF1bGFzdD1Q

dXRzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0MTM2MTQ8L2N1c3Rv

bTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwOTMvam5j

aS9kanMyODU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5N

RURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92

aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xp

c2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlB1dHM8L0F1dGhvcj48

WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjAzOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

MjAzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3Qy

MHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDM1MjkzNTQ3Ij4y

MDM5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QdXRzLCBNLiBULjwv

YXV0aG9yPjxhdXRob3I+U2FudG9zLCBCLjwvYXV0aG9yPjxhdXRob3I+SGFyZHQsIEouPC9hdXRo

b3I+PGF1dGhvcj5Nb25ldHRlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+

PGF1dGhvcj5BdGVuYWZ1LCBFLiBHLjwvYXV0aG9yPjxhdXRob3I+U3ByaW5nYWxsLCBFLjwvYXV0

aG9yPjxhdXRob3I+QWxpYmhhaSwgUy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5QdXRzLE0gVCBFLiBMYXdyZW5jZSBTLiBCbG9vbWJlcmcgRmFjdWx0

eSBvZiBOdXJzaW5nLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFRvcm9udG8uPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+QW4gdXBkYXRlIG9uIGEgc3lzdGVtYXRpYyByZXZpZXcgb2YgdGhl

IHVzZSBvZiBnZXJpYXRyaWMgYXNzZXNzbWVudCBmb3Igb2xkZXIgYWR1bHRzIGluIG9uY29sb2d5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+QW5uIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+QW5uYWxzIG9mIE9uY29sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGFiYnItMT5Bbm4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2Fs

PjxwYWdlcz4zMDctMTU8L3BhZ2VzPjx2b2x1bWU+MjU8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Dcm9zcy1TZWN0aW9uYWwgU3R1ZGllczwv

a2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvZGkgW0RpYWdub3Npc108L2tleXdv

cmQ+PGtleXdvcmQ+TmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPk5l

b3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGll

czwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IEFzc3VyYW5jZSwgSGVhbHRoIENhcmU8L2tleXdv

cmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0

bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTY5

LTgwNDE8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQyNTY4NDc8L2FjY2Vzc2lvbi1udW0+PHdvcmst

dHlwZT5NZXRhLUFuYWx5c2lzJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBv

czt0JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFt

cDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0MjU2ODQ3PC91cmw+PHVybD5odHRw

Oi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxM

SU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9

aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVk

bCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDkzJTJGYW5u

b25jJTJGbWR0Mzg2JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0MjU2ODQ3JmFtcDtyZnQuaXNzbj0w

OTIzLTc1MzQmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5pc3N1ZT0yJmFtcDtyZnQuc3BhZ2U9

MzA3JmFtcDtyZnQucGFnZXM9MzA3LTE1JmFtcDtyZnQuZGF0ZT0yMDE0JmFtcDtyZnQuanRpdGxl

PUFubmFscytvZitPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1Bbit1cGRhdGUrb24rYStzeXN0ZW1h

dGljK3JldmlldytvZit0aGUrdXNlK29mK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcith

ZHVsdHMraW4rb25jb2xvZ3kuJmFtcDtyZnQuYXVsYXN0PVB1dHM8L3VybD48L3JlbGF0ZWQtdXJs

cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEw

OTMvYW5ub25jL21kdDM4NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFz

ZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3Vh

Z2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+V2lsZGll

cnM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjA0MDwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjA0MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDM1MjkzNTQ3Ij4yMDQwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5X

aWxkaWVycywgSC48L2F1dGhvcj48YXV0aG9yPkhlZXJlbiwgUC48L2F1dGhvcj48YXV0aG9yPlB1

dHMsIE0uPC9hdXRob3I+PGF1dGhvcj5Ub3BpbmtvdmEsIEUuPC9hdXRob3I+PGF1dGhvcj5KYW5z

c2VuLUhlaWpuZW4sIE0uIEwuPC9hdXRob3I+PGF1dGhvcj5FeHRlcm1hbm4sIE0uPC9hdXRob3I+

PGF1dGhvcj5GYWxhbmRyeSwgQy48L2F1dGhvcj48YXV0aG9yPkFydHosIEEuPC9hdXRob3I+PGF1

dGhvcj5CcmFpbiwgRS48L2F1dGhvcj48YXV0aG9yPkNvbGxvY2EsIEcuPC9hdXRob3I+PGF1dGhv

cj5GbGFtYWluZywgSi48L2F1dGhvcj48YXV0aG9yPkthcm5ha2lzLCBULjwvYXV0aG9yPjxhdXRo

b3I+S2VuaXMsIEMuPC9hdXRob3I+PGF1dGhvcj5BdWRpc2lvLCBSLiBBLjwvYXV0aG9yPjxhdXRo

b3I+TW9oaWxlLCBTLjwvYXV0aG9yPjxhdXRob3I+UmVwZXR0bywgTC48L2F1dGhvcj48YXV0aG9y

PlZhbiBMZWV1d2VuLCBCLjwvYXV0aG9yPjxhdXRob3I+TWlsaXNlbiwgSy48L2F1dGhvcj48YXV0

aG9yPkh1cnJpYSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+SW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIEdlcmlhdHJpYyBPbmNvbG9neSBjb25zZW5z

dXMgb24gZ2VyaWF0cmljIGFzc2Vzc21lbnQgaW4gb2xkZXIgcGF0aWVudHMgd2l0aCBjYW5jZXI8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBDbGluIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVs

bC10aXRsZT48YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjI1OTUtNjAzPC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4yNDwvbnVtYmVyPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbnNlbnN1

czwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQvbXQgW01ldGhvZHNdPC9r

ZXl3b3JkPjxrZXl3b3JkPkdlcmlhdHJpY3MvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipHZXJpYXRyaWNzL3N0IFtTdGFuZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipOZW9wbGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMjA8L2RhdGU+PC9wdWItZGF0ZXM+PC9k

YXRlcz48aXNibj4xNTI3LTc3NTU8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUwNzExMjU8L2FjY2Vz

c2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0

JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI1MDcxMTI1PC91cmw+PHVybD5odHRwOi8v

b3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5H

VE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5m

bzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkbCZh

bXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9pZD1pbmZv

OnBtaWQvMjUwNzExMjUmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7cmZ0LnZvbHVtZT0zMiZh

bXA7cmZ0Lmlzc3VlPTI0JmFtcDtyZnQuc3BhZ2U9MjU5NSZhbXA7cmZ0LnBhZ2VzPTI1OTUtNjAz

JmFtcDtyZnQuZGF0ZT0yMDE0JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25j

b2xvZ3kmYW1wO3JmdC5hdGl0bGU9SW50ZXJuYXRpb25hbCtTb2NpZXR5K29mK0dlcmlhdHJpYytP

bmNvbG9neStjb25zZW5zdXMrb24rZ2VyaWF0cmljK2Fzc2Vzc21lbnQraW4rb2xkZXIrcGF0aWVu

dHMrd2l0aCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PVdpbGRpZXJzPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2Ut

bmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkV4dGVybWFubjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

Y051bT4yMDQ3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ3PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2

d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDc8L2tleT48L2ZvcmVpZ24t

a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy

aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkV4dGVybWFubiwgTS48L2F1dGhvcj48YXV0aG9yPkh1

cnJpYSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5F

eHRlcm1hbm4sTWFydGluZS4gSC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciwgVW5pdmVyc2l0

eSBvZiBTb3V0aCBGbG9yaWRhLCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJtYW5uQG1vZmZp

dHQudXNmLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2Vy

aWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODI0LTMx

PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGlvbjwva2V5d29yZD48a2V5d29y

ZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1hbmFnZW1lbnQ8L2tleXdv

cmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvbXQgW01l

dGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9jbyBbQ29tcGxpY2F0aW9uc108L2tl

eXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3BwIFtQaHlzaW9wYXRob2xvZ3ldPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtcy9weCBbUHN5Y2hvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxh

c21zL3RoIFtUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zPC9rZXl3b3JkPjxr

ZXl3b3JkPk51dHJpdGlvbmFsIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb2x5cGhhcm1hY3k8

L2tleXdvcmQ+PGtleXdvcmQ+U29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heSAxMDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE1MjctNzc1NTwvaXNibj48YWNjZXNzaW9uLW51bT4xNzQ4ODk4

MDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0

cmFtdXJhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2

aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3Zp

ZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxs

dGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzQ4ODk4MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhv

c3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJW

SUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2Zt

dDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5n

ZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE3

NDg4OTgwJmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5p

c3N1ZT0xNCZhbXA7cmZ0LnNwYWdlPTE4MjQmYW1wO3JmdC5wYWdlcz0xODI0LTMxJmFtcDtyZnQu

ZGF0ZT0yMDA3JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1w

O3JmdC5hdGl0bGU9Q29tcHJlaGVuc2l2ZStnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIr

cGF0aWVudHMrd2l0aCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PUV4dGVybWFubjwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRh

dGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwv

cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYW1qYXVuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVh

cj48UmVjTnVtPjIwNDE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDE8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXpl

cHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0MTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmFtamF1biwgQS48L2F1dGhvcj48YXV0aG9y

Pk5hc3NpZiwgTS4gTy48L2F1dGhvcj48YXV0aG9yPktyb3RuZXZhLCBTLjwvYXV0aG9yPjxhdXRo

b3I+SHVhbmcsIEEuIFIuPC9hdXRob3I+PGF1dGhvcj5NZWd1ZXJkaXRjaGlhbiwgQS4gTi48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYW1qYXVuLEFsaXlh

LiBEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgTWNHaWxsIFVu

aXZlcnNpdHksIE1vbnRyZWFsLCBDYW5hZGE7IE1jR2lsbCBDbGluaWNhbCBhbmQgSGVhbHRoIElu

Zm9ybWF0aWNzLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwsIENhbmFkYS4gRWxlY3Ryb25p

YyBhZGRyZXNzOiBhbGl5YS5yYW1qYXVuQG1haWwubWNnaWxsLmNhLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkltcHJvdmVkIHRhcmdldGluZyBvZiBjYW5jZXIgY2FyZSBmb3Igb2xkZXIg

cGF0aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgb2YgdGhlIHV0aWxpdHkgb2YgY29tcHJlaGVu

c2l2ZSBnZXJpYXRyaWMgYXNzZXNzbWVudDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFs

IG9mIEdlcmlhdHJpYyBPbmNvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBHZXJp

YXRyIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91

cm5hbCBvZiBHZXJpYXRyaWMgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIEdlcmlhdHIg

T25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgR2VyaWF0cmljIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBHZXJpYXRy

IE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjcxLTgxPC9wYWdlcz48dm9s

dW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwv

a2V5d29yZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJv

dG9jb2xzL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPkFudGluZW9wbGFz

dGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVzZV08

L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL21vIFtNb3J0

YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3Jk

PjxrZXl3b3JkPk51dHJpdGlvbmFsIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb3N0b3BlcmF0

aXZlIENvbXBsaWNhdGlvbnMvZXQgW0V0aW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qb3N0b3Bl

cmF0aXZlIENvbXBsaWNhdGlvbnMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+UHJv

Z25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzktNDA3NjwvaXNibj48YWNjZXNzaW9uLW51

bT4yNDA3MDQ2NDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJldmlldzwvd29yay10eXBlPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dp

P1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZh

bXA7QU49MjQwNzA0NjQ8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0ZWQuZXhsaWJyaXNncm91

cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklDRVNfUEFHRT91cmxfdmVy

PVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6a2V2Om10eDpqb3VybmFs

JmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWRsJmFtcDtyZnQuZ2VucmU9YXJ0aWNsZSZhbXA7

cmZ0X2lkPWluZm86ZG9pLzEwLjEwMTYlMkZqLmpnby4yMDEzLjA0LjAwMiZhbXA7cmZ0X2lkPWlu

Zm86cG1pZC8yNDA3MDQ2NCZhbXA7cmZ0Lmlzc249MTg3OS00MDc2JmFtcDtyZnQudm9sdW1lPTQm

YW1wO3JmdC5pc3N1ZT0zJmFtcDtyZnQuc3BhZ2U9MjcxJmFtcDtyZnQucGFnZXM9MjcxLTgxJmFt

cDtyZnQuZGF0ZT0yMDEzJmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrR2VyaWF0cmljK09uY29s

b2d5JmFtcDtyZnQuYXRpdGxlPUltcHJvdmVkK3RhcmdldGluZytvZitjYW5jZXIrY2FyZStmb3Ir

b2xkZXIrcGF0aWVudHMlM0ErYStzeXN0ZW1hdGljK3JldmlldytvZit0aGUrdXRpbGl0eStvZitj

b21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50LiZhbXA7cmZ0LmF1bGFzdD1SYW1qYXVu

PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRw

Oi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouamdvLjIwMTMuMDQuMDAyPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5h

bWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QdXRzPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjIwNDM8L1JlY051bT48RGlzcGxheVRleHQ+KDIxLTI1KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4yMDQzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9

IjE0MzUyOTM1NDciPjIwNDM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlB1dHMsIE0uIFQuPC9hdXRob3I+PGF1dGhvcj5IYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPk1v

bmV0dGUsIEouPC9hdXRob3I+PGF1dGhvcj5HaXJyZSwgVi48L2F1dGhvcj48YXV0aG9yPlNwcmlu

Z2FsbCwgRS48L2F1dGhvcj48YXV0aG9yPkFsaWJoYWksIFMuIE0uPC9hdXRob3I+PC9hdXRob3Jz

PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UHV0cyxNIFQgRS4gTGF3cmVuY2UgUy4gQmxv

b21iZXJnIEZhY3VsdHkgb2YgTnVyc2luZywgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRv

LCBPTiwgQ2FuYWRhLiBtYXJ0aW5lLnB1dHNAdXRvcm9udG8uY2E8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5Vc2Ugb2YgZ2VyaWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIGFkdWx0cyBp

biB0aGUgb25jb2xvZ3kgc2V0dGluZzogYSBzeXN0ZW1hdGljIHJldmlldzwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIHRoZSBOYXRpb25hbCBDYW5jZXIgSW5zdGl0dXRlPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIE5hdGwgQ2FuY2VyIEluc3Q8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIHRoZSBOYXRpb25hbCBDYW5j

ZXIgSW5zdGl0dXRlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBOYXRsIENhbmNlciBJbnN0PC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIHRo

ZSBOYXRpb25hbCBDYW5jZXIgSW5zdGl0dXRlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBOYXRsIENh

bmNlciBJbnN0PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTEzMy02MzwvcGFnZXM+

PHZvbHVtZT4xMDQ8L3ZvbHVtZT48bnVtYmVyPjE1PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3Jk

PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdv

cmQ+Q2FuYWRhPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3Jk

PkV1cm9wZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1lZGljYWwgT25jb2xvZ3kvc3QgW1N0

YW5kYXJkc108L2tleXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvdGQgW1RyZW5kc108

L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtczwva2V5d29yZD48a2V5d29yZD5OdXRyaXRpb24g

QXNzZXNzbWVudDwva2V5d29yZD48a2V5d29yZD5Qc3ljaG9tZXRyaWNzPC9rZXl3b3JkPjxrZXl3

b3JkPlF1ZXN0aW9ubmFpcmVzL3N0IFtTdGFuZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPipRdWVz

dGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8

L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDg8L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4xNDYwLTIxMDU8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjI4NTEyNjk8

L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym

YXBvczt0JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIyODUxMjY5PC91cmw+PHVybD5o

dHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9X

RUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9m

bXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6

bWVkbCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDkzJTJG

am5jaSUyRmRqczI4NSZhbXA7cmZ0X2lkPWluZm86cG1pZC8yMjg1MTI2OSZhbXA7cmZ0Lmlzc249

MDAyNy04ODc0JmFtcDtyZnQudm9sdW1lPTEwNCZhbXA7cmZ0Lmlzc3VlPTE1JmFtcDtyZnQuc3Bh

Z2U9MTEzMyZhbXA7cmZ0LnBhZ2VzPTExMzMtNjMmYW1wO3JmdC5kYXRlPTIwMTImYW1wO3JmdC5q

dGl0bGU9Sm91cm5hbCtvZit0aGUrTmF0aW9uYWwrQ2FuY2VyK0luc3RpdHV0ZSZhbXA7cmZ0LmF0

aXRsZT1Vc2Urb2YrZ2VyaWF0cmljK2Fzc2Vzc21lbnQrZm9yK29sZGVyK2FkdWx0cytpbit0aGUr

b25jb2xvZ3krc2V0dGluZyUzQSthK3N5c3RlbWF0aWMrcmV2aWV3LiZhbXA7cmZ0LmF1bGFzdD1Q

dXRzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0MTM2MTQ8L2N1c3Rv

bTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwOTMvam5j

aS9kanMyODU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5N

RURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92

aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xp

c2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlB1dHM8L0F1dGhvcj48

WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjAzOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

MjAzOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjIyc3Qy

MHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDM1MjkzNTQ3Ij4y

MDM5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QdXRzLCBNLiBULjwv

YXV0aG9yPjxhdXRob3I+U2FudG9zLCBCLjwvYXV0aG9yPjxhdXRob3I+SGFyZHQsIEouPC9hdXRo

b3I+PGF1dGhvcj5Nb25ldHRlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+

PGF1dGhvcj5BdGVuYWZ1LCBFLiBHLjwvYXV0aG9yPjxhdXRob3I+U3ByaW5nYWxsLCBFLjwvYXV0

aG9yPjxhdXRob3I+QWxpYmhhaSwgUy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5QdXRzLE0gVCBFLiBMYXdyZW5jZSBTLiBCbG9vbWJlcmcgRmFjdWx0

eSBvZiBOdXJzaW5nLCBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFRvcm9udG8uPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+QW4gdXBkYXRlIG9uIGEgc3lzdGVtYXRpYyByZXZpZXcgb2YgdGhl

IHVzZSBvZiBnZXJpYXRyaWMgYXNzZXNzbWVudCBmb3Igb2xkZXIgYWR1bHRzIGluIG9uY29sb2d5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+QW5uIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+QW5uYWxzIG9mIE9uY29sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGFiYnItMT5Bbm4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2Fs

PjxwYWdlcz4zMDctMTU8L3BhZ2VzPjx2b2x1bWU+MjU8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJl

cj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+

PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Dcm9zcy1TZWN0aW9uYWwgU3R1ZGllczwv

a2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvZGkgW0RpYWdub3Npc108L2tleXdv

cmQ+PGtleXdvcmQ+TmVvcGxhc21zL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPk5l

b3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGll

czwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IEFzc3VyYW5jZSwgSGVhbHRoIENhcmU8L2tleXdv

cmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0

bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTY5

LTgwNDE8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQyNTY4NDc8L2FjY2Vzc2lvbi1udW0+PHdvcmst

dHlwZT5NZXRhLUFuYWx5c2lzJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBv

czt0JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov

L292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFt

cDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0MjU2ODQ3PC91cmw+PHVybD5odHRw

Oi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxM

SU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9

aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVk

bCZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8xMC4xMDkzJTJGYW5u

b25jJTJGbWR0Mzg2JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0MjU2ODQ3JmFtcDtyZnQuaXNzbj0w

OTIzLTc1MzQmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5pc3N1ZT0yJmFtcDtyZnQuc3BhZ2U9

MzA3JmFtcDtyZnQucGFnZXM9MzA3LTE1JmFtcDtyZnQuZGF0ZT0yMDE0JmFtcDtyZnQuanRpdGxl

PUFubmFscytvZitPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1Bbit1cGRhdGUrb24rYStzeXN0ZW1h

dGljK3JldmlldytvZit0aGUrdXNlK29mK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcith

ZHVsdHMraW4rb25jb2xvZ3kuJmFtcDtyZnQuYXVsYXN0PVB1dHM8L3VybD48L3JlbGF0ZWQtdXJs

cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEw

OTMvYW5ub25jL21kdDM4NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFz

ZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJv

dmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3Vh

Z2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+V2lsZGll

cnM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MjA0MDwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjA0MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDM1MjkzNTQ3Ij4yMDQwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5X

aWxkaWVycywgSC48L2F1dGhvcj48YXV0aG9yPkhlZXJlbiwgUC48L2F1dGhvcj48YXV0aG9yPlB1

dHMsIE0uPC9hdXRob3I+PGF1dGhvcj5Ub3BpbmtvdmEsIEUuPC9hdXRob3I+PGF1dGhvcj5KYW5z

c2VuLUhlaWpuZW4sIE0uIEwuPC9hdXRob3I+PGF1dGhvcj5FeHRlcm1hbm4sIE0uPC9hdXRob3I+

PGF1dGhvcj5GYWxhbmRyeSwgQy48L2F1dGhvcj48YXV0aG9yPkFydHosIEEuPC9hdXRob3I+PGF1

dGhvcj5CcmFpbiwgRS48L2F1dGhvcj48YXV0aG9yPkNvbGxvY2EsIEcuPC9hdXRob3I+PGF1dGhv

cj5GbGFtYWluZywgSi48L2F1dGhvcj48YXV0aG9yPkthcm5ha2lzLCBULjwvYXV0aG9yPjxhdXRo

b3I+S2VuaXMsIEMuPC9hdXRob3I+PGF1dGhvcj5BdWRpc2lvLCBSLiBBLjwvYXV0aG9yPjxhdXRo

b3I+TW9oaWxlLCBTLjwvYXV0aG9yPjxhdXRob3I+UmVwZXR0bywgTC48L2F1dGhvcj48YXV0aG9y

PlZhbiBMZWV1d2VuLCBCLjwvYXV0aG9yPjxhdXRob3I+TWlsaXNlbiwgSy48L2F1dGhvcj48YXV0

aG9yPkh1cnJpYSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+SW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIEdlcmlhdHJpYyBPbmNvbG9neSBjb25zZW5z

dXMgb24gZ2VyaWF0cmljIGFzc2Vzc21lbnQgaW4gb2xkZXIgcGF0aWVudHMgd2l0aCBjYW5jZXI8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBDbGluIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVs

bC10aXRsZT48YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjI1OTUtNjAzPC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4yNDwvbnVtYmVyPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbnNlbnN1

czwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQvbXQgW01ldGhvZHNdPC9r

ZXl3b3JkPjxrZXl3b3JkPkdlcmlhdHJpY3MvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipHZXJpYXRyaWNzL3N0IFtTdGFuZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5

d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3JkPjxrZXl3b3Jk

PipOZW9wbGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcgMjA8L2RhdGU+PC9wdWItZGF0ZXM+PC9k

YXRlcz48aXNibj4xNTI3LTc3NTU8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjUwNzExMjU8L2FjY2Vz

c2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0

JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI1MDcxMTI1PC91cmw+PHVybD5odHRwOi8v

b3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5H

VE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5m

bzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkbCZh

bXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9pZD1pbmZv

OnBtaWQvMjUwNzExMjUmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7cmZ0LnZvbHVtZT0zMiZh

bXA7cmZ0Lmlzc3VlPTI0JmFtcDtyZnQuc3BhZ2U9MjU5NSZhbXA7cmZ0LnBhZ2VzPTI1OTUtNjAz

JmFtcDtyZnQuZGF0ZT0yMDE0JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25j

b2xvZ3kmYW1wO3JmdC5hdGl0bGU9SW50ZXJuYXRpb25hbCtTb2NpZXR5K29mK0dlcmlhdHJpYytP

bmNvbG9neStjb25zZW5zdXMrb24rZ2VyaWF0cmljK2Fzc2Vzc21lbnQraW4rb2xkZXIrcGF0aWVu

dHMrd2l0aCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PVdpbGRpZXJzPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2Ut

bmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkV4dGVybWFubjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

Y051bT4yMDQ3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ3PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2

d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDc8L2tleT48L2ZvcmVpZ24t

a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy

aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkV4dGVybWFubiwgTS48L2F1dGhvcj48YXV0aG9yPkh1

cnJpYSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5F

eHRlcm1hbm4sTWFydGluZS4gSC4gTGVlIE1vZmZpdHQgQ2FuY2VyIENlbnRlciwgVW5pdmVyc2l0

eSBvZiBTb3V0aCBGbG9yaWRhLCBUYW1wYSwgRkwgMzM2MTIsIFVTQS4gZXh0ZXJtYW5uQG1vZmZp

dHQudXNmLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUgZ2Vy

aWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+

PGFiYnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xODI0LTMx

PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4xNDwvbnVtYmVyPjxrZXl3b3Jkcz48

a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGlvbjwva2V5d29yZD48a2V5d29y

ZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1hbmFnZW1lbnQ8L2tleXdv

cmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48

a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+Kk1lZGljYWwgT25jb2xvZ3kvbXQgW01l

dGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy9jbyBbQ29tcGxpY2F0aW9uc108L2tl

eXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL3BwIFtQaHlzaW9wYXRob2xvZ3ldPC9rZXl3b3JkPjxr

ZXl3b3JkPk5lb3BsYXNtcy9weCBbUHN5Y2hvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxh

c21zL3RoIFtUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zPC9rZXl3b3JkPjxr

ZXl3b3JkPk51dHJpdGlvbmFsIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb2x5cGhhcm1hY3k8

L2tleXdvcmQ+PGtleXdvcmQ+U29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heSAxMDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjE1MjctNzc1NTwvaXNibj48YWNjZXNzaW9uLW51bT4xNzQ4ODk4

MDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0

cmFtdXJhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2

aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3Zp

ZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxs

dGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzQ4ODk4MDwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhv

c3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJW

SUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2Zt

dDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5n

ZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE3

NDg4OTgwJmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MjUmYW1wO3JmdC5p

c3N1ZT0xNCZhbXA7cmZ0LnNwYWdlPTE4MjQmYW1wO3JmdC5wYWdlcz0xODI0LTMxJmFtcDtyZnQu

ZGF0ZT0yMDA3JmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1w

O3JmdC5hdGl0bGU9Q29tcHJlaGVuc2l2ZStnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIr

cGF0aWVudHMrd2l0aCtjYW5jZXIuJmFtcDtyZnQuYXVsYXN0PUV4dGVybWFubjwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRh

dGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwv

cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYW1qYXVuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVh

cj48UmVjTnVtPjIwNDE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDE8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXpl

cHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0MTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmFtamF1biwgQS48L2F1dGhvcj48YXV0aG9y

Pk5hc3NpZiwgTS4gTy48L2F1dGhvcj48YXV0aG9yPktyb3RuZXZhLCBTLjwvYXV0aG9yPjxhdXRo

b3I+SHVhbmcsIEEuIFIuPC9hdXRob3I+PGF1dGhvcj5NZWd1ZXJkaXRjaGlhbiwgQS4gTi48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYW1qYXVuLEFsaXlh

LiBEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgTWNHaWxsIFVu

aXZlcnNpdHksIE1vbnRyZWFsLCBDYW5hZGE7IE1jR2lsbCBDbGluaWNhbCBhbmQgSGVhbHRoIElu

Zm9ybWF0aWNzLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwsIENhbmFkYS4gRWxlY3Ryb25p

YyBhZGRyZXNzOiBhbGl5YS5yYW1qYXVuQG1haWwubWNnaWxsLmNhLjwvYXV0aC1hZGRyZXNzPjx0

aXRsZXM+PHRpdGxlPkltcHJvdmVkIHRhcmdldGluZyBvZiBjYW5jZXIgY2FyZSBmb3Igb2xkZXIg

cGF0aWVudHM6IGEgc3lzdGVtYXRpYyByZXZpZXcgb2YgdGhlIHV0aWxpdHkgb2YgY29tcHJlaGVu

c2l2ZSBnZXJpYXRyaWMgYXNzZXNzbWVudDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFs

IG9mIEdlcmlhdHJpYyBPbmNvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBHZXJp

YXRyIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91

cm5hbCBvZiBHZXJpYXRyaWMgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIEdlcmlhdHIg

T25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpv

dXJuYWwgb2YgR2VyaWF0cmljIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBHZXJpYXRy

IE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjcxLTgxPC9wYWdlcz48dm9s

dW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwv

a2V5d29yZD48a2V5d29yZD5BbnRpbmVvcGxhc3RpYyBDb21iaW5lZCBDaGVtb3RoZXJhcHkgUHJv

dG9jb2xzL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPkFudGluZW9wbGFz

dGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVzZV08

L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL21vIFtNb3J0

YWxpdHldPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3Jk

PjxrZXl3b3JkPk51dHJpdGlvbmFsIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5Qb3N0b3BlcmF0

aXZlIENvbXBsaWNhdGlvbnMvZXQgW0V0aW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qb3N0b3Bl

cmF0aXZlIENvbXBsaWNhdGlvbnMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+UHJv

Z25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0

ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzktNDA3NjwvaXNibj48YWNjZXNzaW9uLW51

bT4yNDA3MDQ2NDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJldmlldzwvd29yay10eXBlPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dp

P1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZh

bXA7QU49MjQwNzA0NjQ8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0ZWQuZXhsaWJyaXNncm91

cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklDRVNfUEFHRT91cmxfdmVy

PVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6a2V2Om10eDpqb3VybmFs

JmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWRsJmFtcDtyZnQuZ2VucmU9YXJ0aWNsZSZhbXA7

cmZ0X2lkPWluZm86ZG9pLzEwLjEwMTYlMkZqLmpnby4yMDEzLjA0LjAwMiZhbXA7cmZ0X2lkPWlu

Zm86cG1pZC8yNDA3MDQ2NCZhbXA7cmZ0Lmlzc249MTg3OS00MDc2JmFtcDtyZnQudm9sdW1lPTQm

YW1wO3JmdC5pc3N1ZT0zJmFtcDtyZnQuc3BhZ2U9MjcxJmFtcDtyZnQucGFnZXM9MjcxLTgxJmFt

cDtyZnQuZGF0ZT0yMDEzJmFtcDtyZnQuanRpdGxlPUpvdXJuYWwrb2YrR2VyaWF0cmljK09uY29s

b2d5JmFtcDtyZnQuYXRpdGxlPUltcHJvdmVkK3RhcmdldGluZytvZitjYW5jZXIrY2FyZStmb3Ir

b2xkZXIrcGF0aWVudHMlM0ErYStzeXN0ZW1hdGljK3JldmlldytvZit0aGUrdXRpbGl0eStvZitj

b21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50LiZhbXA7cmZ0LmF1bGFzdD1SYW1qYXVu

PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRw

Oi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouamdvLjIwMTMuMDQuMDAyPC9lbGVjdHJvbmljLXJlc291

cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5h

bWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (21-25) There are a large number of studies that show that incorporating such an assessment to the care of older people with cancer can be useful to predict complications of care, estimate mortality or survival and to assist in treatment decision making for older people.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYWlsbGV0PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjIwNDQ8L1JlY051bT48RGlzcGxheVRleHQ+KDIwLTI3KTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yMDQ0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3Rh

bXA9IjE0MzUyOTM1NDciPjIwNDQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkNhaWxsZXQsIFAuPC9hdXRob3I+PGF1dGhvcj5DYW5vdWktUG9pdHJpbmUsIEYuPC9hdXRo

b3I+PGF1dGhvcj5Wb3VyaW90LCBKLjwvYXV0aG9yPjxhdXRob3I+QmVybGUsIE0uPC9hdXRob3I+

PGF1dGhvcj5SZWluYWxkLCBOLjwvYXV0aG9yPjxhdXRob3I+S3J5cGNpYWssIFMuPC9hdXRob3I+

PGF1dGhvcj5CYXN0dWppLUdhcmluLCBTLjwvYXV0aG9yPjxhdXRob3I+Q3VsaW5lLCBTLjwvYXV0

aG9yPjxhdXRob3I+UGFpbGxhdWQsIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+Q2FpbGxldCxQaGlsaXBwZS4gVW5pdmVyc2l0eSBvZiBQYXJpcyBFc3Qg

Q3JldGVpbCwgTGFib3JhdG9pcmUgZCZhcG9zO0ludmVzdGlnYXRpb24gQ2xpbmljcXVlIEVBIDQz

OTMsIEFzc2l0YW5jZSBQdWJsaXF1ZS1Ib3BpdGF1eCBkZSBQYXJpcyBIZW5yaSBNb25kb3IsIENy

ZXRlaWwsIEZyYW5jZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUg

Z2VyaWF0cmljIGFzc2Vzc21lbnQgaW4gdGhlIGRlY2lzaW9uLW1ha2luZyBwcm9jZXNzIGluIGVs

ZGVybHkgcGF0aWVudHMgd2l0aCBjYW5jZXI6IEVMQ0FQQSBzdHVkeTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFs

dC10aXRsZT5KIENsaW4gT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+

SiBDbGluIE9uY29sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBD

bGluIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzYzNi00MjwvcGFnZXM+

PHZvbHVtZT4yOTwvdm9sdW1lPjxudW1iZXI+Mjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+

QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Db2duaXRpb24g

RGlzb3JkZXJzL2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0

eTwva2V5d29yZD48a2V5d29yZD4qRGVjaXNpb24gTWFraW5nPC9rZXl3b3JkPjxrZXl3b3JkPkRl

cHJlc3Npb24vY28gW0NvbXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5

d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFsbnV0cml0aW9u

L2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5NdWx0aXZhcmlhdGUgQW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh

cj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDIwPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNzA5MTk0PC9hY2Nl

c3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkbCZhbXA7QU49MjE3MDkxOTQ8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0

ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklD

RVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6

a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWRsJmFtcDtyZnQuZ2Vu

cmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLzEwLjEyMDAlMkZKQ08uMjAxMC4zMS4wNjY0

JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzIxNzA5MTk0JmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1w

O3JmdC52b2x1bWU9MjkmYW1wO3JmdC5pc3N1ZT0yNyZhbXA7cmZ0LnNwYWdlPTM2MzYmYW1wO3Jm

dC5wYWdlcz0zNjM2LTQyJmFtcDtyZnQuZGF0ZT0yMDExJmFtcDtyZnQuanRpdGxlPUpvdXJuYWwr

b2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9Q29tcHJlaGVuc2l2ZStnZXJpYXRy

aWMrYXNzZXNzbWVudCtpbit0aGUrZGVjaXNpb24tbWFraW5nK3Byb2Nlc3MraW4rZWxkZXJseStw

YXRpZW50cyt3aXRoK2NhbmNlciUzQStFTENBUEErc3R1ZHkuJmFtcDtyZnQuYXVsYXN0PUNhaWxs

ZXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0

dHA6Ly9keC5kb2kub3JnLzEwLjEyMDAvSkNPLjIwMTAuMzEuMDY2NDwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1u

YW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9D

aXRlPjxDaXRlPjxBdXRob3I+RXh0ZXJtYW5uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVj

TnVtPjIwNDc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDc8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3

c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0Nzwva2V5PjwvZm9yZWlnbi1r

ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp

YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+SHVy

cmlhLCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkV4

dGVybWFubixNYXJ0aW5lLiBILiBMZWUgTW9mZml0dCBDYW5jZXIgQ2VudGVyLCBVbml2ZXJzaXR5

IG9mIFNvdXRoIEZsb3JpZGEsIFRhbXBhLCBGTCAzMzYxMiwgVVNBLiBleHRlcm1hbm5AbW9mZml0

dC51c2YuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tcHJlaGVuc2l2ZSBnZXJp

YXRyaWMgYXNzZXNzbWVudCBmb3Igb2xkZXIgcGF0aWVudHMgd2l0aCBjYW5jZXI8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+SiBDbGluIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10aXRsZT48

YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10aXRsZT48YWJi

ci0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE4MjQtMzE8

L3BhZ2VzPjx2b2x1bWU+MjU8L3ZvbHVtZT48bnVtYmVyPjE0PC9udW1iZXI+PGtleXdvcmRzPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgTWFuYWdlbWVudDwva2V5d29y

ZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qTWVkaWNhbCBPbmNvbG9neS9tdCBbTWV0

aG9kc108L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2NvIFtDb21wbGljYXRpb25zXTwva2V5

d29yZD48a2V5d29yZD5OZW9wbGFzbXMvcHAgW1BoeXNpb3BhdGhvbG9neV08L2tleXdvcmQ+PGtl

eXdvcmQ+TmVvcGxhc21zL3B4IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5OZW9wbGFz

bXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXM8L2tleXdvcmQ+PGtl

eXdvcmQ+TnV0cml0aW9uYWwgU3RhdHVzPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHlwaGFybWFjeTwv

a2V5d29yZD48a2V5d29yZD5Tb2NpYWwgU3VwcG9ydDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDA3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5IDEwPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NDg4OTgw

PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRy

YW11cmFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXZp

ZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlk

LmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0

ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE3NDg4OTgwPC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9z

dGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJ

Q0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10

OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkNSZhbXA7cmZ0Lmdl

bnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9pZD1pbmZvOnBtaWQvMTc0

ODg5ODAmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7cmZ0LnZvbHVtZT0yNSZhbXA7cmZ0Lmlz

c3VlPTE0JmFtcDtyZnQuc3BhZ2U9MTgyNCZhbXA7cmZ0LnBhZ2VzPTE4MjQtMzEmYW1wO3JmdC5k

YXRlPTIwMDcmYW1wO3JmdC5qdGl0bGU9Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9neSZhbXA7

cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcitw

YXRpZW50cyt3aXRoK2NhbmNlci4mYW1wO3JmdC5hdWxhc3Q9RXh0ZXJtYW5uPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0

YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9y

ZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkZyZXllcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+

PFJlY051bT4yMDQ4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ4PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4

ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDg8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkZyZXllciwgRy48L2F1dGhvcj48YXV0aG9yPkdl

YXksIEouIEYuPC9hdXRob3I+PGF1dGhvcj5Ub3V6ZXQsIFMuPC9hdXRob3I+PGF1dGhvcj5Qcm92

ZW5jYWwsIEouPC9hdXRob3I+PGF1dGhvcj5XZWJlciwgQi48L2F1dGhvcj48YXV0aG9yPkphY3F1

aW4sIEouIFAuPC9hdXRob3I+PGF1dGhvcj5HYW5lbSwgRy48L2F1dGhvcj48YXV0aG9yPlR1Ymlh

bmEtTWF0aGlldSwgTi48L2F1dGhvcj48YXV0aG9yPkdpc3Nlcm90LCBPLjwvYXV0aG9yPjxhdXRo

b3I+UHVqYWRlLUxhdXJhaW5lLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkZyZXllcixHLiBTZXJ2aWNlIGQmYXBvcztvbmNvbG9naWUgbWVkaWNhbGUs

IENlbnRyZSBIb3NwaXRhbGllciBMeW9uIFN1ZCwgUGllcnJlLUJlbml0ZS4gZ2lsbGVzLmZyZXll

ckBjaHUtbHlvbi5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUg

Z2VyaWF0cmljIGFzc2Vzc21lbnQgcHJlZGljdHMgdG9sZXJhbmNlIHRvIGNoZW1vdGhlcmFweSBh

bmQgc3Vydml2YWwgaW4gZWxkZXJseSBwYXRpZW50cyB3aXRoIGFkdmFuY2VkIG92YXJpYW4gY2Fy

Y2lub21hOiBhIEdJTkVDTyBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2Yg

T25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVs

bC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9h

YmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTc5NS04MDA8L3BhZ2VzPjx2b2x1bWU+MTY8

L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9w

bGFzdGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVz

ZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyYm9wbGF0aW4vYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7

IERvc2FnZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvZHQgW0RydWcg

VGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvbW8gW01vcnRh

bGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvc2MgW1NlY29uZGFy

eV08L2tleXdvcmQ+PGtleXdvcmQ+Q3ljbG9waG9zcGhhbWlkZS9hZCBbQWRtaW5pc3RyYXRpb24g

JmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91

cy9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEs

IFNlcm91cy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5v

bWEsIFNlcm91cy9zYyBbU2Vjb25kYXJ5XTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIFByb2dy

ZXNzaW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0

cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1heGltdW0gVG9sZXJhdGVkIERvc2U8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJy

ZW5jZSwgTG9jYWwvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20g

UmVjdXJyZW5jZSwgTG9jYWwvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk92YXJp

YW4gTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipPdmFyaWFu

IE5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5PdmFyaWFuIE5lb3Bs

YXNtcy9wYSBbUGF0aG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZhbCBS

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPjhOM0RXNzI3MlAgKEN5Y2xvcGhvc3BoYW1pZGUpPC9rZXl3

b3JkPjxrZXl3b3JkPkJHM0Y2Mk9ORDUgKENhcmJvcGxhdGluKTwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkyMy03NTM0PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDkz

Mjc1PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE2MDkz

Mjc1PC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51

cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAw

NCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lk

PWluZm86c2lkL092aWQ6bWVkNSZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZv

OmRvaS8mYW1wO3JmdF9pZD1pbmZvOnBtaWQvMTYwOTMyNzUmYW1wO3JmdC5pc3NuPTA5MjMtNzUz

NCZhbXA7cmZ0LnZvbHVtZT0xNiZhbXA7cmZ0Lmlzc3VlPTExJmFtcDtyZnQuc3BhZ2U9MTc5NSZh

bXA7cmZ0LnBhZ2VzPTE3OTUtODAwJmFtcDtyZnQuZGF0ZT0yMDA1JmFtcDtyZnQuanRpdGxlPUFu

bmFscytvZitPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYyth

c3Nlc3NtZW50K3ByZWRpY3RzK3RvbGVyYW5jZSt0bytjaGVtb3RoZXJhcHkrYW5kK3N1cnZpdmFs

K2luK2VsZGVybHkrcGF0aWVudHMrd2l0aCthZHZhbmNlZCtvdmFyaWFuK2NhcmNpbm9tYSUzQSth

K0dJTkVDTytzdHVkeS4mYW1wO3JmdC5hdWxhc3Q9RnJleWVyPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFt

ZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPkdpcnJlPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjIw

NDY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDY8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZl

ZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxy

ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz

PjxhdXRob3JzPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+PGF1dGhvcj5GYWxjb3UsIE0uIEMu

PC9hdXRob3I+PGF1dGhvcj5HaXNzZWxicmVjaHQsIE0uPC9hdXRob3I+PGF1dGhvcj5HcmlkZWws

IEcuPC9hdXRob3I+PGF1dGhvcj5Nb3NzZXJpLCBWLjwvYXV0aG9yPjxhdXRob3I+Qm91bGV1Yywg

Qy48L2F1dGhvcj48YXV0aG9yPlBvaW5zb3QsIFIuPC9hdXRob3I+PGF1dGhvcj5WZWRyaW5lLCBM

LjwvYXV0aG9yPjxhdXRob3I+T2xsaXZpZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5HYXJhYmlnZSwg

Vi48L2F1dGhvcj48YXV0aG9yPlBpZXJnYSwgSi4gWS48L2F1dGhvcj48YXV0aG9yPkRpZXJhcywg

Vi48L2F1dGhvcj48YXV0aG9yPk1pZ25vdCwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5HaXJyZSxWZXJvbmlxdWUuIEluc3RpdHV0IEN1cmllLCBEZXBh

cnRlbWVudCBkJmFwb3M7T25jb2xvZ2llIE1lZGljYWxlLCBQYXJpcywgRnJhbmNlLiB2ZXJvbmlx

dWUuZ2lycmVAY3VyaWUubmV0PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RG9lcyBhIGdl

cmlhdHJpYyBvbmNvbG9neSBjb25zdWx0YXRpb24gbW9kaWZ5IHRoZSBjYW5jZXIgdHJlYXRtZW50

IHBsYW4gZm9yIGVsZGVybHkgcGF0aWVudHM/PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJu

YWxzIG9mIEdlcm9udG9sb2d5IFNlcmllcyBBLUJpb2xvZ2ljYWwgU2NpZW5jZXMgJmFtcDsgTWVk

aWNhbCBTY2llbmNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBHZXJvbnRvbCBBIEJp

b2wgU2NpIE1lZCBTY2k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5Kb3VybmFscyBvZiBHZXJvbnRvbG9neSBTZXJpZXMgQS1CaW9sb2dpY2FsIFNjaWVuY2VzICZh

bXA7IE1lZGljYWwgU2NpZW5jZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIEdlcm9udG9sIEEgQmlv

bCBTY2kgTWVkIFNjaTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Sm91cm5hbHMgb2YgR2Vyb250b2xvZ3kgU2VyaWVzIEEtQmlvbG9naWNhbCBTY2llbmNl

cyAmYW1wOyBNZWRpY2FsIFNjaWVuY2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBHZXJvbnRvbCBB

IEJpb2wgU2NpIE1lZCBTY2k8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43MjQtMzA8

L3BhZ2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+PGtleXdvcmQ+QWZmZWN0

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92

ZXI8L2tleXdvcmQ+PGtleXdvcmQ+Q2FuY2VyIENhcmUgRmFjaWxpdGllczwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPipNZWRpY2FsIE9uY29sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvdGggW1Ro

ZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipSZWZlcnJhbCBhbmQgQ29uc3VsdGF0aW9uPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5K

dWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDc5LTUwMDY8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTg2OTMyMjc8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODY5MzIyNzwvdXJsPjx1

cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdU

T04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92

YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9P

dmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDty

ZnRfaWQ9aW5mbzpwbWlkLzE4NjkzMjI3JmFtcDtyZnQuaXNzbj0xMDc5LTUwMDYmYW1wO3JmdC52

b2x1bWU9NjMmYW1wO3JmdC5pc3N1ZT03JmFtcDtyZnQuc3BhZ2U9NzI0JmFtcDtyZnQucGFnZXM9

NzI0LTMwJmFtcDtyZnQuZGF0ZT0yMDA4JmFtcDtyZnQuanRpdGxlPUpvdXJuYWxzK29mK0dlcm9u

dG9sb2d5K1NlcmllcytBLUJpb2xvZ2ljYWwrU2NpZW5jZXMrJTI2K01lZGljYWwrU2NpZW5jZXMm

YW1wO3JmdC5hdGl0bGU9RG9lcythK2dlcmlhdHJpYytvbmNvbG9neStjb25zdWx0YXRpb24rbW9k

aWZ5K3RoZStjYW5jZXIrdHJlYXRtZW50K3BsYW4rZm9yK2VsZGVybHkrcGF0aWVudHMlM0YuJmFt

cDtyZnQuYXVsYXN0PUdpcnJlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxh

bmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlB1

dHM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MjA0MzwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjA0MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDM1MjkzNTQ3Ij4yMDQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Q

dXRzLCBNLiBULjwvYXV0aG9yPjxhdXRob3I+SGFyZHQsIEouPC9hdXRob3I+PGF1dGhvcj5Nb25l

dHRlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+PGF1dGhvcj5TcHJpbmdh

bGwsIEUuPC9hdXRob3I+PGF1dGhvcj5BbGliaGFpLCBTLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlB1dHMsTSBUIEUuIExhd3JlbmNlIFMuIEJsb29t

YmVyZyBGYWN1bHR5IG9mIE51cnNpbmcsIFVuaXZlcnNpdHkgb2YgVG9yb250bywgVG9yb250bywg

T04sIENhbmFkYS4gbWFydGluZS5wdXRzQHV0b3JvbnRvLmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+VXNlIG9mIGdlcmlhdHJpYyBhc3Nlc3NtZW50IGZvciBvbGRlciBhZHVsdHMgaW4g

dGhlIG9uY29sb2d5IHNldHRpbmc6IGEgc3lzdGVtYXRpYyByZXZpZXc8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiB0aGUgTmF0aW9uYWwgQ2FuY2VyIEluc3RpdHV0ZTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBOYXRsIENhbmNlciBJbnN0PC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUgTmF0aW9uYWwgQ2FuY2Vy

IEluc3RpdHV0ZTwvZnVsbC10aXRsZT48YWJici0xPkogTmF0bCBDYW5jZXIgSW5zdDwvYWJici0x

PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUg

TmF0aW9uYWwgQ2FuY2VyIEluc3RpdHV0ZTwvZnVsbC10aXRsZT48YWJici0xPkogTmF0bCBDYW5j

ZXIgSW5zdDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjExMzMtNjM8L3BhZ2VzPjx2

b2x1bWU+MTA0PC92b2x1bWU+PG51bWJlcj4xNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5B

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3Jk

PkNhbmFkYTwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5F

dXJvcGU8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NZWRpY2FsIE9uY29sb2d5L3N0IFtTdGFu

ZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPipNZWRpY2FsIE9uY29sb2d5L3RkIFtUcmVuZHNdPC9r

ZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXM8L2tleXdvcmQ+PGtleXdvcmQ+TnV0cml0aW9uIEFz

c2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hvbWV0cmljczwva2V5d29yZD48a2V5d29y

ZD5RdWVzdGlvbm5haXJlcy9zdCBbU3RhbmRhcmRzXTwva2V5d29yZD48a2V5d29yZD4qUXVlc3Rp

b25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9r

ZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyA4PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQ2MC0yMTA1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyODUxMjY5PC9h

Y2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFw

b3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh

bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjg1MTI2OTwvdXJsPjx1cmw+aHR0

cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VM

TElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10

PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1l

ZGwmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTA5MyUyRmpu

Y2klMkZkanMyODUmYW1wO3JmdF9pZD1pbmZvOnBtaWQvMjI4NTEyNjkmYW1wO3JmdC5pc3NuPTAw

MjctODg3NCZhbXA7cmZ0LnZvbHVtZT0xMDQmYW1wO3JmdC5pc3N1ZT0xNSZhbXA7cmZ0LnNwYWdl

PTExMzMmYW1wO3JmdC5wYWdlcz0xMTMzLTYzJmFtcDtyZnQuZGF0ZT0yMDEyJmFtcDtyZnQuanRp

dGxlPUpvdXJuYWwrb2YrdGhlK05hdGlvbmFsK0NhbmNlcitJbnN0aXR1dGUmYW1wO3JmdC5hdGl0

bGU9VXNlK29mK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcithZHVsdHMraW4rdGhlK29u

Y29sb2d5K3NldHRpbmclM0ErYStzeXN0ZW1hdGljK3Jldmlldy4mYW1wO3JmdC5hdWxhc3Q9UHV0

czwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNDEzNjE0PC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDkzL2puY2kv

ZGpzMjg1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVE

TElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5Pdmlk

IFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNo

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5QdXRzPC9BdXRob3I+PFll

YXI+MjAxNDwvWWVhcj48UmVjTnVtPjIwMzk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIw

Mzk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0

d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjAz

OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UHV0cywgTS4gVC48L2F1

dGhvcj48YXV0aG9yPlNhbnRvcywgQi48L2F1dGhvcj48YXV0aG9yPkhhcmR0LCBKLjwvYXV0aG9y

PjxhdXRob3I+TW9uZXR0ZSwgSi48L2F1dGhvcj48YXV0aG9yPkdpcnJlLCBWLjwvYXV0aG9yPjxh

dXRob3I+QXRlbmFmdSwgRS4gRy48L2F1dGhvcj48YXV0aG9yPlNwcmluZ2FsbCwgRS48L2F1dGhv

cj48YXV0aG9yPkFsaWJoYWksIFMuIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+UHV0cyxNIFQgRS4gTGF3cmVuY2UgUy4gQmxvb21iZXJnIEZhY3VsdHkg

b2YgTnVyc2luZywgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRvLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkFuIHVwZGF0ZSBvbiBhIHN5c3RlbWF0aWMgcmV2aWV3IG9mIHRoZSB1

c2Ugb2YgZ2VyaWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIGFkdWx0cyBpbiBvbmNvbG9neTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2YgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+MzA3LTE1PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+

PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MtU2VjdGlvbmFsIFN0dWRpZXM8L2tl

eXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3Jk

PjxrZXl3b3JkPk5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5OZW9w

bGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8

L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBBc3N1cmFuY2UsIEhlYWx0aCBDYXJlPC9rZXl3b3Jk

PjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU2OS04

MDQxPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MjU2ODQ3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDI1Njg0NzwvdXJsPjx1cmw+aHR0cDov

L290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElO

R1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWlu

Zm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwm

YW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTA5MyUyRmFubm9u

YyUyRm1kdDM4NiZhbXA7cmZ0X2lkPWluZm86cG1pZC8yNDI1Njg0NyZhbXA7cmZ0Lmlzc249MDky

My03NTM0JmFtcDtyZnQudm9sdW1lPTI1JmFtcDtyZnQuaXNzdWU9MiZhbXA7cmZ0LnNwYWdlPTMw

NyZhbXA7cmZ0LnBhZ2VzPTMwNy0xNSZhbXA7cmZ0LmRhdGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1B

bm5hbHMrb2YrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9QW4rdXBkYXRlK29uK2Erc3lzdGVtYXRp

YytyZXZpZXcrb2YrdGhlK3VzZStvZitnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIrYWR1

bHRzK2luK29uY29sb2d5LiZhbXA7cmZ0LmF1bGFzdD1QdXRzPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDkz

L2Fubm9uYy9tZHQzODY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2Ut

bmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdl

PkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlJhbWphdW48

L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MjA0MTwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MjA0MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDM1

MjkzNTQ3Ij4yMDQxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5SYW1q

YXVuLCBBLjwvYXV0aG9yPjxhdXRob3I+TmFzc2lmLCBNLiBPLjwvYXV0aG9yPjxhdXRob3I+S3Jv

dG5ldmEsIFMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgQS4gUi48L2F1dGhvcj48YXV0aG9yPk1l

Z3VlcmRpdGNoaWFuLCBBLiBOLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPlJhbWphdW4sQWxpeWEuIERlcGFydG1lbnQgb2YgRXBpZGVtaW9sb2d5IGFuZCBC

aW9zdGF0aXN0aWNzLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwsIENhbmFkYTsgTWNHaWxs

IENsaW5pY2FsIGFuZCBIZWFsdGggSW5mb3JtYXRpY3MsIE1jR2lsbCBVbml2ZXJzaXR5LCBNb250

cmVhbCwgQ2FuYWRhLiBFbGVjdHJvbmljIGFkZHJlc3M6IGFsaXlhLnJhbWphdW5AbWFpbC5tY2dp

bGwuY2EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW1wcm92ZWQgdGFyZ2V0aW5nIG9m

IGNhbmNlciBjYXJlIGZvciBvbGRlciBwYXRpZW50czogYSBzeXN0ZW1hdGljIHJldmlldyBvZiB0

aGUgdXRpbGl0eSBvZiBjb21wcmVoZW5zaXZlIGdlcmlhdHJpYyBhc3Nlc3NtZW50PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgR2VyaWF0cmljIE9uY29sb2d5PC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5KIEdlcmlhdHIgT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEdlcmlhdHJpYyBPbmNvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogR2VyaWF0ciBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBHZXJpYXRyaWMgT25jb2xvZ3k8L2Z1bGwt

dGl0bGU+PGFiYnItMT5KIEdlcmlhdHIgT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxw

YWdlcz4yNzEtODE8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGluZW9wbGFzdGljIENv

bWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdv

cmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQ29tYmluZWQgQ2hlbW90aGVyYXB5IFByb3RvY29s

cy90dSBbVGhlcmFwZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vz

c21lbnQvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5OZW9wbGFzbXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNt

cy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TnV0cml0aW9uYWwgU3RhdHVzPC9rZXl3

b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9ucy9ldCBbRXRpb2xvZ3ldPC9r

ZXl3b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9ucy9tbyBbTW9ydGFsaXR5

XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3Rp

dmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3OS00

MDc2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MDcwNDY0PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDA3MDQ2NDwvdXJsPjx1cmw+aHR0cDovL290

YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RP

Tl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86

b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1w

O3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTAxNiUyRmouamdvLjIw

MTMuMDQuMDAyJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0MDcwNDY0JmFtcDtyZnQuaXNzbj0xODc5

LTQwNzYmYW1wO3JmdC52b2x1bWU9NCZhbXA7cmZ0Lmlzc3VlPTMmYW1wO3JmdC5zcGFnZT0yNzEm

YW1wO3JmdC5wYWdlcz0yNzEtODEmYW1wO3JmdC5kYXRlPTIwMTMmYW1wO3JmdC5qdGl0bGU9Sm91

cm5hbCtvZitHZXJpYXRyaWMrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9SW1wcm92ZWQrdGFyZ2V0

aW5nK29mK2NhbmNlcitjYXJlK2ZvcitvbGRlcitwYXRpZW50cyUzQSthK3N5c3RlbWF0aWMrcmV2

aWV3K29mK3RoZSt1dGlsaXR5K29mK2NvbXByZWhlbnNpdmUrZ2VyaWF0cmljK2Fzc2Vzc21lbnQu

JmFtcDtyZnQuYXVsYXN0PVJhbWphdW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qZ28uMjAxMy4w

NC4wMDI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURM

SU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQg

VGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldpbGRpZXJzPC9BdXRob3I+

PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjIwNDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjIwNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0

MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+

MjA0MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2lsZGllcnMsIEgu

PC9hdXRob3I+PGF1dGhvcj5IZWVyZW4sIFAuPC9hdXRob3I+PGF1dGhvcj5QdXRzLCBNLjwvYXV0

aG9yPjxhdXRob3I+VG9waW5rb3ZhLCBFLjwvYXV0aG9yPjxhdXRob3I+SmFuc3Nlbi1IZWlqbmVu

LCBNLiBMLjwvYXV0aG9yPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+RmFs

YW5kcnksIEMuPC9hdXRob3I+PGF1dGhvcj5BcnR6LCBBLjwvYXV0aG9yPjxhdXRob3I+QnJhaW4s

IEUuPC9hdXRob3I+PGF1dGhvcj5Db2xsb2NhLCBHLjwvYXV0aG9yPjxhdXRob3I+RmxhbWFpbmcs

IEouPC9hdXRob3I+PGF1dGhvcj5LYXJuYWtpcywgVC48L2F1dGhvcj48YXV0aG9yPktlbmlzLCBD

LjwvYXV0aG9yPjxhdXRob3I+QXVkaXNpbywgUi4gQS48L2F1dGhvcj48YXV0aG9yPk1vaGlsZSwg

Uy48L2F1dGhvcj48YXV0aG9yPlJlcGV0dG8sIEwuPC9hdXRob3I+PGF1dGhvcj5WYW4gTGVldXdl

biwgQi48L2F1dGhvcj48YXV0aG9yPk1pbGlzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5IdXJyaWEs

IEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkludGVy

bmF0aW9uYWwgU29jaWV0eSBvZiBHZXJpYXRyaWMgT25jb2xvZ3kgY29uc2Vuc3VzIG9uIGdlcmlh

dHJpYyBhc3Nlc3NtZW50IGluIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yNTk1LTYwMzwv

cGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1iZXI+MjQ8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29y

ZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Db25zZW5zdXM8L2tleXdvcmQ+

PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48a2V5

d29yZD5HZXJpYXRyaWNzL210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmlj

cy9zdCBbU3RhbmRhcmRzXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+Kk5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21z

L3RoIFtUaGVyYXB5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+QXVnIDIwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1MDcxMTI1PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRsJmFtcDtBTj0yNTA3MTEyNTwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3Rl

ZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNF

U19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDpr

ZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1wO3JmdC5nZW5y

ZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI1MDcx

MTI1JmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MzImYW1wO3JmdC5pc3N1

ZT0yNCZhbXA7cmZ0LnNwYWdlPTI1OTUmYW1wO3JmdC5wYWdlcz0yNTk1LTYwMyZhbXA7cmZ0LmRh

dGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29mK0NsaW5pY2FsK09uY29sb2d5JmFtcDty

ZnQuYXRpdGxlPUludGVybmF0aW9uYWwrU29jaWV0eStvZitHZXJpYXRyaWMrT25jb2xvZ3krY29u

c2Vuc3VzK29uK2dlcmlhdHJpYythc3Nlc3NtZW50K2luK29sZGVyK3BhdGllbnRzK3dpdGgrY2Fu

Y2VyLiZhbXA7cmZ0LmF1bGFzdD1XaWxkaWVyczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYWlsbGV0PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjIwNDQ8L1JlY051bT48RGlzcGxheVRleHQ+KDIwLTI3KTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4yMDQ0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3Rh

bXA9IjE0MzUyOTM1NDciPjIwNDQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkNhaWxsZXQsIFAuPC9hdXRob3I+PGF1dGhvcj5DYW5vdWktUG9pdHJpbmUsIEYuPC9hdXRo

b3I+PGF1dGhvcj5Wb3VyaW90LCBKLjwvYXV0aG9yPjxhdXRob3I+QmVybGUsIE0uPC9hdXRob3I+

PGF1dGhvcj5SZWluYWxkLCBOLjwvYXV0aG9yPjxhdXRob3I+S3J5cGNpYWssIFMuPC9hdXRob3I+

PGF1dGhvcj5CYXN0dWppLUdhcmluLCBTLjwvYXV0aG9yPjxhdXRob3I+Q3VsaW5lLCBTLjwvYXV0

aG9yPjxhdXRob3I+UGFpbGxhdWQsIEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+Q2FpbGxldCxQaGlsaXBwZS4gVW5pdmVyc2l0eSBvZiBQYXJpcyBFc3Qg

Q3JldGVpbCwgTGFib3JhdG9pcmUgZCZhcG9zO0ludmVzdGlnYXRpb24gQ2xpbmljcXVlIEVBIDQz

OTMsIEFzc2l0YW5jZSBQdWJsaXF1ZS1Ib3BpdGF1eCBkZSBQYXJpcyBIZW5yaSBNb25kb3IsIENy

ZXRlaWwsIEZyYW5jZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUg

Z2VyaWF0cmljIGFzc2Vzc21lbnQgaW4gdGhlIGRlY2lzaW9uLW1ha2luZyBwcm9jZXNzIGluIGVs

ZGVybHkgcGF0aWVudHMgd2l0aCBjYW5jZXI6IEVMQ0FQQSBzdHVkeTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFs

dC10aXRsZT5KIENsaW4gT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+

SiBDbGluIE9uY29sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Kb3VybmFsIG9mIENsaW5pY2FsIE9uY29sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBD

bGluIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzYzNi00MjwvcGFnZXM+

PHZvbHVtZT4yOTwvdm9sdW1lPjxudW1iZXI+Mjc8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+

QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Db2duaXRpb24g

RGlzb3JkZXJzL2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0

eTwva2V5d29yZD48a2V5d29yZD4qRGVjaXNpb24gTWFraW5nPC9rZXl3b3JkPjxrZXl3b3JkPkRl

cHJlc3Npb24vY28gW0NvbXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5

d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWFsbnV0cml0aW9u

L2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5NdWx0aXZhcmlhdGUgQW5hbHlz

aXM8L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh

cj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDIwPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNzA5MTk0PC9hY2Nl

c3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkbCZhbXA7QU49MjE3MDkxOTQ8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0

ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklD

RVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6

a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWRsJmFtcDtyZnQuZ2Vu

cmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLzEwLjEyMDAlMkZKQ08uMjAxMC4zMS4wNjY0

JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzIxNzA5MTk0JmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1w

O3JmdC52b2x1bWU9MjkmYW1wO3JmdC5pc3N1ZT0yNyZhbXA7cmZ0LnNwYWdlPTM2MzYmYW1wO3Jm

dC5wYWdlcz0zNjM2LTQyJmFtcDtyZnQuZGF0ZT0yMDExJmFtcDtyZnQuanRpdGxlPUpvdXJuYWwr

b2YrQ2xpbmljYWwrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9Q29tcHJlaGVuc2l2ZStnZXJpYXRy

aWMrYXNzZXNzbWVudCtpbit0aGUrZGVjaXNpb24tbWFraW5nK3Byb2Nlc3MraW4rZWxkZXJseStw

YXRpZW50cyt3aXRoK2NhbmNlciUzQStFTENBUEErc3R1ZHkuJmFtcDtyZnQuYXVsYXN0PUNhaWxs

ZXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0

dHA6Ly9keC5kb2kub3JnLzEwLjEyMDAvSkNPLjIwMTAuMzEuMDY2NDwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1u

YW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9D

aXRlPjxDaXRlPjxBdXRob3I+RXh0ZXJtYW5uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVj

TnVtPjIwNDc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDc8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3

c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0Nzwva2V5PjwvZm9yZWlnbi1r

ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp

YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+SHVy

cmlhLCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkV4

dGVybWFubixNYXJ0aW5lLiBILiBMZWUgTW9mZml0dCBDYW5jZXIgQ2VudGVyLCBVbml2ZXJzaXR5

IG9mIFNvdXRoIEZsb3JpZGEsIFRhbXBhLCBGTCAzMzYxMiwgVVNBLiBleHRlcm1hbm5AbW9mZml0

dC51c2YuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tcHJlaGVuc2l2ZSBnZXJp

YXRyaWMgYXNzZXNzbWVudCBmb3Igb2xkZXIgcGF0aWVudHMgd2l0aCBjYW5jZXI8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+SiBDbGluIE9uY29sPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10aXRsZT48

YWJici0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBDbGluaWNhbCBPbmNvbG9neTwvZnVsbC10aXRsZT48YWJi

ci0xPkogQ2xpbiBPbmNvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE4MjQtMzE8

L3BhZ2VzPjx2b2x1bWU+MjU8L3ZvbHVtZT48bnVtYmVyPjE0PC9udW1iZXI+PGtleXdvcmRzPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk

PkNvbW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgTWFuYWdlbWVudDwva2V5d29y

ZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qTWVkaWNhbCBPbmNvbG9neS9tdCBbTWV0

aG9kc108L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zL2NvIFtDb21wbGljYXRpb25zXTwva2V5

d29yZD48a2V5d29yZD5OZW9wbGFzbXMvcHAgW1BoeXNpb3BhdGhvbG9neV08L2tleXdvcmQ+PGtl

eXdvcmQ+TmVvcGxhc21zL3B4IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5OZW9wbGFz

bXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXM8L2tleXdvcmQ+PGtl

eXdvcmQ+TnV0cml0aW9uYWwgU3RhdHVzPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHlwaGFybWFjeTwv

a2V5d29yZD48a2V5d29yZD5Tb2NpYWwgU3VwcG9ydDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDA3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5IDEwPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE3NDg4OTgw

PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRy

YW11cmFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0JiN4RDtSZXZp

ZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlk

LmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0

ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE3NDg4OTgwPC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9z

dGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJ

Q0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAwNCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10

OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lkPWluZm86c2lkL092aWQ6bWVkNSZhbXA7cmZ0Lmdl

bnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZvOmRvaS8mYW1wO3JmdF9pZD1pbmZvOnBtaWQvMTc0

ODg5ODAmYW1wO3JmdC5pc3NuPTA3MzItMTgzWCZhbXA7cmZ0LnZvbHVtZT0yNSZhbXA7cmZ0Lmlz

c3VlPTE0JmFtcDtyZnQuc3BhZ2U9MTgyNCZhbXA7cmZ0LnBhZ2VzPTE4MjQtMzEmYW1wO3JmdC5k

YXRlPTIwMDcmYW1wO3JmdC5qdGl0bGU9Sm91cm5hbCtvZitDbGluaWNhbCtPbmNvbG9neSZhbXA7

cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcitw

YXRpZW50cyt3aXRoK2NhbmNlci4mYW1wO3JmdC5hdWxhc3Q9RXh0ZXJtYW5uPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0

YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9y

ZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkZyZXllcjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+

PFJlY051bT4yMDQ4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDQ4PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMjJzdDIwdHduZGFzemFldzV6ZXB4

ZGY2d3N2c2FmZWU5enBwIiB0aW1lc3RhbXA9IjE0MzUyOTM1NDciPjIwNDg8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkZyZXllciwgRy48L2F1dGhvcj48YXV0aG9yPkdl

YXksIEouIEYuPC9hdXRob3I+PGF1dGhvcj5Ub3V6ZXQsIFMuPC9hdXRob3I+PGF1dGhvcj5Qcm92

ZW5jYWwsIEouPC9hdXRob3I+PGF1dGhvcj5XZWJlciwgQi48L2F1dGhvcj48YXV0aG9yPkphY3F1

aW4sIEouIFAuPC9hdXRob3I+PGF1dGhvcj5HYW5lbSwgRy48L2F1dGhvcj48YXV0aG9yPlR1Ymlh

bmEtTWF0aGlldSwgTi48L2F1dGhvcj48YXV0aG9yPkdpc3Nlcm90LCBPLjwvYXV0aG9yPjxhdXRo

b3I+UHVqYWRlLUxhdXJhaW5lLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkZyZXllcixHLiBTZXJ2aWNlIGQmYXBvcztvbmNvbG9naWUgbWVkaWNhbGUs

IENlbnRyZSBIb3NwaXRhbGllciBMeW9uIFN1ZCwgUGllcnJlLUJlbml0ZS4gZ2lsbGVzLmZyZXll

ckBjaHUtbHlvbi5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvbXByZWhlbnNpdmUg

Z2VyaWF0cmljIGFzc2Vzc21lbnQgcHJlZGljdHMgdG9sZXJhbmNlIHRvIGNoZW1vdGhlcmFweSBh

bmQgc3Vydml2YWwgaW4gZWxkZXJseSBwYXRpZW50cyB3aXRoIGFkdmFuY2VkIG92YXJpYW4gY2Fy

Y2lub21hOiBhIEdJTkVDTyBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2Yg

T25jb2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVs

bC10aXRsZT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9h

YmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTc5NS04MDA8L3BhZ2VzPjx2b2x1bWU+MTY8

L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtleXdvcmQ+KkFudGluZW9w

bGFzdGljIENvbWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvdHUgW1RoZXJhcGV1dGljIFVz

ZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyYm9wbGF0aW4vYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7

IERvc2FnZV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvZHQgW0RydWcg

VGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvbW8gW01vcnRh

bGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBQYXBpbGxhcnkvc2MgW1NlY29uZGFy

eV08L2tleXdvcmQ+PGtleXdvcmQ+Q3ljbG9waG9zcGhhbWlkZS9hZCBbQWRtaW5pc3RyYXRpb24g

JmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEsIFNlcm91

cy9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5vbWEs

IFNlcm91cy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5DeXN0YWRlbm9jYXJjaW5v

bWEsIFNlcm91cy9zYyBbU2Vjb25kYXJ5XTwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIFByb2dy

ZXNzaW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0

cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1heGltdW0gVG9sZXJhdGVkIERvc2U8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20gUmVjdXJy

ZW5jZSwgTG9jYWwvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc20g

UmVjdXJyZW5jZSwgTG9jYWwvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk92YXJp

YW4gTmVvcGxhc21zL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipPdmFyaWFu

IE5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5PdmFyaWFuIE5lb3Bs

YXNtcy9wYSBbUGF0aG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+

PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5TdXJ2aXZhbCBS

YXRlPC9rZXl3b3JkPjxrZXl3b3JkPjhOM0RXNzI3MlAgKEN5Y2xvcGhvc3BoYW1pZGUpPC9rZXl3

b3JkPjxrZXl3b3JkPkJHM0Y2Mk9ORDUgKENhcmJvcGxhdGluKTwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+Tm92PC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDkyMy03NTM0PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDkz

Mjc1PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2Vh

cmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE2MDkz

Mjc1PC91cmw+PHVybD5odHRwOi8vb3RhZ28uaG9zdGVkLmV4bGlicmlzZ3JvdXAuY29tL29wZW51

cmwvV0VMTElOR1RPTi9XRUxMSU5HVE9OX1NFUlZJQ0VTX1BBR0U/dXJsX3Zlcj1aMzkuODgtMjAw

NCZhbXA7cmZ0X3ZhbF9mbXQ9aW5mbzpvZmkvZm10OmtldjptdHg6am91cm5hbCZhbXA7cmZyX2lk

PWluZm86c2lkL092aWQ6bWVkNSZhbXA7cmZ0LmdlbnJlPWFydGljbGUmYW1wO3JmdF9pZD1pbmZv

OmRvaS8mYW1wO3JmdF9pZD1pbmZvOnBtaWQvMTYwOTMyNzUmYW1wO3JmdC5pc3NuPTA5MjMtNzUz

NCZhbXA7cmZ0LnZvbHVtZT0xNiZhbXA7cmZ0Lmlzc3VlPTExJmFtcDtyZnQuc3BhZ2U9MTc5NSZh

bXA7cmZ0LnBhZ2VzPTE3OTUtODAwJmFtcDtyZnQuZGF0ZT0yMDA1JmFtcDtyZnQuanRpdGxlPUFu

bmFscytvZitPbmNvbG9neSZhbXA7cmZ0LmF0aXRsZT1Db21wcmVoZW5zaXZlK2dlcmlhdHJpYyth

c3Nlc3NtZW50K3ByZWRpY3RzK3RvbGVyYW5jZSt0bytjaGVtb3RoZXJhcHkrYW5kK3N1cnZpdmFs

K2luK2VsZGVybHkrcGF0aWVudHMrd2l0aCthZHZhbmNlZCtvdmFyaWFuK2NhcmNpbm9tYSUzQSth

K0dJTkVDTytzdHVkeS4mYW1wO3JmdC5hdWxhc3Q9RnJleWVyPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFt

ZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPkdpcnJlPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjIw

NDY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNDY8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZl

ZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjA0Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxy

ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz

PjxhdXRob3JzPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+PGF1dGhvcj5GYWxjb3UsIE0uIEMu

PC9hdXRob3I+PGF1dGhvcj5HaXNzZWxicmVjaHQsIE0uPC9hdXRob3I+PGF1dGhvcj5HcmlkZWws

IEcuPC9hdXRob3I+PGF1dGhvcj5Nb3NzZXJpLCBWLjwvYXV0aG9yPjxhdXRob3I+Qm91bGV1Yywg

Qy48L2F1dGhvcj48YXV0aG9yPlBvaW5zb3QsIFIuPC9hdXRob3I+PGF1dGhvcj5WZWRyaW5lLCBM

LjwvYXV0aG9yPjxhdXRob3I+T2xsaXZpZXIsIEwuPC9hdXRob3I+PGF1dGhvcj5HYXJhYmlnZSwg

Vi48L2F1dGhvcj48YXV0aG9yPlBpZXJnYSwgSi4gWS48L2F1dGhvcj48YXV0aG9yPkRpZXJhcywg

Vi48L2F1dGhvcj48YXV0aG9yPk1pZ25vdCwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PGF1dGgtYWRkcmVzcz5HaXJyZSxWZXJvbmlxdWUuIEluc3RpdHV0IEN1cmllLCBEZXBh

cnRlbWVudCBkJmFwb3M7T25jb2xvZ2llIE1lZGljYWxlLCBQYXJpcywgRnJhbmNlLiB2ZXJvbmlx

dWUuZ2lycmVAY3VyaWUubmV0PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RG9lcyBhIGdl

cmlhdHJpYyBvbmNvbG9neSBjb25zdWx0YXRpb24gbW9kaWZ5IHRoZSBjYW5jZXIgdHJlYXRtZW50

IHBsYW4gZm9yIGVsZGVybHkgcGF0aWVudHM/PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJu

YWxzIG9mIEdlcm9udG9sb2d5IFNlcmllcyBBLUJpb2xvZ2ljYWwgU2NpZW5jZXMgJmFtcDsgTWVk

aWNhbCBTY2llbmNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBHZXJvbnRvbCBBIEJp

b2wgU2NpIE1lZCBTY2k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs

ZT5Kb3VybmFscyBvZiBHZXJvbnRvbG9neSBTZXJpZXMgQS1CaW9sb2dpY2FsIFNjaWVuY2VzICZh

bXA7IE1lZGljYWwgU2NpZW5jZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIEdlcm9udG9sIEEgQmlv

bCBTY2kgTWVkIFNjaTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Sm91cm5hbHMgb2YgR2Vyb250b2xvZ3kgU2VyaWVzIEEtQmlvbG9naWNhbCBTY2llbmNl

cyAmYW1wOyBNZWRpY2FsIFNjaWVuY2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+SiBHZXJvbnRvbCBB

IEJpb2wgU2NpIE1lZCBTY2k8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43MjQtMzA8

L3BhZ2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8L2tleXdvcmQ+PGtleXdvcmQ+QWZmZWN0

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92

ZXI8L2tleXdvcmQ+PGtleXdvcmQ+Q2FuY2VyIENhcmUgRmFjaWxpdGllczwva2V5d29yZD48a2V5

d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPipNZWRpY2FsIE9uY29sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXMvdGggW1Ro

ZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipSZWZlcnJhbCBhbmQgQ29uc3VsdGF0aW9uPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5K

dWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDc5LTUwMDY8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MTg2OTMyMjc8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODY5MzIyNzwvdXJsPjx1

cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdU

T04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92

YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9P

dmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDty

ZnRfaWQ9aW5mbzpwbWlkLzE4NjkzMjI3JmFtcDtyZnQuaXNzbj0xMDc5LTUwMDYmYW1wO3JmdC52

b2x1bWU9NjMmYW1wO3JmdC5pc3N1ZT03JmFtcDtyZnQuc3BhZ2U9NzI0JmFtcDtyZnQucGFnZXM9

NzI0LTMwJmFtcDtyZnQuZGF0ZT0yMDA4JmFtcDtyZnQuanRpdGxlPUpvdXJuYWxzK29mK0dlcm9u

dG9sb2d5K1NlcmllcytBLUJpb2xvZ2ljYWwrU2NpZW5jZXMrJTI2K01lZGljYWwrU2NpZW5jZXMm

YW1wO3JmdC5hdGl0bGU9RG9lcythK2dlcmlhdHJpYytvbmNvbG9neStjb25zdWx0YXRpb24rbW9k

aWZ5K3RoZStjYW5jZXIrdHJlYXRtZW50K3BsYW4rZm9yK2VsZGVybHkrcGF0aWVudHMlM0YuJmFt

cDtyZnQuYXVsYXN0PUdpcnJlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxh

bmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlB1

dHM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MjA0MzwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjA0MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDM1MjkzNTQ3Ij4yMDQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Q

dXRzLCBNLiBULjwvYXV0aG9yPjxhdXRob3I+SGFyZHQsIEouPC9hdXRob3I+PGF1dGhvcj5Nb25l

dHRlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lycmUsIFYuPC9hdXRob3I+PGF1dGhvcj5TcHJpbmdh

bGwsIEUuPC9hdXRob3I+PGF1dGhvcj5BbGliaGFpLCBTLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlB1dHMsTSBUIEUuIExhd3JlbmNlIFMuIEJsb29t

YmVyZyBGYWN1bHR5IG9mIE51cnNpbmcsIFVuaXZlcnNpdHkgb2YgVG9yb250bywgVG9yb250bywg

T04sIENhbmFkYS4gbWFydGluZS5wdXRzQHV0b3JvbnRvLmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+VXNlIG9mIGdlcmlhdHJpYyBhc3Nlc3NtZW50IGZvciBvbGRlciBhZHVsdHMgaW4g

dGhlIG9uY29sb2d5IHNldHRpbmc6IGEgc3lzdGVtYXRpYyByZXZpZXc8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiB0aGUgTmF0aW9uYWwgQ2FuY2VyIEluc3RpdHV0ZTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SiBOYXRsIENhbmNlciBJbnN0PC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUgTmF0aW9uYWwgQ2FuY2Vy

IEluc3RpdHV0ZTwvZnVsbC10aXRsZT48YWJici0xPkogTmF0bCBDYW5jZXIgSW5zdDwvYWJici0x

PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiB0aGUg

TmF0aW9uYWwgQ2FuY2VyIEluc3RpdHV0ZTwvZnVsbC10aXRsZT48YWJici0xPkogTmF0bCBDYW5j

ZXIgSW5zdDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjExMzMtNjM8L3BhZ2VzPjx2

b2x1bWU+MTA0PC92b2x1bWU+PG51bWJlcj4xNTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5B

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3Jk

PkNhbmFkYTwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5F

dXJvcGU8L2tleXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NZWRpY2FsIE9uY29sb2d5L3N0IFtTdGFu

ZGFyZHNdPC9rZXl3b3JkPjxrZXl3b3JkPipNZWRpY2FsIE9uY29sb2d5L3RkIFtUcmVuZHNdPC9r

ZXl3b3JkPjxrZXl3b3JkPipOZW9wbGFzbXM8L2tleXdvcmQ+PGtleXdvcmQ+TnV0cml0aW9uIEFz

c2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hvbWV0cmljczwva2V5d29yZD48a2V5d29y

ZD5RdWVzdGlvbm5haXJlcy9zdCBbU3RhbmRhcmRzXTwva2V5d29yZD48a2V5d29yZD4qUXVlc3Rp

b25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+U2Vuc2l0aXZpdHkgYW5kIFNwZWNpZmljaXR5PC9r

ZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyA4PC9kYXRlPjwvcHViLWRhdGVz

PjwvZGF0ZXM+PGlzYm4+MTQ2MC0yMTA1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyODUxMjY5PC9h

Y2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFw

b3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh

bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjg1MTI2OTwvdXJsPjx1cmw+aHR0

cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VM

TElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10

PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1l

ZGwmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTA5MyUyRmpu

Y2klMkZkanMyODUmYW1wO3JmdF9pZD1pbmZvOnBtaWQvMjI4NTEyNjkmYW1wO3JmdC5pc3NuPTAw

MjctODg3NCZhbXA7cmZ0LnZvbHVtZT0xMDQmYW1wO3JmdC5pc3N1ZT0xNSZhbXA7cmZ0LnNwYWdl

PTExMzMmYW1wO3JmdC5wYWdlcz0xMTMzLTYzJmFtcDtyZnQuZGF0ZT0yMDEyJmFtcDtyZnQuanRp

dGxlPUpvdXJuYWwrb2YrdGhlK05hdGlvbmFsK0NhbmNlcitJbnN0aXR1dGUmYW1wO3JmdC5hdGl0

bGU9VXNlK29mK2dlcmlhdHJpYythc3Nlc3NtZW50K2ZvcitvbGRlcithZHVsdHMraW4rdGhlK29u

Y29sb2d5K3NldHRpbmclM0ErYStzeXN0ZW1hdGljK3Jldmlldy4mYW1wO3JmdC5hdWxhc3Q9UHV0

czwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNDEzNjE0PC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDkzL2puY2kv

ZGpzMjg1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVE

TElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5Pdmlk

IFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNo

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5QdXRzPC9BdXRob3I+PFll

YXI+MjAxNDwvWWVhcj48UmVjTnVtPjIwMzk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIw

Mzk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0MjB0

d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+MjAz

OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3

PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UHV0cywgTS4gVC48L2F1

dGhvcj48YXV0aG9yPlNhbnRvcywgQi48L2F1dGhvcj48YXV0aG9yPkhhcmR0LCBKLjwvYXV0aG9y

PjxhdXRob3I+TW9uZXR0ZSwgSi48L2F1dGhvcj48YXV0aG9yPkdpcnJlLCBWLjwvYXV0aG9yPjxh

dXRob3I+QXRlbmFmdSwgRS4gRy48L2F1dGhvcj48YXV0aG9yPlNwcmluZ2FsbCwgRS48L2F1dGhv

cj48YXV0aG9yPkFsaWJoYWksIFMuIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+UHV0cyxNIFQgRS4gTGF3cmVuY2UgUy4gQmxvb21iZXJnIEZhY3VsdHkg

b2YgTnVyc2luZywgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBUb3JvbnRvLjwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkFuIHVwZGF0ZSBvbiBhIHN5c3RlbWF0aWMgcmV2aWV3IG9mIHRoZSB1

c2Ugb2YgZ2VyaWF0cmljIGFzc2Vzc21lbnQgZm9yIG9sZGVyIGFkdWx0cyBpbiBvbmNvbG9neTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5Bbm5hbHMgb2YgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFubiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkFubmFscyBvZiBPbmNvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxhYmJyLTE+QW5uIE9uY29sPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+MzA3LTE1PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+

PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MtU2VjdGlvbmFsIFN0dWRpZXM8L2tl

eXdvcmQ+PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3b3JkPkh1

bWFuczwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21zL2RpIFtEaWFnbm9zaXNdPC9rZXl3b3Jk

PjxrZXl3b3JkPk5lb3BsYXNtcy9tbyBbTW9ydGFsaXR5XTwva2V5d29yZD48a2V5d29yZD5OZW9w

bGFzbXMvdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8

L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBBc3N1cmFuY2UsIEhlYWx0aCBDYXJlPC9rZXl3b3Jk

PjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU2OS04

MDQxPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MjU2ODQ3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDI1Njg0NzwvdXJsPjx1cmw+aHR0cDov

L290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElO

R1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWlu

Zm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwm

YW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTA5MyUyRmFubm9u

YyUyRm1kdDM4NiZhbXA7cmZ0X2lkPWluZm86cG1pZC8yNDI1Njg0NyZhbXA7cmZ0Lmlzc249MDky

My03NTM0JmFtcDtyZnQudm9sdW1lPTI1JmFtcDtyZnQuaXNzdWU9MiZhbXA7cmZ0LnNwYWdlPTMw

NyZhbXA7cmZ0LnBhZ2VzPTMwNy0xNSZhbXA7cmZ0LmRhdGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1B

bm5hbHMrb2YrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9QW4rdXBkYXRlK29uK2Erc3lzdGVtYXRp

YytyZXZpZXcrb2YrdGhlK3VzZStvZitnZXJpYXRyaWMrYXNzZXNzbWVudCtmb3Irb2xkZXIrYWR1

bHRzK2luK29uY29sb2d5LiZhbXA7cmZ0LmF1bGFzdD1QdXRzPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDkz

L2Fubm9uYy9tZHQzODY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2Ut

bmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdl

PkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlJhbWphdW48

L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MjA0MTwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MjA0MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIxNDM1

MjkzNTQ3Ij4yMDQxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5SYW1q

YXVuLCBBLjwvYXV0aG9yPjxhdXRob3I+TmFzc2lmLCBNLiBPLjwvYXV0aG9yPjxhdXRob3I+S3Jv

dG5ldmEsIFMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgQS4gUi48L2F1dGhvcj48YXV0aG9yPk1l

Z3VlcmRpdGNoaWFuLCBBLiBOLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPlJhbWphdW4sQWxpeWEuIERlcGFydG1lbnQgb2YgRXBpZGVtaW9sb2d5IGFuZCBC

aW9zdGF0aXN0aWNzLCBNY0dpbGwgVW5pdmVyc2l0eSwgTW9udHJlYWwsIENhbmFkYTsgTWNHaWxs

IENsaW5pY2FsIGFuZCBIZWFsdGggSW5mb3JtYXRpY3MsIE1jR2lsbCBVbml2ZXJzaXR5LCBNb250

cmVhbCwgQ2FuYWRhLiBFbGVjdHJvbmljIGFkZHJlc3M6IGFsaXlhLnJhbWphdW5AbWFpbC5tY2dp

bGwuY2EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW1wcm92ZWQgdGFyZ2V0aW5nIG9m

IGNhbmNlciBjYXJlIGZvciBvbGRlciBwYXRpZW50czogYSBzeXN0ZW1hdGljIHJldmlldyBvZiB0

aGUgdXRpbGl0eSBvZiBjb21wcmVoZW5zaXZlIGdlcmlhdHJpYyBhc3Nlc3NtZW50PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgR2VyaWF0cmljIE9uY29sb2d5PC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5KIEdlcmlhdHIgT25jb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEdlcmlhdHJpYyBPbmNvbG9neTwvZnVsbC10

aXRsZT48YWJici0xPkogR2VyaWF0ciBPbmNvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBHZXJpYXRyaWMgT25jb2xvZ3k8L2Z1bGwt

dGl0bGU+PGFiYnItMT5KIEdlcmlhdHIgT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxw

YWdlcz4yNzEtODE8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFudGluZW9wbGFzdGljIENv

bWJpbmVkIENoZW1vdGhlcmFweSBQcm90b2NvbHMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdv

cmQ+PGtleXdvcmQ+QW50aW5lb3BsYXN0aWMgQ29tYmluZWQgQ2hlbW90aGVyYXB5IFByb3RvY29s

cy90dSBbVGhlcmFwZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vz

c21lbnQvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5

d29yZD5OZW9wbGFzbXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNt

cy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+TnV0cml0aW9uYWwgU3RhdHVzPC9rZXl3

b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9ucy9ldCBbRXRpb2xvZ3ldPC9r

ZXl3b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9ucy9tbyBbTW9ydGFsaXR5

XTwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3Rp

dmUgU3R1ZGllczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3OS00

MDc2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0MDcwNDY0PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5

cGU+UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDA3MDQ2NDwvdXJsPjx1cmw+aHR0cDovL290

YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RP

Tl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86

b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1w

O3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvMTAuMTAxNiUyRmouamdvLjIw

MTMuMDQuMDAyJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI0MDcwNDY0JmFtcDtyZnQuaXNzbj0xODc5

LTQwNzYmYW1wO3JmdC52b2x1bWU9NCZhbXA7cmZ0Lmlzc3VlPTMmYW1wO3JmdC5zcGFnZT0yNzEm

YW1wO3JmdC5wYWdlcz0yNzEtODEmYW1wO3JmdC5kYXRlPTIwMTMmYW1wO3JmdC5qdGl0bGU9Sm91

cm5hbCtvZitHZXJpYXRyaWMrT25jb2xvZ3kmYW1wO3JmdC5hdGl0bGU9SW1wcm92ZWQrdGFyZ2V0

aW5nK29mK2NhbmNlcitjYXJlK2ZvcitvbGRlcitwYXRpZW50cyUzQSthK3N5c3RlbWF0aWMrcmV2

aWV3K29mK3RoZSt1dGlsaXR5K29mK2NvbXByZWhlbnNpdmUrZ2VyaWF0cmljK2Fzc2Vzc21lbnQu

JmFtcDtyZnQuYXVsYXN0PVJhbWphdW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qZ28uMjAxMy4w

NC4wMDI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURM

SU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQg

VGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPldpbGRpZXJzPC9BdXRob3I+

PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjIwNDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjIwNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIyMnN0

MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQzNTI5MzU0NyI+

MjA0MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi

PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+V2lsZGllcnMsIEgu

PC9hdXRob3I+PGF1dGhvcj5IZWVyZW4sIFAuPC9hdXRob3I+PGF1dGhvcj5QdXRzLCBNLjwvYXV0

aG9yPjxhdXRob3I+VG9waW5rb3ZhLCBFLjwvYXV0aG9yPjxhdXRob3I+SmFuc3Nlbi1IZWlqbmVu

LCBNLiBMLjwvYXV0aG9yPjxhdXRob3I+RXh0ZXJtYW5uLCBNLjwvYXV0aG9yPjxhdXRob3I+RmFs

YW5kcnksIEMuPC9hdXRob3I+PGF1dGhvcj5BcnR6LCBBLjwvYXV0aG9yPjxhdXRob3I+QnJhaW4s

IEUuPC9hdXRob3I+PGF1dGhvcj5Db2xsb2NhLCBHLjwvYXV0aG9yPjxhdXRob3I+RmxhbWFpbmcs

IEouPC9hdXRob3I+PGF1dGhvcj5LYXJuYWtpcywgVC48L2F1dGhvcj48YXV0aG9yPktlbmlzLCBD

LjwvYXV0aG9yPjxhdXRob3I+QXVkaXNpbywgUi4gQS48L2F1dGhvcj48YXV0aG9yPk1vaGlsZSwg

Uy48L2F1dGhvcj48YXV0aG9yPlJlcGV0dG8sIEwuPC9hdXRob3I+PGF1dGhvcj5WYW4gTGVldXdl

biwgQi48L2F1dGhvcj48YXV0aG9yPk1pbGlzZW4sIEsuPC9hdXRob3I+PGF1dGhvcj5IdXJyaWEs

IEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkludGVy

bmF0aW9uYWwgU29jaWV0eSBvZiBHZXJpYXRyaWMgT25jb2xvZ3kgY29uc2Vuc3VzIG9uIGdlcmlh

dHJpYyBhc3Nlc3NtZW50IGluIG9sZGVyIHBhdGllbnRzIHdpdGggY2FuY2VyPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkogQ2xpbiBPbmNvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIENsaW4gT25jb2w8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkpvdXJuYWwgb2YgQ2xpbmljYWwgT25jb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnIt

MT5KIENsaW4gT25jb2w8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yNTk1LTYwMzwv

cGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1iZXI+MjQ8L251bWJlcj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29y

ZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5Db25zZW5zdXM8L2tleXdvcmQ+

PGtleXdvcmQ+KkdlcmlhdHJpYyBBc3Nlc3NtZW50L210IFtNZXRob2RzXTwva2V5d29yZD48a2V5

d29yZD5HZXJpYXRyaWNzL210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD4qR2VyaWF0cmlj

cy9zdCBbU3RhbmRhcmRzXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv

cmQ+Kk5lb3BsYXNtcy9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD4qTmVvcGxhc21z

L3RoIFtUaGVyYXB5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFy

PjxwdWItZGF0ZXM+PGRhdGU+QXVnIDIwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+

MTUyNy03NzU1PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1MDcxMTI1PC9hY2Nlc3Npb24tbnVtPjx3

b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRsJmFtcDtBTj0yNTA3MTEyNTwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3Rl

ZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJsL1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNF

U19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQmYW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDpr

ZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1pbmZvOnNpZC9PdmlkOm1lZGwmYW1wO3JmdC5nZW5y

ZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpkb2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzI1MDcx

MTI1JmFtcDtyZnQuaXNzbj0wNzMyLTE4M1gmYW1wO3JmdC52b2x1bWU9MzImYW1wO3JmdC5pc3N1

ZT0yNCZhbXA7cmZ0LnNwYWdlPTI1OTUmYW1wO3JmdC5wYWdlcz0yNTk1LTYwMyZhbXA7cmZ0LmRh

dGU9MjAxNCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29mK0NsaW5pY2FsK09uY29sb2d5JmFtcDty

ZnQuYXRpdGxlPUludGVybmF0aW9uYWwrU29jaWV0eStvZitHZXJpYXRyaWMrT25jb2xvZ3krY29u

c2Vuc3VzK29uK2dlcmlhdHJpYythc3Nlc3NtZW50K2luK29sZGVyK3BhdGllbnRzK3dpdGgrY2Fu

Y2VyLiZhbXA7cmZ0LmF1bGFzdD1XaWxkaWVyczwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48

cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE.DATA (20-27) Few studies have assessed the extent to which CGA or similar broad-based medical review at the time of cancer diagnosis actually alter cancer outcomes. However, those that have assessed this question have, without exception, found that such interventions have a positive impact.Two small studies, one of elderly patients with hepatocellular carcinoma in Indonesia (n=87) ADDIN EN.CITE <EndNote><Cite><Author>Soejono</Author><Year>2006</Year><RecNum>2051</RecNum><DisplayText>(28)</DisplayText><record><rec-number>2051</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1435294093">2051</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Soejono, CH</author></authors></contributors><titles><title>The role of comprehensive geriatric assessment (CGA) in the management of stage 3 hepatocellular carcinoma in the elderly</title><secondary-title>Crit Rev Oncol Hematol</secondary-title></titles><periodical><full-title>Crit Rev Oncol Hematol</full-title></periodical><pages>S20</pages><volume>60</volume><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>(28) and one based in the Veterans Administration system in the U.S. (n=99)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYW88L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxSZWNO

dW0+MjA0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjkpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjIwNDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQz

NTI5MzU0NyI+MjA0OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmFv

LCBBLiBWLjwvYXV0aG9yPjxhdXRob3I+SHNpZWgsIEYuPC9hdXRob3I+PGF1dGhvcj5GZXVzc25l

ciwgSi4gUi48L2F1dGhvcj48YXV0aG9yPkNvaGVuLCBILiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJhbyxBcmF0aSBWLiBHZXJpYXRyaWMgUmVzZWFy

Y2gsIEVkdWNhdGlvbiBhbmQgQ2xpbmljYWwgQ2VudGVyIChHUkVDQykgVmV0ZXJhbnMgQWRtaW5p

c3RyYXRpb24gTWVkaWNhbCBDZW50ZXIsIGFuZCBDZW50ZXIgZm9yIHRoZSBTdHVkeSBvZiBBZ2lu

ZyBhbmQgSHVtYW4gRGV2ZWxvcG1lbnQsIER1a2UgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwg

RHVyaGFtLCBOQyAyNzcxMCwgVVNBLiByYW8wMDAxMkBtYy5kdWtlLmVkdTwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkdlcmlhdHJpYyBldmFsdWF0aW9uIGFuZCBtYW5hZ2VtZW50IHVuaXRz

IGluIHRoZSBjYXJlIG9mIHRoZSBmcmFpbCBlbGRlcmx5IGNhbmNlciBwYXRpZW50PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWxzIG9mIEdlcm9udG9sb2d5IFNlcmllcyBBLUJpb2xvZ2lj

YWwgU2NpZW5jZXMgJmFtcDsgTWVkaWNhbCBTY2llbmNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+SiBHZXJvbnRvbCBBIEJpb2wgU2NpIE1lZCBTY2k8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFscyBvZiBHZXJvbnRvbG9neSBTZXJpZXMgQS1C

aW9sb2dpY2FsIFNjaWVuY2VzICZhbXA7IE1lZGljYWwgU2NpZW5jZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIEdlcm9udG9sIEEgQmlvbCBTY2kgTWVkIFNjaTwvYWJici0xPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbHMgb2YgR2Vyb250b2xvZ3kgU2VyaWVz

IEEtQmlvbG9naWNhbCBTY2llbmNlcyAmYW1wOyBNZWRpY2FsIFNjaWVuY2VzPC9mdWxsLXRpdGxl

PjxhYmJyLTE+SiBHZXJvbnRvbCBBIEJpb2wgU2NpIE1lZCBTY2k8L2FiYnItMT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz43OTgtODAzPC9wYWdlcz48dm9sdW1lPjYwPC92b2x1bWU+PG51bWJlcj42

PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9r

ZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW1idWxhdG9yeSBDYXJlPC9r

ZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GcmFpbCBFbGRlcmx5L3B4

IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qRnJhaWwgRWxkZXJseTwva2V5d29yZD48

a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIENh

cmUgQ29zdHM8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFNlcnZpY2VzL3V0IFtVdGlsaXphdGlv

bl08L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9j

byBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3

b3JkPjxrZXl3b3JkPlN1cnZpdmFsIFJhdGU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjEwNzktNTAwNjwvaXNibj48YWNjZXNzaW9uLW51bT4xNTk4MzE4NjwvYWNjZXNz

aW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtDb21wYXJhdGl2ZSBTdHVkeSYj

eEQ7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1ND

PVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNTk4MzE4

NjwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJs

L1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQm

YW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1p

bmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpk

b2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE1OTgzMTg2JmFtcDtyZnQuaXNzbj0xMDc5LTUwMDYm

YW1wO3JmdC52b2x1bWU9NjAmYW1wO3JmdC5pc3N1ZT02JmFtcDtyZnQuc3BhZ2U9Nzk4JmFtcDty

ZnQucGFnZXM9Nzk4LTgwMyZhbXA7cmZ0LmRhdGU9MjAwNSZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFs

cytvZitHZXJvbnRvbG9neStTZXJpZXMrQS1CaW9sb2dpY2FsK1NjaWVuY2VzKyUyNitNZWRpY2Fs

K1NjaWVuY2VzJmFtcDtyZnQuYXRpdGxlPUdlcmlhdHJpYytldmFsdWF0aW9uK2FuZCttYW5hZ2Vt

ZW50K3VuaXRzK2luK3RoZStjYXJlK29mK3RoZStmcmFpbCtlbGRlcmx5K2NhbmNlcitwYXRpZW50

LiZhbXA7cmZ0LmF1bGFzdD1SYW88L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJh

c2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYW88L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxSZWNO

dW0+MjA0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjkpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjIwNDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSIyMnN0MjB0d25kYXN6YWV3NXplcHhkZjZ3c3ZzYWZlZTl6cHAiIHRpbWVzdGFtcD0iMTQz

NTI5MzU0NyI+MjA0OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmFv

LCBBLiBWLjwvYXV0aG9yPjxhdXRob3I+SHNpZWgsIEYuPC9hdXRob3I+PGF1dGhvcj5GZXVzc25l

ciwgSi4gUi48L2F1dGhvcj48YXV0aG9yPkNvaGVuLCBILiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJhbyxBcmF0aSBWLiBHZXJpYXRyaWMgUmVzZWFy

Y2gsIEVkdWNhdGlvbiBhbmQgQ2xpbmljYWwgQ2VudGVyIChHUkVDQykgVmV0ZXJhbnMgQWRtaW5p

c3RyYXRpb24gTWVkaWNhbCBDZW50ZXIsIGFuZCBDZW50ZXIgZm9yIHRoZSBTdHVkeSBvZiBBZ2lu

ZyBhbmQgSHVtYW4gRGV2ZWxvcG1lbnQsIER1a2UgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwg

RHVyaGFtLCBOQyAyNzcxMCwgVVNBLiByYW8wMDAxMkBtYy5kdWtlLmVkdTwvYXV0aC1hZGRyZXNz

Pjx0aXRsZXM+PHRpdGxlPkdlcmlhdHJpYyBldmFsdWF0aW9uIGFuZCBtYW5hZ2VtZW50IHVuaXRz

IGluIHRoZSBjYXJlIG9mIHRoZSBmcmFpbCBlbGRlcmx5IGNhbmNlciBwYXRpZW50PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWxzIG9mIEdlcm9udG9sb2d5IFNlcmllcyBBLUJpb2xvZ2lj

YWwgU2NpZW5jZXMgJmFtcDsgTWVkaWNhbCBTY2llbmNlczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+SiBHZXJvbnRvbCBBIEJpb2wgU2NpIE1lZCBTY2k8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFscyBvZiBHZXJvbnRvbG9neSBTZXJpZXMgQS1C

aW9sb2dpY2FsIFNjaWVuY2VzICZhbXA7IE1lZGljYWwgU2NpZW5jZXM8L2Z1bGwtdGl0bGU+PGFi

YnItMT5KIEdlcm9udG9sIEEgQmlvbCBTY2kgTWVkIFNjaTwvYWJici0xPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbHMgb2YgR2Vyb250b2xvZ3kgU2VyaWVz

IEEtQmlvbG9naWNhbCBTY2llbmNlcyAmYW1wOyBNZWRpY2FsIFNjaWVuY2VzPC9mdWxsLXRpdGxl

PjxhYmJyLTE+SiBHZXJvbnRvbCBBIEJpb2wgU2NpIE1lZCBTY2k8L2FiYnItMT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz43OTgtODAzPC9wYWdlcz48dm9sdW1lPjYwPC92b2x1bWU+PG51bWJlcj42

PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9r

ZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW1idWxhdG9yeSBDYXJlPC9r

ZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GcmFpbCBFbGRlcmx5L3B4

IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qRnJhaWwgRWxkZXJseTwva2V5d29yZD48

a2V5d29yZD4qR2VyaWF0cmljIEFzc2Vzc21lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIENh

cmUgQ29zdHM8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFNlcnZpY2VzL3V0IFtVdGlsaXphdGlv

bl08L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9j

byBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3

b3JkPjxrZXl3b3JkPlN1cnZpdmFsIFJhdGU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHll

YXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh

dGVzPjxpc2JuPjEwNzktNTAwNjwvaXNibj48YWNjZXNzaW9uLW51bT4xNTk4MzE4NjwvYWNjZXNz

aW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtDb21wYXJhdGl2ZSBTdHVkeSYj

eEQ7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1ND

PVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNTk4MzE4

NjwvdXJsPjx1cmw+aHR0cDovL290YWdvLmhvc3RlZC5leGxpYnJpc2dyb3VwLmNvbS9vcGVudXJs

L1dFTExJTkdUT04vV0VMTElOR1RPTl9TRVJWSUNFU19QQUdFP3VybF92ZXI9WjM5Ljg4LTIwMDQm

YW1wO3JmdF92YWxfZm10PWluZm86b2ZpL2ZtdDprZXY6bXR4OmpvdXJuYWwmYW1wO3Jmcl9pZD1p

bmZvOnNpZC9PdmlkOm1lZDUmYW1wO3JmdC5nZW5yZT1hcnRpY2xlJmFtcDtyZnRfaWQ9aW5mbzpk

b2kvJmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzE1OTgzMTg2JmFtcDtyZnQuaXNzbj0xMDc5LTUwMDYm

YW1wO3JmdC52b2x1bWU9NjAmYW1wO3JmdC5pc3N1ZT02JmFtcDtyZnQuc3BhZ2U9Nzk4JmFtcDty

ZnQucGFnZXM9Nzk4LTgwMyZhbXA7cmZ0LmRhdGU9MjAwNSZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFs

cytvZitHZXJvbnRvbG9neStTZXJpZXMrQS1CaW9sb2dpY2FsK1NjaWVuY2VzKyUyNitNZWRpY2Fs

K1NjaWVuY2VzJmFtcDtyZnQuYXRpdGxlPUdlcmlhdHJpYytldmFsdWF0aW9uK2FuZCttYW5hZ2Vt

ZW50K3VuaXRzK2luK3RoZStjYXJlK29mK3RoZStmcmFpbCtlbGRlcmx5K2NhbmNlcitwYXRpZW50

LiZhbXA7cmZ0LmF1bGFzdD1SYW88L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJh

c2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (29) found that incorporating geriatric-led care into the care of cancer patients resulted in improvements in functional status and quality of life. A larger randomised controlled trial (n= 375) evaluated an intervention that primarily focused on providing specialised post-surgical care to elderly patients who had undergone cancer surgery. The intervention involved comprehensive clinical assessment (including assessment of physical, emotional and functional) status and referrals to specialist medical care as required by advanced practice nurses.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0NvcmtsZTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+

PFJlY051bT4yMDUwPC9SZWNOdW0+PERpc3BsYXlUZXh0PigzMCk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjA1MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1w

PSIxNDM1MjkzNTQ3Ij4yMDUwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5NY0NvcmtsZSwgUi48L2F1dGhvcj48YXV0aG9yPlN0cnVtcGYsIE4uIEUuPC9hdXRob3I+PGF1

dGhvcj5OdWFtYWgsIEkuIEYuPC9hdXRob3I+PGF1dGhvcj5BZGxlciwgRC4gQy48L2F1dGhvcj48

YXV0aG9yPkNvb2xleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPkplcHNvbiwgQy48L2F1dGhvcj48

YXV0aG9yPkx1c2ssIEUuIEouPC9hdXRob3I+PGF1dGhvcj5Ub3Jvc2lhbiwgTS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NY0NvcmtsZSxSLiBDZW50ZXIg

Zm9yIEV4Y2VsbGVuY2UgaW4gQ2hyb25pYyBJbGxuZXNzIENhcmUsIFNjaG9vbCBvZiBOdXJzaW5n

LCBZYWxlIFVuaXZlcnNpdHksIE5ldyBIYXZlbiwgQ29ubmVjdGljdXQgMDY1MzYtMDc0MCwgVVNB

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkEgc3BlY2lhbGl6ZWQgaG9tZSBjYXJlIGlu

dGVydmVudGlvbiBpbXByb3ZlcyBzdXJ2aXZhbCBhbW9uZyBvbGRlciBwb3N0LXN1cmdpY2FsIGNh

bmNlciBwYXRpZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIHRoZSBBbWVy

aWNhbiBHZXJpYXRyaWNzIFNvY2lldHk8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogQW0g

R2VyaWF0ciBTb2M8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

b3VybmFsIG9mIHRoZSBBbWVyaWNhbiBHZXJpYXRyaWNzIFNvY2lldHk8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEFtIEdlcmlhdHIgU29jPC9m

dWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE3MDctMTM8L3BhZ2VzPjx2b2x1bWU+

NDg8L3ZvbHVtZT48bnVtYmVyPjEyPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPipBZnRlcmNh

cmUvb2cgW09yZ2FuaXphdGlvbiAmYW1wOyBBZG1pbmlzdHJhdGlvbl08L2tleXdvcmQ+PGtleXdv

cmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5DYW5jZXIgQ2FyZSBGYWNpbGl0aWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD4qSGVhbHRoIFNlcnZpY2VzIGZvciB0aGUgQWdlZC9vZyBbT3JnYW5pemF0

aW9uICZhbXA7IEFkbWluaXN0cmF0aW9uXTwva2V5d29yZD48a2V5d29yZD4qSG9tZSBDYXJlIFNl

cnZpY2VzLCBIb3NwaXRhbC1CYXNlZC9vZyBbT3JnYW5pemF0aW9uICZhbXA7IEFkbWluaXN0cmF0

aW9uXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvbW8g

W01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9udSBbTnVyc2luZ108L2tl

eXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9zdSBbU3VyZ2VyeV08L2tleXdvcmQ+PGtleXdvcmQ+

Kk51cnNlIENsaW5pY2lhbnMvb2cgW09yZ2FuaXphdGlvbiAmYW1wOyBBZG1pbmlzdHJhdGlvbl08

L2tleXdvcmQ+PGtleXdvcmQ+TnVyc2luZyBFdmFsdWF0aW9uIFJlc2VhcmNoPC9rZXl3b3JkPjxr

ZXl3b3JkPipPbmNvbG9neSBOdXJzaW5nL29nIFtPcmdhbml6YXRpb24gJmFtcDsgQWRtaW5pc3Ry

YXRpb25dPC9rZXl3b3JkPjxrZXl3b3JkPk91dGNvbWUgQXNzZXNzbWVudCAoSGVhbHRoIENhcmUp

PC9rZXl3b3JkPjxrZXl3b3JkPlBlbm5zeWx2YW5pYTwva2V5d29yZD48a2V5d29yZD4qUG9zdG9w

ZXJhdGl2ZSBDYXJlL251IFtOdXJzaW5nXTwva2V5d29yZD48a2V5d29yZD5Qcm9ncmFtIEV2YWx1

YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+UHJvcG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3

b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4wMDAyLTg2MTQ8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTExMjk3NjU8L2Fj

Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBUcmlhbCYjeEQ7UmFuZG9taXplZCBDb250

cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3QsIFAuSC5T

Ljwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNCZhbXA7QU49MTExMjk3NjU8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0

ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklD

RVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6

a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWQ0JmFtcDtyZnQuZ2Vu

cmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLyZhbXA7cmZ0X2lkPWluZm86cG1pZC8xMTEy

OTc2NSZhbXA7cmZ0Lmlzc249MDAwMi04NjE0JmFtcDtyZnQudm9sdW1lPTQ4JmFtcDtyZnQuaXNz

dWU9MTImYW1wO3JmdC5zcGFnZT0xNzA3JmFtcDtyZnQucGFnZXM9MTcwNy0xMyZhbXA7cmZ0LmRh

dGU9MjAwMCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29mK3RoZStBbWVyaWNhbitHZXJpYXRyaWNz

K1NvY2lldHkmYW1wO3JmdC5hdGl0bGU9QStzcGVjaWFsaXplZCtob21lK2NhcmUraW50ZXJ2ZW50

aW9uK2ltcHJvdmVzK3N1cnZpdmFsK2Ftb25nK29sZGVyK3Bvc3Qtc3VyZ2ljYWwrY2FuY2VyK3Bh

dGllbnRzLiZhbXA7cmZ0LmF1bGFzdD1NY0NvcmtsZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0NvcmtsZTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+

PFJlY051bT4yMDUwPC9SZWNOdW0+PERpc3BsYXlUZXh0PigzMCk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjA1MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1w

PSIxNDM1MjkzNTQ3Ij4yMDUwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5NY0NvcmtsZSwgUi48L2F1dGhvcj48YXV0aG9yPlN0cnVtcGYsIE4uIEUuPC9hdXRob3I+PGF1

dGhvcj5OdWFtYWgsIEkuIEYuPC9hdXRob3I+PGF1dGhvcj5BZGxlciwgRC4gQy48L2F1dGhvcj48

YXV0aG9yPkNvb2xleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPkplcHNvbiwgQy48L2F1dGhvcj48

YXV0aG9yPkx1c2ssIEUuIEouPC9hdXRob3I+PGF1dGhvcj5Ub3Jvc2lhbiwgTS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NY0NvcmtsZSxSLiBDZW50ZXIg

Zm9yIEV4Y2VsbGVuY2UgaW4gQ2hyb25pYyBJbGxuZXNzIENhcmUsIFNjaG9vbCBvZiBOdXJzaW5n

LCBZYWxlIFVuaXZlcnNpdHksIE5ldyBIYXZlbiwgQ29ubmVjdGljdXQgMDY1MzYtMDc0MCwgVVNB

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkEgc3BlY2lhbGl6ZWQgaG9tZSBjYXJlIGlu

dGVydmVudGlvbiBpbXByb3ZlcyBzdXJ2aXZhbCBhbW9uZyBvbGRlciBwb3N0LXN1cmdpY2FsIGNh

bmNlciBwYXRpZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIHRoZSBBbWVy

aWNhbiBHZXJpYXRyaWNzIFNvY2lldHk8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogQW0g

R2VyaWF0ciBTb2M8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

b3VybmFsIG9mIHRoZSBBbWVyaWNhbiBHZXJpYXRyaWNzIFNvY2lldHk8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEFtIEdlcmlhdHIgU29jPC9m

dWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE3MDctMTM8L3BhZ2VzPjx2b2x1bWU+

NDg8L3ZvbHVtZT48bnVtYmVyPjEyPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPipBZnRlcmNh

cmUvb2cgW09yZ2FuaXphdGlvbiAmYW1wOyBBZG1pbmlzdHJhdGlvbl08L2tleXdvcmQ+PGtleXdv

cmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5DYW5jZXIgQ2FyZSBGYWNpbGl0aWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5

d29yZD48a2V5d29yZD4qSGVhbHRoIFNlcnZpY2VzIGZvciB0aGUgQWdlZC9vZyBbT3JnYW5pemF0

aW9uICZhbXA7IEFkbWluaXN0cmF0aW9uXTwva2V5d29yZD48a2V5d29yZD4qSG9tZSBDYXJlIFNl

cnZpY2VzLCBIb3NwaXRhbC1CYXNlZC9vZyBbT3JnYW5pemF0aW9uICZhbXA7IEFkbWluaXN0cmF0

aW9uXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5

d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9wbGFzbXMvbW8g

W01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9udSBbTnVyc2luZ108L2tl

eXdvcmQ+PGtleXdvcmQ+Kk5lb3BsYXNtcy9zdSBbU3VyZ2VyeV08L2tleXdvcmQ+PGtleXdvcmQ+

Kk51cnNlIENsaW5pY2lhbnMvb2cgW09yZ2FuaXphdGlvbiAmYW1wOyBBZG1pbmlzdHJhdGlvbl08

L2tleXdvcmQ+PGtleXdvcmQ+TnVyc2luZyBFdmFsdWF0aW9uIFJlc2VhcmNoPC9rZXl3b3JkPjxr

ZXl3b3JkPipPbmNvbG9neSBOdXJzaW5nL29nIFtPcmdhbml6YXRpb24gJmFtcDsgQWRtaW5pc3Ry

YXRpb25dPC9rZXl3b3JkPjxrZXl3b3JkPk91dGNvbWUgQXNzZXNzbWVudCAoSGVhbHRoIENhcmUp

PC9rZXl3b3JkPjxrZXl3b3JkPlBlbm5zeWx2YW5pYTwva2V5d29yZD48a2V5d29yZD4qUG9zdG9w

ZXJhdGl2ZSBDYXJlL251IFtOdXJzaW5nXTwva2V5d29yZD48a2V5d29yZD5Qcm9ncmFtIEV2YWx1

YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+UHJvcG9ydGlvbmFsIEhhemFyZHMgTW9kZWxzPC9rZXl3

b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+

PC9kYXRlcz48aXNibj4wMDAyLTg2MTQ8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTExMjk3NjU8L2Fj

Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBUcmlhbCYjeEQ7UmFuZG9taXplZCBDb250

cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBVLlMuIEdvdiZhcG9zO3QsIFAuSC5T

Ljwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNCZhbXA7QU49MTExMjk3NjU8L3VybD48dXJsPmh0dHA6Ly9vdGFnby5ob3N0

ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5HVE9OL1dFTExJTkdUT05fU0VSVklD

RVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRfdmFsX2ZtdD1pbmZvOm9maS9mbXQ6

a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQvT3ZpZDptZWQ0JmFtcDtyZnQuZ2Vu

cmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLyZhbXA7cmZ0X2lkPWluZm86cG1pZC8xMTEy

OTc2NSZhbXA7cmZ0Lmlzc249MDAwMi04NjE0JmFtcDtyZnQudm9sdW1lPTQ4JmFtcDtyZnQuaXNz

dWU9MTImYW1wO3JmdC5zcGFnZT0xNzA3JmFtcDtyZnQucGFnZXM9MTcwNy0xMyZhbXA7cmZ0LmRh

dGU9MjAwMCZhbXA7cmZ0Lmp0aXRsZT1Kb3VybmFsK29mK3RoZStBbWVyaWNhbitHZXJpYXRyaWNz

K1NvY2lldHkmYW1wO3JmdC5hdGl0bGU9QStzcGVjaWFsaXplZCtob21lK2NhcmUraW50ZXJ2ZW50

aW9uK2ltcHJvdmVzK3N1cnZpdmFsK2Ftb25nK29sZGVyK3Bvc3Qtc3VyZ2ljYWwrY2FuY2VyK3Bh

dGllbnRzLiZhbXA7cmZ0LmF1bGFzdD1NY0NvcmtsZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgB=

ADDIN EN.CITE.DATA (30) This trial found that those in the intervention arm had substantially improved survival (HR=2.04; 1.33-3.12 after adjustment for stage of disease and surgical hospitalisation length of stay).More recently, Temel et al (2010) carried out an RCT designed to assess the impact of early versus late referral to palliative care for patients with metastatic non-small cell lung cancer.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZW1lbDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4yMDA0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigzMSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjAwNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDIxODcxMjUyIj4yMDA0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5U

ZW1lbCwgSi4gUy48L2F1dGhvcj48YXV0aG9yPkdyZWVyLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+

TXV6aWthbnNreSwgQS48L2F1dGhvcj48YXV0aG9yPkdhbGxhZ2hlciwgRS4gUi48L2F1dGhvcj48

YXV0aG9yPkFkbWFuZSwgUy48L2F1dGhvcj48YXV0aG9yPkphY2tzb24sIFYuIEEuPC9hdXRob3I+

PGF1dGhvcj5EYWhsaW4sIEMuIE0uPC9hdXRob3I+PGF1dGhvcj5CbGluZGVybWFuLCBDLiBELjwv

YXV0aG9yPjxhdXRob3I+SmFjb2JzZW4sIEouPC9hdXRob3I+PGF1dGhvcj5QaXJsLCBXLiBGLjwv

YXV0aG9yPjxhdXRob3I+QmlsbGluZ3MsIEouIEEuPC9hdXRob3I+PGF1dGhvcj5MeW5jaCwgVC4g

Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UZW1lbCxK

ZW5uaWZlciBTLiBNYXNzYWNodXNldHRzIEdlbmVyYWwgSG9zcGl0YWwsIEJvc3RvbiwgTUEgMDIx

MTQsIFVTQS4ganRlbWVsQHBhcnRuZXJzLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkVhcmx5IHBhbGxpYXRpdmUgY2FyZSBmb3IgcGF0aWVudHMgd2l0aCBtZXRhc3RhdGljIG5vbi1z

bWFsbC1jZWxsIGx1bmcgY2FuY2VyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldyBFbmdsYW5k

IEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk4gRW5nbCBK

IE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmds

YW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9k

aWNhbD48cGFnZXM+NzMzLTQyPC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9sdW1lPjxudW1iZXI+ODwv

bnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZmZlY3Q8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwv

a2V5d29yZD48a2V5d29yZD5DYXJjaW5vbWEsIE5vbi1TbWFsbC1DZWxsIEx1bmcvbW8gW01vcnRh

bGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBOb24tU21hbGwtQ2VsbCBMdW5nL3B4

IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5DYXJjaW5vbWEsIE5vbi1TbWFsbC1DZWxs

IEx1bmcvc2MgW1NlY29uZGFyeV08L2tleXdvcmQ+PGtleXdvcmQ+KkNhcmNpbm9tYSwgTm9uLVNt

YWxsLUNlbGwgTHVuZy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2lvbi9l

cCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uL3BjIFtQcmV2ZW50

aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2FwbGFuLU1laWVyIEVzdGltYXRlPC9rZXl3

b3JkPjxrZXl3b3JkPkxpbmVhciBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBOZW9wbGFz

bXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBOZW9wbGFzbXMvcHggW1Bz

eWNob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipMdW5nIE5lb3BsYXNtcy90aCBbVGhlcmFweV08

L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5

d29yZD48a2V5d29yZD4qUGFsbGlhdGl2ZSBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPipRdWFsaXR5

IG9mIExpZmU8L2tleXdvcmQ+PGtleXdvcmQ+VGVybWluYWwgQ2FyZTwva2V5d29yZD48a2V5d29y

ZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyAxOTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjE1MzMtNDQwNjwvaXNibj48YWNjZXNzaW9uLW51bT4yMDgxODg3NTwvYWNjZXNzaW9uLW51bT48

d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9y

dCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVy

bD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtO

RVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA4MTg4NzU8L3VybD48

dXJsPmh0dHA6Ly9vdGFnby5ob3N0ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5H

VE9OL1dFTExJTkdUT05fU0VSVklDRVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRf

dmFsX2ZtdD1pbmZvOm9maS9mbXQ6a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQv

T3ZpZDptZWQ1JmFtcDtyZnQuZ2VucmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLzEwLjEw

NTYlMkZORUpNb2ExMDAwNjc4JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzIwODE4ODc1JmFtcDtyZnQu

aXNzbj0wMDI4LTQ3OTMmYW1wO3JmdC52b2x1bWU9MzYzJmFtcDtyZnQuaXNzdWU9OCZhbXA7cmZ0

LnNwYWdlPTczMyZhbXA7cmZ0LnBhZ2VzPTczMy00MiZhbXA7cmZ0LmRhdGU9MjAxMCZhbXA7cmZ0

Lmp0aXRsZT1OZXcrRW5nbGFuZCtKb3VybmFsK29mK01lZGljaW5lJmFtcDtyZnQuYXRpdGxlPUVh

cmx5K3BhbGxpYXRpdmUrY2FyZStmb3IrcGF0aWVudHMrd2l0aCttZXRhc3RhdGljK25vbi1zbWFs

bC1jZWxsK2x1bmcrY2FuY2VyLiZhbXA7cmZ0LmF1bGFzdD1UZW1lbDwvdXJsPjwvcmVsYXRlZC11

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAwNjc4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFi

YXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5n

dWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZW1lbDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4yMDA0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigzMSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjAwNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjIyc3QyMHR3bmRhc3phZXc1emVweGRmNndzdnNhZmVlOXpwcCIgdGltZXN0YW1wPSIx

NDIxODcxMjUyIj4yMDA0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5U

ZW1lbCwgSi4gUy48L2F1dGhvcj48YXV0aG9yPkdyZWVyLCBKLiBBLjwvYXV0aG9yPjxhdXRob3I+

TXV6aWthbnNreSwgQS48L2F1dGhvcj48YXV0aG9yPkdhbGxhZ2hlciwgRS4gUi48L2F1dGhvcj48

YXV0aG9yPkFkbWFuZSwgUy48L2F1dGhvcj48YXV0aG9yPkphY2tzb24sIFYuIEEuPC9hdXRob3I+

PGF1dGhvcj5EYWhsaW4sIEMuIE0uPC9hdXRob3I+PGF1dGhvcj5CbGluZGVybWFuLCBDLiBELjwv

YXV0aG9yPjxhdXRob3I+SmFjb2JzZW4sIEouPC9hdXRob3I+PGF1dGhvcj5QaXJsLCBXLiBGLjwv

YXV0aG9yPjxhdXRob3I+QmlsbGluZ3MsIEouIEEuPC9hdXRob3I+PGF1dGhvcj5MeW5jaCwgVC4g

Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UZW1lbCxK

ZW5uaWZlciBTLiBNYXNzYWNodXNldHRzIEdlbmVyYWwgSG9zcGl0YWwsIEJvc3RvbiwgTUEgMDIx

MTQsIFVTQS4ganRlbWVsQHBhcnRuZXJzLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkVhcmx5IHBhbGxpYXRpdmUgY2FyZSBmb3IgcGF0aWVudHMgd2l0aCBtZXRhc3RhdGljIG5vbi1z

bWFsbC1jZWxsIGx1bmcgY2FuY2VyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldyBFbmdsYW5k

IEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk4gRW5nbCBK

IE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmds

YW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9k

aWNhbD48cGFnZXM+NzMzLTQyPC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9sdW1lPjxudW1iZXI+ODwv

bnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZmZlY3Q8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwv

a2V5d29yZD48a2V5d29yZD5DYXJjaW5vbWEsIE5vbi1TbWFsbC1DZWxsIEx1bmcvbW8gW01vcnRh

bGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+Q2FyY2lub21hLCBOb24tU21hbGwtQ2VsbCBMdW5nL3B4

IFtQc3ljaG9sb2d5XTwva2V5d29yZD48a2V5d29yZD5DYXJjaW5vbWEsIE5vbi1TbWFsbC1DZWxs

IEx1bmcvc2MgW1NlY29uZGFyeV08L2tleXdvcmQ+PGtleXdvcmQ+KkNhcmNpbm9tYSwgTm9uLVNt

YWxsLUNlbGwgTHVuZy90aCBbVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2lvbi9l

cCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uL3BjIFtQcmV2ZW50

aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+S2FwbGFuLU1laWVyIEVzdGltYXRlPC9rZXl3

b3JkPjxrZXl3b3JkPkxpbmVhciBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBOZW9wbGFz

bXMvbW8gW01vcnRhbGl0eV08L2tleXdvcmQ+PGtleXdvcmQ+THVuZyBOZW9wbGFzbXMvcHggW1Bz

eWNob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipMdW5nIE5lb3BsYXNtcy90aCBbVGhlcmFweV08

L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5

d29yZD48a2V5d29yZD4qUGFsbGlhdGl2ZSBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPipRdWFsaXR5

IG9mIExpZmU8L2tleXdvcmQ+PGtleXdvcmQ+VGVybWluYWwgQ2FyZTwva2V5d29yZD48a2V5d29y

ZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVh

cj48cHViLWRhdGVzPjxkYXRlPkF1ZyAxOTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2Ju

PjE1MzMtNDQwNjwvaXNibj48YWNjZXNzaW9uLW51bT4yMDgxODg3NTwvYWNjZXNzaW9uLW51bT48

d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9y

dCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVy

bD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtO

RVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA4MTg4NzU8L3VybD48

dXJsPmh0dHA6Ly9vdGFnby5ob3N0ZWQuZXhsaWJyaXNncm91cC5jb20vb3BlbnVybC9XRUxMSU5H

VE9OL1dFTExJTkdUT05fU0VSVklDRVNfUEFHRT91cmxfdmVyPVozOS44OC0yMDA0JmFtcDtyZnRf

dmFsX2ZtdD1pbmZvOm9maS9mbXQ6a2V2Om10eDpqb3VybmFsJmFtcDtyZnJfaWQ9aW5mbzpzaWQv

T3ZpZDptZWQ1JmFtcDtyZnQuZ2VucmU9YXJ0aWNsZSZhbXA7cmZ0X2lkPWluZm86ZG9pLzEwLjEw

NTYlMkZORUpNb2ExMDAwNjc4JmFtcDtyZnRfaWQ9aW5mbzpwbWlkLzIwODE4ODc1JmFtcDtyZnQu

aXNzbj0wMDI4LTQ3OTMmYW1wO3JmdC52b2x1bWU9MzYzJmFtcDtyZnQuaXNzdWU9OCZhbXA7cmZ0

LnNwYWdlPTczMyZhbXA7cmZ0LnBhZ2VzPTczMy00MiZhbXA7cmZ0LmRhdGU9MjAxMCZhbXA7cmZ0

Lmp0aXRsZT1OZXcrRW5nbGFuZCtKb3VybmFsK29mK01lZGljaW5lJmFtcDtyZnQuYXRpdGxlPUVh

cmx5K3BhbGxpYXRpdmUrY2FyZStmb3IrcGF0aWVudHMrd2l0aCttZXRhc3RhdGljK25vbi1zbWFs

bC1jZWxsK2x1bmcrY2FuY2VyLiZhbXA7cmZ0LmF1bGFzdD1UZW1lbDwvdXJsPjwvcmVsYXRlZC11

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAwNjc4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFi

YXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5n

dWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (31) The intervention included review by a palliative care physician and advanced practice nurse with follow-up at monthly intervals (or as required). The intervention involved assessment of physical and psychosocial symptoms, and active coordination of care of the patient. The intervention group performed better in terms of quality of life over a variety of measures, had lower depression rates at 12 weeks, but also unexpectedly, had significantly better survival than the control group (11.9 months compared with 8.9 months; p=0.02). Finally, a recent cohort study recruited older cancer patients prior to the start of chemotherapy. ADDIN EN.CITE <EndNote><Cite><Author>Kalsi</Author><Year>2015</Year><RecNum>2076</RecNum><DisplayText>(32)</DisplayText><record><rec-number>2076</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1438458798">2076</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kalsi, T</author><author>Babic-Illman, G</author><author>Ross, PJ</author><author>Maisey, NR</author><author>Hughes, S</author><author>Fields, P</author><author>Martin, FC</author><author>Wang, Y.</author><author>Harari, D</author></authors></contributors><titles><title>The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people</title><secondary-title>British Journal of Cancer</secondary-title></titles><periodical><full-title>British Journal of Cancer</full-title><abbr-1>Br J Cancer</abbr-1></periodical><pages>1435-44</pages><volume>112</volume><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>(32) Outcomes among those who underwent review and care plan development by a geriatrician (n=65) were compared with those who received usual care (n=70) within a single London hospital. The intervention was developed specifically for the study, and the non-intervention and intervention aspects were delivered sequentially. Patients who underwent the intervention were first screened to identify low and higher risk patients on the basis of presence of comorbidity, recent hospital admission, suboptimal functional status or reduced quality of life. Seventy percent of the intervention arm underwent full geriatric-led review, but 7 of the remaining 19 patients also had some intervention from the geriatric team. Those in the intervention group experienced lower treatment toxicity, more treatment completions and fewer treatment modifications compared with the control group. There was only six months of follow up time, during which 15% of the intervention group died compared with 20% of the control group, a difference that was not statistically significant although the study was not powered to detect a difference in survival.Whilst in combination, this body of research provides a strong rationale for comprehensive medical review at diagnosis for at least some cancer patients, there are substantial gaps in the evidence base which we seek to address. None of the studies provide evidence from adequately powered prospective intervention trials. To date, all studies have been limited to elderly patients. This is important because a substantial proportion of patients under the age of 70 years experience significant comorbidity. For example, one in five patients aged 51-60 years and nearly one in three patients aged 61-70 years with colon cancer had at least one of the 17 conditions included in the Charlson comorbidity index. ADDIN EN.CITE <EndNote><Cite><Author>Sarfati</Author><Year>2011</Year><RecNum>1656</RecNum><DisplayText>(3)</DisplayText><record><rec-number>1656</rec-number><foreign-keys><key app="EN" db-id="22st20twndaszaew5zepxdf6wsvsafee9zpp" timestamp="1365712730">1656</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sarfati, Diana</author><author>Tan, Lavinia</author><author>Blakely, Tony</author><author>Pearce, Neil</author></authors></contributors><titles><title>Comorbidity among patients with colon cancer in New Zealand</title><secondary-title>New Zealand Medical Journal</secondary-title></titles><periodical><full-title>New Zealand Medical Journal</full-title><abbr-1>N Z Med J</abbr-1></periodical><pages>76-88</pages><volume>124</volume><number>1338</number><dates><year>2011</year></dates><accession-num>21946965</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>;(3) No studies have included these higher risk younger patients. This is particularly important given that Māori and Pacific people tend to experience more severe comorbidity at a younger age than European people. Purpose of the current proposalAs part of an HRC Programme Grant Application (in progress) we propose a multi-centre prospective controlled intervention study assessing the impact of a comprehensive medical assessment (led by Geriatricians), comprehensive medication review, and personalised medical plan in patients with colorectal cancer. Prior to embarking on an ambitious multi-centre intervention study, several questions regarding feasibility must be addressed. The current proposal is a feasibility study that will be conducted prior to embarking on the larger multicentre study. We propose a pilot study to assess the appropriateness and effectiveness of the screening tools aimed to identify patients with comorbidity, and the acceptability of a comprehensive medical assessment in patients diagnosed with colorectal cancer. ParticipantsInclusion criteriaEITHER:All patients with newly diagnosed colorectal adenocarcinoma who have undergone or who are planned to undergo major resectionOR Metastatic relapse of colorectal adenocarcinoma, as judged by histological confirmation of relapse or as confirmed by a specialist multi-disciplinary team meeting (MDTM)OR Undifferentiated carcinoma (grade 4) with clinical features consistent with colorectal cancer (and confirmed by a MDTM) will be permittedExclusion criteriaHistological or cytological diagnosis of cancer type other than adenocarcinoma Adenocarcinoma or colon or rectum with polypectomy or local excision as only treatmentTreatment acuity such that intervention not able to be administered without potentially compromising patient outcome (e.g. acute or sub-acute bowel obstruction, incipient perforation, major GI haemorrhage)Note that these patients may be able to be enrolled post-operatively Unable to give informed consent Not able to comply with follow upLocally recurrent rectal cancer without metastatic relapseLife expectancy less than three months from diagnosis.There are explicitly no restrictions by:age; involvement in other trials;ECOG performance status.Study proceduresPatient identificationPotential participants will be identified by clinicians at colonoscopy, MDTM, or after post acute ward rounds. A trial-specific Research Nurse would be notified of potential eligibility. Potential participants will be approached by the Research Nurse and offered a written Patient Information Sheet (Patient Information Sheet)After having time to consider whether they wish to participate in the study, including having time to discuss with family, whanau and/or friends, potential participants may consent to entering the study and offer written informed consentScreening toolA screening tool to identify comorbidity will be administered by the Research Nurse Medicines reconciliation:The patient is asked to identify what medications they takeThe notes are reviewed to identify what medications are recorded on the admission noteThe patient’s GP and usual Pharmacy are contacted and reconciliation undertaken, identifying accuracy of current prescriptionInteraction check:Medications are entered into the Lexi-Comp online interaction checker (). A printout of potential interactions is provided to the Study ClinicianComprehensive Medical AssessmentPatients who are identified via the screening tool are invited to attend a Comprehensive Medical AssessmentThe individualised comprehensive medical assessment will include:Physician (geriatrician) led medical assessment of comorbidity, with medical optimisation, investigations or further referrals where indicated, and treatment of medical comorbidity. Assessment of mental health status with referral as necessary.Analgesia and pain management review, and assessment of impact on blood pressure, cognition, balance and mood.Specific assessment of ECOG performance status.Review of social circumstances and risk factors such as living alone, social isolation.Referral to occupational therapy, physiotherapy, social worker, dietician and palliative care as appropriate.Follow-up appointment prior at three months from first assessment or when indicated (if shorter).Note that assessment of inpatients is intended to focus on offering advice on management of comorbidity rather than issues pertaining directly to surgical management.Outcome Measures Proportion of patients with colorectal adenocarcinoma who are approached who consent to enter.Proportion of patients who consent to enter whom complete screening criteria and fulfil criteria to proceed to CMA.Narrative of comorbid conditions identified at CMA.Medication review:Discrepancy between medications identified at admission and those held by GP and at Pharmacy.Potential interactions, graded as “clinically significant” or “potentially significant”.Completion rate of QoL tool. Narrative feedback from participants (including clinicians).Statistical AnalysesNo formal hypothesis testing nor statistical analyses are planned – this is a feasibility study. There are no “gold standards” against which our proposed tools can be validated. We propose to enrol approximately 30 patients into the screening process to progress up to 20 patients in the Comprehensive Medical Assessment moduleRisks/Harms to participants:Potential participants who have recently learned they have been diagnosed with a cancer are likely to be distressed.They may consider that participation in the study influences their care (either favourably or unfavourably).Participants’ distress may influence their willingness to undertake study procedures.Participants may conflate participation in the study with their routine care.There are unlikely to be medical harms from having additional review from a specialist physician.If additional comorbidity or medical issues are identified as part of the CMA, then these issues will be raised with the responsible clinician whom can determine whether this should impact on their cancer treatment (risk grid).FundingThere is no external funding of this pilot study.Investigators are undertaking this pilot as “time only”.Research nurse salary is covered by surplus funds from commercial trials led by Dr Jackson.Screening toolBaseline dataColorectal cancer DiagnosisNew primary diagnosis of CRC 9460324214Metastatic relapse of known CRC 514353111500Date of diagnosis_ _ / _ _ / _ _Method of diagnosisPlease select most relevant optionHistology confirming adenocarcinomaSuspicious lesion visualised directlySuspicious lesion visualised on imaging463552514600044450-311150004635531242000Clinical picture consistent with CRCOther (please specify below)_______________________501653981450042545-26162000Co-morbidity AssessmentEvidence of co-morbidityPlease select all options that applyMedical recordSelf-reportedOn regular medication5143517780000514353886200051435000Hospitalised in last 12 monthsAny significant functional or QoL limitations on questionnaire42545914400051435-51244500Co-morbidities recorded up to and including date of diagnosisAny comorbidities documented?ASA: O 1. Yes O 2. NoCardiovascular systemAngina or coronary artery disease (includes CABG) OHypertension 3. Previous myocardial infarction OCardiac arrhythmia (includes supraventricular tachycardia, atrial fibrillation or flutter, heart block)5. Valvular disease (includes valvular stenosis,valvular insufficiency/regurgitation, rheumatic heart disease, history of valve surgery)O6. Congestive heart failure 7. Peripheral vascular disease (including claudication, skin ulcers)O8. Previous pulmonary embolism (PE) 9. Other cardiovascular system disorder (e.g. cardiomyopathy, aneurysms).....................................................................................................................................Respiratory1. AsthmaO2. Chronic airways disease (includes emphysema, bronchitis)3. Other respiratory conditions .................................................................................................................................Haematological1. Blood loss anaemia (incl iron deficiency)O2. Other anaemia (e.g. megaloblastic, haemolytic)3. Other haematological disorder (e.g. clotting disorders, thalassaemias, myelodysplastic syndrome, myeloproliferative disorders. Do not include haematological malignancies) ..............................................................................................................Gastrointestinal1. Ulcer disease (includes GORD, peptic ulcer disease, oesophagitis)O2. Inflammatory bowel disease (includes Crohns disease and ulcerative colitis)3. Liver disease (includes chronic hepatitis, cirrhosis, haemachromatosis, Wilson’s disease. Do not include cancers.)O4. Other GI conditions ............................................................Neurological1. Previous stroke or TIAsO2. Parkinson’s disease3. DementiaO4. Multiple sclerosis5. Other neurological conditions ...........................................................................................................................................................Endocrine(1=history noted but not currently active; 2=currently on medication, controlled; 3=currently active and not well controlled)Diabetes mellitus1 O 2 O 3 OO 3. HypothyroidismO4. Other endocrine disorder (e.g. hyperthyroidism, hyper/hypoparathyroidism, Addison’s disease, Cushings syndrome hypopituitarism) ...........................................Other malignancy1. LeukaemiaO2. Lymphoma3. Solid tumourO4. Metastatic tumourSpecify (if available:.....................................................................Specifiy (if available:..................................................................Mental health disorder (1=history noted but not currently active; 2=currently on medication, controlled; 3=currently active and not well controlled)1. Substance dependence/abuseO2. Alcohol dependence/abuse Major depression 1 O 2 O 3 OOAnxiety disorders 1 O 2 O 3 OBipolar disorder OSchizophrenia and other psychoses 5. Other .................................................................................................................................Other1. Connective tissue disease (incl systemic lupus erythematosus, scleroderma, polymyositis, rheumatoid arthritis)O2. Chronic kidney disease5. osteoarthritis and other non-specific arthritis6. Other .................................................................................................................................Please list all current medications Quality of life assessmentQLQ-C30-English Eligibility check listInclusion CriteriaAny selection of “No” means the patient is ineligible for the studyYesNoKnown or presumed diagnosis of colorectal cancer (including metastatic relapse)Evidence of current co-morbidityAbility to understand and the willingness to sign a written informed consent document.Exclusion CriteriaAny selection of “Yes” means the patient is ineligible for the studyYesNoLife expectancy less than 3 monthsColorectal adenocarcinoma treated by polypectomy onlyNon-adenocarcinoma histologyUnable or un-willing to comply with follow-up ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download