Cdn-links.lww.com



SUPPLEMENTAL DIGITAL CONTENT 1. Previously Published Studies of Complete Blood Cell Count Indices in Late-onset Sepsis

Years |N |Culture positive |Population |Marker |Sens |Spec |PPV |NPV |+LR |–LR | | 1975–801 |56 |41% |All infants |WBC 20,000 |25 |88 |50 | |2.1 |0.9 | | | | | |I/T >0.2 |58 |79 |41 | |2.7 |0.5 | |1986–882 |139 |17% |All infants |WBC >9000 |74 |56 |13 |96 |1.7 |0.6 | | |  |  |  |ANC >5000 |67 |65 |14 |96 |1.9 |0.5 | | | | | |I/T >0.65 |79 |47 |12 |96 |1.5 |0.5 | | | | | |Platelets 20,000 |18 | |15 | | | | | | | | |ANC 0.2 |47 | |16 | | | | |19924 |185 |27% |All infants |I/T >0.2 |68 |85 |59 |90 |4.5 |0.4 | |19945 |147 |19% |All infants |WBC 20,000 |36 |80 |29 |84 |1.8 |0.8 | | | | | |I/T >0.2

|18 |96 |50 |83 |4.3 |0.9 | |1998–20036 |1026 |16% |VLBW |ANC 0.3 |37 | | | | | | | 2005–067 |163 |24% |All infants |ANC >6500 |84 |34 |50 |74 |1.3 |0.5 | | | | | |I/T >0.12 |33 |100 |100 |66 | |0.7 | |

VLBW indicates very low birth weight; WBC, white blood cell; ANC, absolute neutrophil count; I/T, immature-to-total neutrophils; N, total number of infants in study; sens, sensitivity; spec, specificity; PPV, positive predictive value; NPV, negative predictive value; +LR, positive likelihood ratio; –LR, negative likelihood ratio.

1. Philip AG. Detection of neonatal sepsis of late onset. JAMA. 1982;247:489–492.

2. Gonzalez BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V. Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile. J Perinat Med. 2003;31:60–68.

3. Fanaroff AA, Korones SB, Wright LL, et al. Incidence, presenting features, risk factors and significance of late-onset septicemia in very-low-birth-weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J. 1998;17:593–598.

4. Krediet T, Gerards L, Fleer A, van Stekelenburg G. The predictive value of CRP and I/T-ratio in neonatal infection. J Perinat Med. 1992;20:479–485.

5. DaSilva O, Hammerberg O. Diagnostic value of leukocyte indices in late neonatal sepsis. Pediatr Infect Dis J. 1994;13:409–411.

6. Sarkar S, Bhagat I, Hieber S, Donn SM. Can neutrophil responses in very-low-birth-weight infants predict the organisms responsible for late-onset bacterial or fungal sepsis? J Perinatol. 2006;26:501–505.

7. Bhandari V, Wang C, Rinder C, Rinder H. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics. 2008;121:129–134.

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download