Dove Press



Figure Supplementary 1 Demonstration of Horner’s syndrome and autotomic behaviour following brachial plexus avulsion injury.(A) A rat showed complete paralysis of the right forelimb (red arrow 1) and the Horner's syndrome, including ptosis and concave eyeballs (red arrow 2). (B) Autotomic behaviour of biting the toe on the right side following global BPAI (red arrow 3).BPAI = brachial plexus avulsion injury.Figure Supplementary 2 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and model groups at day 28. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 3 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and sham EA groups at day 28. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significant higher 18F-FDG uptake in the EA group than that in the sham EA group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 4 Brain regions showing significant differences in the 18F-FDG uptake value between the model and normal groups at day 28. L = left hemisphere; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the model group than that in the normal group, while the cold colour indicated a significantly lower 18F-FDG uptake in the model group.Figure Supplementary 5 Brain regions showing significant differences in the 18F-FDG uptake value between the sham EA and model groups at day 28. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the sham EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the sham EA group.Figure Supplementary 6 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and model groups at day 84. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 7 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and sham EA groups at day 84. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the EA group than that in the sham EA group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 8 Brain regions showing significant differences in the 18F-FDG uptake value between the model and normal groups at day 84. L = left hemisphere; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the model than that in the normal group, while the cold colour indicated a significantly lower 18F-FDG uptake in the model group.Figure Supplementary 9 Brain regions showing significant differences in the 18F-FDG uptake value between the sham EA and model groups at day 84. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the sham EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the sham EA group.Figure Supplementary 10 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and model groups at day 112. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 11 Brain regions showing significant differences in the 18F-FDG uptake value between the EA and sham EA groups at day 112. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the EA group than that in the sham EA group, while the cold colour indicated a significantly lower 18F-FDG uptake in the EA group.Figure Supplementary 12 Brain regions showing significant differences in the 18F-FDG uptake value between the model and normal groups at day 112. L = left hemisphere; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the model group than that in the normal group, while the cold colour indicated a significantly lower 18F-FDG uptake in the model group.Figure Supplementary 13 Brain regions showing significant differences in the 18F-FDG uptake value between the sham EA and model groups at day 112. L = left hemisphere; EA = electroacupuncture; 18F-FDG = 18F-fluorodeoxyglucose. The warm colour indicated significantly higher 18F-FDG uptake in the sham EA group than that in the model group, while the cold colour indicated a significantly lower 18F-FDG uptake in the sham EA group.Table S1. The average autotomic score and incidence rate of autotomic behaviour in four groups (mean ± SD (incidence rate)).ForelimbHindlimbLeftRightLeftRightNormal groupBaseline0 (0%)0 (0%)0 (0%)0 (0%)Day 1120 (0%)0.13±0.35 (12.5%)0 (0%)0 (0%)Model groupBaseline0 (0%)0 (0%)0 (0%)0 (0%)Day 1122.88 ± 3.97 (37.5%)5.50 ± 3.55 (75.0%) *3.13 ± 4.32 (37.5%)3.38 ± 3.70 (50%)Sham EA groupBaseline0 (0%)0 (0%)0 (0%)0 (0%)Day 1123.25±3.69(50%)4.88 ± 4.09 (62.5%)2.25 ± 3.15 (37.5%)3.00 ±3.59 (50%)EA groupBaseline0 (0%)0 (0%)0 (0%)0 (0%)Day 1122.5 ± 3.55 (37.5%)3.63 ± 4.00 (50%)1.75± 2.43 (37.5%)1.38 ± 2.56 (25%)EA = electroacupuncture. * indicated significant differences between the normal and model groups at the Day 112 (p<0.05)Table S2 Brain regions of significant metabolism changes on Days 28 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with Model group (p<0.005）Metabolism changes EA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related brain regions PositiveR_Cortex_Motor2215-894076.408 R_Cortex_Somatosensory6113-372656.381 R_Globus_Pallidus26-22-37903.572R_Thalamus_Dorsolateral18-20-17824.137L_Cortex_Visual-17361694.224R_Cortex_Visual591329674.290L_Cortex_Motor-2828-87534.348R_ic24-36-9503.478L_Cortex_Somatosensory-5620-41304.747L_Globus_Pallidus-30-13-35183.272L_Cortex_Piriform-52-42-41143.908R_Superior_Colliculus2432964.569R_Cortex_Piriform61-32-1753.088NegativeL_Thalamus_Dorsolateral-44-9-152-4.171L_Thalamus_Ventromedial-3-20-3524-3.702R_Thalamus_Dorsolateral42-16-318-3.837R_Thalamus_Midline_Dorsal1-7-2715-3.240L_Cortex_Somatosensory-1724-4114-3.407L_Cortex_Frontal_Association-926-9711-3.473L_Mesencephalic_Region-11-24295-3.123Emotion and cognition related brain regionsPositiveR_Amygdala26-51-31735.160L_Cortex_Medial_Prefrontal-33-79423.722R_Cortex_Medial_Prefrontal35-77193.365R_Hippocampus_Ventral63-125153.342NegativeR_Septum13-4762-4.386L_Hippocampus_Ventral-40-321145-3.925R_Cortex_Retrosplenial3282130-4.374L_Hippocampus_Postero_Dorsal-3217-316-3.341Positive indicated EA group > Model group, and negative indicated EA group < Model groupTable S3 Brain regions of significant metabolism changes on Days 28 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with sham electroacupuncture (sham EA) group (p<0.005）Metabolism changes EA group vs sham EA groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveR_Cortex_Somatosensory4430-3312536.114R_Cortex_Motor4226-633235.942R_Cortex_Visual263472195.128L_Cortex_Visual-17361563.913L_Cortex_Motor-3228-71373.683R_Caudate_Putamen20-9-51213.535R_Thalamus_Dorsolateral18-14-17173.402L_Cortex_Somatosensory-4226-15173.475R_Substantia_Nigra22-38383.180R_Cortex_Piriform42-18-8173.585NegativeR_Caudate_Putamen369-2756-3.623L_Caudate_Putamen-303-3128-6.226R_Thalamus_Dorsolateral163-3123-3.544R_Pons5-551522-4.691L_Cortex_Somatosensory-469-7310-3.335L_Thalamus_Dorsolateral-245-278-3.433Pain-related regionsPositiveL_Raphe-5-3617153.313NegativeR_Periaqueductal_Grey5-719219-4.578L_Periaqueductal_Grey-3-723120-6.988Emotion and cognition related brain regionsPositiveR_Cortex_Medial_Prefrontal33-75873.936R_Cortex_Orbitofrontal2811-93553.689L_Cortex_Retrosplenial-534-19183.143R_Cortex_Retrosplenial134-19103.094L_Cortex_Medial_Prefrontal-37-81403.477NegativeL_Hippocampus_Ventral-42-3211106-4.645R_Amygdala48-40-1393-3.532L_Hippocampus_Antero_Dorsal-2415-1193-3.956L_Hypothalamus_Medial-7-28-935-4.726L_Amygdala-38-44-2335-4.638R_Septum3-22-5729-4.632L_Hippocampus_Posterior-48-131919-3.312R_Hippocampus_Postero_Dorsal3811-113-3.110L_Septum-3-22-537-3.373R_Hypothalamus_Medial3-32-95-3.285Positive indicated EA group > sham EA group, and negative indicated EA group < sham EA groupTable S4 Brain regions of significant metabolism changes on Days 28 after brachial plexus avulsion injury (BPAI) of Model group compared with Normal group (p<0.005）Metabolism changes Model group vs Normal groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveR_Cortex_Piriform58-44-17784.788L_Mesencephalic_Region-7-2627403.958R_Caudate_Putamen11-9-59294.059R_Globus_Pallidus44-13-27144.443L_Cortex_Piriform-55-50-19145.684R_Pons22-3629104.977L_Cortex_Parietal_Association-3838-183.793L_Cortex_Somatosensory-4411-5963.615R_Cortex_Temporal_Association75-91554.973R_Mesencephalic_Region7-222543.286R_Cortex_Motor738-4923.272NegativeL_Caudate_Putamen-54-21-2342-3.793L_Cortex_Piriform-52-42-3523-4.729L_Cortex_Somatosensory-67-13-3915-4.009R_Cortex_Piriform40-38-5512-3.412R_Cortex_Somatosensory6315-358-3.895L_Cortex_Motor-3030-898-3.804R_Cortex_Visual5913297-3.539R_Cortex_Parietal_Association2244-93-3.141R_Thalamus_Dorsolateral381-112-3.145Pain-related regionsPositiveR_Raphe1-28365.542L_Periaqueductal_Grey-3-20113.406NegativeR_Cortex_Insular71-15-2327-5.175L_Cortex_Insular-61-9-614-3.172Emotion and cognition related brain regionsPositiveL_Septum-9-30-35493.857R_Hypothalamus_Medial1-26-1294.778R_Hippocampus_Postero_Dorsal505-1183.716L_VTA-5-303185.067R_Cortex_Orbitofrontal48-19-69103.470L_Thalamus_Midline_Dorsal-7-15-15103.369R_Substantia_Innominata24-42-4393.497R_Cortex_Retrosplenial338-733.233L_Amygdala-59-42123.215NegativeR_Hippocampus_Postero_Dorsal3417-1136-4.144L_Hippocampus_Antero_Dorsal-1513-994-4.847L_AcbSh-26-40-5984-9.603R_Hypothalamus_Lateral19-38-3314-3.533L_Septum-3-26-6313-3.645R_Cortex_Entorhinal69-2058-3.420L_Hippocampus_Postero_Dorsal-4015116-3.394L_Cortex_Entorhinal-61-15-156-3.243L_Amygdala-42-48-336-3.378R_Septum3-24-592-3.708R_AcbSh5-28-632-3.163L_Hypothalamus_Medial-3-48-252-3.322Positive indicated Model group > Normal group, and negative indicated Model group < Normal groupTable S5 Brain regions of significant metabolism changes on Days 28 after brachial plexus avulsion injury (BPAI) of sham electroacupuncture (sham EA) group compared with Model group (p<0.005）metabolism changes sham EA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Cortex_Motor-3228-891185.535R_Thalamus_Dorsolateral327-51154.319R_Cortex_Somatosensory657-23334.020L_Caudate_Putamen-54-17-27314.216R_Cortex_Motor4215-83213.477L_Cortex_Somatosensory-67-7-4173.495R_Mesencephalic_Region15-151353.235R_Cortex_Visual54192743.240L_Cortex_Piriform-34-15-8133.124R_Pons15-521723.274L_Thalamus_Dorsolateral-223-2923.074NegativeL_Cortex_Somatosensory-467-59130-4.698R_Caudate_Putamen151-6572-4.552L_Cortex_Visual-36321331-3.743R_Cortex_Somatosensory5015-1922-3.408R_Cortex_Motor2236-4919-3.428L_Cortex_Motor-1938-6518-4.047R_Cortex_Piriform71-34-95-4.450L_Thalamus_Midline_Dorsal-3-7-152-3.227Pain-related regionsPositiveR_Cortex_Cingulate726-8112.988Emotion and cognition related brain regionsPositiveR_Septum3-24-59685.852R_Cortex_Orbitofrontal26-7-81604.609L_Hippocampus_Antero_Dorsal-511-21564.202R_Cortex_Retrosplenial131517363.549L_Septum-3-26-59234.330R_Amygdala46-42-1383.277R_Hippocampus_Antero_Dorsal2615-1553.156R_Hypothalamus_Lateral19-42-3543.124L_Hippocampus_Subiculum-54-92123.013L_Cortex_Parietal_Association-5030-113.028L_Diagonal_Band-3-40-4912.990NegativeR_Hippocampus_Postero_Dorsal523-357-4.458R_Cortex_Frontal_Association3611-9720-3.870L_Cortex_Orbitofrontal-311-8716-3.272L_Cortex_Frontal_Association-1126-9714-3.360R_Cortex_Temporal_Association73-7214-3.115R_Cortex_Medial_Prefrontal311-853-3.193Positive indicated sham EA group > Model group, and negative indicated sham EA group < Model groupTable S6 Brain regions of significant metabolism changes on Days 84 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with Model group (p<0.005)Metabolism changesEA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Mesencephalic_Region-20-2412165.031L_Caudate_Putamen-32-21-471454.415L_Thalamus_Dorsolateral-32-9131083.685L_Cortex_Somatosensory-6311-351065.337R_Caudate_Putamen443-39973.938L_Pons-9-5229394.236L_Cortex_Piriform-50-44-33225.336L_Cortex_Motor-2626-67193.573R_Cortex_Visual65172183.578L_Cortex_Visual-42302133.229R_Cortex_Piriform54-42-2923.120R_Cortex_Motor3430-6923.081NegativeL_Thalamus_Dorsolateral-32-7-11294-4.363L_Cortex_Somatosensory-2840-13218-4.631L_Cortex_Auditory-71-1-7114-4.242R_Cortex_Motor1128-4370-3.856R_Thalamus_Dorsolateral15-3-1740-4.600L_Cortex_Visual-26342739-3.841R_Cortex_Somatosensory63-5-3521-4.784R_Cortex_Parietal_Association3430-518-3.314L_Cortex_Frontal_Association-1722-9312-3.372L_Cortex_Motor-2616-8511-3.327R_Superior_Colliculus713297-3.220R_Caudate_Putamen245-492-3.130Pain-related regionsPositiveR_Cortex_Insular54-9-59343.634L_Cortex_Insular-67-19-2723.117NegativeR_Cortex_Insular40-3-716-3.482Emotion and cognition related brain regionsPositiveL_Amygdala-42-46-5104.064R_Hypothalamus_Lateral9-38-753.076NegativeL_Cortex_Retrosplenial-532-27215-4.377R_Cortex_Retrosplenial930-1948-3.619L_Cortex_Medial_Prefrontal-3-3-7522-5.749L_Hypothalamus_Medial-9-36-1918-3.998L_Hippocampus_Postero_Dorsal-329717-4.086R_Cortex_Medial_Prefrontal1-3-7512-4.616Positive indicated EA group > Model group, and negative indicated EA group < Model groupTable S7 Brain regions of significant metabolism changes on Days 84 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with sham electroacupuncture (sham EA) group (p<0.005）Metabolism changes EA group vs sham EA groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveR_Cortex_Somatosensory5417-572584.498L_Thalamus_Dorsolateral-32-175824.358L_Cortex_Somatosensory-6122-37814.279L_Caudate_Putamen-44-26-31643.614L_Superior_Colliculus-111111283.830R_Thalamus_Dorsolateral24-3-25213.859R_Cortex_Motor4815-77133.577R_Caudate_Putamen443-37103.211R_Cortex_Piriform63-38-3173.850L_Cortex_Motor-2426-6363.236L_Cortex_Piriform-50-44-3733.121NegativeL_Cortex_Auditory-69-3-5225-4.213L_Cortex_Somatosensory-637-1977-5.283R_Cortex_Motor926-4340-3.908L_Cortex_Motor-4226-7531-3.786R_Cortex_Somatosensory69-5-3923-3.860L_Cortex_Visual-24362717-3.195R_Cortex_Visual2236294-3.421R_Thalamus_Midline_Dorsal5-5-352-2.987Pain-related regionsPositiveR_Cortex_Cingulate915-61173.336NegativeR_Cortex_Insular71-20-339-3.365L_Cortex_Insular-67-17-333-3.245Emotion and cognition related brain regionsPositiveL_Cortex_Medial_Prefrontal-11-7-751014.467L_AcbSh-26-34-55404.564L_Cortex_Orbitofrontal-287-95385.522R_Hippocampus_Ventral50-205373.765L_Amygdala-34-48-19173.396L_Pons-18-5029153.328R_Cortex_Frontal_Association3220-9363.855R_Hippocampus_Subiculum38171533.283R_Cortex_Orbitofrontal347-9313.004R_Amygdala40-54-2913.089NegativeL_Cortex_Parietal_Association-651111225-4.995R_Septum9-3-4190-4.420R_Cortex_Retrosplenial13261356-4.070L_Hippocampus_Subiculum-34131148-3.737R_Amygdala36-38-1938-4.499L_Cortex_Frontal_Association-1722-9738-4.300R_Hypothalamus_Lateral22-40-2922-4.407L_Cortex_Medial_Prefrontal-1111-718-3.282Positive indicated EA group > sham EA group, and negative indicated EA group < sham EA groupTable S8 Brain regions of significant metabolism changes on Days 84 after brachial plexus avulsion injury (BPAI) of Model group compared with Normal group (p<0.005）Metabolism changesModel group vs Normal groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Cortex_Auditory-611-12434.845L_Thalamus_Dorsolateral-24-11-151926.346R_Thalamus_Dorsolateral22-15-9834.329R_Superior_Colliculus3727453.637L_Cortex_Somatosensory-3638-49444.328L_Caudate_Putamen-221-47294.126L_Superior_Colliculus-979153.279R_Cortex_Motor1324-91123.889L_Cortex_Piriform-55-32-57103.520R_Cortex_Piriform30-15-8343.039R_Cortex_Somatosensory5724-5123.246R_Mesencephalic_Region11-221713.014NegativeL_Mesencephalic_Region-13-172393-3.952R_Cortex_Visual63131786-4.642R_Cortex_Motor3022-6345-3.737L_ic-42-5-1945-5.341R_Cortex_Somatosensory4632-4737-4.035L_Cortex_Visual-6351916-4.113L_Cortex_Somatosensory-677-3311-3.474L_Pons-5-522110-3.337L_Thalamus_Midline_Dorsal-9-13-17-3.668R_ic19-22-354-3.112L_Caudate_Putamen-50-23-413-3.033R_Cortex_Piriform63-32-392-2.981R_Caudate_Putamen38-32-532-3.391Pain-related regionsPositiveR_Cortex_Insular32-5-73283.563R_Raphe1-28333.483L_Zona_Incerta-9-32-1712.993NegativeL_Cortex_Insular-57-23-3327-3.664R_Cortex_Insular54-9-593-3.025Emotion and cognition related brain regionsPositiveR_Cortex_Medial_Prefrontal13-71624.226R_Hypothalamus_Medial1-30-3373.780L_AcbC-15-19-65313.850R_Cortex_Orbitofrontal71-93173.823L_Cortex_Medial_Prefrontal-35-71123.600L_Hypothalamus_Medial-11-36-21113.804L_Hypothalamus_Lateral-3-32-3113.943L_Cortex_Retrosplenial-3342383.417R_Cortex_Retrosplenial3322933.124NegativeL_Cortex_Entorhinal-40-21-6382-4.340R_Cortex_Entorhinal69-142555-4.146R_Septum1-1-4947-5.162L_Amygdala-32-40-2942-3.575R_Hippocampus_Postero_Dorsal3013131-3.880L_Septum-7-17-5326-3.828R_Hippocampus_Ventral46-2855-3.317L_Cortex_Orbitofrontal-205-953-3.731R_Cortex_Retrosplenial1517152-3.011Positive indicated sham Model group > Normal group, and negative indicated Model group < Normal groupTable S9 Brain regions of significant metabolism changes on Days 84 after brachial plexus avulsion injury (BPAI) of sham electroacupuncture (sham EA) group compared with Model group (p<0.005）metabolism changessham EA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Cortex_Somatosensory-651-331527.412R_Cortex_Somatosensory71-7-39403.935R_Cortex_Motor3426-79353.870L_Mesencephalic_Region-11-163174.420L_Cortex_Motor-4226-73144.927L_Caudate_Putamen-46-20-41133.746R_ic34-30-15113.661L_Pons-11-6123113.628L_Cortex_Visual-40302383.451R_Cortex_Visual65151963.348R_Caudate_Putamen36-28-5333.157L_Cortex_Auditory-719512.954NegativeR_Thalamus_Midline_Dorsal14-5-27233-3.138R_Thalamus_Dorsolateral34-14-27233-4.665L_Thalamus_Dorsolateral-28-9-13118-5.257R_Cortex_Motor2034-8997-4.046R_Cortex_Somatosensory5115-5184-4.537L_Superior_Colliculus-991177-5.237R_Cortex_Piriform32-18-8374-4.069L_Caudate_Putamen-46-11-5156-4.197R_Caudate_Putamen26-3-4946-4.386R_Mesencephalic_Region7-12732-3.759L_Cortex_Motor-3613-7912-3.296L_Thalamus_Ventromedial-3-28-2910-3.966R_Superior_Colliculus209195-3.282L_Cortex_Somatosensory-6126-74-3.206R_Cortex_Auditory75-3152-3.431L_Cortex_Visual-5922212-3.052L_Cortex_Auditory-75-992-3.177R_Thalamus_Ventromedial1-26-271-3.076Pain-related regionsPositiveL_Cortex_Insular-67-20-33824.720L_Periaqueductal_Grey-9-729495.789R_Cortex_Insular61-7-59343.790NegativeR_Cortex_Insular42-1-7373-5.111Emotion and cognition related brain regionsPositiveR_Amygdala34-38-151054.070R_Septum5-1-45323.553R_Hypothalamus_Lateral18-40-3173.790L_Diagonal_Band-3-26-4773.420R_Hippocampus_Postero_Dorsal3415363.873L_Hypothalamus_Medial-3-30-4343.836L_Cortex_Parietal_Association-6522543.020R_Hypothalamus_Medial3-30-4333.014R_Cortex_Temporal_Association69-12933.027NegativeL_Cortex_Medial_Prefrontal-3-5-75259-10.640R_Cortex_Medial_Prefrontal313-69164-7.757R_Cortex_Orbitofrontal227-8574-3.772L_Hippocampus_Postero_Dorsal-5011754-4.210L_Hypothalamus_Medial-7-30-1945-4.916L_Hippocampus_Antero_Dorsal-1311-2727-3.845L_Cortex_Orbitofrontal-289-9317-4.225R_Septum3-24-5915-4.026L_Cortex_Parietal_Association-3240-715-3.530R_Hippocampus_Ventral55-161311-3.394R_Amygdala59-28-910-4.058R_Cortex_Parietal_Association4538-75-3.464L_Amygdala-38-53-274-3.240R_Hypothalamus_Lateral13-36-412-3.236L_Cortex_Temporal_Association-75-15-12-3.462R_Hippocampus_Postero_Dorsal913-11-2.976R_Cortex_Frontal_Association3420-931-2.971Positive indicated sham EA group > Model group, and negative indicated sham EA group < Model groupTable S10 Brain regions of significant metabolism changes on Days 112 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with Model group (p<0.005）Metabolism changes EA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveR_Caudate_Putamen347-571644.148L_Superior_Colliculus-99231335.298L_Cortex_Somatosensory-3228-411304.056L_Thalamus_Dorsolateral-153-17724.284R_Cortex_Motor336-37603.871L_Medial_Geniculate-32-71393.864L_Cortex_Motor-1334-87224.512R_Cortex_Somatosensory4415-27153.184R_Thalamus_Dorsolateral17-11-13143.250L_Caudate_Putamen-133-57113.043R_Thalamus_Midline_Dorsal7-26153.595R_Cortex_Temporal_Association7112133.178L_Mesencephalic_Region-20-1523.239R_Cortex_Visual11382313.389NegativeL_Cortex_Somatosensory-577-39177-6.957R_Superior_Colliculus26-32340-4.428L_Cortex_Motor-3614-6536-3.666R_Ventral_Pallidum28-44-4720-3.408L_Cortex_Piriform-34-21-8115-3.644R_Cortex_Somatosensory5713-6514-3.421L_Thalamus_Midline_Dorsal-28-2256-3.413L_Substantia_Nigra-30-2652-3.103Emotion and cognition related brain regionsPositiveL_Hypothalamus_Medial-18-28-29243.494R_Cortex_Orbitofrontal405-8953.727R_Hippocampus_Postero_Dorsal523-333.177L_Cortex_Medial_Prefrontal-75-7712.925NegativeL_Cortex_Medial_Prefrontal-920-9573-4.921L_Cortex_Entorhinal-69-191148-4.473L_Amygdala-48-32-1747-3.618R_Cortex_Entorhinal69-222114-3.292R_Amygdala48-38-1911-3.289R_Cortex_Orbitofrontal3-1-871-2.932L_Hypothalamus_Medial-5-54-51-2.926Positive indicated EA group > Model group, and negative indicated EA group < Model groupTable S11 Brain regions of significant metabolism changes on Days 112 after brachial plexus avulsion injury (BPAI) of electroacupuncture (EA) group compared with sham electroacupuncture (sham EA) group (p<0.005）metabolism changesEA group vs sham EA groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Superior_Colliculus-241213407.396R_Thalamus_Midline_Dorsal9-3-311529.483L_Thalamus_Dorsolateral-30-311264.673R_Thalamus_Dorsolateral361-17824.689L_Cortex_Motor-1534-89374.958L_Cortex_Auditory-73-5-13184.569L_Cortex_Visual-403611124.357L_Cortex_Somatosensory-4614-57123.517R_Superior_Colliculus911384.721R_Caudate_Putamen345-5983.175L_Thalamus_Midline_Dorsal-3-5-2973.219L_Pons-18-572964.196R_Cortex_Visual48321954.114R_Cortex_Motor2430-8733.014R_Cortex_Auditory75-1-1333.382R_Mesencephalic_Region7-182523.136NegativeL_Globus_Pallidus-36-24-39258-7.709L_Cortex_Somatosensory-617-39145-5.509L_Thalamus_Dorsolateral-28-195122-4.842R_Mesencephalic_Region19-241781-4.103R_Cortex_Somatosensory6315-2373-5.052L_Cortex_Piriform-34-38-5955-4.128R_ic40-17-2745-3.542L_Cortex_Visual-2842131-4.161R_Caudate_Putamen40-24-3915-3.293L_Cortex_Auditory-655-117-3.589R_Cortex_Visual6121216-3.182Pain-related regionsPositiveL_Zona_Incerta-11-30-29944.016R_Cortex_Insular50-17-7323.095L_Cortex_Insular-67-23-4113.026Emotion and cognition related brain regionsPositiveL_Hippocampus_Subiculum-52-7252464.927R_Cortex_Retrosplenial153429473.547R_Hippocampus_Postero_Dorsal48-513394.168R_Hippocampus_Ventral50-26-1384.199R_Hippocampus_Subiculum42-2619334.411L_Cortex_Entorhinal-55-3623223.933R_Hypothalamus_Lateral19-36-29193.471L_Hippocampus_Postero_Dorsal-461583.154NegativeR_Cortex_Entorhinal69-15-15146-4.826R_Cortex_Temporal_Association69-1617141-3.472L_Hippocampus_Ventral-26-441122-4.059L_Cortex_Orbitofrontal-36-1-7739-3.485L_Cortex_Entorhinal-69-26-1734-4.443L_Hypothalamus_Medial-9-40-4323-4.148R_AcbSh17-15-7317-3.126L_AcbSh-11-26-5513-3.594L_Cortex_Frontal_Association-2418-9712-3.177R_Cortex_Medial_Prefrontal71-854-3.193R_Amygdala30-50-252-3.595Positive indicated EA group > sham EA group, and negative indicated EA group < sham EA groupTable S12 Brain regions of significant metabolism changes on Days 112 after brachial plexus avulsion injury (BPAI) of Model group compared with Normal group (p<0.005）metabolism changesModel-group vs Normal-groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveL_Mesencephalic_Region-26-2217383.625L_Globus_Pallidus-36-28-31373.684R_Superior_Colliculus51111323.938R_Thalamus_Ventromedial3-19-19153.365L_Cortex_Piriform-36-21-81154.066L_Cortex_Somatosensory-5626-41103.586L_Cortex_Auditory-6916-143.398L_Cortex_Visual-44321933.143L_Cortex_Temporal_Association-73-171333.104R_Cortex_Piriform54-36-4913.041NegativeR_Cortex_Motor2628-63481-7.122R_Cortex_Somatosensory2032-19462-4.805R_Cortex_Visual571721388-5.237L_Cortex_Motor-2830-87318-4.926R_Cortex_Auditory715-1300-3.760R_Caudate_Putamen40-19-55278-4.765L_Cortex_Somatosensory-3634-37256-4.839R_Cortex_Medial_Prefrontal35-79178-3.458L_Caudate_Putamen-15-3-53136-4.300L_Cortex_Visual-52309119-5.602R_Thalamus_Dorsolateral20-9-1387-4.074R_Cortex_Piriform54-50-299-3.878L_Superior_Colliculus-37239-3.596L_Thalamus_Dorsolateral-30-5-298-3.130R_Superior_Colliculus15231-2.949Pain-related regionsNegativeR_Cortex_Insular71-22-2191-4.627L_Cortex_Cingulate-724-6940-3.702L_Cortex_Insular-48-7-714-3.292R_Cortex_Cingulate128-632-3.085Emotion and cognition related brain regionsPositiveL_Amygdala-50-40-12035.175L_Cortex_Entorhinal-50-1929705.363L_Cortex_Frontal_Association-524-93394.084R_Cortex_Entorhinal52-1829263.587L_Hypothalamus_Lateral-13-44-33193.739R_VTA3-2811183.393R_Hypothalamus_Medial1-54-9153.284R_Hippocampus_Postero_Dorsal4071363.134R_Septum73-5553.188L_Septum-37-4123.063R_Amygdala56-40-512.997NegativeL_Cortex_Medial_Prefrontal-79-77638-4.457L_Cortex_Orbitofrontal-283-89319-4.717R_Hippocampus_Postero_Dorsal4019-3284-4.056R_Cortex_Orbitofrontal305-91208-4.705R_Hippocampus_Ventral61-22327-3.892Positive indicated sham Model group > Normal group, and negative indicated Model group < Normal groupTable S13 Brain regions of significant metabolism changes on Days 112 after brachial plexus avulsion injury (BPAI) of sham electroacupuncture (sham EA) group compared with Model group (p<0.005）metabolism changessham EA group vs Model groupBrain regionsMNI coordinatesExtentt-valuexyzSensorimotor related regionsPositiveR_Cortex_Somatosensory6115-232207.340L_Cortex_Somatosensory-3228-131234.654R_Mesencephalic_Region15-2417754.412R_Cortex_Visual612121414.332R_Cortex_Motor4418-87243.679L_Cortex_Piriform-61-48-13203.578L_Cortex_Visual-5422393.633R_Thalamus_Midline_Dorsal7-28163.550R_Thalamus_Dorsolateral20-13-1533.153R_Caudate_Putamen3011-3123.014R_Substantia_Nigra22-401713.178NegativeL_Cortex_Piriform-40-48-1576-4.177R_Thalamus_Midline_Dorsal1-3-3166-4.514R_Superior_Colliculus26-32147-4.223L_Thalamus_Midline_Dorsal-3-1-3144-4.488L_Thalamus_Dorsolateral-305-737-3.333L_Cortex_Auditory-73-5-1312-4.402L_Cortex_Somatosensory-549-3911-3.220R_Cortex_Visual2236298-3.389R_Cortex_Somatosensory4018-697-3.280R_ic44-3-176-3.483L_Cortex_Motor-2432-655-3.020R_Pons1-57234-3.125R_Cortex_Motor1142-333-3.176R_Cortex_Auditory691571-3.057L_Pons-18-54271-3.011Pain-related regionsPositiveL_Cortex_Insular-34-1-75123.404R_Cortex_Insular67-15-2163.266R_Zona_Incerta19-28-553.118NegativeR_Cortex_Cingulate113-437-3.296L_Cortex_Cingulate-315-436-3.303Emotion and cognition related brain regionsPositiveL_Cortex_Medial_Prefrontal-97-77516.226L_Cortex_Parietal_Association-5015-1143.365L_VTA-9-38333.029R_Cortex_Orbitofrontal32-13-7112.963NegativeL_Hippocampus_Ventral-61-1511191-4.739L_Hippocampus_Postero_Dorsal-44-17191-3.817R_Hippocampus_Ventral46-20-1112-3.371R_Hippocampus_Postero_Dorsal46113112-4.694R_Hypothalamus_Medial9-48-1726-4.346L_Amygdala-48-40-522-3.732L_Hypothalamus_Medial-3-42-3521-4.962L_Hypothalamus_Lateral-13-42-3316-3.582L_Hippocampus_Antero_Dorsal-57-2912-3.746R_Hippocampus_Antero_Dorsal17-278-3.484R_Hippocampus_Subiculum44-26196-3.340Positive indicated sham EA group > Model group, and negative indicated sham EA group < Model group ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download