Sacubitril and Valsartan (ENTRESTO™)
angiotensin II. Inhibition of neprilysin increases the levels of several of these substances, reducing vasoconstriction and sodium retention. The ARB component inhibits angiotensin II by selectively blocking the angiotensin II type-I (AT 1) receptor, reducing vasoconstriction and aldosterone release. Indication(s) Under Review in this document ................
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