Single Patient IND



Melphalan

FDA Approved

Risks Associated with Melphalan

Frequent (Between a 10-50% chance that this will happen)

• Sores in the mouth and esophagus, which may be painful and cause difficulty swallowing.

Occasional (Between a 1-10% chance that this will happen)

• A low number of white blood cells may increase the risk of infection. It may become life-threatening. Symptoms of infection may include fever, pain, redness, and/or difficulty breathing.

• Low number of red blood cells that can causes tiredness and shortness of breath. May require a blood transfusion.

• Allergic reaction that may include a rash, hives, fever, difficulty breathing, and low blood pressure. Although usually reversible with treatment, it can be severe or life threatening.

• Kidney failure, which is when both of your kidneys fail and your body holds fluid which can be serious or life threatening. Your blood pressure rises and harmful wastes build up in your body. You may experience fatigue, nausea, and loss of appetite. When this happens, you need treatment to replace the work of your failed kidneys such as dialysis.

• Scarring of the lungs that can affect your ability to breath and may make you short of breath. This may be serious or life threatening.

• Low number of platelets, which may cause bleeding and bruising. Bleeding may be serious or life threatening and may required a blood transfusion.

• Hepatitis which may cause yellow eyes and skin, tiredness

• A second cancer related to the treatment of your first cancer. This usually occurs years after treatment for the first cancer.

Rare (Less than a 1% chance that this will happen)

• Sudden, unexpected stopping of the heart. This is serious and life-threatening.

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DANA-FARBER / HARVARD CANCER CENTER

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