Breastin



Case Reports

*Case Report 1: Breast cancer with secondary brain metastasis

A terminal case of breast cancer with a history of right mastectomy. The left breast on examination was free and the left axilla showed painful, hard, multiple mobile lymph nodes (3x4 cm) with no skin involvement. According to a CT – scan brain staging, a small (< 1cm) enhancing lesions was seen in the right parietal region in the midline and no evidence of surrounding edema was noted. The lesions showed to be as secondary metastasis when the case presented to the clinic, the patient was sick with a huge edema in the right axilla with loss of vision….etc.

She started the treatment with Breastin using both the routes (IM & OD). Three weeks later the patient showed significant changes in the reduction of the right axillary edema and the severity of pains decreased.

Five weeks after the treatment with Breastin the patient was put on weight (3kg) and the size of the left axillary lymph nodes showed significant reduction in size. The treatment with Breastin continued for almost one year and during which the patient was doing well both physically and clinically.

A CT- scan performed after one year of treatment with Breastin showed that the size of the lesion in the parietal region and the huge edema in the right axilla was reduced significantly to great extent. Unfortunately, the patient died after surgical operation.

*Case Report 2: A Recto – sigmoid Cancer / stage 4

A known case of a recto – sigmoid cancer stage 4 (Dukeُs D) was presented with a colicky pains in the lower abdomen with severe pains at the anal area….etc.

She started the treatment with Breastin using both the IM and OD routes. Two months later a CT – scan performed and showed that the internal iliac lymph node was getting even smaller than the previous scan (before treatment with Breastin). The CEA at the same time reduced significantly to 4 nanogram (much more before Breastin treatment).

Colonoscopy was performed after 4 months of treatment with Breastin showed that the tumour size inside the lumen was of egg size which is more smaller than before. Further, the mass became very friable and the impression was regression of the size was noticed. All these findings were accompanied by improvement in the appetite and the disappearance of pains in the abdomen and the perianal area and no more constipation associated with bleeding.

The treatment with Breastin continued for about two years during which a careful follow – up was followed using CT–scan, laboratory tests….etc. indeed the patient was even look different compared to previous and significant improvements were achieved in the tumour size and the mass was very regressed. In addition, the physical performance of the patient was almost normal and almost all the laboratory findings were within the normal limits.

A CT – scan was performed after two years of treatment with Breastin showed a complete regression of the mass from the lumen. The patient continued the maintenance treatment for another two years later.

*Case Report 3: Osteogenic Sarcoma

A terminal case of osteogenic sarcoma which was discovered through a biopsy from the upper tibial end. His family refused to give him neither chemotherapy nor radiotherapy and they insisted that he should be treated with Breastin.

He started the treatment with Breastin using both the IM and OD routes. One month later he showed a bleeding in the tibial region. A bone scan revealed that there was a new periosteal growth and new osteocytes growing in the upper left tibia. The compression at the area was also reduced and the swelling was reduced too. A chest X – ray done at the same time showed no lung metastasis.

Six months later another CT – scan performed to the upper tibial region which revealed a healing process and the swelling in the area was significantly reduced. One year after treatment with Breastin another CT- scan was performed and showed more osteocytes were observed and more periosteal growth was revealed. The patient was progressing and he was psychologically impressed by the treatment. A chest X – ray was done at the same time and showed no lung metastasis.

14 months later another CT – scan was performed which revealed complete healing and remission to the upper left tibia.

Another chest X – ray was performed at the same time and indicated that the lungs are free from any metastasis. The patient went on for maintenance therapy for another 14 months with Breastin. The patient is still OK after almost 4 years of treatment with Breastin.

*Case – Report 4: Malignant Lymphoma

A 55-years old lady presented with a pain in the left chest, cough and weakness. The clinical examination revealed loss of breathing sound in the left lung. A chest X – ray confirmed the presence of fluid in the same lung and a tumour mass. An FNA was performed and was diagnosed as malignant lymphoma.

The patient refused to take chemotherapy and decided to take Breastin instead. One month after the treatment with Breastin, an X – ray report showed a significant regression in the tumour mass. Three months later another X – ray was performed and showed that the tumour mass was regressed to a bout the half and the physical performance was improved remarkable too.

Six months later another X – ray scan was performed and showed the complete regression of the mass, however, we advised her to continue the treatment with Breastin. So the started the maintenance treatment and continued the treatment for another six months. She had indeed no more complains and she was physically and psychologically OK.

Another X – ray was done after one year and again no mass was demonstrated. A biopsy was taken for pathological study and no pathological findings were noted.

*Case – Report 5: Glioblastoma multiform

A 49 – years – old right – handed man, presented with a right homonomous hemianopia. CT – scan performed on the head revealed evidence of a mass lesion in the left parietal – occipital region. There was significant surrounding edema with this. The patient reported visual changes occurring over a several week interval prior to his evaluation at the hospital.

His wife noted increasing difficulty with confusion. The patient revealed on examination the evidence for a dense right homonomous hemianopia as well evidence of for parietal – lobe syndrome…..etc. The patient was admitted to a hospital to undergo craniotomy with debulking on the brain tumour and biopsy.

The results of the fresh frozen section obtained at the time of craniotomy showed:

Glioblastoma multiform status post craniotomy. The patient had a high grade astrocytoma.

In addition to craniotomy and radiation therapy, the patient also was treated with chemotherapy, however, the condition of the patient was deteriorated and the hospital discharged him. He and his wife decided to take Breastin as the last choice.

He started the treatment with Breastin, however, he was in a very poor medical condition. He was being carried on a stretcher and unable to stand up due to the feebleness occurring in his legs & arms.

Two months after treatment with Breastin using both routes, the patient was doing well. The feebleness in his legs and arms as well as his uncomfortable and agitated appearance had almost disappeared.

Five months after the treatment with Breastin the patient could walk without any help and according to a brain CT – scan performed demonstrated considerable regression of the mass.

Another brain CT – scan performed after 10 months revealed “no relapse in the tumour lesion” and the patient was progressing well.

Another brain CT – scan performed after 18 months revealed no change with respect to the previous CT – scan.

The patient was advised to start a maintenance therapy for another period (equal to 18 months). The patient lives later his normal life and he was free from any symptoms.

From the above studies it appears clearly that Breastin has a remarkable anticancer properties against many cancer types especially the breast, lung, prostate, colorectal adenocarcinomas, however, other cancer types also showed some response to treatment with Breastin such as urinary bladder, squamous cell, basal cells carcinoma…..etc.

A careful overall analysis to the anticancer activity of Breastin against different types of cancer as clearly indicated from the pooled results obtained from phase I/II and late phase II on more than 380 patients (Table ). The following:

Table 1 . Pooled Anticancer Results obtained using Breastin During phase I/II and late phase II

|Types of Cancer |No. of Patient |% Response |

|Breast / adenocarcinoma |109 |69.6 |

|Colorectals / adenocarcinoma |39 |53.3 |

|Prostate / adenocarcinoma |32 |68 |

|Stomach / adenocarcinoma |14 |61.5 |

|Lung / adenocarcinoma |33 |62.3 |

|Larynx / squamous cell |3 |72 |

|Chronic Lymphocytic Leukemia |13 |7.5 |

|Acute Lymphocytic Leukemia |10 |22 |

|Lymphoma (Malt) |2 |10 |

|Thyroid / Carcinoids |8 |71 |

|Skin / basal cell |15 |65 |

|Skin / Melanoma |4 |55 |

|Glioblastoma multiform |5 |45 |

|Osteosarcoma |13 |47.6 |

|Nasopharynx / squamous |6 |62 |

|Non – Hodgkin’s Lymphoma |5 |2 |

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