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Supplemental Table 22. Strength of evidence for possible risk factors for deliriumVariablesPositive associationNegative associationNo associationLevel of evidencePredisposing variables:Patient characteristics:AgeAbelha 2012 ADDIN EN.CITE <EndNote><Cite><Author>Abelha</Author><Year>2012</Year><RecNum>2478</RecNum><DisplayText>[1]</DisplayText><record><rec-number>2478</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507739890">2478</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abelha, F. J.</author><author>Fernandes, V.</author><author>Botelho, M.</author><author>Santos, P.</author><author>Santos, A.</author><author>Machado, J. C.</author><author>Barros, H.</author></authors></contributors><auth-address>Anesthesiology and Perioperative Care Unit, Surgical Department, Faculty of Medicine, University of Porto, Porto, Portugal, abelha@mail.telepac.pt.</auth-address><titles><title>Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery</title><secondary-title>J Anesth</secondary-title><alt-title>Journal of anesthesia</alt-title></titles><periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></periodical><alt-periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></alt-periodical><edition>2012/02/04</edition><dates><year>2012</year><pub-dates><date>Feb 01</date></pub-dates></dates><isbn>0913-8668</isbn><accession-num>22302107</accession-num><urls></urls><electronic-resource-num>10.1007/s00540-012-1326-5</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[1]Angles 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbmdsZXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [2]Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3]Pandharipande 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE.DATA [4]Serafim 2012 ADDIN EN.CITE <EndNote><Cite><Author>Serafim</Author><Year>2012</Year><RecNum>2050</RecNum><DisplayText>[5]</DisplayText><record><rec-number>2050</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2050</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Serafim, Rodrigo Bernardo</author><author>Dutra, Maximiliano F.</author><author>Saddy, Felipe</author><author>Tura, Bernardo</author><author>de Castro, Jose Eduardo Couto</author><author>Villarinho, Luciana C.</author><author>da Gloria Santos, Maria</author><author>Bozza, Fernando Augusto</author><author>Rocco, José Rodolfo</author></authors></contributors><auth-address>Ventilatory Care Unit, Copa D'Or Hospital, Rio de Janeiro, Brazil. rodrigobserafim@.</auth-address><titles><title>Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes</title><secondary-title>Ann. Intensive Care</secondary-title></titles><periodical><full-title>Ann. Intensive Care</full-title></periodical><pages>51</pages><volume>2</volume><number>1</number><dates><year>2012</year><pub-dates><date>2012/12/31</date></pub-dates></dates><isbn>2110-5820</isbn><urls><related-urls><url> Papers/S/Serafim et al. 2012 - Delirium in postoperative nonventilated intensive care patients - risk factors and outcomes.pdf</url></pdf-urls></urls><electronic-resource-num>10.1186/2110-5820-2-51</electronic-resource-num></record></Cite></EndNote>[5]Shehabi 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVoYWJpPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA [6]Veiga 2012 ADDIN EN.CITE <EndNote><Cite><Author>Veiga</Author><Year>2012</Year><RecNum>2053</RecNum><DisplayText>[7]</DisplayText><record><rec-number>2053</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2053</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Veiga, Dalila</author><author>Luis, Clara</author><author>Parente, Daniela</author><author>Fernandes, Vera</author><author>Botelho, Miguela</author><author>Santos, Patricia</author><author>Abelha, Fernando</author></authors></contributors><auth-address>Department of Anesthesiology, Centro Hospitalar de S?o Jo?o, Porto, Portugal.</auth-address><titles><title>Postoperative delirium in intensive care patients: risk factors and outcome</title><secondary-title>Rev. Bras. Anestesiol.</secondary-title></titles><periodical><full-title>Rev. Bras. Anestesiol.</full-title></periodical><pages>469-483</pages><volume>62</volume><number>4</number><dates><year>2012</year><pub-dates><date>2012/7</date></pub-dates></dates><isbn>0034-7094</isbn><urls><related-urls><url>(12)70146-0</url><url>(12)70146-0</url></related-urls><pdf-urls><url>All Papers/V/Veiga et al. 2012 - Postoperative delirium in intensive care patients - risk factors and outcome.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/S0034-7094(12)70146-0</electronic-resource-num></record></Cite></EndNote>[7]Yoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]Schreiber 2014 ADDIN EN.CITE <EndNote><Cite><Author>Schreiber</Author><Year>2014</Year><RecNum>379</RecNum><DisplayText>[9]</DisplayText><record><rec-number>379</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">379</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schreiber, Matthew P.</author><author>Colantuoni, Elizabeth</author><author>Bienvenu, Oscar J.</author><author>Neufeld, Karin J.</author><author>Chen, Kuan-Fu</author><author>Shanholtz, Carl</author><author>Mendez-Tellez, Pedro A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>Corticosteroids and transition to delirium in patients with acute lung injury</title><secondary-title>Crit. Care Med.</secondary-title></titles><periodical><full-title>Crit. Care Med.</full-title></periodical><pages>1480-1486</pages><volume>42</volume><number>6</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2014</year><pub-dates><date>2014/6</date></pub-dates></dates><isbn>0090-3493</isbn><urls><related-urls><url>;[9]Bryczkowski 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccnljemtvd3NraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll
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ADDIN EN.CITE.DATA [10]Colombo 2012 ADDIN EN.CITE <EndNote><Cite><Author>Colombo</Author><Year>2012</Year><RecNum>1839</RecNum><DisplayText>[11]</DisplayText><record><rec-number>1839</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232808">1839</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colombo, R.</author><author>Corona, A.</author><author>Praga, F.</author><author>Minari, C.</author><author>Giannotti, C.</author><author>Castelli, A.</author><author>Raimondi, F.</author></authors></contributors><auth-address>Intensive Care Unit, Azienda Ospedaliera Luigi Sacco, University of Milan, Italy.</auth-address><titles><title>A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study</title><secondary-title>Minerva Anestesiol.</secondary-title></titles><periodical><full-title>Minerva Anestesiol.</full-title></periodical><pages>1026-1033</pages><volume>78</volume><number>9</number><dates><year>2012</year><pub-dates><date>2012/9</date></pub-dates></dates><isbn>0375-9393</isbn><urls><related-urls><url>;[11]Shi 2010 ADDIN EN.CITE <EndNote><Cite><Author>Shi</Author><Year>2010</Year><RecNum>2589</RecNum><DisplayText>[12]</DisplayText><record><rec-number>2589</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2589</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shi, C. M.</author><author>Wang, D. X.</author><author>Chen, K. S.</author><author>Gu, X. E.</author></authors></contributors><auth-address>Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing, China.</auth-address><titles><title>Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery</title><secondary-title>Chin Med J (Engl)</secondary-title><alt-title>Chinese medical journal</alt-title></titles><periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></periodical><alt-periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></alt-periodical><pages>993-9</pages><volume>123</volume><number>8</number><edition>2010/05/26</edition><keywords><keyword>Aged</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*epidemiology/etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>0366-6999 (Print)
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ADDIN EN.CITE.DATA [17]Kamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]Morandi 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JhbmRpPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48
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ADDIN EN.CITE.DATA [20]Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Lin 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [23]Zaal 2012 ADDIN EN.CITE <EndNote><Cite><Author>Zaal</Author><Year>2012</Year><RecNum>89</RecNum><DisplayText>[14]</DisplayText><record><rec-number>89</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232703">89</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zaal, Irene J.</author><author>Slooter, Arjen J. C.</author></authors></contributors><auth-address>Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands. i.j.zaal-2@umcutrecht.nl</auth-address><titles><title>Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management</title><secondary-title>Drugs</secondary-title></titles><periodical><full-title>Drugs</full-title></periodical><pages>1457-1471</pages><volume>72</volume><number>11</number><keywords><keyword>ICU Rehab 2015</keyword></keywords><dates><year>2012</year><pub-dates><date>2012/7/30</date></pub-dates></dates><isbn>0012-6667</isbn><urls><related-urls><url> Papers/Z/Zaal and Slooter 2012 - Delirium in critically ill patients - epidemiology, pathophysiology, diagnosis and management.pdf</url></pdf-urls></urls><electronic-resource-num>10.2165/11635520-000000000-00000</electronic-resource-num></record></Cite></EndNote>[14]Leite 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWl0ZTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [16]StrongEthnicityKamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]InconclusiveBody Mass IndexSkrobik 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ta3JvYmlrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA [20]Dubois 2001 ADDIN EN.CITE <EndNote><Cite><Author>Dubois</Author><Year>2001</Year><RecNum>378</RecNum><DisplayText>[27]</DisplayText><record><rec-number>378</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dubois, M. J.</author><author>Bergeron, N.</author><author>Dumont, M.</author><author>Dial, S.</author><author>Skrobik, Y.</author></authors></contributors><titles><title>Delirium in an intensive care unit: a study of risk factors</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>1297-1304</pages><volume>27</volume><number>8</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2001</year><pub-dates><date>2001/8</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url>;[27]Mehta 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [23]ModerateAlcohol useOuimet 2007 ADDIN EN.CITE <EndNote><Cite><Author>Ouimet</Author><Year>2007</Year><RecNum>2206</RecNum><DisplayText>[28]</DisplayText><record><rec-number>2206</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232830">2206</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ouimet, Sébastien</author><author>Kavanagh, Brian P.</author><author>Gottfried, Stewart B.</author><author>Skrobik, Yoanna</author></authors></contributors><auth-address>Department of Medicine, University of Montreal, Montreal, Canada.</auth-address><titles><title>Incidence, risk factors and consequences of ICU delirium</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>66-73</pages><volume>33</volume><number>1</number><dates><year>2007</year><pub-dates><date>2007/1</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url> Papers/O/Ouimet et al. 2007 - Incidence, risk factors and consequences of ICU delirium.pdf</url></pdf-urls></urls><electronic-resource-num>10.1007/s00134-006-0399-8</electronic-resource-num></record></Cite></EndNote>[28]van Rompaey 2009 ADDIN EN.CITE <EndNote><Cite><Author>Van Rompaey</Author><Year>2009</Year><RecNum>1709</RecNum><DisplayText>[29]</DisplayText><record><rec-number>1709</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232801">1709</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Van Rompaey, Bart</author><author>Elseviers, Monique M.</author><author>Schuurmans, Marieke J.</author><author>Shortridge-Baggett, Lillie M.</author><author>Truijen, Steven</author><author>Bossaert, Leo</author></authors></contributors><auth-address>University of Antwerp, Faculty of Medicine, Division of Nursing Science and Midwifery, Universiteitsplein 1, 2610 Wilrijk, Belgium. bart.vanrompaey@ua.ac.be</auth-address><titles><title>Risk factors for delirium in intensive care patients: a prospective cohort study</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>R77</pages><volume>13</volume><number>3</number><keywords><keyword>PAD-ES Agitation/Sedation Manuscript</keyword></keywords><dates><year>2009</year><pub-dates><date>2009/5/20</date></pub-dates></dates><publisher>ccforum.</publisher><isbn>0270-7462</isbn><urls><related-urls><url> Papers/V/Van Rompaey et al. 2009 - Risk factors for delirium in intensive care patients - a prospective cohort study.pdf</url></pdf-urls></urls><electronic-resource-num>10.1186/cc7892</electronic-resource-num></record></Cite></EndNote>[29]Heymann 2007 ADDIN EN.CITE <EndNote><Cite><Author>Heymann</Author><Year>2007</Year><RecNum>2620</RecNum><DisplayText>[30]</DisplayText><record><rec-number>2620</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783336">2620</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Heymann, A</author><author>Sander, M</author><author>Krahne, D</author><author>Deja, M</author><author>Weber-Carstens, S</author><author>MacGuill, M</author><author>Kastrup, M</author><author>Wernecke, KD</author><author>Nachtigall, I</author><author>Spies, CD</author></authors></contributors><titles><title>Hyperactive delirium and blood glucose control in critically ill patients</title><secondary-title>Journal of International Medical Research</secondary-title></titles><periodical><full-title>Journal of International Medical Research</full-title></periodical><pages>666-677</pages><volume>35</volume><number>5</number><dates><year>2007</year></dates><isbn>0300-0605</isbn><urls></urls></record></Cite></EndNote>[30]Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Zhang 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaGFuZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [23]InconclusiveRecreational drug useHsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]InconclusiveChronic pathology:Vascular system:Cardiac diseaseAbelha 2012 ADDIN EN.CITE <EndNote><Cite><Author>Abelha</Author><Year>2012</Year><RecNum>2478</RecNum><DisplayText>[1]</DisplayText><record><rec-number>2478</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507739890">2478</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abelha, F. J.</author><author>Fernandes, V.</author><author>Botelho, M.</author><author>Santos, P.</author><author>Santos, A.</author><author>Machado, J. C.</author><author>Barros, H.</author></authors></contributors><auth-address>Anesthesiology and Perioperative Care Unit, Surgical Department, Faculty of Medicine, University of Porto, Porto, Portugal, abelha@mail.telepac.pt.</auth-address><titles><title>Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery</title><secondary-title>J Anesth</secondary-title><alt-title>Journal of anesthesia</alt-title></titles><periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></periodical><alt-periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></alt-periodical><edition>2012/02/04</edition><dates><year>2012</year><pub-dates><date>Feb 01</date></pub-dates></dates><isbn>0913-8668</isbn><accession-num>22302107</accession-num><urls></urls><electronic-resource-num>10.1007/s00540-012-1326-5</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[1]Mehta 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [22]ModerateNervous systemStrokeLimpawattana 2014 ADDIN EN.CITE <EndNote><Cite><Author>Limpawattana</Author><Year>2016</Year><RecNum>2621</RecNum><DisplayText>[32]</DisplayText><record><rec-number>2621</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783448">2621</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Limpawattana, Panita</author><author>Panitchote, Anupol</author><author>Tangvoraphonkchai, Kawin</author><author>Suebsoh, Naluttaporn</author><author>Eamma, Wanaporn</author><author>Chanthonglarng, Bunruam</author><author>Tiamkao, Somsak</author></authors></contributors><titles><title>Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults</title><secondary-title>Aging & mental health</secondary-title></titles><periodical><full-title>Aging & mental health</full-title></periodical><pages>74-80</pages><volume>20</volume><number>1</number><dates><year>2016</year></dates><isbn>1360-7863</isbn><urls></urls></record></Cite></EndNote>[32]Shi 2010 ADDIN EN.CITE <EndNote><Cite><Author>Shi</Author><Year>2010</Year><RecNum>2589</RecNum><DisplayText>[12]</DisplayText><record><rec-number>2589</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2589</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shi, C. M.</author><author>Wang, D. X.</author><author>Chen, K. S.</author><author>Gu, X. E.</author></authors></contributors><auth-address>Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing, China.</auth-address><titles><title>Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery</title><secondary-title>Chin Med J (Engl)</secondary-title><alt-title>Chinese medical journal</alt-title></titles><periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></periodical><alt-periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></alt-periodical><pages>993-9</pages><volume>123</volume><number>8</number><edition>2010/05/26</edition><keywords><keyword>Aged</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*epidemiology/etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>0366-6999 (Print)
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ADDIN EN.CITE.DATA [22]InconclusiveDementiaMcNicoll 2003 ADDIN EN.CITE <EndNote><Cite><Author>McNicoll</Author><Year>2003</Year><RecNum>22</RecNum><DisplayText>[33]</DisplayText><record><rec-number>22</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232699">22</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McNicoll, Lynn</author><author>Pisani, Margaret A.</author><author>Zhang, Ying</author><author>Ely, E. Wesley</author><author>Siegel, Mark D.</author><author>Inouye, Sharon K.</author></authors></contributors><auth-address>Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. lmcnicoll@</auth-address><titles><title>Delirium in the intensive care unit: occurrence and clinical course in older patients</title><secondary-title>J. Am. Geriatr. Soc.</secondary-title></titles><periodical><full-title>J. Am. Geriatr. Soc.</full-title></periodical><pages>591-598</pages><volume>51</volume><number>5</number><keywords><keyword>ICU Rehab 2015</keyword></keywords><dates><year>2003</year><pub-dates><date>2003/5</date></pub-dates></dates><isbn>0002-8614</isbn><urls><related-urls><url>(Apr-17-08).pdf</url></related-urls><pdf-urls><url>All Papers/M/McNicoll et al. 2003 - Delirium in the intensive care unit - occurrence and clinical course in older patients.pdf</url></pdf-urls></urls></record></Cite></EndNote>[33]Pisani 2007 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QaXNhbmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [24]InconclusiveOther:Diabetes MellitusLin 2008 ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2008</Year><RecNum>2054</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2054</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2054</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, Shu-Min</author><author>Huang, Chien-Da</author><author>Liu, Chien-Ying</author><author>Lin, Horng-Chyuan</author><author>Wang, Chun-Hua</author><author>Huang, Pei-Yao</author><author>Fang, Yueh-Fu</author><author>Shieh, Meng-Heng</author><author>Kuo, Han-Pin</author></authors></contributors><auth-address>Department of Thoracic Medicine, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taipei 333, Taiwan.</auth-address><titles><title>Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients</title><secondary-title>J. Crit. Care</secondary-title></titles><periodical><full-title>J. Crit. Care</full-title></periodical><pages>372-379</pages><volume>23</volume><number>3</number><dates><year>2008</year><pub-dates><date>2008/9</date></pub-dates></dates><isbn>0883-9441</isbn><urls><related-urls><url>(06)00121-3</url><url>(06)00121-3</url></related-urls><pdf-urls><url>All Papers/L/Lin et al. 2008 - Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/j.jcrc.2006.09.001</electronic-resource-num></record></Cite></EndNote>[36]InconclusiveLiver dysfunctionSkrobik 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ta3JvYmlrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA [24]ModeratePrecipitating variables:Acute illness:Emergency surgery or traumaAbelha 2012 ADDIN EN.CITE <EndNote><Cite><Author>Abelha</Author><Year>2012</Year><RecNum>2478</RecNum><DisplayText>[1]</DisplayText><record><rec-number>2478</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507739890">2478</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abelha, F. J.</author><author>Fernandes, V.</author><author>Botelho, M.</author><author>Santos, P.</author><author>Santos, A.</author><author>Machado, J. C.</author><author>Barros, H.</author></authors></contributors><auth-address>Anesthesiology and Perioperative Care Unit, Surgical Department, Faculty of Medicine, University of Porto, Porto, Portugal, abelha@mail.telepac.pt.</auth-address><titles><title>Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery</title><secondary-title>J Anesth</secondary-title><alt-title>Journal of anesthesia</alt-title></titles><periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></periodical><alt-periodical><full-title>J Anesth</full-title><abbr-1>Journal of anesthesia</abbr-1></alt-periodical><edition>2012/02/04</edition><dates><year>2012</year><pub-dates><date>Feb 01</date></pub-dates></dates><isbn>0913-8668</isbn><accession-num>22302107</accession-num><urls></urls><electronic-resource-num>10.1007/s00540-012-1326-5</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[1]Serafim 2012 ADDIN EN.CITE <EndNote><Cite><Author>Serafim</Author><Year>2012</Year><RecNum>2582</RecNum><DisplayText>[37]</DisplayText><record><rec-number>2582</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2582</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Serafim, R. B.</author><author>Dutra, M. F.</author><author>Saddy, F.</author><author>Tura, B.</author><author>de Castro, J. E.</author><author>Villarinho, L. C.</author><author>da Gloria Santos, M.</author><author>Bozza, F. A.</author><author>Rocco, J. R.</author></authors></contributors><auth-address>Ventilatory Care Unit, Copa D'Or Hospital, Rio de Janeiro, Brazil. rodrigobserafim@.</auth-address><titles><title>Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes</title><secondary-title>Ann Intensive Care</secondary-title><alt-title>Annals of intensive care</alt-title></titles><periodical><full-title>Ann Intensive Care</full-title><abbr-1>Annals of intensive care</abbr-1></periodical><alt-periodical><full-title>Ann Intensive Care</full-title><abbr-1>Annals of intensive care</abbr-1></alt-periodical><pages>51</pages><volume>2</volume><number>1</number><edition>2013/01/01</edition><dates><year>2012</year><pub-dates><date>Dec 31</date></pub-dates></dates><isbn>2110-5820</isbn><accession-num>23272945</accession-num><urls></urls><custom2>PMC3544687</custom2><electronic-resource-num>10.1186/2110-5820-2-51</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[37]Veiga 2012 ADDIN EN.CITE <EndNote><Cite><Author>Veiga</Author><Year>2012</Year><RecNum>2053</RecNum><DisplayText>[7]</DisplayText><record><rec-number>2053</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2053</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Veiga, Dalila</author><author>Luis, Clara</author><author>Parente, Daniela</author><author>Fernandes, Vera</author><author>Botelho, Miguela</author><author>Santos, Patricia</author><author>Abelha, Fernando</author></authors></contributors><auth-address>Department of Anesthesiology, Centro Hospitalar de S?o Jo?o, Porto, Portugal.</auth-address><titles><title>Postoperative delirium in intensive care patients: risk factors and outcome</title><secondary-title>Rev. Bras. Anestesiol.</secondary-title></titles><periodical><full-title>Rev. Bras. Anestesiol.</full-title></periodical><pages>469-483</pages><volume>62</volume><number>4</number><dates><year>2012</year><pub-dates><date>2012/7</date></pub-dates></dates><isbn>0034-7094</isbn><urls><related-urls><url>(12)70146-0</url><url>(12)70146-0</url></related-urls><pdf-urls><url>All Papers/V/Veiga et al. 2012 - Postoperative delirium in intensive care patients - risk factors and outcome.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/S0034-7094(12)70146-0</electronic-resource-num></record></Cite></EndNote>[7]StrongDelirium previous day (e.g. mental status <24h)Agarwal 2010 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ2Fyd2FsPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48
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ADDIN EN.CITE.DATA [17]Ouimet 2007 ADDIN EN.CITE <EndNote><Cite><Author>Ouimet</Author><Year>2007</Year><RecNum>2206</RecNum><DisplayText>[28]</DisplayText><record><rec-number>2206</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232830">2206</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ouimet, Sébastien</author><author>Kavanagh, Brian P.</author><author>Gottfried, Stewart B.</author><author>Skrobik, Yoanna</author></authors></contributors><auth-address>Department of Medicine, University of Montreal, Montreal, Canada.</auth-address><titles><title>Incidence, risk factors and consequences of ICU delirium</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>66-73</pages><volume>33</volume><number>1</number><dates><year>2007</year><pub-dates><date>2007/1</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url> Papers/O/Ouimet et al. 2007 - Incidence, risk factors and consequences of ICU delirium.pdf</url></pdf-urls></urls><electronic-resource-num>10.1007/s00134-006-0399-8</electronic-resource-num></record></Cite></EndNote>[28]Mehta 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [24]StrongFeverAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveSepsisLin 2008 ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2008</Year><RecNum>2054</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2054</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2054</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, Shu-Min</author><author>Huang, Chien-Da</author><author>Liu, Chien-Ying</author><author>Lin, Horng-Chyuan</author><author>Wang, Chun-Hua</author><author>Huang, Pei-Yao</author><author>Fang, Yueh-Fu</author><author>Shieh, Meng-Heng</author><author>Kuo, Han-Pin</author></authors></contributors><auth-address>Department of Thoracic Medicine, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taipei 333, Taiwan.</auth-address><titles><title>Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients</title><secondary-title>J. Crit. Care</secondary-title></titles><periodical><full-title>J. Crit. Care</full-title></periodical><pages>372-379</pages><volume>23</volume><number>3</number><dates><year>2008</year><pub-dates><date>2008/9</date></pub-dates></dates><isbn>0883-9441</isbn><urls><related-urls><url>(06)00121-3</url><url>(06)00121-3</url></related-urls><pdf-urls><url>All Papers/L/Lin et al. 2008 - Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/j.jcrc.2006.09.001</electronic-resource-num></record></Cite></EndNote>[36]Aldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
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ADDIN EN.CITE.DATA [40]Pandharipande 2006 Pandharipande 2008 Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Pisani 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QaXNhbmk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [24]Svenningsen 2013 ADDIN EN.CITE <EndNote><Cite><Author>Svenningsen</Author><Year>2013</Year><RecNum>1905</RecNum><DisplayText>[42]</DisplayText><record><rec-number>1905</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232812">1905</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Svenningsen, H.</author><author>Egerod, I.</author><author>Videbech, P.</author><author>Christensen, D.</author><author>Frydenberg, M.</author><author>T?nnesen, E. K.</author></authors></contributors><auth-address>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital,N?rrebrogade 44, Aarhus C, Denmark. hellsven@rm.dk</auth-address><titles><title>Fluctuations in sedation levels may contribute to delirium in ICU patients</title><secondary-title>Acta Anaesthesiol. Scand.</secondary-title></titles><periodical><full-title>Acta Anaesthesiol. Scand.</full-title></periodical><pages>288-293</pages><volume>57</volume><number>3</number><dates><year>2013</year><pub-dates><date>2013/3</date></pub-dates></dates><isbn>0001-5172</isbn><urls><related-urls><url> Papers/S/Svenningsen et al. 2013 - Fluctuations in sedation levels may contribute to delirium in ICU patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1111/aas.12048</electronic-resource-num></record></Cite></EndNote>[42]Schreiber 2014 ADDIN EN.CITE <EndNote><Cite><Author>Schreiber</Author><Year>2014</Year><RecNum>379</RecNum><DisplayText>[9]</DisplayText><record><rec-number>379</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">379</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schreiber, Matthew P.</author><author>Colantuoni, Elizabeth</author><author>Bienvenu, Oscar J.</author><author>Neufeld, Karin J.</author><author>Chen, Kuan-Fu</author><author>Shanholtz, Carl</author><author>Mendez-Tellez, Pedro A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>Corticosteroids and transition to delirium in patients with acute lung injury</title><secondary-title>Crit. Care Med.</secondary-title></titles><periodical><full-title>Crit. Care Med.</full-title></periodical><pages>1480-1486</pages><volume>42</volume><number>6</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2014</year><pub-dates><date>2014/6</date></pub-dates></dates><isbn>0090-3493</isbn><urls><related-urls><url>;[9]Ely 2007 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FbHk8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [4] Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3] Bryczkowski 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccnljemtvd3NraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll
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ADDIN EN.CITE.DATA [10]StrongOpioid Dubois 2001 ADDIN EN.CITE <EndNote><Cite><Author>Dubois</Author><Year>2001</Year><RecNum>378</RecNum><DisplayText>[27]</DisplayText><record><rec-number>378</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dubois, M. J.</author><author>Bergeron, N.</author><author>Dumont, M.</author><author>Dial, S.</author><author>Skrobik, Y.</author></authors></contributors><titles><title>Delirium in an intensive care unit: a study of risk factors</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>1297-1304</pages><volume>27</volume><number>8</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2001</year><pub-dates><date>2001/8</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url>;[27]Svenningsen 2013 ADDIN EN.CITE <EndNote><Cite><Author>Svenningsen</Author><Year>2013</Year><RecNum>1905</RecNum><DisplayText>[42]</DisplayText><record><rec-number>1905</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232812">1905</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Svenningsen, H.</author><author>Egerod, I.</author><author>Videbech, P.</author><author>Christensen, D.</author><author>Frydenberg, M.</author><author>T?nnesen, E. K.</author></authors></contributors><auth-address>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital,N?rrebrogade 44, Aarhus C, Denmark. hellsven@rm.dk</auth-address><titles><title>Fluctuations in sedation levels may contribute to delirium in ICU patients</title><secondary-title>Acta Anaesthesiol. Scand.</secondary-title></titles><periodical><full-title>Acta Anaesthesiol. Scand.</full-title></periodical><pages>288-293</pages><volume>57</volume><number>3</number><dates><year>2013</year><pub-dates><date>2013/3</date></pub-dates></dates><isbn>0001-5172</isbn><urls><related-urls><url> Papers/S/Svenningsen et al. 2013 - Fluctuations in sedation levels may contribute to delirium in ICU patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1111/aas.12048</electronic-resource-num></record></Cite></EndNote>[42]Agarwal 2010 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZ2Fyd2FsPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48
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ADDIN EN.CITE.DATA [38]Pandharipande 2008 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2008</Year><RecNum>377</RecNum><DisplayText>[43]</DisplayText><record><rec-number>377</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">377</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Cotton, Bryan A.</author><author>Shintani, Ayumi</author><author>Thompson, Jennifer</author><author>Pun, Brenda Truman</author><author>Morris, John A.</author><author>Dittus, Robert</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients</title><secondary-title>J. Trauma</secondary-title></titles><periodical><full-title>J. Trauma</full-title></periodical><pages>34-41</pages><volume>65</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2008</year><pub-dates><date>2008/7</date></pub-dates></dates><isbn>0022-5282</isbn><urls><related-urls><url>;[43]Schreiber 2014 ADDIN EN.CITE <EndNote><Cite><Author>Schreiber</Author><Year>2014</Year><RecNum>379</RecNum><DisplayText>[9]</DisplayText><record><rec-number>379</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">379</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schreiber, Matthew P.</author><author>Colantuoni, Elizabeth</author><author>Bienvenu, Oscar J.</author><author>Neufeld, Karin J.</author><author>Chen, Kuan-Fu</author><author>Shanholtz, Carl</author><author>Mendez-Tellez, Pedro A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>Corticosteroids and transition to delirium in patients with acute lung injury</title><secondary-title>Crit. Care Med.</secondary-title></titles><periodical><full-title>Crit. Care Med.</full-title></periodical><pages>1480-1486</pages><volume>42</volume><number>6</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2014</year><pub-dates><date>2014/6</date></pub-dates></dates><isbn>0090-3493</isbn><urls><related-urls><url>;[9]Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3]Pandharipande 2008 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2008</Year><RecNum>377</RecNum><DisplayText>[43]</DisplayText><record><rec-number>377</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">377</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Cotton, Bryan A.</author><author>Shintani, Ayumi</author><author>Thompson, Jennifer</author><author>Pun, Brenda Truman</author><author>Morris, John A.</author><author>Dittus, Robert</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients</title><secondary-title>J. Trauma</secondary-title></titles><periodical><full-title>J. Trauma</full-title></periodical><pages>34-41</pages><volume>65</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2008</year><pub-dates><date>2008/7</date></pub-dates></dates><isbn>0022-5282</isbn><urls><related-urls><url>;[43]Pandharipande 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE.DATA [23]Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Mehta 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [25]Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Wolters 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Xb2x0ZXJzPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
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ADDIN EN.CITE.DATA [44]Inconclusive(Analgo)sedation Colombo 2012 ADDIN EN.CITE <EndNote><Cite><Author>Colombo</Author><Year>2012</Year><RecNum>1839</RecNum><DisplayText>[11]</DisplayText><record><rec-number>1839</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232808">1839</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colombo, R.</author><author>Corona, A.</author><author>Praga, F.</author><author>Minari, C.</author><author>Giannotti, C.</author><author>Castelli, A.</author><author>Raimondi, F.</author></authors></contributors><auth-address>Intensive Care Unit, Azienda Ospedaliera Luigi Sacco, University of Milan, Italy.</auth-address><titles><title>A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study</title><secondary-title>Minerva Anestesiol.</secondary-title></titles><periodical><full-title>Minerva Anestesiol.</full-title></periodical><pages>1026-1033</pages><volume>78</volume><number>9</number><dates><year>2012</year><pub-dates><date>2012/9</date></pub-dates></dates><isbn>0375-9393</isbn><urls><related-urls><url>;[11]Simons 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1vbnM8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [10]InconclusivePsychoactive medicationvan Rompaey 2009 ADDIN EN.CITE <EndNote><Cite><Author>Van Rompaey</Author><Year>2009</Year><RecNum>1709</RecNum><DisplayText>[29]</DisplayText><record><rec-number>1709</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232801">1709</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Van Rompaey, Bart</author><author>Elseviers, Monique M.</author><author>Schuurmans, Marieke J.</author><author>Shortridge-Baggett, Lillie M.</author><author>Truijen, Steven</author><author>Bossaert, Leo</author></authors></contributors><auth-address>University of Antwerp, Faculty of Medicine, Division of Nursing Science and Midwifery, Universiteitsplein 1, 2610 Wilrijk, Belgium. bart.vanrompaey@ua.ac.be</auth-address><titles><title>Risk factors for delirium in intensive care patients: a prospective cohort study</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>R77</pages><volume>13</volume><number>3</number><keywords><keyword>PAD-ES Agitation/Sedation Manuscript</keyword></keywords><dates><year>2009</year><pub-dates><date>2009/5/20</date></pub-dates></dates><publisher>ccforum.</publisher><isbn>0270-7462</isbn><urls><related-urls><url> Papers/V/Van Rompaey et al. 2009 - Risk factors for delirium in intensive care patients - a prospective cohort study.pdf</url></pdf-urls></urls><electronic-resource-num>10.1186/cc7892</electronic-resource-num></record></Cite></EndNote>[29]Mehta 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [24]Pisani 2009 ADDIN EN.CITE <EndNote><Cite><Author>Pisani</Author><Year>2009</Year><RecNum>2057</RecNum><DisplayText>[45]</DisplayText><record><rec-number>2057</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2057</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pisani, Margaret A.</author><author>Kong, So Yeon Joyce</author><author>Kasl, Stanislav V.</author><author>Murphy, Terrence E.</author><author>Araujo, Katy L. B.</author><author>Van Ness, Peter H.</author></authors></contributors><auth-address>Department of Internal Medicine, Pulmonary & Critical Care Section, and the Program on Aging, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208057, New Haven, CT 06520-8057, USA. 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Care Med.</full-title></periodical><pages>1092-1097</pages><volume>180</volume><number>11</number><dates><year>2009</year><pub-dates><date>2009/12/1</date></pub-dates></dates><isbn>1073-449X</isbn><urls><related-urls><url> Papers/P/Pisani et al. 2009 - Days of delirium are associated with 1-year mortality in an older intensive care unit population.pdf</url></pdf-urls></urls><electronic-resource-num>10.1164/rccm.200904-0537OC</electronic-resource-num></record></Cite></EndNote>[45]Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3]ModerateAnticholinergic drugsPandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3]InconclusiveH2 blokker Pandharipande 2008 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2008</Year><RecNum>377</RecNum><DisplayText>[43]</DisplayText><record><rec-number>377</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">377</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Cotton, Bryan A.</author><author>Shintani, Ayumi</author><author>Thompson, Jennifer</author><author>Pun, Brenda Truman</author><author>Morris, John A.</author><author>Dittus, Robert</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients</title><secondary-title>J. Trauma</secondary-title></titles><periodical><full-title>J. Trauma</full-title></periodical><pages>34-41</pages><volume>65</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2008</year><pub-dates><date>2008/7</date></pub-dates></dates><isbn>0022-5282</isbn><urls><related-urls><url>;[43]InconclusivePropofolHsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. 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ADDIN EN.CITE.DATA [40]Svenningsen 2013 ADDIN EN.CITE <EndNote><Cite><Author>Svenningsen</Author><Year>2013</Year><RecNum>1905</RecNum><DisplayText>[42]</DisplayText><record><rec-number>1905</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232812">1905</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Svenningsen, H.</author><author>Egerod, I.</author><author>Videbech, P.</author><author>Christensen, D.</author><author>Frydenberg, M.</author><author>T?nnesen, E. K.</author></authors></contributors><auth-address>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital,N?rrebrogade 44, Aarhus C, Denmark. hellsven@rm.dk</auth-address><titles><title>Fluctuations in sedation levels may contribute to delirium in ICU patients</title><secondary-title>Acta Anaesthesiol. Scand.</secondary-title></titles><periodical><full-title>Acta Anaesthesiol. Scand.</full-title></periodical><pages>288-293</pages><volume>57</volume><number>3</number><dates><year>2013</year><pub-dates><date>2013/3</date></pub-dates></dates><isbn>0001-5172</isbn><urls><related-urls><url> Papers/S/Svenningsen et al. 2013 - Fluctuations in sedation levels may contribute to delirium in ICU patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1111/aas.12048</electronic-resource-num></record></Cite></EndNote>[42]ModeratePaired sedation and ventilator weaning protocol vs sedation per usual care plus daily ventilator weaningGirard 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaXJhcmQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA [46]InconclusiveReceived sedative infusion while not mechanically ventilatedKamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]InconclusiveReceived sedative infusion while mechanically ventilatedKamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]InconclusiveAnestheticsPandharipande 2008 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2008</Year><RecNum>377</RecNum><DisplayText>[43]</DisplayText><record><rec-number>377</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">377</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Cotton, Bryan A.</author><author>Shintani, Ayumi</author><author>Thompson, Jennifer</author><author>Pun, Brenda Truman</author><author>Morris, John A.</author><author>Dittus, Robert</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients</title><secondary-title>J. Trauma</secondary-title></titles><periodical><full-title>J. Trauma</full-title></periodical><pages>34-41</pages><volume>65</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2008</year><pub-dates><date>2008/7</date></pub-dates></dates><isbn>0022-5282</isbn><urls><related-urls><url>;[43]InconclusiveEpidural analgesiaDubois 2001 ADDIN EN.CITE <EndNote><Cite><Author>Dubois</Author><Year>2001</Year><RecNum>2064</RecNum><DisplayText>[47]</DisplayText><record><rec-number>2064</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2064</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dubois, M. J.</author><author>Bergeron, N.</author><author>Dumont, M.</author><author>Dial, S.</author><author>Skrobik, Y.</author></authors></contributors><auth-address>Division of Critical Care, Université de Montréal, Montréal, Canada.</auth-address><titles><title>Delirium in an intensive care unit: a study of risk factors</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>1297-1304</pages><volume>27</volume><number>8</number><dates><year>2001</year><pub-dates><date>2001/8</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url>;[47]Yoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]InconclusiveOther medication:Emergency admissionZaal 2012 ADDIN EN.CITE <EndNote><Cite><Author>Zaal</Author><Year>2012</Year><RecNum>89</RecNum><DisplayText>[14]</DisplayText><record><rec-number>89</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232703">89</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zaal, Irene J.</author><author>Slooter, Arjen J. C.</author></authors></contributors><auth-address>Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands. i.j.zaal-2@umcutrecht.nl</auth-address><titles><title>Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management</title><secondary-title>Drugs</secondary-title></titles><periodical><full-title>Drugs</full-title></periodical><pages>1457-1471</pages><volume>72</volume><number>11</number><keywords><keyword>ICU Rehab 2015</keyword></keywords><dates><year>2012</year><pub-dates><date>2012/7/30</date></pub-dates></dates><isbn>0012-6667</isbn><urls><related-urls><url> Papers/Z/Zaal and Slooter 2012 - Delirium in critically ill patients - epidemiology, pathophysiology, diagnosis and management.pdf</url></pdf-urls></urls><electronic-resource-num>10.2165/11635520-000000000-00000</electronic-resource-num></record></Cite></EndNote>[14]InconclusiveMelatoninYoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]InconclusiveUses pharmacological sleep aids at homeKamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]InconclusiveBlood values /enzymes/proteins:HyperglycemiaHeymann 2007 ADDIN EN.CITE <EndNote><Cite><Author>Heymann</Author><Year>2007</Year><RecNum>2620</RecNum><DisplayText>[30]</DisplayText><record><rec-number>2620</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783336">2620</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Heymann, A</author><author>Sander, M</author><author>Krahne, D</author><author>Deja, M</author><author>Weber-Carstens, S</author><author>MacGuill, M</author><author>Kastrup, M</author><author>Wernecke, KD</author><author>Nachtigall, I</author><author>Spies, CD</author></authors></contributors><titles><title>Hyperactive delirium and blood glucose control in critically ill patients</title><secondary-title>Journal of International Medical Research</secondary-title></titles><periodical><full-title>Journal of International Medical Research</full-title></periodical><pages>666-677</pages><volume>35</volume><number>5</number><dates><year>2007</year></dates><isbn>0300-0605</isbn><urls></urls></record></Cite></EndNote>[30]InconclusiveAnemiaAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31] InconclusiveBilirubine Dubois 2001 ADDIN EN.CITE <EndNote><Cite><Author>Dubois</Author><Year>2001</Year><RecNum>378</RecNum><DisplayText>[27]</DisplayText><record><rec-number>378</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dubois, M. J.</author><author>Bergeron, N.</author><author>Dumont, M.</author><author>Dial, S.</author><author>Skrobik, Y.</author></authors></contributors><titles><title>Delirium in an intensive care unit: a study of risk factors</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>1297-1304</pages><volume>27</volume><number>8</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2001</year><pub-dates><date>2001/8</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url>;[27]Aldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveHypoalbuminemiaLin 2008 ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2008</Year><RecNum>2054</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2054</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2054</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, Shu-Min</author><author>Huang, Chien-Da</author><author>Liu, Chien-Ying</author><author>Lin, Horng-Chyuan</author><author>Wang, Chun-Hua</author><author>Huang, Pei-Yao</author><author>Fang, Yueh-Fu</author><author>Shieh, Meng-Heng</author><author>Kuo, Han-Pin</author></authors></contributors><auth-address>Department of Thoracic Medicine, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taipei 333, Taiwan.</auth-address><titles><title>Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients</title><secondary-title>J. Crit. Care</secondary-title></titles><periodical><full-title>J. Crit. Care</full-title></periodical><pages>372-379</pages><volume>23</volume><number>3</number><dates><year>2008</year><pub-dates><date>2008/9</date></pub-dates></dates><isbn>0883-9441</isbn><urls><related-urls><url>(06)00121-3</url><url>(06)00121-3</url></related-urls><pdf-urls><url>All Papers/L/Lin et al. 2008 - Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/j.jcrc.2006.09.001</electronic-resource-num></record></Cite></EndNote>[36]InconclusiveHypocalcemiaAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveHyponatremiaAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveCreatinine > 2mg/dLPisani 2007 ADDIN EN.CITE <EndNote><Cite><Author>Pisani</Author><Year>2007</Year><RecNum>2564</RecNum><DisplayText>[39]</DisplayText><record><rec-number>2564</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2564</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pisani, M. A.</author><author>Murphy, T. E.</author><author>Van Ness, P. H.</author><author>Araujo, K. L.</author><author>Inouye, S. K.</author></authors></contributors><auth-address>Pulmonary & Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8057, USA. Margaret.Pisani@yale.edu</auth-address><titles><title>Characteristics associated with delirium in older patients in a medical intensive care unit</title><secondary-title>Arch Intern Med</secondary-title><alt-title>Archives of internal medicine</alt-title></titles><periodical><full-title>Arch Intern Med</full-title><abbr-1>Archives of internal medicine</abbr-1></periodical><alt-periodical><full-title>Arch Intern Med</full-title><abbr-1>Archives of internal medicine</abbr-1></alt-periodical><pages>1629-34</pages><volume>167</volume><number>15</number><edition>2007/08/19</edition><keywords><keyword>Aged</keyword><keyword>*Delirium/diagnosis/therapy</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Prospective Studies</keyword></keywords><dates><year>2007</year><pub-dates><date>Aug 13-27</date></pub-dates></dates><isbn>0003-9926 (Print)
0003-9926</isbn><accession-num>17698685</accession-num><urls></urls><electronic-resource-num>10.1001/archinte.167.15.1629</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[39]InconclusiveArterial pH <7.35Pisani 2007 ADDIN EN.CITE <EndNote><Cite><Author>Pisani</Author><Year>2007</Year><RecNum>2564</RecNum><DisplayText>[39]</DisplayText><record><rec-number>2564</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2564</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pisani, M. A.</author><author>Murphy, T. E.</author><author>Van Ness, P. H.</author><author>Araujo, K. L.</author><author>Inouye, S. K.</author></authors></contributors><auth-address>Pulmonary & Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8057, USA. Margaret.Pisani@yale.edu</auth-address><titles><title>Characteristics associated with delirium in older patients in a medical intensive care unit</title><secondary-title>Arch Intern Med</secondary-title><alt-title>Archives of internal medicine</alt-title></titles><periodical><full-title>Arch Intern Med</full-title><abbr-1>Archives of internal medicine</abbr-1></periodical><alt-periodical><full-title>Arch Intern Med</full-title><abbr-1>Archives of internal medicine</abbr-1></alt-periodical><pages>1629-34</pages><volume>167</volume><number>15</number><edition>2007/08/19</edition><keywords><keyword>Aged</keyword><keyword>*Delirium/diagnosis/therapy</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Prospective Studies</keyword></keywords><dates><year>2007</year><pub-dates><date>Aug 13-27</date></pub-dates></dates><isbn>0003-9926 (Print)
0003-9926</isbn><accession-num>17698685</accession-num><urls></urls><electronic-resource-num>10.1001/archinte.167.15.1629</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[39]InconclusiveReactive hyperemia indexInconclusiveElevated serum urea nitrogenAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveElevated hepatic enzymesAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveHyperamylasemiaAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
1364-8535</isbn><accession-num>11737901</accession-num><urls></urls><custom2>PMC83853</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[31]InconclusiveMetabolic acidosisAldemir 2001 ADDIN EN.CITE <EndNote><Cite><Author>Aldemir</Author><Year>2001</Year><RecNum>2480</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2480</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507741482">2480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aldemir, M.</author><author>Ozen, S.</author><author>Kara, I. H.</author><author>Sir, A.</author><author>Bac, B.</author></authors></contributors><auth-address>Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. maldemir21@</auth-address><titles><title>Predisposing factors for delirium in the surgical intensive care unit</title><secondary-title>Crit Care</secondary-title><alt-title>Critical care (London, England)</alt-title></titles><periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></periodical><alt-periodical><full-title>Crit Care</full-title><abbr-1>Critical care (London, England)</abbr-1></alt-periodical><pages>265-70</pages><volume>5</volume><number>5</number><edition>2001/12/12</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Delirium/diagnosis/*etiology</keyword><keyword>Emergencies</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Length of Stay</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Sex Distribution</keyword></keywords><dates><year>2001</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1364-8535 (Print)
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ADDIN EN.CITE.DATA [50]InconclusiveSerum cortisol Shi 2010 ADDIN EN.CITE <EndNote><Cite><Author>Shi</Author><Year>2010</Year><RecNum>2589</RecNum><DisplayText>[12]</DisplayText><record><rec-number>2589</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2589</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shi, C. M.</author><author>Wang, D. X.</author><author>Chen, K. S.</author><author>Gu, X. E.</author></authors></contributors><auth-address>Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing, China.</auth-address><titles><title>Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery</title><secondary-title>Chin Med J (Engl)</secondary-title><alt-title>Chinese medical journal</alt-title></titles><periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></periodical><alt-periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></alt-periodical><pages>993-9</pages><volume>123</volume><number>8</number><edition>2010/05/26</edition><keywords><keyword>Aged</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*epidemiology/etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>0366-6999 (Print)
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ADDIN EN.CITE.DATA [4]InconclusiveTyrosine/LNAA ratioPandharipande 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE.DATA [4]InconclusivePhenylalanine/LNAA ratioPandharipande 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE.DATA [4]InconclusiveVentilation:Mechanical ventilationGuillamondegui 2011 ADDIN EN.CITE <EndNote><Cite><Author>Guillamondegui</Author><Year>2011</Year><RecNum>2031</RecNum><DisplayText>[51]</DisplayText><record><rec-number>2031</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232819">2031</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Guillamondegui, Oscar D.</author><author>Richards, Justin E.</author><author>Ely, E. Wesley</author><author>Jackson, James C.</author><author>Archer, Kristin R.</author><author>Archer-Swygert, Kristin</author><author>Norris, Patrick R.</author><author>Obremskey, William T.</author></authors></contributors><auth-address>Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA. oscar.guillamondegui@vanderbilt.edu</auth-address><titles><title>Does hypoxia affect intensive care unit delirium or long-term cognitive impairment after multiple trauma without intracranial hemorrhage?</title><secondary-title>J. Trauma</secondary-title></titles><periodical><full-title>J. Trauma</full-title></periodical><pages>910-915</pages><volume>70</volume><number>4</number><dates><year>2011</year><pub-dates><date>2011/4</date></pub-dates></dates><isbn>0022-5282</isbn><urls><related-urls><url> Papers/G/Guillamondegui et al. 2011 - Does hypoxia affect intensive care unit del ... tive impairment after multiple trauma without intracranial hemorrhage.pdf</url></pdf-urls></urls><electronic-resource-num>10.1097/TA.0b013e3182114f18</electronic-resource-num></record></Cite></EndNote>[51]Bryczkowski 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccnljemtvd3NraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll
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ADDIN EN.CITE.DATA [10]van Rompaey 2009 ADDIN EN.CITE <EndNote><Cite><Author>Van Rompaey</Author><Year>2009</Year><RecNum>1709</RecNum><DisplayText>[29]</DisplayText><record><rec-number>1709</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232801">1709</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Van Rompaey, Bart</author><author>Elseviers, Monique M.</author><author>Schuurmans, Marieke J.</author><author>Shortridge-Baggett, Lillie M.</author><author>Truijen, Steven</author><author>Bossaert, Leo</author></authors></contributors><auth-address>University of Antwerp, Faculty of Medicine, Division of Nursing Science and Midwifery, Universiteitsplein 1, 2610 Wilrijk, Belgium. bart.vanrompaey@ua.ac.be</auth-address><titles><title>Risk factors for delirium in intensive care patients: a prospective cohort study</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>R77</pages><volume>13</volume><number>3</number><keywords><keyword>PAD-ES Agitation/Sedation Manuscript</keyword></keywords><dates><year>2009</year><pub-dates><date>2009/5/20</date></pub-dates></dates><publisher>ccforum.</publisher><isbn>0270-7462</isbn><urls><related-urls><url> Papers/V/Van Rompaey et al. 2009 - Risk factors for delirium in intensive care patients - a prospective cohort study.pdf</url></pdf-urls></urls><electronic-resource-num>10.1186/cc7892</electronic-resource-num></record></Cite></EndNote>[29]Hsieh 2014 ADDIN EN.CITE <EndNote><Cite><Author>Hsieh</Author><Year>2014</Year><RecNum>2617</RecNum><DisplayText>[21]</DisplayText><record><rec-number>2617</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783180">2617</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hsieh, SJ</author><author>Soto, GJ</author><author>Hope, AA</author><author>Ponea, A</author><author>Gong, MN</author></authors></contributors><titles><title>The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients</title><secondary-title>Am J Respir Crit Care Med</secondary-title></titles><periodical><full-title>Am J Respir Crit Care Med</full-title><abbr-1>American journal of respiratory and critical care medicine</abbr-1></periodical><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[21]Kamdar 2015 ADDIN EN.CITE <EndNote><Cite><Author>Kamdar</Author><Year>2015</Year><RecNum>599</RecNum><DisplayText>[18]</DisplayText><record><rec-number>599</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232732">599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kamdar, Biren B.</author><author>Combs, Michael P.</author><author>Colantuoni, Elizabeth</author><author>King, Lauren M.</author><author>Niessen, Timothy</author><author>Neufeld, Karin J.</author><author>Collop, Nancy A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU</title><secondary-title>Crit. Care</secondary-title></titles><periodical><full-title>Crit. Care</full-title></periodical><pages>261</pages><volume>19</volume><keywords><keyword>ICU Rehab 2016</keyword><keyword>PAD-ES Early Mobility Manuscript</keyword></keywords><dates><year>2015</year><pub-dates><date>2015</date></pub-dates></dates><isbn>1364-8535</isbn><urls><related-urls><url>;[18]Zhang 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaGFuZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [20]Yoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]Lin 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [50]Ouimet 2007 ADDIN EN.CITE <EndNote><Cite><Author>Ouimet</Author><Year>2007</Year><RecNum>2206</RecNum><DisplayText>[28]</DisplayText><record><rec-number>2206</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232830">2206</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ouimet, Sébastien</author><author>Kavanagh, Brian P.</author><author>Gottfried, Stewart B.</author><author>Skrobik, Yoanna</author></authors></contributors><auth-address>Department of Medicine, University of Montreal, Montreal, Canada.</auth-address><titles><title>Incidence, risk factors and consequences of ICU delirium</title><secondary-title>Intensive Care Med.</secondary-title></titles><periodical><full-title>Intensive Care Med.</full-title></periodical><pages>66-73</pages><volume>33</volume><number>1</number><dates><year>2007</year><pub-dates><date>2007/1</date></pub-dates></dates><isbn>0342-4642</isbn><urls><related-urls><url> Papers/O/Ouimet et al. 2007 - Incidence, risk factors and consequences of ICU delirium.pdf</url></pdf-urls></urls><electronic-resource-num>10.1007/s00134-006-0399-8</electronic-resource-num></record></Cite></EndNote>[28]Pandharipande 2006 ADDIN EN.CITE <EndNote><Cite><Author>Pandharipande</Author><Year>2006</Year><RecNum>376</RecNum><DisplayText>[3]</DisplayText><record><rec-number>376</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">376</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pandharipande, Pratik</author><author>Shintani, Ayumi</author><author>Peterson, Josh</author><author>Pun, Brenda Truman</author><author>Wilkinson, Grant R.</author><author>Dittus, Robert S.</author><author>Bernard, Gordon R.</author><author>Ely, E. Wesley</author></authors></contributors><titles><title>Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients</title><secondary-title>Anesthesiology</secondary-title></titles><periodical><full-title>Anesthesiology</full-title></periodical><pages>21-26</pages><volume>104</volume><number>1</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2006</year><pub-dates><date>2006</date></pub-dates></dates><isbn>0003-3022</isbn><urls><related-urls><url>;[3]Pandharipande 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5kaGFyaXBhbmRlPC9BdXRob3I+PFllYXI+MjAwOTwv
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ADDIN EN.CITE.DATA [4]Schreiber 2014 ADDIN EN.CITE <EndNote><Cite><Author>Schreiber</Author><Year>2014</Year><RecNum>379</RecNum><DisplayText>[9]</DisplayText><record><rec-number>379</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232720">379</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schreiber, Matthew P.</author><author>Colantuoni, Elizabeth</author><author>Bienvenu, Oscar J.</author><author>Neufeld, Karin J.</author><author>Chen, Kuan-Fu</author><author>Shanholtz, Carl</author><author>Mendez-Tellez, Pedro A.</author><author>Needham, Dale M.</author></authors></contributors><titles><title>Corticosteroids and transition to delirium in patients with acute lung injury</title><secondary-title>Crit. Care Med.</secondary-title></titles><periodical><full-title>Crit. Care Med.</full-title></periodical><pages>1480-1486</pages><volume>42</volume><number>6</number><keywords><keyword>ICU Rehab 2016</keyword></keywords><dates><year>2014</year><pub-dates><date>2014/6</date></pub-dates></dates><isbn>0090-3493</isbn><urls><related-urls><url>;[9]Yoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]Zhang 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaGFuZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [20]Serafim 2012 ADDIN EN.CITE <EndNote><Cite><Author>Serafim</Author><Year>2012</Year><RecNum>2050</RecNum><DisplayText>[5]</DisplayText><record><rec-number>2050</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2050</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Serafim, Rodrigo Bernardo</author><author>Dutra, Maximiliano F.</author><author>Saddy, Felipe</author><author>Tura, Bernardo</author><author>de Castro, Jose Eduardo Couto</author><author>Villarinho, Luciana C.</author><author>da Gloria Santos, Maria</author><author>Bozza, Fernando Augusto</author><author>Rocco, José Rodolfo</author></authors></contributors><auth-address>Ventilatory Care Unit, Copa D'Or Hospital, Rio de Janeiro, Brazil. rodrigobserafim@.</auth-address><titles><title>Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes</title><secondary-title>Ann. Intensive Care</secondary-title></titles><periodical><full-title>Ann. Intensive Care</full-title></periodical><pages>51</pages><volume>2</volume><number>1</number><dates><year>2012</year><pub-dates><date>2012/12/31</date></pub-dates></dates><isbn>2110-5820</isbn><urls><related-urls><url> Papers/S/Serafim et al. 2012 - Delirium in postoperative nonventilated intensive care patients - risk factors and outcomes.pdf</url></pdf-urls></urls><electronic-resource-num>10.1186/2110-5820-2-51</electronic-resource-num></record></Cite></EndNote>[5]Heymann 2007 ADDIN EN.CITE <EndNote><Cite><Author>Heymann</Author><Year>2007</Year><RecNum>2620</RecNum><DisplayText>[30]</DisplayText><record><rec-number>2620</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783336">2620</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Heymann, A</author><author>Sander, M</author><author>Krahne, D</author><author>Deja, M</author><author>Weber-Carstens, S</author><author>MacGuill, M</author><author>Kastrup, M</author><author>Wernecke, KD</author><author>Nachtigall, I</author><author>Spies, CD</author></authors></contributors><titles><title>Hyperactive delirium and blood glucose control in critically ill patients</title><secondary-title>Journal of International Medical Research</secondary-title></titles><periodical><full-title>Journal of International Medical Research</full-title></periodical><pages>666-677</pages><volume>35</volume><number>5</number><dates><year>2007</year></dates><isbn>0300-0605</isbn><urls></urls></record></Cite></EndNote>[30]Pisani 2009 ADDIN EN.CITE <EndNote><Cite><Author>Pisani</Author><Year>2009</Year><RecNum>2565</RecNum><DisplayText>[35]</DisplayText><record><rec-number>2565</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2565</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pisani, M. A.</author><author>Murphy, T. E.</author><author>Araujo, K. L.</author><author>Slattum, P.</author><author>Van Ness, P. H.</author><author>Inouye, S. K.</author></authors></contributors><auth-address>Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, USA. margaret.pisani@yale.edu</auth-address><titles><title>Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population</title><secondary-title>Crit Care Med</secondary-title><alt-title>Critical care medicine</alt-title></titles><alt-periodical><full-title>Critical care medicine</full-title></alt-periodical><pages>177-83</pages><volume>37</volume><number>1</number><edition>2008/12/04</edition><keywords><keyword>Aged</keyword><keyword>Analgesics, Opioid/*adverse effects</keyword><keyword>Benzodiazepines/*adverse effects</keyword><keyword>Delirium/*epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Intensive Care Units</keyword><keyword>Male</keyword><keyword>Prospective Studies</keyword><keyword>Time Factors</keyword></keywords><dates><year>2009</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0090-3493</isbn><accession-num>19050611</accession-num><urls></urls><custom2>PMC2700732</custom2><custom6>NIHMS117966</custom6><electronic-resource-num>10.1097/CCM.0b013e318192fcf9</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[35]Shi 2010 ADDIN EN.CITE <EndNote><Cite><Author>Shi</Author><Year>2010</Year><RecNum>2589</RecNum><DisplayText>[12]</DisplayText><record><rec-number>2589</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2589</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shi, C. M.</author><author>Wang, D. X.</author><author>Chen, K. S.</author><author>Gu, X. E.</author></authors></contributors><auth-address>Department of Anesthesiology and Surgical Intensive Care, Peking University First Hospital, Beijing, China.</auth-address><titles><title>Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery</title><secondary-title>Chin Med J (Engl)</secondary-title><alt-title>Chinese medical journal</alt-title></titles><periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></periodical><alt-periodical><full-title>Chin Med J (Engl)</full-title><abbr-1>Chinese medical journal</abbr-1></alt-periodical><pages>993-9</pages><volume>123</volume><number>8</number><edition>2010/05/26</edition><keywords><keyword>Aged</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*epidemiology/etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Postoperative Complications</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2010</year><pub-dates><date>Apr 20</date></pub-dates></dates><isbn>0366-6999 (Print)
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ADDIN EN.CITE.DATA [16]Zaal 2012 ADDIN EN.CITE <EndNote><Cite><Author>Zaal</Author><Year>2012</Year><RecNum>89</RecNum><DisplayText>[14]</DisplayText><record><rec-number>89</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232703">89</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zaal, Irene J.</author><author>Slooter, Arjen J. C.</author></authors></contributors><auth-address>Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands. i.j.zaal-2@umcutrecht.nl</auth-address><titles><title>Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management</title><secondary-title>Drugs</secondary-title></titles><periodical><full-title>Drugs</full-title></periodical><pages>1457-1471</pages><volume>72</volume><number>11</number><keywords><keyword>ICU Rehab 2015</keyword></keywords><dates><year>2012</year><pub-dates><date>2012/7/30</date></pub-dates></dates><isbn>0012-6667</isbn><urls><related-urls><url> Papers/Z/Zaal and Slooter 2012 - Delirium in critically ill patients - epidemiology, pathophysiology, diagnosis and management.pdf</url></pdf-urls></urls><electronic-resource-num>10.2165/11635520-000000000-00000</electronic-resource-num></record></Cite></EndNote>[14]Ely 2007PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FbHk8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA [13]InconclusiveDuring hospital stay:Bed change > 3Limpawattana 2016 ADDIN EN.CITE <EndNote><Cite><Author>Limpawattana</Author><Year>2016</Year><RecNum>2621</RecNum><DisplayText>[32]</DisplayText><record><rec-number>2621</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783448">2621</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Limpawattana, Panita</author><author>Panitchote, Anupol</author><author>Tangvoraphonkchai, Kawin</author><author>Suebsoh, Naluttaporn</author><author>Eamma, Wanaporn</author><author>Chanthonglarng, Bunruam</author><author>Tiamkao, Somsak</author></authors></contributors><titles><title>Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults</title><secondary-title>Aging & mental health</secondary-title></titles><periodical><full-title>Aging & mental health</full-title></periodical><pages>74-80</pages><volume>20</volume><number>1</number><dates><year>2016</year></dates><isbn>1360-7863</isbn><urls></urls></record></Cite></EndNote>[32]InconclusivePhysical restraintsLimpawattana 2016 ADDIN EN.CITE <EndNote><Cite><Author>Limpawattana</Author><Year>2016</Year><RecNum>2621</RecNum><DisplayText>[32]</DisplayText><record><rec-number>2621</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508783448">2621</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Limpawattana, Panita</author><author>Panitchote, Anupol</author><author>Tangvoraphonkchai, Kawin</author><author>Suebsoh, Naluttaporn</author><author>Eamma, Wanaporn</author><author>Chanthonglarng, Bunruam</author><author>Tiamkao, Somsak</author></authors></contributors><titles><title>Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults</title><secondary-title>Aging & mental health</secondary-title></titles><periodical><full-title>Aging & mental health</full-title></periodical><pages>74-80</pages><volume>20</volume><number>1</number><dates><year>2016</year></dates><isbn>1360-7863</isbn><urls></urls></record></Cite></EndNote>[32]Mehta 2015Zhang 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaGFuZzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA [22]InconclusiveDuration of surgeryYoshitaka 2013 ADDIN EN.CITE <EndNote><Cite><Author>Yoshitaka</Author><Year>2013</Year><RecNum>2610</RecNum><DisplayText>[8]</DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780436">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yoshitaka, S.</author><author>Egi, M.</author><author>Morimatsu, H.</author><author>Kanazawa, T.</author><author>Toda, Y.</author><author>Morita, K.</author></authors></contributors><auth-address>Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikatachou, Okayama, Okayama700-8525, Japan.</auth-address><titles><title>Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium</title><secondary-title>J Crit Care</secondary-title><alt-title>Journal of critical care</alt-title></titles><alt-periodical><full-title>Journal of critical care</full-title></alt-periodical><pages>236-42</pages><volume>28</volume><number>3</number><edition>2013/01/15</edition><keywords><keyword>Apache</keyword><keyword>Aged</keyword><keyword>Chi-Square Distribution</keyword><keyword>Comorbidity</keyword><keyword>*Critical Illness</keyword><keyword>Delirium/*blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Melatonin/*blood</keyword><keyword>Middle Aged</keyword><keyword>Postoperative Period</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0883-9441</isbn><accession-num>23312124</accession-num><urls></urls><electronic-resource-num>10.1016/j.jcrc.2012.11.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[8]InconclusiveAnxietyOuimet 2007 ADDIN EN.CITE <EndNote><Cite><Author>Ouimet</Author><Year>2007</Year><RecNum>2556</RecNum><DisplayText>[52]</DisplayText><record><rec-number>2556</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1508780435">2556</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ouimet, S.</author><author>Kavanagh, B. P.</author><author>Gottfried, S. B.</author><author>Skrobik, Y.</author></authors></contributors><auth-address>Department of Medicine, University of Montreal, Montreal, Canada.</auth-address><titles><title>Incidence, risk factors and consequences of ICU delirium</title><secondary-title>Intensive Care Med</secondary-title><alt-title>Intensive care medicine</alt-title></titles><alt-periodical><full-title>Intensive Care Medicine</full-title></alt-periodical><pages>66-73</pages><volume>33</volume><number>1</number><edition>2006/11/15</edition><keywords><keyword>Delirium/*epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Intensive Care Units</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2007</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0342-4642 (Print)
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ADDIN EN.CITE.DATA [26]Veiga 2012 ADDIN EN.CITE <EndNote><Cite><Author>Veiga</Author><Year>2012</Year><RecNum>2053</RecNum><DisplayText>[7]</DisplayText><record><rec-number>2053</rec-number><foreign-keys><key app="EN" db-id="v9razzrwmtv29zeet5tvadzm9d5dffdd0s55" timestamp="1507232821">2053</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Veiga, Dalila</author><author>Luis, Clara</author><author>Parente, Daniela</author><author>Fernandes, Vera</author><author>Botelho, Miguela</author><author>Santos, Patricia</author><author>Abelha, Fernando</author></authors></contributors><auth-address>Department of Anesthesiology, Centro Hospitalar de S?o Jo?o, Porto, Portugal.</auth-address><titles><title>Postoperative delirium in intensive care patients: risk factors and outcome</title><secondary-title>Rev. Bras. Anestesiol.</secondary-title></titles><periodical><full-title>Rev. Bras. Anestesiol.</full-title></periodical><pages>469-483</pages><volume>62</volume><number>4</number><dates><year>2012</year><pub-dates><date>2012/7</date></pub-dates></dates><isbn>0034-7094</isbn><urls><related-urls><url>(12)70146-0</url><url>(12)70146-0</url></related-urls><pdf-urls><url>All Papers/V/Veiga et al. 2012 - Postoperative delirium in intensive care patients - risk factors and outcome.pdf</url></pdf-urls></urls><electronic-resource-num>10.1016/S0034-7094(12)70146-0</electronic-resource-num></record></Cite></EndNote>[7]StrongHigh quality studies are shown in bold, investigations of acceptable quality in italics, and low quality studies are underlined. APACHE=Acute Physiology and Chronic Health Evaluation, APOE=apolioprotein E, ASA score= American Society of Anesthesiology score, CVVH=continuous veno-venous hemofiltration? GCS=Glasgow Coma Scale, ICU=Intensive Care Unit, IGF-1=Insuline-like growth factor-1, LNAA=Large Neutral Amino Acids, LOS=length of stay, MMP-9=Matrix Metalloproteinase-9, NRS=Numeric Rating Scale, RASS= Richmond Agitation-Sedation Scale, RBC=red blood cells, RCSQ= Richards–Campbell Sleep Questionnaire, SOFA= Sequential Organ Failure Assessment, sTNFR1=soluble Tumor Necrosis Factor Receptor-1, TBI=Traumatic Brain Injury, 25-OHD=25-hydroxyvitamin D.References ADDIN EN.REFLIST 1.Abelha FJ, Fernandes V, Botelho M, Santos P, Santos A, Machado JC, Barros H: Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery. Journal of anesthesia 2012.2.Angles EM, Robinson TN, Biffl WL, Johnson J, Moss M, Tran ZV, Moore EE: Risk factors for delirium after major trauma. American journal of surgery 2008, 196(6):864-869; discussion 869-870.3.Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW: Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006, 104(1):21-26.4.Pandharipande PP, Morandi A, Adams JR, Girard TD, Thompson JL, Shintani AK, Ely EW: Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med 2009, 35(11):1886-1892.5.Serafim RB, Dutra MF, Saddy F, Tura B, de Castro JEC, Villarinho LC, da Gloria Santos M, Bozza FA, Rocco JR: Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes. Ann Intensive Care 2012, 2(1):51.6.Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A et al: Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med 2013, 39(5):910-918.7.Veiga D, Luis C, Parente D, Fernandes V, Botelho M, Santos P, Abelha F: Postoperative delirium in intensive care patients: risk factors and outcome. Rev Bras Anestesiol 2012, 62(4):469-483.8.Yoshitaka S, Egi M, Morimatsu H, Kanazawa T, Toda Y, Morita K: Perioperative plasma melatonin concentration in postoperative critically ill patients: its association with delirium. J Crit Care 2013, 28(3):236-242.9.Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen K-F, Shanholtz C, Mendez-Tellez PA, Needham DM: Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med 2014, 42(6):1480-1486.10.Bryczkowski SB, Lopreiato MC, Yonclas PP, Sacca JJ, Mosenthal AC: Delirium prevention program in the surgical intensive care unit improved the outcomes of older adults. J Surg Res 2014, 190(1):280-288.11.Colombo R, Corona A, Praga F, Minari C, Giannotti C, Castelli A, Raimondi F: A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study. Minerva Anestesiol 2012, 78(9):1026-1033.12.Shi CM, Wang DX, Chen KS, Gu XE: Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery. Chinese medical journal 2010, 123(8):993-999.13.Simons KS, Workum JD, Slooter AJC, van den Boogaard M, van der Hoeven JG, Pickkers P: Effect of preadmission sunlight exposure on intensive care unit-acquired delirium: a multicenter study. J Crit Care 2014, 29(2):283-286.14.Zaal IJ, Slooter AJC: Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management. Drugs 2012, 72(11):1457-1471.15.Van Rompaey B, Elseviers MM, Van Drom W, Fromont V, Jorens PG: The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care 2012, 16(3):R73.16.Leite MA, Osaku EF, Costa CR, Candia MF, Toccolini B, Covatti C, Costa NL, Nogueira ST, Ogasawara SM, de Albuquerque CE et al: Delirium during Weaning from Mechanical Ventilation. Critical care research and practice 2014, 2014:546349.17.Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandharipande P et al: Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 2007, 35(1):112-117.18.Kamdar BB, Combs MP, Colantuoni E, King LM, Niessen T, Neufeld KJ, Collop NA, Needham DM: The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU. Crit Care 2015, 19:261.19.Morandi A, Rogers BP, Gunther ML, Merkle K, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S et al: The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Crit Care Med 2012, 40(7):2182-2189.20.Zhang Z, Pan L, Deng H, Ni H, Xu X: Prediction of delirium in critically ill patients with elevated C-reactive protein. J Crit Care 2014, 29(1):88-92.21.Hsieh S, Soto G, Hope A, Ponea A, Gong M: The Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients. American journal of respiratory and critical care medicine 2014.22.Lin WL, Chen YF, Wang J: Factors Associated with the Development of Delirium in Elderly Patients in Intensive Care Units. Journal of Nursing Research 2015, 23(4):322-329.23.Skrobik Y, Leger C, Cossette M, Michaud V, Turgeon J: Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med 2013, 41(4):999-1008.24.Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinberg M, Granton J, Ferguson N et al: Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med 2015, 43(3):557-566.25.Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM: Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med 2014, 42(6):1480-1486.26.Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson MR, Mashour GA, Avidan MS: Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. Anesthesia and analgesia 2014, 118(4):809-817.27.Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y: Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 2001, 27(8):1297-1304.28.Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y: Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 2007, 33(1):66-73.29.Van Rompaey B, Elseviers MM, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L: Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care 2009, 13(3):R77.30.Heymann A, Sander M, Krahne D, Deja M, Weber-Carstens S, MacGuill M, Kastrup M, Wernecke K, Nachtigall I, Spies C: Hyperactive delirium and blood glucose control in critically ill patients. Journal of International Medical Research 2007, 35(5):666-677.31.Aldemir M, Ozen S, Kara IH, Sir A, Bac B: Predisposing factors for delirium in the surgical intensive care unit. Critical care (London, England) 2001, 5(5):265-270.32.Limpawattana P, Panitchote A, Tangvoraphonkchai K, Suebsoh N, Eamma W, Chanthonglarng B, Tiamkao S: Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults. Aging & mental health 2016, 20(1):74-80.33.McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK: Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc 2003, 51(5):591-598.34.Pisani MA, Bramley K, Vest MT, Akgün KM, Araujo KLB, Murphy TE: Patterns of opiate, benzodiazepine, and antipsychotic drug dosing in older patients in a medical intensive care unit. Am J Crit Care 2013, 22(5):e62-e69.35.Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK: Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med 2009, 37(1):177-183.36.Lin S-M, Huang C-D, Liu C-Y, Lin H-C, Wang C-H, Huang P-Y, Fang Y-F, Shieh M-H, Kuo H-P: Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients. J Crit Care 2008, 23(3):372-379.37.Serafim RB, Dutra MF, Saddy F, Tura B, de Castro JE, Villarinho LC, da Gloria Santos M, Bozza FA, Rocco JR: Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes. Annals of intensive care 2012, 2(1):51.38.Agarwal V, O'Neill PJ, Cotton BA, Pun BT, Haney S, Thompson J, Kassebaum N, Shintani A, Guy J, Ely EW et al: Prevalence and risk factors for development of delirium in burn intensive care unit patients. Journal of burn care & research : official publication of the American Burn Association 2010, 31(5):706-715.39.Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK: Characteristics associated with delirium in older patients in a medical intensive care unit. Archives of internal medicine 2007, 167(15):1629-1634.40.Seymour CW, Pandharipande PP, Koestner T, Hudson LD, Thompson JL, Shintani AK, Ely EW, Girard TD: Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med 2012, 40(10):2788-2796.41.Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH: Days of delirium are associated with 1-year mortality in an older intensive care unit population. American journal of respiratory and critical care medicine 2009, 180(11):1092-1097.42.Svenningsen H, Egerod I, Videbech P, Christensen D, Frydenberg M, T?nnesen EK: Fluctuations in sedation levels may contribute to delirium in ICU patients. Acta Anaesthesiol Scand 2013, 57(3):288-293.43.Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA, Dittus R, Ely EW: Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 2008, 65(1):34-41.44.Wolters AE, Zaal IJ, Veldhuijzen DS, Cremer OL, Devlin JW, Van Dijk D, Slooter AJC: Anticholinergic Medication Use and Transition to Delirium in Critically Ill Patients: A Prospective Cohort Study. Crit Care Med 2015, 43(9):1846-1852.45.Pisani MA, Kong SYJ, Kasl SV, Murphy TE, Araujo KLB, Van Ness PH: Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009, 180(11):1092-1097.46.Girard TD, Kress JP, Fuchs BD, Thomason JWW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA et al: Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008, 371(9607):126-134.47.Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y: Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 2001, 27(8):1297-1304.48.Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, Jackson JC, Dittus RS, Ely EW: Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med 2012, 38(12):1965-1973.49.Morandi A, Gunther ML, Pandharipande PP, Jackson JC, Thompson JL, Shintani AK, Ely EW, Girard TD: Insulin-like growth factor-1 and delirium in critically ill mechanically ventilated patients: a preliminary investigation. International psychogeriatrics 2011, 23(7):1175-1181.50.Morandi A, Barnett N, Miller RR, 3rd, Girard TD, Pandharipande PP, Ely EW, Ware LB: Vitamin D and delirium in critically ill patients: a preliminary investigation. J Crit Care 2013, 28(3):230-235.51.Guillamondegui OD, Richards JE, Ely EW, Jackson JC, Archer KR, Archer-Swygert K, Norris PR, Obremskey WT: Does hypoxia affect intensive care unit delirium or long-term cognitive impairment after multiple trauma without intracranial hemorrhage? J Trauma 2011, 70(4):910-915.52.Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y: Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 2007, 33(1):66-73. ................
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