NIH: National Institute of Allergy and Infectious Diseases ...



Supplemental MaterialSupp. Table 1. Pregnant patients with disseminated coccidioidomycosisAs: Asian, B: Black, L: Latina, Nat Am: Native American, NR: Not reported, PP: Post-Partum, W: WhiteCase No.First Author/Reference No.Age (y)RaceTrimesterSites of DiseaseFetal OutcomeMaternal Outcome1Mendenhall (1)30W1Pulmonary, probable meninges, kidney, liverDied, no infectionDied at 5 mo gestation2Smale (2)37BNRPulmonary, skin, meninges, bone, soft tissueStillbornDied, day 3 PP3Smale (2)28B3Pulmonary, meningesDied, prematurityDied, day 1 PP4Smale (2)34B3Pulmonary, meningesHealthy, survivedSurvived5Smale (2)27B3Pulmonary (miliary), spleenDied, undelivered, no infectionDied, third trimester6Conan (3) 30WPPUterine, skin, fungemiaHealthy, survivedDied 2 years PP7Vaughn (4)20B1SkinSpontaneous abortionDied8Vaughn (4)34L2MeningesHealthy, survivedSurvived9Vaughn (4)22B2Meninges, skinDied, prematurity, no infectionDied10Vaughn (4)29W3Disseminated, site not reportedHealthy, survivedDied11Vaughn (4)31W3Disseminated, site not reportedHealthy, survivedDied12Vaughn (4)24A3MeningesHealthy, survivedDied13Vaughn (4)37B3Disseminated, site not reportedStillborn, no infectionDied14Vaughn (4)28B3Disseminated, site not reportedHealthy, survivedDied15Vaughn (4)27B3Disseminated, site not reportedDied, no infectionDied, undelivered16Vaughn (4)19B3Disseminated, site not reportedHealthy, survivedDied17Cohen (5)22B2Pulmonary (miliary), skin, boneDied, immature, no infectionDied, 14 days PP18Cohen (5)34B2Pulmonary (miliary), meninges, skinSpontaneous abortion, no infectionDied at childbirth19Baker (6)32W3Pulmonary, meninges, brain parenchymaHealthy, survivedDied, 9 days PP20Harrison (7)20W2Pulmonary, skin, meningesImmature, diedDied21Mongan (8)21W2Pulmonary, liver, urinaryDied before birthDied in second trimester22Harris (9)22W3Pulmonary (miliary), liverHealthy, survivedDied23Harris (9)38W3Pulmonary (miliary), liverHealthy, survivedDied24Harris (9)21B2BoneHealthy, survivedSurvived 25Hadsall (10)38L3SkinHealthy, survivedSurvived 26Hadsall (10)26BSkinSpontaneous abortion; second pregnancy survivedSurvived 27Purtilo (11)22W3Pulmonary, meninges, liverImmature, diedDied28VanBergen (12)27W2Pulmonary (miliary), meninges, fungemiaHealthy, survivedDied29Steele (13)17WPulmonary, meningesHealthy, survivedSurvived 30Shafai (14)35B3Pulmonary, disseminatedTwins died of infection and prematurityDied 1 day PP31McCaffree20 (15)34NR2Pulmonary, skinHealthy, survivedSurvived32McCaffree20 (15)NRNR3MeningesHealthy, survivedSurvived33Bernstein (16)32A3CervixDied of infectionSurvived34Salgia (17)33LUterineHealthy, survivedSurvived 35Wack (18)28W2SkinHealthy, survivedSurvived 36Wack (18)26WPulmonary, meningesHealthy, survivedSurvived 37Babycos (19)21B3Pulmonary, skin, bone marrow, heartBorn prematurely, healthy, no infectionDied PP38Lee (20)19B3Disseminated, meningesNo mention of outcome of first pregnancy; second infant born prematurely with fluconazole-related defects; no infectionSurvived39Pursley (21)22NR3DisseminatedFour pregnancies: two healthy and two with fluconazole tetragonic findingSurvived40Aleck (22)27L3MeningesHealthy, survivedSurvived41Charlton (23)20L3Pulmonary, disseminated to liver, placentaPneumonia, survivedDied42Crum (24)21L3Pulmonary (miliary), bone, skinHealthy, survivedSurvived43Arnold (25)30L3PlacentaHealthy, survivedSurvived44Hooper (26)27NR2PlacentaDiedSurvived45Anstead (27)24B2Disseminated, site not reportedDiedSurvived46Cunningham (28)31NR2MeningesElective abortionSurvived47Crum (29)24ASkinHealthy, survivedSurvived48Calderon (30)22L3MeningesHealthy, survivedDied49Calderon (30)23L3MeningesHealthy, survivedDied50Calderon (30)24L2Meninges and CNS abscess, lymphadenitis, soft tissHealthy, survivedDied51Calderon (30)27L3Soft TissueDiedDied52Peterson (31)21BNRSkinDiedSurvivedSupp. Table 2. Patients with exogenous immunosuppression and disseminated coccidioidomycosisAs: Asian, B: Black, L: Latino/a, Nat Am: Native American, NR: Not reported, W: WhiteCase No.First AuthorAge (Y)RaceGenderReason for ImmunosuppressionMedication/DoseReduction or withdrawal of immunosuppressionSymptom improvement < 1 mo after reduction or withdrawal of immunosuppressionPulmonary DiseaseLocation of DisseminationFinal Outcome1Bravo (32)16WMALLCOG AALL0232 protocolIntrathecal methotrexate continued; 5-day prednisone pulses were d/c for 3 monthsYNAppendicular osteomyelitis, cutaneous, meningesSurvived2Bravo (32)20WMALLCOG AALL0232 protocolOff therapy for 8 months at time of fungal presentationN/ANAxial osteomyelitis, cutaneous, soft tissueSurvived3Bravo (32)6NRMSymptomatic treatment of fatigue, fevers, weight lossPrednisone, 5 day course/ dose NRYNYBlood, axial osteomyelitis, soft tissue (2 or more locations)Died4Blodget (33)23LMKidney transplantAnti-thymocyte globulin (1 mg/kg daily for 4 days), tacrolimus 1 mg q 12 h, MMF 500 mg b.i.d., methylprednisoloneNRNRYBlood, soft tissueSurvived5Blodget (33)66LMHeart transplantMMF 1500 mg b.i.d., prednisone 10 mg b.i.d., tacrolimus 2 mg AM and 1 mg PM.NR, died 6 days after CM diagnosisNRYBlood, soft tissue (2 or more locations)Died6Blodget (33)40BMKidney transplantMMF 500mg daily, prednisone 10 mg daily, tacrolimus 3mg q AM and 4mg q PMNR, died 5 days after CM diagnosisNRYBlood, soft tissue (2 or more locations)Died7Dierberg (34)19BMKidney transplantTacrolimus, prednisone, MMF/ dose NRNRNRYBloodSurvived8Dierberg (34)45WFKidney/pancreas transplantTacrolimus, prednisone, MMF/ dose NRNR, CM was diagnosed postmortemNRYBloodDied9Keckich (35)49BFKidney transplantThymoglobulin, tacrolimus, prednisone/ dose NRNRNRYMeningesSurvived10Keckich (35)64WMLiver transplantTacrolimus, prednisone/ dose NRNRNRYSoft tissueSurvived11Kokseng (36)18AFKidney transplantMMF, tacrolimus/ dose NRMMF d/c, tacrolimus dose decreasedYNCutaneous, meningesSurvived12Mitter (37)50NRMCrohn’s disease100?mg 6-mercaptopurine daily, adalimumab/ dose NRBoth were d/cNYAppendicular osteomyelitis, cutaneous, meninges and CNS abscess, soft tissueDied13Carvalho (38)62WMKidney transplantCyclosporine and prednisolone/ dose NRDoses of both were reducedNNCNS abscessDied14Keckich (39)74WMType of malignancy NRSteroids/ dose NRNRNRYBloodSurvived15Keckich (39)79WFRheumatoid arthritisAzathioprine/ dose NRNRNRYBloodDied16Keckich (39)66WFDermatomyositisSteroids/ dose NRNRNRYBloodSurvived17Trentman (40)37NRMSarcoidosisPrednisone/ dose NRNRNRNAppendicular osteomyelitis, cutaneousSurvived18Wollina (41)52NRFSarcoidosisPrednisolone and methotrexate (MTX) / dose NRBoth were d/cYYCutaneousSurvived19Stagliano (42)3WMWilms' tumorChemotherapy for tumor/ medications and doses NRNoN/AYBlood, cutaneous, soft tissueSurvived20Kappel (43)48NRMHIVN/AViral load and CD4 count were NRN/AYCutaneousSurvived21Assi (44)64NRFLiver transplantCorticosteroids/ dose NRNRNRYAppendicular osteomyelitisSurvived22Sohail (45)72NRMArachnoiditisDexamethasone/dose NRNRNRYSoft tissueDied of other cause23Sohail (45)56NRMKidney transplantPrednisone, azathioprine, cyclosporine/ dose NRNRNRYSoft tissueDied of other cause24Ugurlu (46)77NRFSuspected giant cell arteritisHigh dose prednisone/ dose NRPrednisone D/CNRNCutaneous, soft tissueSurvived25Wang (47)71AMIntermittent feverPrednisolone/ 30 mg/dayNRNRYBlood, meningesDied26Glenn (48)42LMGVHD prophylaxis and control after HSCT for chronic myelogenous leukemiaCyclosporine methotrexate/ dose NR Prednisone/ 120 mg/dayNoN/AYAxial osteomyelitis, blood, lymphadenitis, soft tissue (2 or more locations)Died of other cause27Blair (49)60NRMKidney transplantPrednisone 15 mg daily, tacrolimus 2 mg b.i.d, MMF 1 g b.i.d.NRNRYAppendicular osteomyelitis, soft tissueSurvived28Lewicky (50)36BFPresumed sarcoidosisPrednisone 15 mg dailyPrednisone d/cNYAxial osteomyelitis, soft tissue (2 or more locations)Survived29Miller (51)61NRNRLung transplantMethylprednisone, azathioprine, and cyclosporine/ dose NRNRNRYSoft tissue (2 or more locations)Died30Kuberski (52)57BFPresumed costochondritisPrednisone/ dose NRNRNRYAxial osteomyelitisSurvived31Antony (53)75AMUnrelenting exophthalmosPrednisone taper over several weeks starting at 60 mg dailyPrednisone d/cNYAxial osteomyelitisSurvived32Wright (54)46WMLiver transplantRegimen and dose NRNRNRYAxial osteomyelitis, CNS abscess, soft tissue (2 or more locations)Died33Wright (54)28BMKidney transplantRegimen and dose NRNRNRYAxial osteomyelitis, CNS abscess, soft tissue (2 or more locations)Died34Yorgin (55)13NRFLupus nephritisPulse cyclophosphamide/ 500 mg/m2, daily steroids/ dose NRNRNRYCNS abscess, lymphadenitis, soft tissue (2 or more locations)Died35Fishco (56)40NRFSarcoidosisPrednisone, 10 mg and 20 mg on alternate daysNRNRNAppendicular osteomyelitisSurvived36Erly (57)74NRMWaldenstr?m's macroglobulinemiaSteroid therapy for 2 years and intermittent chemotherapy for 5 years/ dose NRNRNRYAxial osteomyelitis, soft tissue (2 or more locations)Died37Smilack (58)72NRFPulmonary sarcoidosisVarying doses of prednisone for 5.5 years/ doses NRPrednisone d/cNYAxial osteomyelitis, cutaneous, soft tissue (2 or more locations)Survived38Banuelos (59)50LMLiver transplantAzathioprine, prednisone, tacrolimus/ dose NRNRNRYAxial osteomyelitis, CNS abscess and meningesSurvived39Wagner (60)34LFNon-Hodgkin's lymphomaTwo courses of ONCEP, one course of ESHAP/ doses NRImmunosuppressive therapy was delayedNYAxial osteomyelitisDied40Mischel (61)30LMHIVNo ART givenCD4 count 80/ μLN/A/ diagnosed postmortemYCNS abscess and meningesDied41Gold (62)36NRMHIVTreated with zidovudineCD4 count 7/μLN/AYCutaneous, lymphadenitis, meninges, soft tissue (2 or more locations)Died42Zar (63)28NRMHIVNo ART givenCD4 count 576/μLN/ANAxial osteomyelitis, blood, meninges, soft tissueSurvived43Dodd (64)60LMLiver transplant Prednisone and cyclosporine/ doses NRNRNRYSoft tissueDied44Byrne (65)57NRMHIVNo ART givenCD4 count 10/ μLN/AYBlood, meninges, soft tissueDied of other cause45Prichard (66)28LMHIVNo ART givenCD4 count NRN/AYAxial osteomyelitis, cutaneousDied46Vartivarian (67)29WMHeart transplantCyclosporine, 400 mg daily, rabbit antithymocyte globulin, 500 mg intramuscular daily, and prednisone 60 mg daily.Prednisone was tapered to 5 mg/dayPatient died <1 mo after infection presentation; CM diagnosed postmortemYAxial osteomyelitis, blood, cutaneous, soft tissue (2 or more locations)Died47Ampel (68)20LMKidney transplantAzathioprine 150 mg daily, prednisone 25 mg dailyBoth were reducedY but later relapsedYBlood, soft tissueDied48Ampel (68)83WMChronic lymphocytic leukemiaDexamethasone 24 mg dailyNRNRYBloodDied49Ampel (68)6LMLymphoblastic lymphomaDexamethasone 3 mg dailyNRNRYBloodDied50Ampel (68)81WMChronic lymphocytic leukemiaPrednisone 10 mg dailyNRNRYBlood, soft tissueDied51Ampel (68)63Nat AmMBacterial osteomyelitisDexamethasone 16 mg dailyNRNRYBloodDied52Ampel (68)54WFBreast carcinomaPrednisone 5 mg dailyNRNRYBlood, soft tissueDied53Ampel (68)68WMLarge cell carcinoma of lung; squamous cell carcinoma of the hypopharynxDexamethasone 16 mg dailyNRNRYBloodDied54Ampel (68)24WMHIVART NRCD4 count NRNRYBloodSurvived55Ampel (68)62WMChronic lung disease; Idiopathic cardiomyopathyPrednisone 25 mg dailyNRNRYBloodDied56Ampel (68)46WMChronic lung diseasePrednisone 70 mg dailyNRNRYBloodSurvived57Ampel (68)71WMGlioblastomaDexamethasone 4 mg t.i.d.NRNRYBloodDied58Ampel (68)58WMHIVART NRCD4 count NRN/AYBloodDied59Ampel (68)32BMHIVNo ART givenCD4 count NRN/AYBloodDied60Wolf (69)36WMHIVNo ART givenCD4 count 6.1 KN/ANCutaneous, lymphadenitis, soft tissueSurvived61Parker (70)30NRMLupus nephritisPrednisone 200 mg daily, cyclophosphamide 300 mg dailyPrednisone was taperedYYAxial osteomyelitis, soft tissueSurvived62Abrams (71)30WMHIVNo ART givenCD4 count 2.7 KN/AYAxial osteomyelitis, blood, lymphadenitis, soft tissue (2 or more locations)Died63Kovacs (72)30LMHIVNo ART givenCD4 count 2.9 KN/AYLymphadenitis, soft tissueDied of other cause64Howard (73)39Nat AmMKidney transplantPrednisone 40 mg daily, azathioprine 125 mg dailyNRNR, patient died 1 week after hospitalization for infectionYSoft tissueDied 65Howard (73)32WMLupus nephritisPrednisone 5 mg dailyNRNRYAxial osteomyelitis, blood, meninges, soft tissue (2 or more locations)Survived66Brewer (74)51WMHeart transplantAzathioprine, methylprednisone, antilymphocyte globulin/ doses NRNRNRYCNS abscess, soft tissue (2 or more locations)Died67MacDonald (75)5.5WMALL Monthly doses of vincristine sulfate (1.5 mg intravenously), prednisone (40 mg/day for 5 days), weekly oral doses of methotrexate (20 mg per dose), and daily doses of mercaptopurine (75 mg)All immunosuppressives were heldYYCutaneous, lymphadenitisSurvived68Allen (76)66WMEmphysemaPrednisone/ 35 mg dailyNoDied three days after CM diagnosed and antifungals givenYSoft tissue (2 or more locations)Died69Gardner (77)1WMRhinitis, stridor and cough unresponsive to antibioticsDexamethasone/ dose NRD/CYYSoft tissueSurvived70Kaplan (78)20WMKidney transplantPrednisone 30 mg every other day, azathioprine, 50 mg daily.Both were d/cYYCutaneous, meninges, soft tissueSurvived71Davis (79)32BMPresumed pulmonary sarcoidosisSteroids/ dose NRD/CNYMeningesSurvived72Halpern (80)23BMSarcoidosisSteroids/ dose NRNRNRYAxial osteomyelitis, lymphadenitis, soft tissue (2 or more locations)Survived73Harvey (81)23LFLupus nephritisPrednisone 60 mg dailyTapered to 12.5 mg/dayNNAxial osteomyelitis, soft tissueSurvived74Schroter (82)44LFKidney transplantPrednisone 200 mg daily, azathioprine 150 dailyNCM Diagnosed postmortemYLymphadenitis, soft tissue (2 or more locations)Died75Lee (83)48NRFKidney transplantPrednisone 20 mg daily; azathioprine 150 mgNRNAYCutaneousSurvived76Krulig (84)57LMPemphigus vulgarisBetamethasone 12 mg daily, azathioprine 200 mg dailyNCM Diagnosed postmortemYAxial osteomyelitis, lymphadenitis, soft tissue (2 or more locations)Died77Deresinski (85)32LFHodgkin’s lymphomaPrednisone 40 mg dailyNRCM diagnosed postmortemYAxial osteomyelitis, lymphadenitis, meninges, soft tissue (2 or more locations)Died78Deresinski (85)16WMHodgkin’s lymphomaMOPPNRPatient died 9 days after nodules appearedYAxial osteomyelitis, lymphadenitis, soft tissue (2 or more locations)Died79Deresinski (85)37LMHodgkin’s lymphomaMOPMOP D/CN; died 6 months after CM diagnosis despite antifungalsNMeningesDiedSupp Table 3. Demographic information of patients with exogenous immune suppression and disseminated coccidioidomycosis*Other: Native American (2), Not reported (19)Total SurvivedDied Death from other cause Total, n (%)7935 (44)39 (49)5 (6)Age, years, median (IQR)44 (28 – 62)36 (23 – 57)46 (30 – 63)56 (36 – 65)Gender, Male, n (%)59 (75)23 (66)31 (79)5 (100)Race, n (%) Black9 (11)6 (17)3 (8)0 (0) White29 (37)13 (37)16 (41)0 (0) Asian3 (4)2 (6)1 (3)0 (0) Latino16 (20)3 (9)11 (28)2 (40) *Other22 (28)11 (31)8 (21)3 (60)Immune suppression Cause, n(%) Transplant regimen24 (30)9 (26)13 (33)2 (40) Isolated steroid therapy29 (37)16 (46)12 (31)1 (20) Cancer chemotherapy8 (10)4 (11)4 (10)0 (0) HIV12 (15)4 (11)6 (15)2 (40) Regimens for autoimmune disease6 (8)2 (6)4 (10)0 (0)Site of dissemination, n (%) Pulmonary disease68 (86)26 (74)37 (95)5 (100) Osteomyelitis29 (37)16 (46)12 (31)1 (20) Axial 23 (29) 11 (31) 11 (28) 1 (20) Appendicular 6 (8) 5 (14) 1 (3) 0 (0) CNS Infection20 (25)8 (23)11 (28)1 (20) Meningitis 12 (15) 7 (20) 4 (10) 1 (20) Abscess 5 (6) 0 (0) 5 (13) 0 (0) Meningitis and abscess 3 (4) 1 (3) 2 (5) 0 (0) Lymphadenitis12 (15)3 (9)7 (18)2 (40) Cutaneous17 (22)13 (37)4 (11)0 (0) Soft tissue44 (56)16 (46)23 (59)5 (100) 2 or more locations 22 (28) 4 (11) 17 (44) 1 (20) Blood29 (37)8 (23)21 (54)0 (0)Year Published, n (%) 2000 - 201335 (44)20 (57)12 (31)3 (60) 1990 - 19998 (10)3 (9)5 (13)0 (0) 1980 - 198927 (34)8 (23)17 (44)2 (40) 1970 - 19799 (11)4 (11)5 (13)0 (0)Supp. Table 4. Location of coccidioidomycosis dissemination by racial group in patients with exogenous immunosuppression. *Other: Native American (2), Not reported (19)Total, n (%)Black White Latino Asian*OtherTotal, n7992916322Pulmonary disease68 (86)9 (100)25 (86)14 (88)2 (67)18 (82)Osteomyelitis29 (37)4 (44)7 (24)7 (44)1 (33)10 (45) Axial 23 (29) 4 (44) 6 (21) 7 (44) 1 (33) 5 (23) Appendicular 6 (8) 0 (0) 1 (3) 0 (0) 0 (0) 5 (23)CNS20 (25)3 (33)6 (21)4 (25)2 (67)5 (23) Meningitis 12 (15) 2 (22) 3 (10) 2 (13) 2 (67) 3 (14) Abscess 5 (6) 1 (11) 3 (10) 0 (0) 0 (0) 1 (5) Meningitis and abscess 3 (4) 0 (0) 0 (0) 2 (13) 0 (0) 1 (5)Lymphadenitis12 (15)1 (11)4 (14)5 (31)0 (0)2 (9)Cutaneous lesions17 (22)0 (0)7 (24)1 (6)1 (33)8 (36)Soft Tissue 44 (56)4 (44)15 (52)10 (63)0 (0)15 (68) 2 or more locations 22 (28) 4 (44) 7 (24) 5 (31) 0 (0) 6 (27)Blood 29 (37)3 (33)17 (59)5 (31)1 (33)3 (14)Supp. Table 5. Patients with multi-site disseminated coccidioidomycosis (MDCM)As: Asian, B: Black, L: Latino/a, Nat Am: Native American, NR: Not reported, W: White A: Amphotericin, C: Caspofungin, D: Difulcan, F: Fluconazole, I: Itraconazole, K: Ketoconazole, LA: Liposomal amphotericin, M: Miconazole, P: Posaconazole, V: VoriconazoleCase No.First AuthorAge (Y)RaceSexPMHPulmonary diseaseLocation of DisseminationAntifungals UsedSurgeryAbscess/ Fluid DrainageNo. of RelapsesFinal Outcome1Fierer (86)52BMOther illnessNCutaneous, soft tissueLA, F, PNN0Survived2Duplessis (87)30BMOther infectionYAxial/ appendicular osteomyelitisLA, P, IFN- γNN0Survived3Duplessis (87)23BMNoneNAxial osteomyelitis (multiple locations)LA, I, P, IFN- γYN0Survived4Silva-Hernandez (88)20LMOther infectionYCutaneous, soft tissueLA, FNN1Death from other causes5Keckich (39)70WMOther illnessYBlood, Meninges, soft tissueFNN0Survived6Keckich (39)63BMOther illnessYBlood, Soft tissue (2 or more locations)FNN0Survived7Keckich (39)47WMOther illnessYBlood8Kwok (89)50NRMNoneYCutaneous, lymphadenitisFNN0Survived9Kwok (89)42NRMOther infection/ Other illnessNAxial osteomyelitis, soft tissueA, FNN0Death from other causes10Wilde (90)42BFOther illnessYAxial osteomyelitis, soft tissueA, FNN1Death from other causes11Nolt (91)0NRMOther infectionYCNS abscess, lymphadenitisFNN0Survived12Crum-Cianflone (92)19LFNoneYLymphadenitis, soft tissueLA, FYY0Survived13Crum-Cianflone (92)31BMOther illnessYCutaneous, lymphadenitis, soft tissueLA, FYY0Survived14Crum-Cianflone (92)65AsMOther illnessYAppendicular osteomyelitis, soft tissueLA, FNY0Survived15Rosendahl (93)32WMNoneYCNS abscess, cutaneousFNN1Survived16Crum (94)59LFOther illnessYAxial osteomyelitis, cutaneous, lymphadenitisLA, INN0Survived17Anstead (27)17BFNoneYOsteomyelitis unspecified location, cutaneous, soft tissueLA, F, P, V, C, IFN-γYY1Died18Anstead (27)20BMNoneYAxial and appendicular osteomyelitis, cutaneousA, LA, F, I, K, PNN1Survived19La Via (95)10LMOther illnessYMeninges, soft tissue (2 or more locations)A, LA, F, IYN1Survived20Biller (96)24BFNoneYAxial osteomyelitis, CNS abscess, lymphadenitisLA, F, VNY0Survived21Prabhu (97)31BMNoneYAxial and appendicular osteomyelitis, soft tissueA, LA, F, I, V, CNN1Survived22Arnold (98)17AsFNoneYAxial and appendicular osteomyelitis, cutaneousA, FNN0Survived23Arnold (98)29AsMNoneYAxial osteomyelitis, cutaneous, soft tissueA, FNN0NR24Baddley (99)28BFNoneNAxial osteomyelitis, cutaneous, soft tissueA, LA, FNY0Survived25Crum and Lederman (29)20LMNoneNAxial and appendicular osteomyelitis, soft tissueA, INN0Survived26Crum and Lederman (29)21BMNoneYAxial osteomyelitis, soft tissueA, LA, INN1Survived27Crum and Lederman (29)22BMNoneYAxial and appendicular osteomyelitis, cutaneousA, INN0Survived28Crum and Lederman (29)59LFNoneYAxial osteomyelitis, cutaneousA, F, INN0Survived29Crum and Lederman (29)25LFNoneYAppendicular osteomyelitis, cutaneous, lymphadenitisA, FNN1Survived30Crum and Lederman (29)23BMNoneYAxial osteomyelitis, cutaneousA, INN0Survived31Crum and Lederman (29)29AsMNoneNAxial osteomyelitis, cutaneous, lymphadenitisA, INN1Survived32Crum and Lederman (29)36BMNoneNAxial and appendicular osteomyelitisA, FNN0Survived33Crum and Lederman (29)49AsFNoneYCutaneous, lymphadenitisFNN1Survived34Crum and Lederman (29)52WMNoneYAxial and appendicular osteomyelitis , cutaneousA, F, INN0Survived35Crum and Lederman (29)35LMNoneNAxial osteomyelitis, cutaneous, meningesFNN0Survived36Crum and Lederman (29)42AsMOther illnessYAxial osteomyelitis, cutaneous, soft tissueA, F, INN0Survived37Crum and Lederman (29)40AsFNoneYLymphadenitis, soft tissueFNN0Survived38Crum and Lederman (29)45AsMNoneNCutaneous, meninges and CNS abscess, lymphadenitisA, FNN2Survived39Crum and Lederman (29)52AsMNoneNCutaneous, meningesA, FYY2Survived40Danaher (100)20BMNRYAxial and appendicular osteomyelitis, cutaneous, soft tissueA, LA, F, PYN3Survived41Crum (94)22BMNoneYAxial and appendicular osteomyelitis, cutaneousLANN0Survived42Crum (94)59LFNoneYAxial osteomyelitis, cutaneousA, INN0Survived43Crum (94)19AsMNoneNAxial and appendicular osteomyelitis, soft tissueANY0Survived44Crum (94)21BMNoneYAxial osteomyelitis, soft tissue (2 or more locations)A, IYNN/ASurvived45Crum (94)21BMNRYAxial osteomyelitis, lymphadenitis, soft tissueA, IYNN/ASurvived46Holley (101)32NRMNRNAxial osteomyelitis, soft tissueA, INN0Survived47Erly (57)33NRMNoneNMeninges and CNS abscess, soft tissueFNN1Died48Polesky (102)41BFNoneNLymphadenitis, soft tissueA, F, INN4Survived49Polesky (102)48PakistaniMOther illnessYCutaneous, lymphadenitis, soft tissueA, F, INN1Survived50Koehler (103)32AsMNoneYOsteomyelitis (unspecified location), cutaneous, lymphadenitis, soft tissueA, LA, F, I, KNN0Survived51Cunningham (28)32BMNoneYAxial and appendicular osteomyelitis, cutaneous, soft tissueA, FNNN/ANR52Westphal (104)25NRMNRNAxial osteomyelitis, cutaneousA, FNN2Died53Herron (105)34BMNRNAxial osteomyelitis, soft tissueAYY0Survived54Woo (106)63NRFNoneYCutaneous, lymphadenitis, soft tissue (2 or more locations)ANN0Died55Banuelos (59)45LMOther illnessYOsteomyelitis (unspecified location), meninges and CNS abscess, soft tissueAYN1Died56Banuelos (59)21WMOther illnessYAxial osteomyelitis, CNS abscess, soft tissueA, FYN0Survived57Banuelos (59)63WMOther illnessYLymphadenitis, meninges and CNS abscess, soft tissue (2 or more locations)A, FNN1Died58Olson (107)27BMOther infectionNAxial osteomyelitis, soft tissue (2 or more locations)ANN0Survived59Olson (107)27AsMNRYAppendicular osteomyelitis, cutaneous, lymphadenitisA, FNY1Survived60Oudiz (108)24AsMOther illnessYLymphadenitis, soft tissue (2 or more locations)NoneNY0Died61Hicks (109)24BMNoneYCutaneous, lymphadenitis, soft tissueA, KNN0Survived62Beard (110)25BMNoneYAxial osteomyleitis, cutaneous, soft tissueA, FNN0Survived63Lopez (111)70NRMNRYLymphadenitis, soft tissueANN0Died64Lopez (111)65NRMOther illnessNSoft tissue (2 or more locations)NoneNN0Died65Schwartz (112)71WMOther illnessYMeninges, soft tissue (2 or more locations)A, F, KNN1Survived66Chen (113)28AsMNoneYCutaneous, lymphadenitisFNN1Survived67Jitsukawa (114)39AsMOther illnessYAxial osteomyelitis, cutaneous, soft tissueI, MNN2Survived68Ampel (68)19WMNoneYBlood, Soft tissue (2 or more locations)ANN0Survived69Ampel (68)23BMNoneNBlood, Cutaneous, soft tissueANN0Survived70Gillespie (115)1BMNoneNAxial and appendicular osteomyelitis, soft tissueA, I, KYN0Survived71Weisman (116)21WMNoneNLymphadenitis, soft tissue (2 or more locations)A, I, KYY2Survived72Parker (70)37NRMNRYAxial osteomyelitis, cutaneous, meningesANN0Survived73Howard (73)19WMNoneYBlood, Soft tissue (2 or more locations)ANN0Survived74Meyer (117)44WMOther infectionYCutaneous, meninges and CNS abscess, lymphadenitis, soft tissue (2 or more locations)AYY4Died75Burch (118)35BMNoneNAxial osteomyelitis, cutaenousANN1Death from other causes76Johnson (119)39NRFOther illnessNAppendicular osteomyelitis, meninges and CNS abscess, soft tissueANY0Died77Blumenkranz (120)57WMNoneYMeninges, soft tissueA, K, MNN0Survived78Blumenkranz (120)48LMOther infection/ Other illnessYMeninges, soft tissueA, KNN0Death from other causes79Blumenkranz (120)40Nat AmMNRYMeninges, soft tissueA, MNY2Survived80McGahan (121)26BMOther illnessNAxial osteomyelitis, cutaneousANN0Survived81McGahan (121)21BMNRYAxial and appendicular osteomyelitis, lymphadenitis, soft tissueA, MNN1Survived82McGahan (121)20LMNRNAxial and appendicular osteomyelitis, cutaneous, lymphadenitis soft tissueANN0NR83McGahan (121)62BMNRNAxial osteomyelitis, soft tissueANN0Died84Graybill (122)73NRFOther illnessYAxial osteomyelitis, cutaneous, soft tissueA, K, MNN2Death from other causes85Graybill (122)28LMNRYAxial and appendicular osteomyelitis, lymphadenitis, meninges, soft tissueA, K, MNN4Survived86Goldstein (123)35WMOther illnessYLymphadenitis, meninges, soft tissue (2 or more locations)ANN0Died87Meyer (124)51BMNRNAxial and appendicular osteomyelitis, cutaneous, soft tissue (2 or more locations)A, MNY2Survived88Meyer (124)54BMNRYAxial and appendicular osteomyelitis, soft tissueA, MNY1Survived89Meyer (124)52WMOther illnessYAxial and appendicular osteomyelitis, cutaneous, lymphadenitis, meninges and CNS abscess, soft tissue (2 or more locations)A, MYY0Death from other causes90Meyer (124)54BMNRYAxial osteomyelitis, cutaneous, lymphadenitis, meninges, soft tissueA, MNN3Died91Meyer (124)34BMNoneYMeninges, soft tissueA, MYY0Died92Danoff (125)40NRMOther illnessYCutaneous, lymphadenitis, meningesA, MYN5Died93Harvey (81)43WMNRYLymphadenitis, soft tissueAYY2Survived94Lee (83)31NRMNRYAxial and appendicular osteomyelitis, meningesA, MNN0Died95Thadepalli (126)26BMNRYOsteomyelitis (unspecified location), meninges, soft tissueAYN2Survived96Armbuster (127)33WMNRYAxial and appendicular osteomyelitis, cutaneous, meningesA, MNN0Survived97Armbuster (127)30BMNRYAxial and appendicular osteomyelitis, cutaneous, lymphadenitisANN0Survived98Kaplan (128)36WMOther infectionNAxial osteomyelitis, cutaneous, lymphadenitisANN1Survived99Sung (129)50BMNoneNAxial osteomyelitis, cutaneous, soft tissueA, MNY1Survived100Winter (130)27BMNRYAxial and appendicular osteomyelitis, meninges, soft tissueAYN1SurvivedSupp. Table 6. Demographic information of patients with multi-site disseminated coccidioidomycosis (MDCM)*Other: Native American (1), Pakistani (1), Not reported (14)$Time to outcome is days to final follow-up with patients in published reports. It typically represented time from presentation of disseminated coccidioidomycosis symptoms to cure, death, follow-up on long-term antifungals, or termination of antifungal therapy.Total SurvivedDiedDeath from other causeOutcome Not Reported Total, n100 721873Age, years, median (IQR)33 (23 – 48)30 (22 - 45)42 (33 – 62)42 (35 - 52)29 (20 – 32)Gender, Male, n (%)84 (84) 61 (85)15 (83)5 (71)3 (100)Race, n (%) Black39 (39)32 (44)4 (22)2 (29)1 (33) White17 (17)12 (17)4 (22)1 (14)0 (0) Latino13 (13)9 (13)1 (6)2 (29)1 (33) Asian15 (15)13 (18)1 (6)0 (0)1 (33) *Other16 (16)6 (8)8 (44)2 (29)0 (0)Location of Dissemination, n (%) Pulmonary disease71 (71)51 (71)13 (72)5 (71)2 (67) Osteomyelitis62 (62)47 (65)7 (39)5 (71)3 (100) Axial 31 (31) 23 (32) 3 (17) 4 (57) 1 (33) Appendicular 4 (4) 3 (4) 1 (6) 0 (0) 0 (0) Axial/ Appendicular 23 (23) 19 (26) 1 (6) 1 (14) 2 (67) Unspecified location 4 (4) 2 (3) 2 (11) 0 (0) 0 (0) Central Nervous System29 (29)17 (24)10 (56)2 (29)0 (0) Meninges 18 (18) 12 (17) 5 (28) 1 (14) 0 (0) Brain abscess 4 (4) 4 (6) 0 (0) 0 (0) 0 (0) Meninges and abscess 7 (7) 1 (1) 5 (28) 1 (14) 0 (0) Lymphadenitis34 (34)24 (33)8 (44)1 (14)1 (33) Cutaneous lesions52 (52)38 (53)6 (33)5 (71)3 (100) Soft Tissue 66 (66)43 (60)14 (78)6 (86)3 (100) 2 or more tissues 15 (15) 8 (11) 6 (33) 1 (14) 0 (0) Blood 6 (6)5 (7)1 (6)0 (0)0 (0)Number of antifungals given, median (IQR)2 (1 - 2)2 (1 - 3)1 (1 - 2)2 (2 - 2)2 (1 - 2)Given 1 yr or more of medication, n (%)51 (51)42 (58)6 (33)3 (43)0 (0)Surgery, n (%)21 (21)15 (21)5 (28)1 (14)0 (0)Abscess/ fluid drainage, n (%) 21 (21)15 (21)5 (28)1 (14)0 (0)Relapse, n (%)40 (41)28 (40)8 (44)4 (57)0 (0)Time to outcome (days)$, median (IQR)365 (188 – 730)365 (270 - 730)296 (40 – 1186)480 (210 – 545)N/APast medical history, n (%) No significant history45 (45)38 (53)4 (22)1 (14)2 (66) Other Infection 6 (6)4 (6)1 (6)1 (14)0 (0) Other Illness 24 (24)13 (18)8 (44)3 (43)0 (0) Other infection/ other Illness2 (2)0 (0)0 (0)2 (29)0 (0) Not Reported 23 (23)17 (24)5 (28)0 (0)1 (33)Supp. Table 7: Location of coccidioidomycosis dissemination in each racial group in patients with multi-site disseminated coccidioidomycosis (MDCM)*Other: Native American (1), Pakistani (1), Not reported (14)Total, n (%)Black White Latino Asian *OtherTotal, n1003917131516Pulmonary disease71 (71)25 (64)15 (88)10 (77)11 (73)10 (63)Osteomyelitis62 (62)32 (82)5 (29)9 (69)9 (60)7 (44) Axial 31 (31) 16 (41) 2 (12) 4 (31) 4 (27) 5 (31) Appendicular 4 (4) 0 (0) 0 (0) 1 (8) 2 (13) 1 (6) Axial/ Appendicular 23 (23) 14 (36) 3 (18) 3 (23) 2 (13) 1 (6) Unspecified location 4 (4) 2 (5) 0 (0) 1 (8) 1 (7) 0 (0)Central Nervous System29 (29)5 (13)10 (59)5 (38)2 (13)7 (44) Meninges 18 (18) 4 (10) 5 (29) 4 (31) 1 (7) 4 (25) Brain abscess 4 (4) 1 (3) 2 (12) 0 (0) 0 (0) 1 (6) Meninges and abscess 7 (7) 0 (0) 3 (18) 1 (8) 1 (7) 2 (13)Lymphadenitis34 (34)8 (21)7 (41)5 (38)8 (53)6 (38)Cutaneous lesions52 (52)20 (51)6 (35)8 (62)11 (73)7 (44)Soft Tissue 66 (66)28 (72)12 (71)8 (62)8 (53)10 (63) 2 or more tissues 15 (15) 3 (8) 8 (47) 1 (8) 1 (7) 2 (13)Blood 6 (6)2 (5)4 (24)0 (0)0 (0)0 (0)Supp. Table 8. Patients with single site disseminated coccidioidomycosis (SDCM).Case No.First AuthorAge (Y)RaceGender Location of DisseminationFinal Outcome1Arora (131)44BlackMaleAxial osteomyelitisSurvived2Kumar (132)68NRMaleAppendicular osteomyelitisSurvived3Newlon (133) 45BlackMaleCutaneousSurvived4Evans (134)36BlackMaleSoft tissueSurvived5Reach (135)28BlackFemaleAxial osteomyelitisSurvived6Gaidici (136)37NRFemaleLymphadenitisSurvived7Crum-Cianflone (92)61AsianMaleSoft tissueSurvived8Park (137)31AsianMaleCutaneousSurvived9Hwang (138)53WhiteMaleMeningitisSurvived10Chuang (139)34AsianMaleCutaneousSurvived11Sohail (45)61NRMaleSoft tissueSurvived12Sohail (45)82NRMaleSoft tissueSurvived13Sohail (45)84NRMaleSoft tissueSurvived14Sohail (45)68NRMaleSoft tissueSurvived15Snyder (140)66WhiteFemaleMeningitisSurvived16Rodriguez (141)56LatinoMaleSoft tissueSurvived17Crum (29)25AsianMaleCutaneousSurvived18Crum (29)17BlackMaleAppendicular osteomyelitisSurvived19Crum (29)75BlackMaleAxial osteomyelitisSurvived20Crum (29)21BlackMaleAxial osteomyelitisSurvived21Crum (29)47AsianMaleSoft tissueSurvived22Crum (29)27BlackMaleCutaneousSurvived23Crum (29)66AsianFemaleMeningitisSurvived24Crum (29)20WhiteMaleAppendicular osteomyelitisSurvived25Crum (29)58AsianMaleCutaneousSurvived26Crum (29)28BlackMaleCutaneousSurvived27Crum (29)23BlackFemaleAxial osteomyelitisSurvived28Crum (29)28BlackMaleAxial osteomyelitisSurvived29Crum (29)32WhiteMaleCutaneousSurvived30Crum (29)54AsianMaleSoft tissueSurvived31Crum (29)56AsianFemaleAppendicular osteomyelitisSurvived32Crum (29)66WhiteFemaleAppendicular osteomyelitisSurvived33Crum (29)40AsianMaleMeningitisSurvived34Crum (29)26WhiteMaleMeningitisSurvived35Crum (29)43BlackMaleCutaneousSurvived36Crum (29)52AsianMaleAppendicular osteomyelitisSurvived37Crum (29)22AsianFemaleAppendicular osteomyelitisSurvived38Crum (29)33BlackMaleAxial osteomyelitisSurvived39Crum (29)25BlackMaleAxial osteomyelitisSurvived40Crum (29)37BlackMaleAppendicular osteomyelitisSurvived41Crum (29)46AsianMaleAppendicular osteomyelitisSurvived42Crum (29)22NRMaleMeningitisSurvived43Crum (29)25BlackMaleAxial osteomyelitisSurvived44Crum (29)52AsianMaleLymphadenitisSurvived45Crum (29)10BlackFemaleSoft tissueSurvived46Crum (29)51BlackMaleSoft tissueSurvived47Crum (29)26AsianMaleMeningitisSurvived48Crum (29)35LatinoMaleCutaneousSurvived49Crum (29)1BlackFemaleAxial osteomyelitisSurvived50Crum (29)45AsianMaleMeningitisSurvived51Crum (29)67AsianMaleAppendicular osteomyelitisSurvived52Crum (29)27WhiteMaleAppendicular osteomyelitisSurvived53Crum (29)20BlackMaleAppendicular osteomyelitisSurvived54Crum (29)50BlackMaleAppendicular osteomyelitisSurvived55Crum (29)40NRMaleSoft tissueSurvived56Crum (29)49Native AmericanFemaleAxial osteomyelitisSurvived57Crum (29)62BlackMaleSoft tissueSurvived58Crum (29)35WhiteFemaleMeningitisSurvived59Crum (29)44AsianMaleCutaneousSurvived60Crum (29)37WhiteMaleAppendicular osteomyelitisSurvived61Crum (29)23NRMaleAxial osteomyelitisSurvived62Werle (142)50LatinoMaleAxial osteomyelitisSurvived63Reuss (143) 40WhiteMaleSoft tissueDied of other causes64Truett (144)65BlackMaleSoft tissueSurvived65Truett (144)53WhiteMaleSoft tissueSurvived66Arnold (98)11AsianFemaleSoft tissueSurvived67Crum (145)21BlackMaleAxial osteomyelitisSurvived68Crum (145)17BlackMaleAppendicular osteomyelitisSurvived69Crum (145)24AsianMaleCutaneousSurvived70Buchmiller-Crair (146) 36BlackMaleSoft tissueSurvived71Kim (147)50WhiteMaleCutaneousSurvived72Rance (148) 78WhiteMaleCutaneousSurvived73Shibili (149)23BlackMaleAxial osteomyelitisSurvived74Nakamura (150)28AsianMaleAxial osteomyelitisSurvived75Holley (101)21NRFemaleAppendicular osteomyelitisSurvived76Holley (101)27NRMaleAxial osteomyelitisSurvived77Holley (101)69NRFemaleAppendicular osteomyelitisSurvived78Holley (101)54NRMaleAxial osteomyelitisSurvived79Holley (101)35NRMaleAppendicular osteomyelitisSurvived80Holley (101)20NRMaleAppendicular osteomyelitisSurvived81Holley (101)38NRMaleAppendicular osteomyelitisSurvived82Holley (101)32NRMaleAxial osteomyelitisSurvived83Holley (101)25NRMaleAppendicular osteomyelitisSurvived84Holley (101)30NRFemaleAxial osteomyelitisDied of other causes85Holley (101)29NRMaleAxial osteomyelitisSurvived86Robertson (151) 48BlackMaleSoft tissueSurvived87Faul (152)20NRMaleSoft tissueSurvived88Olivere (153) 35WhiteMaleSoft tissueSurvived89Smilack (58)78NRMaleSoft tissueSurvived90Herron (105)27WhiteMaleAxial osteomyelitisSurvived91Herron (105)45BlackMaleAxial osteomyelitisSurvived92Herron (105)51WhiteFemaleAxial osteomyelitisSurvived93Herron (105)76WhiteMaleAxial osteomyelitisSurvived94Herron (105)35BlackMaleAxial osteomyelitisSurvived95Herron (105)31BlackMaleAxial osteomyelitisSurvived96Herron (105)63WhiteMaleAxial osteomyelitisSurvived97Herron (105)27BlackMaleAxial osteomyelitisSurvived98Herron (105)50BlackMaleAxial osteomyelitisSurvived99Herron (105)62Native AmericanMaleAxial osteomyelitisSurvived100Herron (105)23BlackMaleAxial osteomyelitisSurvived101Herron (105)55BlackMaleAxial osteomyelitisSurvived102Herron (105)21BlackMaleAxial osteomyelitisSurvived103Banuelos (59)36LatinoMaleMeningitisSurvived104Banuelos (59)42AsianMaleMeningitisSurvived105Low (154)4NRFemaleAxial osteomyelitisSurvived106Olson (107) 24BlackMaleAxial osteomyelitisSurvived107Cardone (155) 27LatinoMaleCutaneousSurvived108Cardone (155)53WhiteFemaleCutaneousSurvived109Harley (156)23BlackMaleCutaneousSurvived110Bickel (157) 0LatinoMaleAppendicular osteomyelitisSurvived111Kohn (158) 33WhiteMaleMeningitisSurvived112Sherman (159) 22BlackFemaleAxial osteomyelitisDied of other causes113Boyle (160)40WhiteFemaleLymphadenitisSurvived114Sprinkle (161)60LatinoMaleAppendicular osteomyelitisSurvived115Kuntze (162)34WhiteMaleSoft tissueSurvived116Dudley (163) 21NRFemaleSoft tissueSurvived117Dudley (163)13NRFemaleSoft tissueSurvived118Golden (164) 0LatinoMaleSoft tissueSurvived119Dickinson (165)34LatinoMaleCutaneousSurvived120Moreno (166) 22WhiteMaleCutaneousSurvived121Schwartz (167)83BlackMaleCutaneousSurvived122Davidson (168)66NRMaleSoft tissueSurvived123Parker (169) 25WhiteFemaleSoft tissueSurvived124Blumenkranz (120) 24WhiteMaleSoft tissueSurvived125Graybill (122)24BlackMaleAppendicular osteomyelitisSurvived126Sung (170) 62LatinoMaleSoft tissueSurvived127Igo (171) 47WhiteMaleAxial osteomyelitisSurvived128Meyer (124) 45BlackMaleMeningitisSurvived129Meyer (124)57WhiteMaleAppendicular osteomyelitisSurvived130Lee (83) 17NRMaleLymphadenitisDied131Armbuster (127)27LatinoMaleAppendicular osteomyelitisSurvived132Armbuster (127)41WhiteMaleAppendicular osteomyelitisSurvived133Armbuster (127)61AsianMaleAppendicular osteomyelitisSurvived134Turner (172) 37BlackMaleSoft tissueSurvived135Ward (173) 0LatinoMaleSoft tissueSurvived136Winter (130) 49AsianMaleAppendicular osteomyelitisSurvived137Winter (130)22WhiteMaleAppendicular osteomyelitisSurvived138Winter (130)2NRMaleAppendicular osteomyelitisSurvived139Zeller (174) 43BlackMaleCutaneousSurvivedSupp. Table 9. Demographic information of patients with single site disseminated coccidioidomycosis (SDCM).*Other: Not reported (28), Native American (2)Total Survived Died Death from other cause Total, n (%)139135 (97)1 (1)3 (2)Age, years, median (IQR)36 (24 – 52)36 (25 – 53)1730 (22 – 40)Gender, Male, n (%)115 (83)113 (84)1 (100)1 (33)Race, n (%) Black44 (32)43 (32)0 (0)1 (33) White29 (21)28 (21)0 (0)1 (33) Asian24 (17)24 (18)0 (0)0 (0) Latino12 (9)12 (9)0 (0)0 (0) Other*30 (22)28 (21)1 (100)1 (33)Site of dissemination, n (%) Osteomyelitis69 (50)67 (50)0(0)2 (67) Axial 38 (27) 36 (27) 0 (0) 2 (67) Appendicular 31 (22) 31 (23) 0 (0) 0 (0) Meningitis13 (9)13 (10)0 (0)0 (0) Lymphadenitis4 (3)3 (2)1 (100)0 (0) Cutaneous21 (15)21 (16)0 (0)0 (0) Soft tissue32 (23)31 (23)0 (0)1 (33)Year Published, n (%) 2000 - 201285 (61)83 (61)0 (0)2 (67) 1990 - 199928 (20)27 (20)0 (0)1 (33) 1980 - 198912 (9)12 (9)0 (0)0 (0) 1970 - 197914 (10)13 (10)1 (100)0 (0)Supp. Table 10. Location of coccidioidomycosis dissemination by racial group in patients with single-site disseminated coccidioidomycosis (SDCM). *Other: Native American (2), Not reported (28)Total, n (%)Black White Latino Asian *OtherTotal, n 1394429122430Osteomyelitis69 (50)28 (64)12 (41)4 (33)8 (33)17 (57) Axial 38 (28) 22 (50) 5 (17) 1 (8) 1 (4) 9 (30) Appendicular 31 (22) 6 (14) 7 (24) 3 (25) 7 (29) 8 (27)Meningitis13 (9)1 (2)5 (17)1 (8)5 (21)1 (3)Lymphadenitis4 (3)0 (0)1 (3)0 (0)1 (4)2 (6)Cutaneous lesions21 (15)7 (16)5 (17)3 (25)6 (25)0 (0)Soft Tissue 32 (23)8 (18)6 (21)4 (33)4 (17)10 (33)References1. MENDENHALL JC, BLACK WC, POTTZ GE. Progressive (disseminated) coccidioidomycosis during pregnancy. Rocky Mt Med J. 1948;45(6):472–6. 2. SMALE LE, BIRSNER JW. Maternal deaths from coccidioidomycosis. J Am Med Assoc. 1949;140(14):1152–4. 3. Conan J, Hyman GA. Disseminated coccidioidomycosis. Treatment with protoanemonin. Am J Med. 1950;9(3):408–13. 4. J.E. Vaughn, H. Rameriz. 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