Vancomycin per Protocol - Stanford Health Care
12/15/2015
Extended Infusion Beta-lactam Protocols
Go-Live: December 22, 2015
Emily Mui, PharmD, BCPS Lina Meng, PharmD, BCPS
Stanford Antimicrobial Safety and Sustainability (SASS) Program
Housewide Default to Extended Infusion Protocols
Extended infusion Zosyn ? ? Live since April 2015 - Old: 4.5g Q6H (30 min) - New: 3.375g x1 (over 30 min), then 3.375g Q8H* (over 4 hours)
Extended infusion cefepime, meropenem ? Dec 22, 2015 Go-Live - Same dosing regimens except: New: Initial "load/bolus" given over 30 minutes New: subsequent doses given over 3 or 4 hours
Examples: Cefepime 1-2g x1 over 30 min, then 1-2g q8h* (over 4 hours) Meropenem 1-2g x1 over 30 min, then 1-2g q8h* (over 3 hours) Zosyn 3.375g x1 (over 30 min), then 3.375g Q8H* (over 4 hours) *starts 4 hours after 1st dose
Confidential ? For Discussion Purposes Only
2
Rationale
Maximize the time-dependent bactericidal activity - Time which the free drug concentration exceeds the MIC of the organism (fT>MIC)
Target pathogens with high MIC (e.g. pseudomonas) Improved mortality and lower length of stay
Goal target attainments by beta-lactam class
Pathogen
Carbapenems Cephalosporins
Penicillins
Gram positive
20-30% fT>MIC 40-50% fT>MIC 30-40% fT>MIC
Gram negative
40-50% fT>MIC 60-70% fT>MIC 50-50% fT>MIC
Confidential ? For Discussion Purposes Only
3
Lodise et al, CID 2007, Lodise et al, Pharmacotherapy 2006
Process
All orders will default to the extended-infusion regimen for Zosyn?, cefepime, and meropenem except: - One-time orders in the ER - OR/PACU/pre-op - Ambulatory care areas
Please contact floor pharmacist to opt out - Medication scheduling and/or drug compatibility conflicts that cannot be resolved without placing additional lines - Patients who are on a prolonged course of antibiotics (e.g. osteomyelitis), are clinically improving, AND the organism has an MIC 4
Confidential ? For Discussion Purposes Only
4
Vancomycin per Pharmacy Protocol
Go-Live: January 5, 2016
Policy
Upon provider request, SHC pharmacists will manage inpatient IV vancomycin therapy in accordance with evidence-based guidelines and best practice standards
Pharmacist will: - Based on MD/APP specified indication, select goal trough level per protocol/IDSA guidelines - Enter necessary drug and lab orders Vancomycin doses Vancomycin troughs ($342 each) SCr
Exclusion Criteria: - One-time dose - Surgical/peri-operative prophylaxis - Pediatric patients ( 90 51-89 30-50 10-29 10 mcg/ml are recommended to avoid microbial resistance.
Goal Trough (mcg/ml)** 10 ? 15
15 ? 20
What if you request a goal that does not match the protocol?
- If it is close to/within the protocol goal range, pharmacist will document the rationale and proceed
- If it is significantly different than protocol goal range, pharmacist will request that it not be managed per protocol
Confidential ? For Discussion Purposes Only
10
Documentation
Pharmacist progress note will not be entered daily - Daily documentation will occur in pharmacist EPIC flowsheet
Pharmacists will only enter notes in the following instances: - Initiation of protocol (new start) - New trough level results - Change in dose - Change in patient's status that impacts vancomycin dosing
Confidential ? For Discussion Purposes Only
11
Questions?
Protocol links - SHC Intranet Policies Pharmacy Policies Manual Section 7: Medication Monitoring - -
Contact: - ID Pharmacists: ABX@ - Janjri Desai, Pharmacy Manager of Clinical Effectiveness: jdesai@
Website: -
Confidential ? For Discussion Purposes Only
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