UNIVERSITY OF WASHINGTON



UNIVERSITY OF WASHINGTON September 26, 2005

SCHOOL OF MEDICINE CURRICULUM VITAE

Lucas R. Hoffman, MD, PhD

1. Personal Data: Born January 12, 1968 in Cambridge, Massachusetts.

2. Education:

|INSTITUTION AND LOCATION |DEGREE |YEAR(s) |FIELD OF STUDY |

|University of California, Berkeley |BS |1990 |Chemistry |

|College of Chemistry | | | |

|Berkeley, CA | | | |

|University of California, San Francisco |PhD |1996 |Biochemistry |

|Department of Biochemistry | | | |

|San Francisco, CA | | | |

|University of California, San Francisco |MD |1998 |Medicine |

|School of Medicine | | | |

|San Francisco, CA | | | |

3. Postgraduate Training:

2001-2005 Fellowship in Pediatric Pulmonology, Children’s Hospital

and Regional Medical Center, Seattle, WA

1998-2001 Residency in Pediatrics, Children's Hospital and Regional

Medical Center, Seattle, WA

4. Faculty Positions Held:

2005-present Acting Assistant Professor in Pediatrics, Children’s Hospital and

Regional Medical Center, Seattle, WA

2004-present Acting Instructor in Pediatrics, Children’s Hospital and

Regional Medical Center, Seattle, WA

5. Hospital Positions Held: None.

6. Honors:

2004-2005 Leroy Matthews Physician Scientist Award

2004 Children’s Hospital and Regional Medical Center Fellows Research Day Presentation Award

2003-2004 Cystic Fibrosis Foundation Third-year Research Fellowship Training Award

2002-2003 Cystic Fibrosis Foundation Clinical Fellowship Second-year Training Award

2001-2002 Cystic Fibrosis Foundation Clinical Fellowship First-year Training Award

1996. Young Scientist Award for the meeting Options for the Control of Influenza III, Cairns, Australia

1994. Richard Fineberg Memorial Student Teaching Award, UCSF

1990-1998 Medical Scientist Training Program Award

1990 University Citation, UC Berkeley (One of top 10 Univ. grads)

Departmental Citation (valedictorian), College of Chemistry,

UC Berkeley

Invited graduation speaker

1988-1990 Thompson Chemistry Scholarship

Howard Chemistry Scholarship

1988 Phi Beta Kappa (Junior year)

1986-1990 Regents' Scholarship, UC Berkeley

7. Board Certification: American Board of Pediatrics, 2001.

8. Current License(s) to Practice: Washington State full license, number 025209MD00040283 Issued 8/8/01, expires 1/12/06

9. Professional Organizations:

American Academy of Pediatrics

American Association for the Advancement of Science

American College of Chest Physicians

American Thoracic Society

10. Teaching Responsibilities:

2001 Assistant Chief Resident in Pediatrics, Children’s Hospital and Regional Medical Center, Seattle, WA

1994 Teaching assistant for Macromolecular Interactions, Department of Pharmaceutical Chemistry, UCSF

11. Editorial Responsibilities: None.

12. Special National Responsibilities: None

13. Special Local Responsibilities: None.

14. Research Funding:

Mentored Clinical Scientist Development Award (K08)

PI: Lucas Hoffman Sponsor: Samuel I. Miller

Source: NIH, National Institute of Allergy and Infectious Disease

Title: Antibiotic-mediated adaptation of Pseudomonas aeruginosa.

Dates of proposed support: July 15, 2005-May 31, 2008

Annual direct cost: $116,950

Leroy Matthews Physician Scientist (career development) Award

Active: project number HOFFMA04L0

PI: Lucas Hoffman Sponsor: Samuel I. Miller

Source: Cystic Fibrosis Foundation

Title: Alteration of Pseudomonas aeruginosa gene expression by sublethal cationic antibiotic concentrations: Adaptation to the CF airway.

Dates of approval: July 1, 2004- June 30, 2005

Annual direct cost: $67,500

Title: Cystic Fibrosis Foundation Third-year Research Fellowship Training Award

PI: Lucas Hoffman – Sponsor: Samuel Miller

Source: Cystic Fibrosis Foundation

Dates: July 1, 2003 – June 30, 2004

Annual direct costs: $62,600

Title: Cystic Fibrosis Foundation Second-year Research Fellowship Training Award

PI: Lucas Hoffman – Sponsor: Samuel Miller

Source: Cystic Fibrosis Foundation

Dates: July 1, 2002 – June 30, 2003

Annual direct costs: $43,750

Title: Cystic Fibrosis Foundation First Year Research Fellowship Training Award

PI: Lucas Hoffman – Sponsor: Samuel Miller

Source: Cystic Fibrosis Foundation

Dates: July 1, 2001 – June 30, 2002

Annual direct costs: $42,000

15. Research Funding Applications Pending:

Leroy Matthews Physician Scientist (career development) Award Renewal

Project number HOFFMA04L0

PI: Lucas Hoffman Sponsor: Samuel I. Miller

Source: Cystic Fibrosis Foundation

Title: Alteration of Pseudomonas aeruginosa gene expression by sublethal cationic antibiotic concentrations: Adaptation to the CF airway.

Dates of approval: July 1, 2008- June 30, 20010

Annual direct cost: $85,000

16. Bibliography

a) Manuscripts in Refereed Journals

1. Stearns, DM; Hoffman, LR; and Armstrong, WH. Structure of N,N-[Bis(2-pyridylmethyl)-gamma-aminobutyrato]copper (II) Bromide Methanol Solvate. Acta Crystallographica Section C- Crystal Structure Communications, 1992. V48 FEB: 253-256.

2. Hoffman, LR. The Low pH-induced Conformational Change in the Influenza Hemagglutinin: Inhibitor Design. 1996. PhD thesis, UCSF.

3. Hernandez, LD; Hoffman, LR; Wolfsberg, TG; and White, JM. Virus-Cell and Cell-Cell Fusion. Annual Review of Cell and Developmental Biology, 1996. 12:627-661.

4. Hoffman, LR; Kuntz, ID; and White, JM. Structure-based Identification of an Inducer of the Low-pH Conformational Change in the Influenza Hemagglutinin: Irreversible Inhibition of Infectivity. Journal of Virology, 1997. 71(11):8808-8820.

5. Rutenber, EE; De Voss, JJ; Hoffman, LR; Stroud, RM; Lee, KH; Alvarez, J; McPhee, F; Craik, C; and Ortiz de Montellano, PR. The Discovery, Characterization, and Crystallographically Determined Binding Mode of an FMOC Containing Inhibitor of HIV-1 Protease. Bioorganic and Medicinal Chemistry, 1997. 5(7): 1311-1320.

6. Quiao, H; Pelletier, SL; Hoffman, LR; Hacker, J; Armstrong, RT; and White, JM. A Specific Proline Substitution in the Coiled-Coil Region of the Influenza Hemagglutinin Impairs its Membrane Fusion Activity. Journal of Cell Biology, 1998. 141(6):1335-1347.

7. Hoffman LR; D'Argenio DA; MacCoss MJ; Zhang Z; Jones RA; Miller SI; Aminoglycoside Antibiotics Induce Bacterial Biofilm Formation. Nature, 2005. 436(7054):1171-5.

8. Hoffman, LR*; Yen, YH*; Gibson, RL; Van Niel, CW. Lipoid Pneumonia due to Mexican Folk Remedies: Cultural Barriers to Diagnosis. Archives of Pediatrics and Adolescent Medicine, 2005. 159:1043-1048. *These two authors contributed equally.

b) Book chapters

1. White, JM; Hoffman, LR; Arevalo, JH; and Wilson, IA. Attachment and Entry of Influenza Virus into Host Cells: Pivotal Roles of the Hemagglutinin. In: Structural Biology of Viruses, Chiu,W; Burnett, RM; and Garcea, RL; eds. 1997. Oxford Press, New York.

2. Hoffman, LR; White, JM; and Kuntz, ID. Fusion Mechanism of the Influenza Hemagglutinin: Inhibitor Design. In: Options for the Control of Influenza III: Proceedings. Brown, LE; Hampson, AW; and Webster, RG; eds. 1996. Elsevier Science, BV, The Netherlands.

c) Published books, videos, software, etc.

None.

d) Other publications, e.g., in non-refereed journals and letters to the Editor

None.

e) Manuscripts submitted or in press

1. Hoffman, LR; Emerson, J; Gibson, RL; Redding, GJ. Return to Best Spirometric Baseline After Admission for Cystic Fibrosis Pulmonary Exacerbation. Submitted to: American Journal of Respiratory and Critical Care Medicine, April 7, 2004; in revision.

f) Abstracts and posters:

1. Hoffman, LR; Emerson, J; Gibson, RL; Redding, GJ. Frequency of Return to Best PFT Baseline After CF Cleanout: A Pilot Quality Improvement (QI) Project. Presented at: 2003 American Thoracic Society International Conference in Seattle, Washington, May 21, 2003. Am J Resp Crit Care Med, 2003. 167(7): 23.

2. Debley, JS; Hoffman, L; Redding, G. Thoracic Index as a Measure of Hyperinflation during and Following RSV Hospitalization. Presented at: 2003 ATS International Conference in Seattle, Washington, May 19, 2003. Am J Resp Crit Care Med, 2003. 167(7): 507.

3. Hoffman, LR; D’Argenio, D; Jacobs, M; Miller, SI. The response of Pseudomonas aeruginosa to sublethal tobramycin concentrations. Presented at: 2004 Williamsburg Conference on Cystic Fibrosis in Williamsburg, VA, June 6, 2004.

4. Hoffman LR; D’Argenio D; Ernst RK; Miller SI. Effect of the antibiotic tobramycin on biofilm formation by Pseudomonas aeruginosa. Presented at: 2004 Gordon Conference on Bacterial Cell Surfaces in New London, NH, June 28, 2004.

5. Hoffman LR; D'Argenio DA; MacCoss MJ; Zhang Z; Jones RA; Miller SI; Aminoglycoside Antibiotics Induce Bacterial Biofilm Formation. Presented at: 2005 Williamsburg Conference on Cystic Fibrosis in Williamsburg, VA, June 6, 2005.

6. Hoffman LR; D'Argenio DA; MacCoss MJ; Zhang Z; Jones RA; Miller SI; Aminoglycoside Antibiotics Induce Bacterial Biofilm Formation. Presented at: 2005 International Meeting on Pseudomonas in Marseille, France, August 26, 2005.

g) National invitational lectures, etc.

1. Fusion Mechanism of the Influenza Hemagglutinin: Inhibitor Design. At: The World Health Organization: Options for the Control of Influenza III; Cairns, Australia. May 4-9, 1996.

2. Preliminary Structure-based Searches for RSV/HIV Integrase Inhibitors. At: The Tenth Meeting of Groups Studying the Structure of AIDS-related Systems and Their Application to Targeted Drug Design; NIH campus, Bethesda, Maryland. June 25-27, 1996.

3. Case Presentation: Refractory Mycobacterial Pulmonary Infection in a Patient With Cystic Fibrosis. At: Seattle CF Center and Affiliate Centers Annual Clinical Conference, University of Washington, Seattle, Washington. July 19, 2002. And at: The 16th Annual North American CF Conference (NACFC), New Orleans, LA October 4, 2002.

4. Sublethal Tobramycin Concentrations Alter Pseudomonas aeruginosa Virulence and Biofilm Formation. At: Children’s Hospital and Regional Medical Center Fellows’ Research Day. April 20, 2004.

5. Return to Best Spirometric Baseline After Admission for CF Exacerbation. At: Seattle CF Center and Affiliate Centers Annual Clinical Conference, University of Washington, Seattle, Washington. July 15, 2004.

6. Antibiotic Induction of Pseudomonas aeruginosa Biofilm Formation. At: University of Washington Inderdepartmental Microbial Pathogenesis Seminar. December 9, 2004.

Languages Spoken:

16. Fluent in Spanish, working knowledge of Russian and German.

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8/26/05 - mzs

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