FREQUENTLY ASKED QUESTIONS - Greyhound Products Direct

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FREQUENTLY ASKED QUESTIONS

REFERENCE GUIDE

1 Tasty Chew.

3 MONTHS PROTECTION.*

3 MONTHS AGAINST FLEAS

4 MONTHS AGAINST PARALYSIS TICKS

*Refer to label for full claim details.

FREQUENTLY ASKED QUESTIONS REFERENCE GUIDE

When is it safe for the owner to touch their dog after Bravecto

administration?

Bravecto is an oral product so there is no reason to stop touching the dog

when treating with Bravecto.

Can I use Bravecto all year-round?

Bravecto can be used all year-round. Fleas are often a year-round

problem, indoors and outdoors. Applying Bravecto every 3 months

ensures pet dogs will be protected from fleas throughout the year.

How does Bravecto kill fleas and ticks?

Fluralaner, the active ingredient, is absorbed systemically. When fleas and

ticks commence feeding they will take up fluralaner. Fluralaner causes a

dysfunction of the nervous system of fleas and ticks and prevents them

from moving and functioning normally.1,2 Bravecto will provide effective

control of fleas within 8 hours, and paralysis ticks within 24 hours after

treatment.3

Does Bravecto kill fleas before they can lay eggs?

Yes. Bravecto kills newly emerged fleas before they lay eggs and breaks

the flea life cycle.3 Breaking the flea life cycle is important for ongoing

flea control.

Can dead ticks still be found attached to treated dogs?

Yes. Due to the systemic nature of action of Bravecto, dead attached ticks

can still be seen on animals following treatment. These ticks may appear

partially engorged. Dead ticks can be easily removed as opposed to live

ticks which take some force to dislodge from the skin of dogs.

LIVE

ATTACHED

ENGORGED TICK

DEAD

ATTACHED

UNENGORGED

Is it necessary to use additional insecticides to control flea stages

in the environment? How does Bravecto work to control flea life

stages in the environment?

Bravecto provides 3 months flea efficacy, a time period that covers the entire

flea life cycle.3,4 It is not necessary to use additional insecticides to control

flea stages in the environment. Fleas which have fed on a Bravecto treated

dog cannot produce a new flea generation, and due to the long duration of

efficacy, the flea life stages in the environment are also eliminated over time.

Juvenile life stages (eggs, larvae, pupae) which are present in the

environment will mature to adult fleas. Once these fleas get on the treated

dog to start feeding, they are also killed before they can lay eggs.3

Can Bravecto be used in breeding/pregnant/lactating dogs?

Yes. Bravecto is approved for use in breeding, pregnant and lactating dogs.3

Does Bravecto help manage flea allergy dermatitis?

Yes. An Australian dermatologist run study has confirmed that Bravecto

treats and reduces the incidence of flea allergy dermatitis.3

Is Bravecto effective against other dog parasites

(e.g. mosquitoes/flies/mites/lice/nematodes)?

No. Bravecto is approved for control of fleas, paralysis ticks

and brown dog ticks only.3

Can Bravecto be used in other pets?

Bravecto is designed for administration to dogs

and is not approved for use in other animals.

FREQUENTLY ASKED QUESTIONS REFERENCE GUIDE

Can I give Bravecto to cats?

No. Bravecto is not approved for use in cats.

What pack sizes does Bravecto come in?

Bravecto is available in 5 weight ranges for dogs from 2 ¨C 56 kg. Each

pack contains a single tasty chew which provides 3 months protection

against fleas and 4 months protection against paralysis ticks.

What time of day should I give my dog Bravecto?

Bravecto can be given to your dog any time of the day, however it is

recommended that Bravecto be administered at or around the time of

feeding due to its greater absorption into the circulation.7 Bravecto may be

given with food or administered in the same way as other tablets. The dog

should be observed to confirm that the tablet is swallowed.3

Is there any difference in efficacy if a dog chews the tablet, or

swallows without chewing?

No. A study was conducted which revealed no differences between dogs

which were pilled and dogs which were allowed to chew the tablet.3

When should dogs start treatment with Bravecto?

Bravecto can be administered as early as 8 weeks of age. Dogs should

weigh at least 2 kg.

Is it okay to give Bravecto to a dog that is taking other

medications?

During clinical field testing, no interactions between Bravecto and

routinely used medicinal products were observed.3,5,6

How tasty is Bravecto?

Bravecto is a highly palatable, pork flavoured chew that is easy to

administer ¨C studies show that more than 91.7% of dogs voluntarily

accept Bravecto.3

Can a dog swim or be shampooed after they receive Bravecto?

Bravecto is an ideal choice for dogs with a love of swimming or dogs that

require shampooing and bathing due to its systemic activity.

How soon after giving another flea or tick treatment should I wait

before administering Bravecto?

Bravecto works systemically with a mechanism of action different from

spot-on products. It is recommended that ample time should elapse

between product application. You may consider speaking to the

veterinarian for further advice.

Can I use Bravecto to protect against

fleas if I am not in a paralysis or

brown dog tick area?

Yes. Bravecto provides extended protection

against fleas with 3 months flea control

following a single tasty chew.

FREQUENTLY ASKED QUESTIONS REFERENCE GUIDE

How does Bravecto fit into an annual wellness program for dogs?

In many parts of Australia flea treatment is required all year-round.

Bravecto is the only oral chew to deliver 3 months flea protection from a

single tasty chew. Bravecto therefore fits in easily with a gastrointestinal

worming program, where treatment commonly occurs every 3 months.

Annual vaccination visits also provide veterinary clinics the opportunity to

dispense clients four doses of Bravecto, along with four gastrointestinal

worming doses, providing a whole year¡¯s treatment program for fleas and

gastrointestinal worms.

Why is Bravecto¡¯s duration of efficacy against brown dog tick

shorter than for paralysis tick?

Different species have different sensitivities to fluralaner. In efficacy

studies, the paralysis tick demonstrated greater susceptibility to fluralaner

than other tick species.3

How often should I administer Bravecto?

Bravecto provides 3 months protection against fleas, 4 months protection

against paralysis ticks and 8 weeks protection against brown dog ticks. In

dogs older than 8 weeks, treatment every 8 weeks has been shown to be

well tolerated.

How might our clients benefit from Bravecto?

? Bravecto is a highly efficacious treatment for fleas. It has a rapid onset

of action, killing newly emerged adult fleas before they lay eggs for a

whole 3 months.

? Bravecto is effective against fipronil-resistant strains of fleas.

? Bravecto controls existing paralysis tick infestations within 24 hours

and controls paralysis ticks for 4 months.

? Bravecto is an easy to administer, tasty oral chew.

How is Bravecto¡¯s duration of efficacy different to some other products on the market for flea and paralysis tick control in dogs?

Bravecto contains a new active ingredient from a recently developed class of chemicals ¨C it is unique in that it contains fluralaner which has an extended duration of efficacy.*

Bravecto vs Advantix?

Bravecto vs Frontline? Original and Frontline? Plus

Bravecto vs Comfortis?

Bravecto vs Nexgard?

NEW

Bravecto works 3 times longer against fleas and 8 times longer against paralysis ticks from a single treatment.#

Bravecto works 3 times longer against fleas and 8 times longer against paralysis ticks from a single treatment.#

Bravecto works 3 times longer against fleas from a single treatment.#

Comfortis does not protect against paralysis ticks, Bravecto provides paralysis tick control for 4 months.

Bravecto works 3 times longer against fleas and 4 times longer against paralysis ticks from a single treatment.#

THE ONLY ORAL CHEW TO DELIVER 3 MONTHS

FLEA AND 4 MONTHS PARALYSIS TICK

PROTECTION FOR DOGS IN A SINGLE DOSE.

For further information or to order Bravecto contact your MSD Animal Health representative or call the Bravecto Hotline on 1800 230 833. .au

References 1. Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: elective inhibition of arthropod g-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect Biochem Mol Biol. (2014) 45:111-124. 2. Ozoe Y, Asahi M, Ozoe F, Nakahira K and Mita T. The antiparasitic isoxazoline A1443 is a potent

blocker of ligand-gated chloride channels . Biochemical and Biophysical Research Communications (2010) 391:744-749. 3. MSD Data on file. 4. Ross DH, Arthur, et al. Evaluation of the efficacy of topically administered imidacloprid + pyriproxyfen and orally administered spinosad against cat fleas (Ctenocephalides felis): Impact of treated dogs on flea life stages in a simulated home

environment. Parasites & Vectors (2012). 5:192. 5. Rohdich N, Roepke R, Zchiesche E. A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto? (fluralaner) against Frontline? (fipronil) in flea- and tick-infested dogs. Parasites & Vectors 2014 7:83. 6. Meadows C, Geurino F and Sun F. A randomized, blinded, controlled USA

field study to assess the use of fluralaner tablets in controlling canine flea infestations. Parasites &Vectors (2014) 7:375. 7. Walter FM, Allan MJ, Roepke R and Nuernberger MC. The effect of food on the pharmacokinetics of oral fluralaner in dogs. Parasites & Vectors (2014) 7:84. * Refer to label for full claim details. # Comparison based on approved label claims, February 2015.

Advantix? is a registered trademark of Bayer AG. Leverkusen, Germany. Frontline? and Nexgard? are registered trademarks of Merial. Comfortis? is a registered trademark of Eli Lilly and Company. Intervet Australia Pty Limited trading as MSD Animal Health ABN 79 008 467 034. Toll free: 1800 033 461. msd-animal-.au AU/BRV/0215/0013

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