PDF Drug Testing - Mayo Medical Laboratories

[Pages:30]Drug Testing

An Overview of Mayo Clinic Tests Designed for Detecting Drug Abuse

Printed on December 11, 2012 4:13 pm CST

?2012 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. MAYO, MAYO CLINIC, MAYO MEDICAL LABORATORIES and the triple-shield Mayo logo are trademarks and/or service marks of MFMER.

Table of Contents

3

Limits of Detection (LOD) Table -

4

Approximate Detection Times Table -

9

Alcohol

12

Amphetamine-Type Stimulants (ATS)

14

Barbiturates

15

Benzodiazepines

16

Buprenorphine

18

Cocaine and Metabolite

19

Fentanyl

20

Ketamine

21

Lysergic Acid Diethylamide (LSD)

22

Marijuana delta9-Tetrahydrocannabinol (THC)

23

Methadone

24

Methaqualone

25

Opiates

26

Phencyclidine (PCP)

28

Propoxyphene

29

Masking Agents/Adulterants

30

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Page 3

Limits of Detection (LOD) Table -

Prescription and OTC Drugs

Last Updated January 2011

The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably detected. If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory quality criteria for identification.

Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet laboratory quality criteria for identification.

Note: Submission of less than the minimum sample volume requires increasing the limit of detection.

Generic Name Acetaminophen Amitriptyline Amobarbital

Bupropion Butabarbital

Butalbital

Caffeine Carbamazepine Carisoprodol Chlordiazepoxide

Chlorpheniramine Chlorpromazine Chlorpropamide Citalopram

LOD (mcg/mL)

Notes

Urine

10.0

1.0

Variability in

the LOD

1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

1.0

1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

10.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

15.0

2.0

5.0

5.0 Preferred test for detection of

Variability in

benzodiazepines is a specific request; the LOD

see Specific Drug Group Confirmation

1.0

5.0

5.0

1.0 Unable to differentiate between Rand S-citalopram, reported as citalopram.

Variability in the LOD

Serum

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Page 4

Generic Name

Clomipramine

Clozapine Cyclobenzaprine Desipramine

Dextromethorphan Diazepam

Diltiazem Diphenhydramine Doxepin

Doxylamine EDDP (methadone metabolite)

Ethosuximide Etomidate Felbamate Fentanyl

Fluconazole Fluoxetine Gemfibrozil Hydrocodone

Hydroxyzine

Ibuprofen

Imipramine

Lamotrigine

LOD (mcg/mL)

Notes

Urine

Serum

1.0

Variability in

the LOD

1.0

1.0

5.0

Variability in Variability in

the LOD

the LOD

5.0

0.5 Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation

1.0

0.5

1.0

Variability in

the LOD

5.0

2.5 Preferred test for detection of methadone and metabolite is a specific request; see Specific Drug Group Confirmation

Only detected in urine

5.0

1.0

5.0

1.0 Preferred test for detection of fentanyl is a specific request; see Specific Drug Group Confirmation

5.0

4.0

5.0

5.0 Preferred test for detection of opiates Variability in is a specific request; see Specific Drug the LOD Group Confirmation

5.0

Variability in

the LOD

25.0

Variability in

the LOD

0.5

Variability in

the LOD

25.0

Variability in

the LOD

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Page 5

Generic Name Lidocaine Lorazepam

Meperidine Mephobarbital

Meprobamate Metaxalone Methadone

Methocarbamol Methsuximide Methylphenidate Metronidazole Midazolam

Mirtazapine Naproxen Nordiazepam Normethsuximide Norpropoxyphene

Nortriptyline Oxcarbazepine Metabolite Paroxetine Pentazocine Pentobarbital

Pentoxifylline

LOD (mcg/mL)

Notes

Urine

Serum

1.0

5.0 Preferred test for detection of

Variability in

benzodiazepines is a specific request; the LOD

see Specific Drug Group Confirmation

1.0

Variability in

the LOD

1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

5.0

1.0

1.0 Preferred test for detection of methadone is a specific request; see Specific Drug Group Confirmation

Variability in the LOD

2.5

Variability in

the LOD

1.0

10.0

5.0

1.0 Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation

1.0

30.0

1.0

10.0

10.0 Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation

1.0

Variability in

the LOD

5.0

20.0

5.0 5.0 Preferred test for detection of

barbiturates is a specific request; see Specific Drug Group Confirmation 1.0

Variability in Variability in

the LOD

the LOD

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Page 6

Generic Name

Phencyclidine

Phenobarbital

Phenytoin Primidone Promethazine Propofol Propoxyphene

Quetiapine

Quinidine

Salicylate Secobarbital

Sertraline

Temazepam

Theophylline Thiopental

Thioridazine Ticlopidine Topiramate Tramadol Trazodone Trimipramine Valproic Acid Venlafaxine Verapamil

LOD (mcg/mL)

Notes

Urine

Serum

1.0 Preferred test for detection of PCP is a specific request; see Specific Drug Group Confirmation

5.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

5.0

5.0

1.0

5.0

0.5 Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation

5.0

Variability in Variability in

the LOD

the LOD

5.0

Variability in

the LOD

5.0

1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

1.0

Variability in Variability in

the LOD

the LOD

1.0 Preferred test for detection of

Variability in

benzodiazepines is a specific request; the LOD

see Specific Drug Group Confirmation

5.0

1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation

1.0

1.0

5.0

5.0

2.0

1.0

5.0

2.0

1.0

Printed on December 11, 2012 4:13 pm CST

Page 7

Generic Name Zolpidem

LOD (mcg/mL)

Notes

1.0

Urine

Serum

Printed on December 11, 2012 4:13 pm CST

Page 8

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