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Six to 8 weeks is needed before retesting TSH after changing the L-T4 dose or brand of thyroid medication. Intermittent or non-compliance with levothyroxine (L-T4) replacement therapy will result in discordant serum TSH and FT4 values (high TSH/high FT4) because of a persistently unstable thyroid state (Guideline 2). ................
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