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Online Table. Some Circulating microRNAs Found Associated with Cardiovascular DiseasesmiRNAMisexpressionSpecimenStudy PopulationSettingRef.Acute myocardial infarction (STEMI+NSTEMI)miR-1Up-regulated in AMI patients within 4h of the onset of symptoms, peak at 8hplasma17 AMI patients and 25 controlsHospital admissionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb25nPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA (1)miR-1Up-regulated in AMI patients, normalized at dischargeplasma93 AMI patients and 66 controlsHospital admissionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BaTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051
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ADDIN EN.CITE.DATA (2)miR-133Up-regulated in AMI patients within 4h of the onset of symptoms, correlated with miR-328 and cTnIplasma51 AMI patients and 28 controlsHospital Admission ADDIN EN.CITE <EndNote><Cite><Author>Wang</Author><Year>2011</Year><RecNum>642</RecNum><DisplayText>(3)</DisplayText><record><rec-number>642</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">642</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wang, R.</author><author>Li, N.</author><author>Zhang, Y.</author><author>Ran, Y.</author><author>Pu, J.</author></authors></contributors><auth-address>Pathology and Physiology Research Center, and Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, China.</auth-address><titles><title>Circulating microRNAs are promising novel biomarkers of acute myocardial infarction</title><secondary-title>Intern Med</secondary-title></titles><periodical><full-title>Intern Med</full-title></periodical><pages>1789-95</pages><volume>50</volume><number>17</number><edition>2011/09/02</edition><keywords><keyword>Aged</keyword><keyword>Biological Markers/blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>MicroRNAs/*blood</keyword><keyword>Middle Aged</keyword><keyword>Myocardial Infarction/*blood/*diagnosis</keyword><keyword>Up-Regulation/physiology</keyword></keywords><dates><year>2011</year></dates><isbn>1349-7235 (Electronic)
0918-2918 (Linking)</isbn><accession-num>21881276</accession-num><work-type>Comparative Study
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(3)miR-133a, miR-1miR-133a and miR-1 are elevated early after the onset of symptoms; miR-133a is elevated also in UA and TT patientsserum29 ACS patients (18 STEMI, 3 NSTEMI, 8 UA patients) and 42 controlsCCUPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdXdhYmFyYTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+
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ADDIN EN.CITE.DATA (6)miR-499Up-regulated in AMI patients within 3h of the onset of symptomsplasma510 AMI patients (113 NSTEMI, 397 STEMI) and 87 controlsCCUPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZXZhdXg8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA (8)miR-30a, miR-195Up-regulated in AMI patientsplasma18 AMI patients and 30 controlsHospital admission or CCU ADDIN EN.CITE <EndNote><Cite><Author>Long</Author><Year>2012</Year><RecNum>650</RecNum><DisplayText>(9)</DisplayText><record><rec-number>650</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">650</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Long, G.</author><author>Wang, F.</author><author>Duan, Q.</author><author>Yang, S.</author><author>Chen, F.</author><author>Gong, W.</author><author>Yang, X.</author><author>Wang, Y.</author><author>Chen, C.</author><author>Wang, D. W.</author></authors></contributors><auth-address>Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.</auth-address><titles><title>Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction</title><secondary-title>PlOS One</secondary-title><alt-title>PloS one</alt-title></titles><periodical><full-title>PlOS One</full-title></periodical><alt-periodical><full-title>PlOS One</full-title></alt-periodical><pages>e50926</pages><volume>7</volume><number>12</number><edition>2012/12/14</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Biological Markers/blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>MicroRNAs/*blood</keyword><keyword>Middle Aged</keyword><keyword>Myocardial Infarction/blood/*diagnosis</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)
1932-6203 (Linking)</isbn><accession-num>23236408</accession-num><work-type>Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(9)miR-1 and miR-133aSignificantly increased at early after AMIserum21 TASH patientsCath Lab ADDIN EN.CITE <EndNote><Cite><Author>Liebetrau</Author><Year>2013</Year><RecNum>444</RecNum><DisplayText>(10)</DisplayText><record><rec-number>444</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">444</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liebetrau, C.</author><author>Mollmann, H.</author><author>Dorr, O.</author><author>Szardien, S.</author><author>Troidl, C.</author><author>Willmer, M.</author><author>Voss, S.</author><author>Gaede, L.</author><author>Rixe, J.</author><author>Rolf, A.</author><author>Hamm, C.</author><author>Nef, H.</author></authors></contributors><auth-address>Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany; University of Giessen, Medizinische Klinik I, Kardiologie und Angiologie, Giessen, Germany. Electronic address: c.liebetrau@kerckhoff-klinik.de.</auth-address><titles><title>Release Kinetics of Circulating Muscle-Enriched MicroRNAs in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy</title><secondary-title>J Am Coll Cardiol</secondary-title><alt-title>Journal of the American College of Cardiology</alt-title></titles><periodical><full-title>J Am Coll Cardiol</full-title><abbr-1>Journal of the American College of Cardiology</abbr-1></periodical><alt-periodical><full-title>J Am Coll Cardiol</full-title><abbr-1>Journal of the American College of Cardiology</abbr-1></alt-periodical><pages>992-8</pages><volume>62</volume><number>11</number><edition>2013/06/12</edition><dates><year>2013</year><pub-dates><date>Sep 10</date></pub-dates></dates><isbn>1558-3597 (Electronic)
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ADDIN EN.CITE.DATA (11)ST-Elevated myocardial infarctionmiR-1, miR-133a, miR-133b, miR-499-5pUp-regulated in STEMI patientsplasma33 STEMI patients and 17 controlsCCUPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EJmFwb3M7QWxlc3NhbmRyYTwvQXV0aG9yPjxZZWFyPjIw
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ADDIN EN.CITE.DATA (13)miR-1, miR-133a/b, miR-208a/b, and miR-499–5pUp-regulated in AMIplasma37 TTC patients, 27 STEMI patients and 28 controlsHospital admission ADDIN EN.CITE <EndNote><Cite><Author>Jaguszewski</Author><Year>2013</Year><RecNum>546</RecNum><DisplayText>(14)</DisplayText><record><rec-number>546</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">546</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jaguszewski, M.</author><author>Osipova, J.</author><author>Ghadri, J. R.</author><author>Napp, L. C.</author><author>Widera, C.</author><author>Franke, J.</author><author>Fijalkowski, M.</author><author>Nowak, R.</author><author>Fijalkowska, M.</author><author>Volkmann, I.</author><author>Katus, H. A.</author><author>Wollert, K. C.</author><author>Bauersachs, J.</author><author>Erne, P.</author><author>Luscher, T. F.</author><author>Thum, T.</author><author>Templin, C.</author></authors></contributors><auth-address>Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistr. 100, Zurich 8091, Switzerland.</auth-address><titles><title>A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction</title><secondary-title>Eur Heart J</secondary-title><alt-title>European heart journal</alt-title></titles><periodical><full-title>Eur Heart J</full-title></periodical><edition>2013/09/21</edition><dates><year>2013</year><pub-dates><date>Sep 17</date></pub-dates></dates><isbn>1522-9645 (Electronic)
0195-668X (Linking)</isbn><accession-num>24046434</accession-num><urls><related-urls><url>;(14)Acute coronary syndrome and non S-T myocardial infarctionmiR-499-5pUp-regulated in NSTEMI patients vs. AHF patients and controlsplasma92 NSTEMI patients + 81 AHF patients without AMI and 99 controlsCCU ADDIN EN.CITE <EndNote><Cite><Author>Olivieri</Author><Year>2013</Year><RecNum>658</RecNum><DisplayText>(15)</DisplayText><record><rec-number>658</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">658</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Olivieri, F.</author><author>Antonicelli, R.</author><author>Lorenzi, M.</author><author>D'Alessandra, Y.</author><author>Lazzarini, R.</author><author>Santini, G.</author><author>Spazzafumo, L.</author><author>Lisa, R.</author><author>La Sala, L.</author><author>Galeazzi, R.</author><author>Recchioni, R.</author><author>Testa, R.</author><author>Pompilio, G.</author><author>Capogrossi, M. C.</author><author>Procopio, A. D.</author></authors></contributors><auth-address>Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy. f.olivieri@univpm.it</auth-address><titles><title>Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction</title><secondary-title>Int J Cardiol</secondary-title><alt-title>International journal of cardiology</alt-title></titles><periodical><full-title>Int J Cardiol</full-title><abbr-1>International journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Int J Cardiol</full-title><abbr-1>International journal of cardiology</abbr-1></alt-periodical><pages>531-6</pages><volume>167</volume><number>2</number><edition>2012/02/15</edition><dates><year>2013</year><pub-dates><date>Jul 31</date></pub-dates></dates><isbn>1874-1754 (Electronic)
0167-5273 (Linking)</isbn><accession-num>22330002</accession-num><work-type>Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(15)miR-133a, miR-499Released from the heart into the coronary circulation on myocardial injury in patients with CADplasma19 NSTEMI patients+ 31 CAD patients + 7 controlsCath Lab ADDIN EN.CITE <EndNote><Cite><Author>De Rosa</Author><Year>2011</Year><RecNum>660</RecNum><DisplayText>(16)</DisplayText><record><rec-number>660</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">660</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>De Rosa, S.</author><author>Fichtlscherer, S.</author><author>Lehmann, R.</author><author>Assmus, B.</author><author>Dimmeler, S.</author><author>Zeiher, A. M.</author></authors></contributors><auth-address>Division of Cardiology, Department of Medicine III, Goethe University Frankfurt, Frankfurt, Germany.</auth-address><titles><title>Transcoronary concentration gradients of circulating microRNAs</title><secondary-title>Circulation</secondary-title><alt-title>Circulation</alt-title></titles><periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></periodical><alt-periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></alt-periodical><pages>1936-44</pages><volume>124</volume><number>18</number><edition>2011/10/05</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Biological Markers/blood</keyword><keyword>Cardiac Catheterization</keyword><keyword>Coronary Artery Disease/diagnosis/*genetics/*metabolism</keyword><keyword>Coronary Circulation/*physiology</keyword><keyword>Coronary Sinus/metabolism</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>MicroRNAs/*blood</keyword><keyword>Middle Aged</keyword><keyword>Troponin T/blood</keyword></keywords><dates><year>2011</year><pub-dates><date>Nov 1</date></pub-dates></dates><isbn>1524-4539 (Electronic)
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ADDIN EN.CITE.DATA (17)miR-126Positive association with subsequent AMIplasma250 population-based individuals (Bruneck Study)Hospital admissionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYW1wZXRha2k8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy
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ADDIN EN.CITE.DATA (18)Vascular disease: diabetes mellitus, aortic aneurysmmiR-126Down-regulated in DMplasma822 population-based individualsHospital admissionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYW1wZXRha2k8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy
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ADDIN EN.CITE.DATA (20)Pulmonary hypertensionmiR-21, miR-130a, miR-133b, miR-191, miR-204, miR-208b, miR-1, miR-26a, miR-29cmiR-1, miR-26a, miR-29c down-regulated in PAH; miR-21, miR-130a, miR-133b, miR-191, miR-204, miR-208b up-regulated in PAHwhole blood32 PAH patients + 16 controlsHospital admission ADDIN EN.CITE <EndNote><Cite><Author>Wei</Author><Year>2013</Year><RecNum>469</RecNum><DisplayText>(21)</DisplayText><record><rec-number>469</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">469</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wei, C.</author><author>Henderson, H.</author><author>Spradley, C.</author><author>Li, L.</author><author>Kim, I. K.</author><author>Kumar, S.</author><author>Hong, N.</author><author>Arroliga, A. C.</author><author>Gupta, S.</author></authors></contributors><auth-address>Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Scott & White, Central Texas Veterans Health Care System, Temple, Texas, United States of America.</auth-address><titles><title>Circulating miRNAs as potential marker for pulmonary hypertension</title><secondary-title>PlOS One</secondary-title><alt-title>PloS one</alt-title></titles><periodical><full-title>PlOS One</full-title></periodical><alt-periodical><full-title>PlOS One</full-title></alt-periodical><pages>e64396</pages><volume>8</volume><number>5</number><edition>2013/05/30</edition><dates><year>2013</year></dates><isbn>1932-6203 (Electronic)
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ADDIN EN.CITE.DATA (22)Acute pulmonary embolismmiR-134Elevated in APE patientsplasma32 APE patients + 32 controls +22 dyspnoic non-APE patientsHospital admission ADDIN EN.CITE <EndNote><Cite><Author>Xiao</Author><Year>2011</Year><RecNum>753</RecNum><DisplayText>(23)</DisplayText><record><rec-number>753</rec-number><foreign-keys><key app="EN" db-id="zs5xza95xp9zawefr5sv50z6f9dxeweefpa5">753</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Xiao, Junjie</author><author>Jing, Zhi-Cheng</author><author>Ellinor, Patrick</author><author>Liang, Dandan</author><author>Zhang, Hong</author><author>Liu, Ying</author><author>Chen, Xiaoli</author><author>Pan, Lei</author><author>Lyon, Robert</author><author>Liu, Yi</author><author>Peng, Lu-Ying</author><author>Liang, Xingqun</author><author>Sun, Yunfu</author><author>Popescu, Laurentiu</author><author>Condorelli, Gianluigi</author><author>Chen, Yi-Han</author></authors></contributors><titles><title>MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism</title><secondary-title>Journal of Translational Medicine</secondary-title></titles><periodical><full-title>Journal of Translational Medicine</full-title></periodical><pages>159</pages><volume>9</volume><number>1</number><dates><year>2011</year></dates><isbn>1479-5876</isbn><accession-num>doi:10.1186/1479-5876-9-159</accession-num><urls><related-urls><url>;(23)AA, aortic aneurysm; AMI, acute myocardial infarction; APE, acute pulmonary embolism; BAV, bicuspid aortic valve; CAD, coronary artery disease; CCU, coronary care unit; DCM, dilated cardiomyopathy; DM, diabetes mellitus; ED, emergency department; HCM, hypertrophic cardiomyopathy; NSTEMI, non-ST elevated myocardial infarction; NYHA, New York Hear Association; PAH, pulmonary artery hypertension; PBMCs, peripheral blood mononuclear cells; STEMI, ST-elevated myocardial infarction; TASH, transcoronary ablation of septal hypertrophy; TAV, tricuspid aortic valve; TTC, Tako-Tsubo cardiomyopathy; UA, unstable angina.Supplementary References ADDIN EN.REFLIST 1.Long G, Wang F, Duan Q, et al. Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. Int J Biol Sci 2012;8:811-8.2.Ai J, Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun 2010;391:73-7.3.Wang R, Li N, Zhang Y, Ran Y, Pu J. Circulating microRNAs are promising novel biomarkers of acute myocardial infarction. Intern Med 2011;50:1789-95.4.Kuwabara Y, Ono K, Horie T, et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet 2011;4:446-54.5.Corsten MF, Dennert R, Jochems S, et al. Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet 2010;3:499-506.6.Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010;31:659-66.7.Devaux Y, Vausort M, Goretti E, et al. Use of circulating microRNAs to diagnose acute myocardial infarction. Clin Chem 2012;58:559-67.8.Meder B, Keller A, Vogel B, et al. MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol 2011;106:13-23.9.Long G, Wang F, Duan Q, et al. Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction. PlOS One 2012;7:e50926.10.Liebetrau C, Mollmann H, Dorr O, et al. Release Kinetics of Circulating Muscle-Enriched MicroRNAs in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy. J Am Coll Cardiol 2013;62:992-8.11.Varrone F, Gargano B, Carullo P, et al. The circulating level of FABP3 is an indirect biomarker of microRNA-1. J Am Coll Cardiol 2013;61:88-95.12.D'Alessandra Y, Devanna P, Limana F, et al. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J 2010;31:2765-73.13.Eitel I, Adams V, Dieterich P, et al. Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction. Am Heart J 2012;164:706-14.14.Jaguszewski M, Osipova J, Ghadri JR, et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J 2013.15.Olivieri F, Antonicelli R, Lorenzi M, et al. Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. Int J Cardiol 2013;167:531-6.16.De Rosa S, Fichtlscherer S, Lehmann R, Assmus B, Dimmeler S, Zeiher AM. Transcoronary concentration gradients of circulating microRNAs. Circulation 2011;124:1936-44.17.Fichtlscherer S, De Rosa S, Fox H, et al. Circulating microRNAs in patients with coronary artery disease. Circ Res 2010;107:677-84.18.Zampetaki A, Willeit P, Tilling L, et al. Prospective study on circulating MicroRNAs and risk of myocardial infarction. J Am Coll Cardiol 2012;60:290-9.19.Zampetaki A, Kiechl S, Drozdov I, et al. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 2010;107:810-7.20.Ikonomidis JS, Ivey CR, Wheeler JB, et al. Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease. J Thorac Cardiovasc Surg 2013;145:1326-33.21.Wei C, Henderson H, Spradley C, et al. Circulating miRNAs as potential marker for pulmonary hypertension. PlOS One 2013;8:e64396.22.Rhodes CJ, Wharton J, Boon RA, et al. Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med 2013;187:294-302.23.Xiao J, Jing Z-C, Ellinor P, et al. MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism. Journal of Translational Medicine 2011;9:159. ................
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