www.thno.org

AR splice variants encode a truncated AR protein that lacks the ligand-binding domain and is constitutively active in the absence of androgens. AR-V7 is the most common AR splice variant. The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains ... ................
................

In order to avoid copyright disputes, this page is only a partial summary.