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Supplementary materialsFull search strategy (including other regions)Summary protocolObjectives and research questionsPrimary objectiveEpidemiology reviewTo conduct an epidemiological review to assess the incidence/prevalence, seroprevalence and case fatality rates of varicella (chickenpox) infectionEconomic burden reviewTo examine the economic burden of varicella, including healthcare resource utilizationVaccination coverage program objectiveTo provide data on current status of vaccination programs including coverage rates and economic evaluations of these programsStudies to includePatient populationAge: Individuals 12 months of age or older; studies with infants <12 months will be categorized separatelyGender: AnyRace: AnyDisease: Patients with primary and/or breakthrough varicella (chickenpox) infectionStudy designThe key study designs to be included are listed below:Epidemiological burdenEpidemiological studies including descriptive studies and ecological studiesCohort studies including historical cohort studies and nested case-control studiesCase-control studiesCross-sectional studiesRegistry/database studiesSeroprevalence studiesRoutine surveillance reportsEconomic burdenCost of illness studiesResource use studiesCost analysesEconomic evaluations for vaccination programsLanguage English language (studies with non-English full-text will be identified and list to be shared with Merck for consideration for inclusion)DatabasesMajor biomedical databasesEmbase? and MEDLINE? (using platform)Regional databasesIndex Medicus for the WHO Eastern Mediterranean Region (IMEMR)Latin American and Caribbean Health Sciences Information (LILACS) database produced by BIREME, the Latin American and Caribbean Center on Health Sciences InformHealth Literature, Library and Information Services (HELLIS), which also contains Index Medicus for the South-East Asia Region (IMSEAR)Additional data sourcesBibliographic reference lists of the included studiesCountry-specific website searching and internet searching to address any data gapsIHME website Region/Country FocusLatin America, Middle East, Eastern Europe and Asia PacificInformation to extractExtraction parameters (List of outcomes to be extracted will be agreed upon with Merck prior to data extraction stage)*Extraction parameters will be finalized after discussion with Merck prior to the data extraction stage. Data extraction would broadly cover the following parameters:Study characteristics (setting, country, data source, inclusion/exclusion etc.)Patient characteristics (age, gender, comorbid diseases, baseline disease characteristics, weight, etc.)Economic parameters (perspective, direct and indirect cost, ICER, DALY, QALY, resource use)Epidemiological parameters (incidence, prevalence, case fatality rates, hospitalization rates)Vaccination program (coverage rates, costs, recommended doses, recommended target population etc.)*Indicative list only. Outcomes to be finalized prior to data extraction after identification of all included studies; DALY: Disability-adjusted life year; EMBASE: Excerpta Medica Database; ICER: Incremental cost-effectiveness ratio; IHME: Institute for Health Metrix and Evaluation; MEDLINE: Medical Literature Analysis and Retrieval System Online; QALY: Quality-adjusted life-year.Search strategy in Embase? and MEDLINE? using platform (searched on 01 Feb 2016)No.(#)QueryDescriptionResults#1 ‘chickenpox’/exp OR varicella:ab,ti OR ‘chicken pox’:ab,ti OR ‘chickenpox’:ab,tiDisease facet20,475#2‘epidemiology’/exp OR epidemi*:ab,ti OR inciden*:ab,ti OR prevalence:ab,tiEpidemiology studies facet3,251,887#3#1 AND #2Combining Disease and epidemiology facet4778#4#3 AND ( [conference review]/lim OR [editorial]/lim OR [letter]/lim OR [note]/lim OR [review]/lim)Excluding reviews, letters, commentary and searches 1177#5#3 NOT #43601#6#5 AND [2012-2016]/pyStudies for all the key markets of interest will be included post-20121046#7#5 AND [<1966-2011]/pyExcluding studies prior to 2012 in countries already covered in previous review2549#8argentina OR australia OR brazil OR canada OR chile OR china OR india OR israel OR japan OR korea OR malaysia OR mexico OR ‘new zealand’ OR philippines OR russia OR ‘saudi arabia’ OR ‘south africa’ OR taiwan OR thailand OR vietnam OR ‘czech republic’ OR czechoslovakia OR england OR france OR hungary OR ireland OR poland OR scotland OR ‘slovak republic’ OR slovenia OR turkey OR uk OR ‘united kingdom’ OR wales15,235,019#9#7 NOT #81137#10#6 OR #9Final epidemiology review number2,183#11‘economics’/de OR ‘economic aspect’/de OR ‘cost’/de OR ‘health care cost’/de OR ‘drug cost’/de OR ‘hospital cost’/de OR ‘health economics’/de OR ‘pharmacoeconomics’/de OR ‘economic evaluation’/exp OR ‘socioeconomics’/de OR ‘health care financing’/de OR ‘low cost’ OR ‘high cost’ OR health*care NEXT/1 cost* OR ‘health care’ NEXT/1 cost* OR cost NEXT/1 estimate* OR ‘fee’/exp OR ‘budget’/exp OR ‘cost variable’ OR unit NEXT/1 cost* OR economic*:ab,ti OR pharmacoeconomic*:ab,ti OR ‘hospital finance’/de OR ‘financial management’/de OR price*:ab,ti OR pricing:ab,ti OR cost* NEAR/3 (treat* OR therap*) OR ‘cost-effectiveness’ OR ‘cost-utility’ OR ‘cost utility’ OR ‘cost benefit’ OR ‘cost minimisation’ OR ‘cost minimization’ OR ‘budget impact’ OR ‘cost consequence’ OR ‘health care utilization’/de OR health*care NEXT/1 (utilisation OR utilization) OR ‘health care’ NEXT/1 (utilisation OR utilization) OR resource NEXT/1 (utilisation OR utilization OR use) OR cost*Economic burden facet1,418,584#12#1 AND #11Combining Disease and economic facet1391#13#12 AND ( [conference review]/lim OR [editorial]/lim OR [letter]/lim OR [note]/lim OR [review]/lim)Excluding reviews, letters, commentary and searches561#14#12 NOT #13830#15#14 AND [2012-2016]/pyStudies for all the key markets of interest will be included post-2012223#16#14 AND [<1966-2011]/pyExcluding studies prior 2012 in countries already covered in previous review606#17argentina OR australia OR brazil OR canada OR chile OR china OR india OR israel OR japan OR korea OR malaysia OR mexico OR ‘new zealand’ OR philippines OR russia OR ‘saudi arabia’ OR ‘south africa’ OR taiwan OR thailand OR vietnam OR ‘czech republic’ OR england OR france OR hungary OR ireland OR poland OR scotland OR ‘slovak republic’ OR slovenia OR turkey OR uk OR ‘united kingdom’ OR wales15,141,096#18#16 NOT #17275#19#15 OR #18Final economic review number498#20‘vaccination’/exp OR ‘immunization’/exp OR immunisation:ab,ti OR immunization:ab,tiVaccination facet267,250#21#1 AND #20Combining Disease and vaccination facet5137#22#21 AND ( [conference review]/lim OR [editorial]/lim OR [letter]/lim OR [note]/lim OR [review]/lim)Excluding reviews, letters, commentary and searches will include all countries 2012 onwards1853#23#21 NOT #223284#24#23 AND [2012-2016]/pyStudies for all the key markets of interest will be included post-2012932#25#23 AND [<1966-2011]/pyExcluding studies prior to 2012 in countries already covered in previous review2345#26argentina OR australia OR brazil OR canada OR chile OR china OR india OR israel OR japan OR korea OR malaysia OR mexico OR ‘new zealand’ OR philippines OR russia OR ‘saudi arabia’ OR ‘south africa’ OR taiwan OR thailand OR vietnam OR ‘czech republic’ OR czechoslovakia OR england OR france OR hungary OR ireland OR poland OR scotland OR ‘slovak republic’ OR slovenia OR turkey OR uk OR ‘united kingdom’ OR wales15,141,096#27#25 NOT #261196#28#27 OR #24Final number for vaccination objective2128Regional databasesSearch strategy for different regional databasesDatabaseWebsiteSearch termsIndex Medicus for the WHO Eastern Mediterranean Region (IMEMR)“chickenpox” OR varicellaLatin American and Caribbean Health Sciences Information (LILACS) database produced by BIREME, the Latin American and Caribbean Center on Health Sciences Inform OR varicella OR chicken pox [Title words] or chickenpox OR varicella OR chicken pox [Abstract words] and not herpes [Title words] Health Literature, Library and Information Services (HELLIS), which also contains Index Medicus for the South-East Asia Region (IMSEAR) OR varicella OR “chicken pox” [Title words]List of country-specific websites Country/Organization WebsiteArgentina; Republic Centre for Disease Prevention and Control)Hungary; ; America Zealand$file/nhc-varicella-vaccine-assessment-report.pdf Arabia\3075_fi_366.pdf&ofile=Adult%2BVaccination%2BGuidelines_HR2+One+PDF.pdfSLIPE Africa Korea; websites may have been used to either include or exclude data from this review. ................
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