CURRICULUM VITAE



Professor Kathryn Maitland

CURRICULUM VITAE

1 Personal Details

Name: Kathryn Maitland

Date of Birth: 8 November 1962

City of Birth Halewood, Liverpool

Citizenship British (United Kingdom)

Address KEMRI-Wellcome Trust Programme

PO Box 230 Kilifi Kenya

Telephone Mobile +254 733411022

UK Mobile: +44 7543721710

Email Kathryn.maitland@

K.maitland@imperial.ac.uk

Current Professional Appointments:

Professor of Paediatric Tropical Infectious Diseases Since 2009 Imperial College, London

Honorary Consultant in Paediatric Infectious Disease Since 2000 Department of Paediatrics Honorary Fellow Medical Research Council Clinical Trials Unit at UCL Since 2009

Current expert appointments

Visiting professor University of Oxford, United Kingdom Since 2015

Visiting professor Busitema University, Mbale, Uganda Since 2015

Board member Institute of Global Health Innovation, Imperial College London Since 2014

2 Other Appointments and Affiliations

Professional Bodies and Organisations

Memberships:

Royal Society of Paediatrics and Child Health

Royal Society of Tropical Medicine and Hygiene.

Committees:

2020 WHO Respiratory Working Group COVID-19 Clinical Management & Characterization

2020 MRC Global Health Faculty of Experts

2020 MRC GCRF: Nutrition review panel committee

2020 NIHR RIGHT (Research and Innovation for Global Health Transformation)

2011-2019 ISARIC Executive committee Member: African Chair

2011-2014 Imperial College: Executive Member of Global Health Group

2014-17 Associate member of the Institute of Global Health Innovation

2017- EDCTP Career Developmental Fellowship Reviewer and Co-Chair

2017-2020 Academy of Medical Sciences: Committee Member for selection of new fellows

2017-2021 Wellcome: Clinical Research Career Development Fellowship Scheme Committee Member

2018 EDCTP Senior Research Fellowship Reviewer and committee member

3 Prizes Awards/Honours

Academic Awards:

2016 Fellowship Academy Medical Sciences

2012 Imperial College: recognition for outstanding achievement and exceptional contribution

2012 FEAST Trial BMJ Paper of the Year Award 2011

2009 Promotion to Professor of Tropical Paediatric Infectious Diseases, Imperial College

2006 Wellcome Trust Value in People award, Imperial College, London

2006 HEFC Clinical Senior Lectureship Award

1999 Wellcome Trust- Imperial Lecturer in Tropical Clinical Medicine

1996 Federation of Infection Society: Prize for Best Research Project

1995 Wellcome Trust Fellowship in Clinical Tropical Medicine

4 Grants

Current

2019 Co-applicant: MRC/DfID/Wellcome Trust Global Health Trials: "Hydroxyurea: Pragmatic Reduction in Mortality and Economic burden (H-PRIME) £4,375,000

2018 Principal Investigator: 209265/Z/17/Z: Severe Malaria Africa – A consortium for Research and Trials (SMAART) consortium Wellcome Collaborative Award in Science Grant £3,944,185.00

2018 Principal Investigator: MR/R018502/1 Gastroenteritis: rehydration for children with severe acute malnutrition MRC Developmental Award (GASTRO-SAM) £162,

2018 Co-Investigator ALERRT: African CoaLition for Epidemic Research, Response and Training (sub contract € 240,942.50 to Mbale Clinical Research Institute)

2017 Principal Investigator: MR/J012483/1 TRACT trial TRansfusion and TReatment of severe Anaemia in Africa Children: a randomised controlled Trial MRC extension £218,060 (April 2017-Oct 2019)

2017 Principal Investigator: 1636 — COAST-Nutrition, EDCTP2 Call for Proposals RIA2016S - Strategic actions supporting large-scale clinical trials Euro 3,394, 200 (October 2017- Sept 2021)

2017 Co-Investigator: MR/P022251/1 Mechanisms underlying enhanced infection prophylaxis for advanced HIV in Africa PI Andy Prendergast Queen Mary, University of London 

MRC Research Grant    36 months   £813,361 (June 2017 –

2017 Principal Investigator: MR/P021492/1 Pharmacokinetics of azithromycin in severe malaria bacterial co-infection in African children 24 months £168,000 (July 2017 –June 2019)

2017 Co-Supervisor: TMA2016SF-1514 EDCTP Senior Fellowship Award to Peter Olupot-Olupot: Strengthening Malaria Epidemiological, Pathophysiological and Intervention Studies in Highly Endemic Eastern Uganda (MEPIE Study) Euro 468,551.

2017 Co-Investigator: An Innovative Passive Dietary Monitoring System - a dietary monitoring system for effective assessment of individual nutrient intake in Low or Middle Income Countries (LMICs) - funded by Bill and Melinda Gates Foundation (US$1.57M)  (Investment ID: OPP1171395)

2017 Co- Investigator: MRC Confidence in Global Nutrition Award (MC_PC_MR/R019258/1) (PI Gary Frost) The Role of Nutrients, Gut Dysfunction and the Gut Microbiome in Determining Health Outcomes in Undernutrition  £183, 444

2016 Co- investigator: MR/P06873/1 Single Tolerability and safety of single low dose primaquine in African children with acute uncomplicated falciparum malaria and glucose 6 phosphate dehydrogenase deficiency, Principal Investigator (PI) Nick Day; Wellcome Trust MRC DFid £1,818,500/= (2017-2019)

2016 Co-Investigator: 203077/Z/16/Z Wellcome Trust East African Major Overseas Programme £45,500,000 1st Oct 2016- 31st Aug 2021; £1,500,000 Allocated to Imperial College for Mbale Clinical Research Institute, Uganda

2013 Principal Investigator: MR/L004364/1 COAST trial Children Oxygen Administration Strategies Trial Wellcome Trust MRC DFid £2,750,000

Imperial College internally managed awards

2017- 2018 Principal Investigator: Development of a therapeutic feeding strategy to support gut integrity in malnourished children in East Africa Imperial (Phase II trial) Confidence in Concepts – Joint Translational £188,000

2018-2019 Principal Investigator: Understanding the Gut Microbiome in African children: stakeholder meeting Research England Global Challenges Research (£35,000)

2019 -2020 Principal Investigator: RETRACT: REalising Transfusion Trial in African Children with Severe anaemia knowledge sharing meeting: Research England Global Challenges Research Fund (£85,000)

Previous Grants

2013 Co-Chief Investigator: Understanding of pathophysiology of sepsis and the tissue effects of fluid resuscitation and transfusion NHMRC, Australia (AUS: 1,000,000)

2012 Principal Investigator: TRACT trial TRansfusion and TReatment of severe Anaemia in Africa Children: a randomised controlled Trial MRC £3,300,000 (MR/J012483)

2011 Co-applicant: REALITY trial  Reduction of EArly HIV mortaLITY in adults and children (coapplicant/site PI) Global Health Trials (Welcome Trust MRC Dfid) £4, 600,000

2011 Co-Principal Investigator: Appropriate Fluid Resuscitation for Shock in Severely Malnourished Children AFRIM STUDY; Medicines Sans Frontieres/EpiCentre (180,000

2011 Principal Investigator: Fluid Management of severely-ill children in Africa. Alexander Fleming Dissemination Award, MRC, London (£30,000) KMaitland Diana Gibb

2010 Co-Principal Investigator: Investigating gut mucosal integrity and gut metabolome in children with severe malnutrition: metabonomic profiling. Halley Stewart Trust (+co-funding Imperial College) K Maitland N Pathen, G Frost, Elaine Holmes

2010 Co-Principal Investigator: CAPMAL: Studies of myocardial function in children with severe malnutrition Else Kroener-Fresenius Stiftung (90,000

2007 Co-applicant: AQUAMAT trial: An open label randomised comparison of injectable artesunate and quinine in patients with severe falciparum malaria in Africa, PI Nick White, Wellcome Trust £2, 000,000

2007 Principal Investigator: Endotoxaemia in severe and complicated malnutrition (XOMA £12,000/Spectral diagnostics)

2007 Principal Investigator: FEAST trial A multi-centre randomised controlled trial of volume expansion in children with severe malaria (FEAST) MRC Clinical Trials Grant £2,700,000

5 Evidence of esteem, external visibility and profession activities

Awards

2011 FEAST Trial won BMJ paper of the year award

2015 Director Imperial College Centre for African Research and Engagement (ICCARE)

2016 Fellow of the Academy of Medical Sciences

Visiting Professor

2015 Visiting professor: MCMasters’ University and Toronto Childrens Hospital; Canada

2013 Visiting professor: Boston Childrens’ Hospital /Harvard Medical School Department of Continuing Education: The origins of the FEAST and beyond.

2011 Visiting professor: University of Pittsburgh (and Medical Center & Childrens’ Hospital)

Annual Oration Awards

2020 John Hinds Lecture: Critical Care Reviews Meeting Belfast, N Ireland

2020 John Snow Oration: Annual Medal: Royal College of Anaesthetists: Manchester

2017 Annual Asmund’s Laerdal Memorial Lecture: Malmo, Sweden

2017 Wallcott Oration: University of Queensland, Brisbane

2016 Annual Bennet Seminar: State of the Art Meeting in Critical Care, London

Advisory/ Guideline committees

2020 NERVTAG COVID-19: supportive care trials subgroup

2019 Roundtable meeting on global clinical research capacity Chair Anne Johnson Academy Of Medical Sciences

2019 Global Task Force for Cholera Control (GTFCC)  Case Management Working Group, New Dehli November 2019 

2018 Expert Advisor: Global Task Force for Cholera Control (GTFCC)  Case Management Working Group  11 – 12 December 2017, the Wellcome Trust, London, UK 

2018 Expert Advisor World Health Organization: Sepsis Technical Expert Meeting  Geneva, Switzerland, 16-17 January 2018 

2014 7th World Congress on Pediatric Intensive and Critical Care May 4-7, 2014, Istanbul, Turkey. Member of the International Scientific Committee in the track The Milieu.

2014 Member of the Review panel of the Institute of Global Health Innovation, Imperial College London

2013 Technical Expert Advisor, Paediatric Emergency Triage Assessment and Treatment Guidelines and Training Materials Review and Scoping Meeting, WHO Geneva March

2013 Advisory Member, Technical Group for Management of Severe and Moderate Malnutrition, International Atomic Energy Agency Bangkok May12th

2013 Acute Dialysis Quality Initiative (ADQI) consensus conference Fluid management in critical illness (Technical Group: ‘When and how to administer fluids for resuscitation’).

2012 Consensus Round Table Symposium on Fluid resuscitation Brussels March 17-19

2012 Kenya Paediatric Association meeting: Management of Shock in African Children- evidence review and guidelines Nairobi October

2011-2012 Member of Technical Review Team; author and editor of review guidelines, Technical Expert Group on Management of Severe Malaria, World Health Organization

2006-2008 Global Sepsis Initiative World Federation of Paediatric Critical Care

2007-2009 Severe Malnutrition Technical Advisory committee WHO Geneva

1999 Health Protection Agency Advisory Committee: UK guidelines for the management of

Severe malaria in children

Guideline Review Committees

• Dilaforette: Sevuparin for severe malaria: Member of Medical Advisory Board, Jan 2014

• WHO Geneva: Emergency Triage and Treatment: Management of Severe Illness in Resource-poor hospitals: Guideline review March 2013

• ADQI XII consensus building conference designed around a modified Delphi, Sept 2013

• Process: Four Phases of Fluid management: September 2013, London

• Consensus Round Table Symposium on Fluid resuscitation Brussels March 17-19 2012

• Kenya Paediatric Association Meeting: Management of Shock in African Children- review of the evidence October 2012

•

Industrial connections

2019 Cipla: Donation of Azithromycin for TABS (Severe Malaria) Trial

2017 Heyek Medical Devices: Biphasic Cuirass Ventilation (BCV) devices for Cerebral malaria trial

2017 Medicines for Malaria Venture (Dr Pierre Hugo Director MMV) donation of antimalarial drugs for SMAART (severe malaria consortium)

2017 UNICEF: donation of Ready-to-Use Therapeutic Feed for COAST Nutrition

2014 Fisher and Paykel: Donation of AVRO system (High Flow Oxygen System) for POST and COAST trials

2013 Cipla: Donation of Cotrimoxazole for TRACT Trial (Dr Hamied (Chairman and MD))

2008 Spectral Diagnostics and XOMA: Endotoxin studies

2008 Baxter, Plasma Division USA: Donation of Albumin and Saline to FEAST trial

Contributions to Industry through Teaching/Training

2014 Dilaforette: Sevuparin for severe malaria: Member of Medical Advisory Board

2008 GSK Phase III vaccine trial – review of clinical definitions, data collection and training materials fluid

Teaching materials

2020 Research England: DVD and online dissemination material TRACT trial and stakeholder meeting February 2020, Kampala, Uganda

2013 DVD dissemination material: The Anatomy of a clinical Trial: FEAST

2013 Harvard Medical School Department of Continuing Education/Boston Children’s Hospital: Open Pediatrics: The FEAST trial (webcast) October 29th 2013

2013 The Anatomy of a Clinical Trial: FEAST 30-minute DVD on the how and why clinical trials are conducted. (watch?v=GdMMuURsZQg

2006 Malaria: ‘Diagnosis in Children’ and ‘Treatment in Children’ Wellcome Trust (CD rom) Expert Advisor Wellcome Trust Publishing Group

2003 Gates e-learning course initiative: Severe Malaria Module, University of Oxford

Editorial boards

Malaria Journal

BMC Medicine

Trial Steering Committees and Data Monitoring Committee

2018 SQUEEZE Trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care (DSMB member)

2014 Parenteral artesunate compared to quinine as a cause of late post-treatment anaemia in African children with hyperparasitaemic P. falciparum malaria (DHART) DMC member

2013 Antimalarial Dose Justification and Tolerability Study of DHA-Piperaquine (Adjust) DMC member

5 Education/Qualifications

Education:

1986 MBBS, St. Bartholomew’s Hospital, University of London, UK

1989 Diploma in Child Health, London, UK

1991 MRC Paediatrics, UK

1997 Diploma of Tropical Medicine and Hygiene, London, UK

2000 PhD, University of London, UK

2015 Fellow of the Royal College of Paediatrics

2016 Fellow Academy of Medical Sciences

6 Professional History

2009 to date Professor of Paediatric Tropical Infectious Diseases

2000 to date: Based fulltime at The Wellcome Trust Unit-KEMRI, Kilifi, Kenya

2006-2009 Senior Lecturer in Tropical Paediatric Infectious Diseases, Honorary Consultant Paediatric infectious diseases, St Marys Hospital

1999-2006 Clinical Lecturer in Tropical Paediatric Infectious Diseases, St Mary Hospital, London

Honorary clinical assistant, Hospital for Tropical Diseases, London

Honorary Specialist Registrar in Microbiology, John Radcliffe, Oxford

1998-1999 Specialist Registrar in Microbiology, John Radcliffe Hospital, Oxford

1998 Specialist Registrar in Paediatrics, John Radcliffe Hospital, Oxford

1995-1998 Wellcome Trust Research Fellow, Centre for Infectious Diseases and Institute of Molecular Medicine, John Radcliffe Hospital, Oxford

1994. Clinical Scientist, Epidemiological studies in Vanuatu, S West Pacific.

1991. Senior Registrar Paediatrics Edgware General Hospital, London

1990. Paediatric Registrar, Alder-Hey Regional rotation, Liverpool

1988-1989 SHO/CMO in Paediatrics, Queen Elizabeth Children’s Hospital, London

1988. Senior House Officer: Obstetrics, Whipps Cross Hospital, London

1986 - 1987 House Surgeon, Hackney-Homerton Hospital, London

House Physician, Whipps Cross Hospital, London

7 Academic Supervision

Current PhD Supervision

Agklinta Kiosia, Exploring the effect of legume enriched feeds on gut health in undernourished children Jan 2020 Co-Supervisor

Dr Eva Nabawanuka: Role of point of care tests and biomarkers in refining the diagnosis of severe pneumonia among children and optimizing benefit of oxygen and nutritional therapy June 2019 Main Supervisor

Dr Damalie Nalwanga Assessment of the relationship between muscle and fat and survival in children suffering from pneumonia and role of nutritional supplementation June 2019 Main Supervisor

Dr Clare Wilson: Does Factor H contribute to severity of Malaria in East Africa? November 2017- Co Supervisor

Dr Fiona McQuaid: Investigation of host red blood cell receptors essential for rosetting in severe Plasmodium falciparum malaria Institute of Immunology and Infection Research University of Edinburgh Registration March 2015 Co-supervisor

Dr Nchafatso Obonyo Myocardial physiology in septic shock and response to volume expansion treatment 2015 Co-supervisor

Completed PhD Students

Kevin Walsh: Impact of gut dysfunction in appetite regulation and susceptibility to infection in African children with severe anaemia (Imperial College, London 2020) 2020 Co-supervisor

Elizabeth George The "acutely sick" African child: applying new statistical methods to delineate mortality risks and identify ways to improve management. (University College, London April 2019) Co-supervisor

Dr Peter Olupot Olupot, Uganda Burden, spectrum, complications and aetiology of severe malaria in East Uganda (Open University, 2015) Main supervisor

Dr Samuel Akech Prevalence, aetiology, and management of shock in children admitted to rural hospitals in East Africa (University of Oxford, 2011) Main supervisor

Dr Oliver Hassall Feasibility of using umbilical cord blood as a source of blood for transfusion for young children with severe anaemia (Liverpool University 2009) Co-supervisor

MSc/MRes supervision:

Dr Eulalia Farre Malnutrition: (MCS, Oxford Brook University, Oxford 2001) Main supervisor

Dr Simon Kotyar Yale Association of spleen size with clinical manifestations of severe malaria (MSC in Tropical Medicine LSTMH) 2010 Co-Supervisor

Dr Adeel Iqbal Severe anaemia, haemoglobin threshold as evidence for transfusion Global Health MSC course Oxford (2011) Co-Supervisor

Nicola Gowan: Investigation of evidence for gut barrier dysfunction and associated risk factors in children hospitalised with malnutrition in a sub-Saharan African population (2012) MRes External Supervisor

Dr Nchafatso Obonyo: Management of Paediatric Shock: physiological considerations for children with septic shock or gastroenteritis Main Supervisor

Dr Angela Aramburo Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa LSHTM Co-Supervisor

MD supervision:

Dr Bernadette Brent Cardiovascular physiology in children with acute severe malnutrition in Kenya Imperial College March 2015 Main supervisor

8 Other Collegiate Activities

Peer Reviewer: Journals

Archives of Disease in Childhood, Annuals of Tropical Medicine, British Medical Journal, BMC Medicine, BMC Paediatrics, Critical Care, Clinical Infectious Disease, Controlled Clinical Trials, European Journal of Neurology, European Journal of Nutrition, International Journal of Infectious Disease, Intensive Care Medicine, International Journal of Infectious Diseases, Journal of International Health, Journal of Infection, JAMA, The Lancet, Malaria Journal, New England Journal of Medicine, Transactions of the Royal Society of Tropical Medicine and Hygiene, Trends in Parasitology, Paediatric Infectious Disease Journal, PloS Journals (One and Medicine)

Peer review: Grant Proposals

Have reviewed grants for: NIHR, Wellcome Trust, Global Health Research Awards, Medical Research Council, Meningitis Research Foundation; EDCTP, Thrasher Foundation

Panel Member

Reviewer and Member of Expert Panel for MRC GCRF Foundation awards, London Nov 21st 2016

Reviewer and co-Chair EDCTP Mid-Career Fellowship Awards. EDCTP, The Hague 9th-11th May 2017

Review and panel Member Fellowships for Academy Medical Sciences, London March 2017

Judge on SPRINT data analysis Challenge Round New England Journal of Medicine, March 2017

PhD examination

2016 Katherine Plewes ‘"Intravascular haemolysis, oxidative stress and acute kidney injury in severe falciparum malaria"

University of Oxford, UK

2015 Lars Holst ‘Benefits and harms of red blood cell transfusions in patients with septic shock in the Intensive Care Unit’

Rigshospitalet, Blegdamsvej 9,DK- 2100 Copenhagen Ø, Denmark

2013 Josh Hanson ‘Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients with Severe Falciparum Malaria’

Charles Darwin University, Darwin, NT Australia.

9 Guest/Plenary lectures to learned Societies- last 8 years

2020

• Plenary and multiple lectures: Scottish Intensive Care Society Annual Meeting, St Andrews Jan

• Oration and multiple lectures: Critical Care Reviews, Belfast Jan

2019

Challenges in Clinical Trials in Critical Ill Hospital: Colloquium Rigshospitalet, Copenhagen

ANZICS CTG 21st Annual Meeting on Clinical Trials in Intensive Care, Noosa, Queensland, Australia

o Guest Speaker: Tract Trial Results

• 6th SG-ANZICS Asia Pacific Intensive Care Forum 2019, Singapor

o Plenary: My Life in Global Health

o Transfusion threshold for children in Africa: The TRACT trial

o GASTRO Trial: Gastroenteritis: aggressive versus slow intravenous rehydration trial

ASID Annual Scientific Meeting 2019 Darwin

o Plenary: Challenges in Critical Illness

o Severe Malaria in African Children: the need for a consortium

• Gordon Research Conference on Malaria Les Diablerets, Switzerland

o TRACT trial results

• International Blood Transfusion conference, Basal, Switzerland

o TRACT trial results

2018

• North East Intensive Care Society Spring Meeting 16th March 2018

Reflections on air & water “What we know, and what we think we know – how unexpected results can help clinical practice”.

Boston World Trade Centre: New England Journal of Medicine/ Massachusetts Medical Society

Can we control the Next Epidemic before it becomes a pandemic?

Keynote Speaker: Acquiring knowledge while saving lives. 27th April 2018

• MEDREACH conference, Glasgow

Sepsis in Children – does evidence from LMIC’s apply in the UK (13.10)

Sepsis Managements and Controversies

• Wellcome Trust/Academy of Medical Science : Exploring Good Clinical Practice Guidelines

                             

2017

• 37th International Symposium on Intensive Care and Emergency Medicine, Brussels, March 21st- 24th March Invited Speaker

o Transfusion in children - Transfusions 

o Managing the sick child in Africa – International perspectives 

o Different targets in children - How much oxygen

• Aligning Incentives for Sharing Clinical Trial Data summit, Boston, USA April 3rd-4th

Invited participant and Judge of SPRINT challenge

• Swedish Annual Paediatric meeting Gothenburg, April 23rd-25th

Plenary: FEAST trial and panel discussion.

• Academy Medical Sciences, London: Strengthening Research in LMICs co-chair of meeting 3rd-4th July

• Critical Care Meetings, Brisbane 24th-25th July

o Emergency Medicine Foundation Symposium

o Research without Boarders: plenary to Critical Care group

• 34th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine Malmo Sept

o Annual Asmund’s Laerdal Memorial Lecture: Deconstructing fluid resuscitation in African Children A forensic analysis of the FEAST trial

o Sepsis management in resource limited Africa: challenges and opportunities

• Critical Care Society of South Africa Annual Congress. Sun City October 19-22th

o Plenary: What happens after bolus therapy in children with septic shock: The Bigger Picture

o Transfusion: issues in Africa

o Is the severely malnourished heart at risk? Important considerations

• Global Health Day 2017: “The UK Contribution to Innovation in Global Health” Francis Crick Institute, London 4 December Emergency and critical care in Africa: where there is no intensive care unit

2016

• BioMalPar Heidelberg, Germany 18th -20th May

o SMAART: Severe Malaria in African children: A Research and Trials consortium

• SMACC Dublin; Ireland 15-17th June

o COAST trial: Childrens Oxygenation Strategies Trial

o Which Children in Africa should be transfused: TRACT trial

o Panel Discussion: Publishing and the future of Critical Care Knowledge Jeff Drazen(NEJM editor) Richard Smith (ex BMJ editor) Kathy Rowan, John Myburgh, Rob Mac Sweeney Sara Bassin, Kath Maitland Chair: Simon Finfer

• 21st International HIV conference Durban 18th-22nd July 2016

• 34th International Congress of the ISBT, Dubai, Sept 2016

o Plenary: Transfusion and Treatment of severe anaemia in African children: a randomised trial  

• Oxford Tropical Network Meeting Sept 2016 : Plenary: Severe Malaria

• World Sepsis Conference Sept 2016: Sepsis in Africa

• MSF international Paediatric Day Sept 23rd Chancery Lane London : invited speaker

• ICS State of the ART 2016 meeting, 5-7th December 2016, ExCeL London. Invited Speaker

o Annual Bennet Seminar: Tropical Tales from the Front Line

o Challenges for Oxygen Therapy The paediatric COAST trial

o Africa: challenges and opportunities: Sepsis in resource poor settings

• 2015

UCT-Imperial Global Health Fellows, Summer School, Cape Town, SA January 29th-30th

• Panel - Global Health: Themes, trends and opportunities –

• My life in Global Health

Oxford Tropical Network Conference 2015, Siem Reap, Cambodia March 9th-11th

• Plenary: Management of Severe Malaria in African Children

ISN World Nephrology Conference Cape Town March 13th -17th

• “Fluid management in acute sepsis” : The kidney in children with critical illness in the developing world

• Fluid and Electrolytes management: paediatrics CPD event

SMACC Chicago 2015; USA 23-26th June

• Fluids and Kids: What Now?

• Cage Match: All Non-Cardiac PICU's Should Close (Pro Con debate)

• Q&A: Paediatrics Controversies

• Malaria : BEAT THE BUGS

Canadian Critical Care Conference Toronto, 26th-28th October

• Fluids: what now?

• Severe malaria: management in resource limited setting

• Issues for transfusion in Africa

2014

Invited Speaker: FEAST trial and management of shock: Ho Chi Minn, Vietnam Intensive Care meeting

Invited Speaker 7th World Congress on Pediatric Intensive and Critical Care May 4-7, 2014, Istanbul

• Fluid boluses-evidence from research

• ICU without ventilators

ASTMH 3-6th November New Orleans

• Plenary: FEAST Trial

• Renal injury in malaria symposium: Malaria and its consequences

• Myocardial function in severe malnutrition

• 14th Annual Education day in Paediatric Anaesthesia St Bartholomews Hospital 18th November

• Invited Speaker FEAST and beyond: insights into mechanisms for poor outcome

2013

• Evidence Live: ‘High Quality Trials in African Children’ Oxford March 2013 Hosted by Centre for Evidence-Based Medicine, The BMJ

• ‘Severe acute and moderate malnutrition in South-East Asia’ (jointly with the International Malnutrition Task Force; IMTF) Technical Meeting; Guest Lecture.

• Plenary: The FEAST trial Association of Anaesthetists of Great Britain & Ireland, Dublin Sept 2013

• Invited Speaker: High quality African trials in emergency care: inform evidence-based, rather than eminence-based, management practice International Primary Care Research Leadership Programme, Worcester College, Oxford 2012

• Keynote Debate: EMSSA 2013 Conference, Cape Town, South Africa: ‘Do fluids kill children’

2012

• Winter Symposium Perioperative Care and Outcome : role of the anesthetist, intensivist and
emergency physician. Leuven, Belgium February 2012

• International Symposium of Intensive Care and Emergency Medicine (ESICM) Brussels March 2012

• MSF expert meeting of fluid management of Pediatric Shock Brussels, 5th March 2012

• Keynote: Annual Conference Royal College of Paediatrics and Child Health Glasgow 22-24 May 2012

• Guest Lecture East African DTMH Moshi 14th Sept 2012: Management of shock and The FEAST trial

• International Keynote Speaker Australian and New Zealand Intensive Care Societies (ANZICS) Adelaide October 25th-27th 2012

o Consent in Vulnerable populations

o FEAST trial

o Managing Sepsis in Resource Poor Settings

o More than just wet: why fluids may harm

• Guest Speaker: FEAST trial Paediatric Anaesthesia Meeting, St Barts Hospital London Nov 2012

• Plenary: FEAST trial TRANSFUSION meeting; Royal College of Pathologists Nov 2012

2011

• Invited Speaker: FEAST trial _ ANZICS annual Meeting; Noosa March 2011

• International Meeting of the World Federation of Pediatric Intensive and Critical Care Societies Sydney March 2011

o Intravenous Fluids – where are we? (Plenary)

o Sepsis in children in Africa (Plenary)

o Severe malnutrition: therapeutic Challenges (Plenary)

• Invited Speaker: Transfusion priorities for African Children: British Society of Haematology Annual Meeting Brighton, April 4-6th 2011.

• Invited Speaker: Public Engagement and Clinical Trials:  New  Models and  Disruptive  Technologies Mount  Sinai  School  Of  Medicine,  New  York, June  27­28th, 2011  

• Invited Speaker: Evidence Based Perioperative Medicine World Congress ‘The Great Fluid Debate’ The Institute of Education, London July 5th 2011

• How do we treat severe malaria? Hot Topics In Infectious Disease, Oxford July 14th 2011

• Plenary: Management of children with severe malnutrition CAPGAN London, July 21st 2011

• Kenya National Malaria Forum, Nairobi Kenya October 2011

• European Society of Intensive Care Medicine (ESICM) Annual Congress Berlin Oct 2011

o FEAST trial

o Management of Sepsis in Critical Sick Children in Africa

• Invited Guest Speaker FEAST Trial: Annual Meeting of the Dutch Paediatric Society, Veldhoven, The Netherland Nov 2011

• Management of Infection in Intensive Care, London 2nd November 2011

10 All Publications

Book Chapters

Blood transfusion in resource-limited settings O. Hassel, I Bates and K Maitland; Hunters Tropical Medicine 9th Edition Magill – Maguire – Ryan – Solomon; 2011

Life-threatening tropical infections K Maitland, B Wills Infectious Diseases in the Pediatric Intensive Care Unit Edited by Simon Nadel & Brett Giroir, Springer London

Malaria Kathryn Maitland, Charles Newton, Rakel and Bope Conns Current Therapy, 2002 W. B Saunders

Papers Published[1-189]

1. Walker SM, Cox E, Revill P, Musiime V, Bwakura-Dangarembizi M, Mallewa J, Cheruiyot P, Maitland K, Ford N, Gibb DM et al: The cost-effectiveness of prophylaxis strategies for individuals with advanced HIV starting treatment in Africa. Journal of the International AIDS Society 2020, 23(3):e25469.

2. Uyoga S, Wanjiku P, Rop JC, Makale J, Macharia AW, Nyutu GM, Shebe M, Awuondo KA, Mturi N, Woodrow CJ et al: Plasma Plasmodium falciparum Histidine-Rich Protein-2 concentrations in children with malaria infections of differing severity in Kilifi, Kenya. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020.

3. Olupot-Olupot P, Wabwire H, Ndila C, Adong R, Ochen L, Amorut D, Abongo G, Okalebo CB, Akello SR, Oketcho JB et al: Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda. Wellcome Open Res 2020, 5:87.

4. Jobarteh ML, McCrory MA, Lo B, Sun M, Sazonov E, Anderson AK, Jia W, Maitland K, Qiu J, Steiner-Asiedu M et al: Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study Protocol. Curr Dev Nutr 2020, 4(2):nzaa020.

5. Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A et al: Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med 2020.

6. Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A et al: Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Critical care medicine 2020.

7. Uyoga S, Mpoya A, Olupot-Olupot P, Kiguli S, Opoka RO, Engoru C, Mallewa M, Kennedy N, M'Baya B, Kyeyune D et al: Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa. Vox sanguinis 2019, 114(4):340-348.

8. Uyoga S, Maitland K: Use of whole blood as the routine transfusion product in Africa. ISBT Science Series 2019.

9. Uyoga S, Macharia AW, Ndila CM, Nyutu G, Shebe M, Awuondo KO, Mturi N, Peshu N, Tsofa B, Scott JAG et al: The indirect health effects of malaria estimated from health advantages of the sickle cell trait. Nat Commun 2019, 10(1):856.

10. Uyoga S, Macharia AW, Mochamah G, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Otiende M et al: The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study. Lancet Glob Health 2019, 7(10):e1458-e1466.

11. Talbert A, Ngari M, Bauni E, Mwangome M, Mturi N, Otiende M, Maitland K, Walson J, Berkley JA: Mortality after inpatient treatment for diarrhea in children: a cohort study. BMC Med 2019, 17(1):20.

12. Silaba M, Ooko M, Bottomley C, Sande J, Benamore R, Park K, Ignas J, Maitland K, Mturi N, Makumi A et al: Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis. Lancet Glob Health 2019, 7(3):e337-e346.

13. Passmore MR, Obonyo NG, Byrne L, Boon AC, Diab SD, Dunster KR, Fung YL, Spanevello MM, Fauzi MH, Pedersen SE et al: Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock. Thromb Res 2019, 176:39-45.

14. Obonyo NG, Byrne L, Tung JP, Simonova G, Diab SD, Dunster KR, Passmore MR, Boon AC, See Hoe L, Engkilde-Pedersen S et al: Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX 2019, 6:1124-1132.

15. Njuguna P, Maitland K, Nyaguara A, Mwanga D, Mogeni P, Mturi N, Mohammed S, Mwambingu G, Ngetsa C, Awuondo K et al: Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya. BMC Med 2019, 17(1):124.

16. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J et al: Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial. Lancet Glob Health 2019, 7(10):e1435-e1447.

17. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Engoru C, Nteziyaremye J, Mallewa M et al: Transfusion Volume for Children with Severe Anemia in Africa. The New England journal of medicine 2019, 381(5):420-431.

18. Maitland K, Ohuma EO, Mpoya A, Uyoga S, Hassall O, Williams TN: Informing thresholds for paediatric transfusion in Africa: the need for a trial. Wellcome Open Research 2019, 4.

19. Maitland K, Kiguli S, Olupot-Olupot P, Engoru C, Mallewa M, Saramago Goncalves P, Opoka RO, Mpoya A, Alaroker F, Nteziyaremye J et al: Immediate Transfusion in African Children with Uncomplicated Severe Anemia. The New England journal of medicine 2019, 381(5):407-419.

20. Maitland K, Gibb DM, Babiker A, team Ft: Secondary re-analysis of the FEAST trial. Lancet Respir Med 2019, 7(10):e29.

21. Maitland K: Emergency fluid bolus therapy studies: first do no harm. Archives of disease in childhood 2019, 104(5):409-410.

22. Houston KA, Gibb J, Olupot-Olupot P, Obonyo N, Mpoya A, Nakuya M, Muhindo R, Uyoga S, Evans JA, Connon R et al: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration. BMC Med 2019, 17(1):122.

23. George EC, Kiguli S, Olupot PO, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Mpoya A, Thomason MJ et al: Mortality risk over time after early fluid resuscitation in African children. Crit Care 2019, 23(1):377.

24. Dauncey JW, Olupot-Olupot P, Maitland K: Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative study. BMC health services research 2019, 19(1):335.

25. Brent B, Obonyo N, Akech S, Shebbe M, Mpoya A, Mturi N, Berkley JA, Tulloh RMR, Maitland K: Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study. JAMA Netw Open 2019, 2(3):e191054.

26. Walsh K, Calder N, Olupot-Olupot P, Ssenyondo T, Okiror W, Okalebo CB, Muhindo R, Mpoya A, Holmes E, Marchesi J et al: Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial. Wellcome Open Res 2018, 3:95.

27. Taylor WR, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J et al: Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa. BMC Med 2018, 16(1):11.

28. Siika A, McCabe L, Bwakura-Dangarembizi M, Kityo C, Mallewa J, Berkley J, Maitland K, Griffiths A, Baleeta K, Mudzingwa S et al: Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018, 66(suppl_2):S140-S146.

29. Post FA, Szubert AJ, Prendergast AJ, Johnston V, Lyall H, Fitzgerald F, Musiime V, Musoro G, Chepkorir P, Agutu C et al: Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018, 66(suppl_2):S132-S139.

30. Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA et al: Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia. Elife 2018, 7.

31. Ominde M, Sande J, Ooko M, Bottomley C, Benamore R, Park K, Ignas J, Maitland K, Bwanaali T, Gleeson F et al: Reliability and validity of the World Health Organization reading standards for paediatric chest radiographs used in the field in an impact study of Pneumococcal Conjugate Vaccine in Kilifi, Kenya. PloS one 2018, 13(7):e0200715.

32. Olupot-Olupot P, Prevatt N, Engoru C, Nteziyaremye J, Amorut D, Chebet M, Senyondo T, Ongodia P, Ndila CM, Williams TN et al: Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda. Wellcome Open Res 2018, 3:130.

33. Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B et al: Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol 2018, 5(8):e333-e345.

34. Mallewa J, Szubert AJ, Mugyenyi P, Chidziva E, Thomason MJ, Chepkorir P, Abongomera G, Baleeta K, Etyang A, Warambwa C et al: Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial. Lancet HIV 2018, 5(5):e231-e240.

35. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et al: Children’s Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Research 2018, 2:100.

36. Macharia AW, Mochamah G, Uyoga S, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Shebe M et al: The clinical epidemiology of sickle cell anemia In Africa. Am J Hematol 2018, 93(3):363-370.

37. Lipson M, Skoglund P, Spriggs M, Valentin F, Bedford S, Shing R, Buckley H, Phillip I, Ward GK, Mallick S et al: Population Turnover in Remote Oceania Shortly after Initial Settlement. Curr Biol 2018, 28(7):1157-1165 e1157.

38. Kotlyar S, Olupot-Olupot P, Nteziyaremye J, Akech SO, Uyoga S, Muhindo R, Moore CL, Maitland K: Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018, 19(3):179-185.

39. Kityo C, Szubert AJ, Siika A, Heyderman R, Bwakura-Dangarembizi M, Lugemwa A, Mwaringa S, Griffiths A, Nkanya I, Kabahenda S et al: Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial. PLoS medicine 2018, 15(12):e1002706.

40. Iro MA, Sell T, Brown N, Maitland K: Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysis. BMC pediatrics 2018, 18(1):44.

41. Houston KA, George EC, Maitland K: Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial. Crit Care 2018, 22(1):119.

42. Byrne L, Obonyo NG, Diab SD, Dunster KR, Passmore MR, Boon AC, See Hoe L, Pedersen S, Hashairi Fauzi M, Pretti Pimenta L et al: Unintended Consequences; Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia. American journal of respiratory and critical care medicine 2018.

43. Byrne L, Obonyo NG, Diab S, Dunster K, Passmore M, Boon AC, Hoe LS, Hay K, Van Haren F, Tung JP et al: An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism. Shock 2018, 49(1):99-107.

44. Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G et al: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa. BMC Med 2018, 16(1):37.

45. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et al: High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946.

46. Obonyo N, Brent B, Olupot-Olupot P, Boele van Hensbroek M, Kuipers I, Wong S, Shiino K, Chan J, Fraser J, van Woensel JBM et al: Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study). Crit Care 2017, 21(1):103.

47. Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC et al: Gender Parity in Critical Care Medicine. American journal of respiratory and critical care medicine 2017, 196(4):425-429.

48. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et al: Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Res 2017, 2:100.

49. Houston KA, Gibb JG, Mpoya A, Obonyo N, Olupot-Olupot P, Nakuya M, Evans JA, George EC, Gibb DM, Maitland K: Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration. Wellcome Open Res 2017, 2(62):62.

50. Houston KA, Gibb JG, Maitland K: Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review. Wellcome Open Res 2017, 2:66.

51. Houston KA, Gibb JG, Maitland K: Intravenous rehydration of malnourished children with acute gastroenteritis and severe dehydration: A systematic review. Wellcome Open Res 2017, 2(65):65.

52. Hakim J, Musiime V, Szubert AJ, Mallewa J, Siika A, Agutu C, Walker S, Pett SL, Bwakura-Dangarembizi M, Lugemwa A et al: Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa. The New England journal of medicine 2017, 377(3):233-245.

53. Obonyo NG, Fanning JP, Ng AS, Pimenta LP, Shekar K, Platts DG, Maitland K, Fraser JF: Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Med Exp 2016, 4(1):38.

54. Nightingale H, Walsh KJ, Olupot-Olupot P, Engoru C, Ssenyondo T, Nteziyaremye J, Amorut D, Nakuya M, Arimi M, Frost G et al: Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment. BMC Nutr 2016, 2.

55. Nabwera HM, Fegan G, Shavadia J, Denje D, Mandaliya K, Bates I, Maitland K, Hassall OW: Pediatric blood transfusion practices at a regional referral hospital in Kenya. Transfusion 2016.

56. Maitland K: Severe Malaria in African Children - The Need for Continuing Investment. The New England journal of medicine 2016, 375(25):2416-2417.

57. Church JA, Nyamako L, Olupot-Olupot P, Maitland K, Urban BC: Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury. Malaria journal 2016, 15(1):54.

58. Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B et al: Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial. Trials 2015, 16(1):593.

59. Maitland K: Management of severe paediatric malaria in resource-limited settings. BMC Med 2015, 13(1):42.

60. Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness. BMC Med 2015, 13(1):21.

61. Hassall OW, Thitiri J, Fegan G, Hamid F, Mwarumba S, Denje D, Wambua K, Mandaliya K, Maitland K, Bates I: Safety and efficacy of allogeneic umbilical cord red blood cell transfusion for children with severe anaemia in a Kenyan hospital: an open-label single-arm trial. The Lancet Haematology 2015, 2(3):e101-e107.

62. George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score. BMC Med 2015, 13(1):174.

63. Brent B: Cardiovascular physiology in children with acute severe malnutrition in Kenya London: Imperial College; 2015.

64. Olupot-Olupot P, Engoru C, Thompson J, Nteziyaremye J, Chebet M, Ssenyondo T, Dambisya CM, Okuuny V, Wokulira R, Amorut D et al: Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia. BMC Med 2014, 12(1):67.

65. Obonyo N, Maitland K: Fluid management of shock in severe malnutrition: what is the evidence for current guidelines and what lessons have been learned from clinical studies and trials in other pediatric populations? Food and nutrition bulletin 2014, 35(2 Suppl):S71-78.

66. Maitland K: New diagnostics for common childhood infections. The New England journal of medicine 2014, 370(9):875-877.

67. Madan J, Ades AE, Price M, Maitland K, Jemutai J, Revill P, Welton NJ: Strategies for efficient computation of the expected value of partial perfect information. Medical decision making : an international journal of the Society for Medical Decision Making 2014, 34(3):327-342.

68. Kotlyar S, Nteziyaremye J, Olupot-Olupot P, Akech SO, Moore CL, Maitland K: Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children. Transactions of the Royal Society of Tropical Medicine and Hygiene 2014, 108(5):283-289.

69. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: Authors' reply to Southall. BMJ 2014, 348:g1619.

70. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ 2014, 348:f7003.

71. Hoste EA, Maitland K, Brudney CS, Mehta R, Vincent JL, Yates D, Kellum JA, Mythen MG, Shaw AD, Group AXI: Four phases of intravenous fluid therapy: a conceptual model. British journal of anaesthesia 2014, 113(5):740-747.

72. Church J, Maitland K: Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review. BMC Med 2014, 12:31.

73. Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS et al: Diagnosis of childhood tuberculosis and host RNA expression in Africa. The New England journal of medicine 2014, 370(18):1712-1723.

74. Severe malaria. Tropical medicine & international health : TM & IH 2014, 19 Suppl 1:7-131.

75. Todd J, Heyderman RS, Musoke P, Peto T: When enough is enough: how the decision was made to stop the FEAST trial: data and safety monitoring in an African trial of Fluid Expansion As Supportive Therapy (FEAST) for critically ill children. Trials 2013, 14:85.

76. Olupot-Olupot P, Urban BC, Jemutai J, Nteziyaremye J, Fanjo HM, Karanja H, Karisa J, Ongodia P, Bwonyo P, Gitau EN et al: Endotoxaemia is common in children with Plasmodium falciparum malaria. BMC infectious diseases 2013, 13:117.

77. Olupot-Olupot P, Maitland K: Management of severe malaria: results from recent trials. Advances in experimental medicine and biology 2013, 764:241-250.

78. Molyneux S, Njue M, Boga M, Akello L, Olupot-Olupot P, Engoru C, Kiguli S, Maitland K: 'The words will pass with the blowing wind': staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals. PloS one 2013, 8(2):e54894.

79. Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G et al: Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med 2013, 11:68.

80. Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD: Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 2013, 79(17):5112-5120.

81. von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, Nguah SB, Bojang K, Deen JL, Evans J et al: Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012, 54(8):1080-1090.

82. Talbert A, Thuo N, Karisa J, Chesaro C, Ohuma E, Ignas J, Berkley JA, Toromo C, Atkinson S, Maitland K: Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome. PloS one 2012, 7(6):e38321.

83. Ramutton T, Hendriksen IC, Mwanga-Amumpaire J, Mtove G, Olaosebikan R, Tshefu AK, Onyamboko MA, Karema C, Maitland K, Gomes E et al: Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria. Malaria journal 2012, 11:276.

84. Maitland K, Babiker A, Kiguli S, Molyneux E: The FEAST trial of fluid bolus in African children with severe infection. Lancet 2012, 379(9816):613; author reply 613-614.

85. Hendriksen IC, Mwanga-Amumpaire J, von Seidlein L, Mtove G, White LJ, Olaosebikan R, Lee SJ, Tshefu AK, Woodrow C, Amos B et al: Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement. PLoS medicine 2012, 9(8):e1001297.

86. Hassall OW, Thitiri J, Fegan G, Pole L, Mwarumba S, Denje D, Wambua K, Lowe B, Parry CM, Mandaliya K et al: The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya. Transfusion 2012, 52(7):1542-1551.

87. Brent B, Obonyo N, Maitland K: Tailoring management of severe and complicated malnutrition: more research is required first. Pathogens and global health 2012, 106(4):197-199.

88. Ala F, Allain JP, Bates I, Boukef K, Boulton F, Brandful J, Dax EM, El Ekiaby M, Farrugia A, Gorlin J et al: External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection. PLoS medicine 2012, 9(9):e1001309.

89. Akech S: Prevalence, aetiology, and management of shock in children admitted to rural hospitals in East Africa. Oxford: University of Oxford; 2012.

90. Thuo N, Ungphakorn W, Karisa J, Muchohi S, Muturi A, Kokwaro G, Thomson AH, Maitland K: Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation. The Journal of antimicrobial chemotherapy 2011, 66(10):2336-2345.

91. Muchohi SN, Thuo N, Karisa J, Muturi A, Kokwaro GO, Maitland K: Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition. Journal of chromatography B, Analytical technologies in the biomedical and life sciences 2011, 879(2):146-152.

92. Moisi JC, Gatakaa H, Berkley JA, Maitland K, Mturi N, Newton CR, Njuguna P, Nokes J, Ojal J, Bauni E et al: Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis. Bulletin of the World Health Organization 2011, 89(10):725-732, 732A.

93. Mogeni P, Twahir H, Bandika V, Mwalekwa L, Thitiri J, Ngari M, Toromo C, Maitland K, Berkley JA: Diagnostic performance of visible severe wasting for identifying severe acute malnutrition in children admitted to hospital in Kenya. Bulletin of the World Health Organization 2011, 89(12):900-906.

94. Maitland K, Molyneux S, Boga M, Kiguli S, Lang T: Use of deferred consent for severely ill children in a multi-centre phase III trial. Trials 2011, 12:90.

95. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T et al: Mortality after fluid bolus in African children with severe infection. The New England journal of medicine 2011, 364(26):2483-2495.

96. Maitland K, Akech SO, Russell EC: Mortality after Fluid Bolus in African Children with Sepsis: Reply. The New England journal of medicine 2011, 365(14):1348-1353.

97. Maitland K: Imaging in severe malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2011, 12(2):237-238.

98. Lubell Y, Staedke SG, Greenwood BM, Kamya MR, Molyneux M, Newton PN, Reyburn H, Snow RW, D'Alessandro U, English M et al: Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey. PloS one 2011, 6(2):e17439.

99. Abubakar A, Holding P, Mwangome M, Maitland K: Maternal perceptions of factors contributing to severe under-nutrition among children in a rural African setting. Rural and remote health 2011, 11:1423.

100. Yacoub S, Lang HJ, Shebbe M, Timbwa M, Ohuma E, Tulloh R, Maitland K: Cardiac function and hemodynamics in Kenyan children with severe malaria. Critical care medicine 2010, 38(3):940-945.

101. Thuo N, Ohuma E, Karisa J, Talbert A, Berkley JA, Maitland K: The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition. Archives of disease in childhood 2010, 95(6):422-426.

102. Pedro R, Akech S, Fegan G, Maitland K: Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya. Malaria journal 2010, 9:307.

103. Ogetii GN, Akech S, Jemutai J, Boga M, Kivaya E, Fegan G, Maitland K: Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage. BMC infectious diseases 2010, 10:334.

104. Maitland K: Antimicrobials in children admitted to hospital in malaria endemic areas. BMJ 2010, 340:c1818.

105. Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC et al: CISH and susceptibility to infectious diseases. The New England journal of medicine 2010, 362(22):2092-2101.

106. Idro R, Gwer S, Williams TN, Otieno T, Uyoga S, Fegan G, Kager PA, Maitland K, Kirkham F, Neville BG et al: Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis. PloS one 2010, 5(11):e14001.

107. Hassall O, Maitland K, Fegan G, Thitiri J, Pole L, Mwakesi R, Denje D, Wambua K, Mandaliya K, Bates I: The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya. Transfusion 2010, 50(3):611-616.

108. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K et al: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010, 376(9753):1647-1657.

109. Akech SO, Karisa J, Nakamya P, Boga M, Maitland K: Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia. BMC pediatrics 2010, 10:71.

110. Akech SO, Jemutai J, Timbwa M, Kivaya E, Boga M, Fegan G, Maitland K: Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria. Critical care medicine 2010, 38(8):1630-1636.

111. Akech S, Ledermann H, Maitland K: Choice of fluids for resuscitation in children with severe infection and shock: systematic review. BMJ 2010, 341:c4416.

112. Talbert A, Atkinson S, Karisa J, Ignas J, Chesaro C, Maitland K: Hypothermia in children with severe malnutrition: low prevalence on the tropical coast of Kenya. Journal of tropical pediatrics 2009, 55(6):413-416.

113. Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ et al: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009, 75(23):7537-7541.

114. Olotu A, Ndiritu M, Ismael M, Mohammed S, Mithwani S, Maitland K, Newton CR: Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children. Resuscitation 2009, 80(1):69-72.

115. Mwaniki MK, Nokes DJ, Ignas J, Munywoki P, Ngama M, Newton CR, Maitland K, Berkley JA: Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study. Bulletin of the World Health Organization 2009, 87(4):263-270.

116. Maitland K: Joint BAPEN and Nutrition Society Symposium on 'Feeding size 0: the science of starvation'. Severe malnutrition: therapeutic challenges and treatment of hypovolaemic shock. The Proceedings of the Nutrition Society 2009, 68(3):274-280.

117. Hassall O, Maitland K, Pole L, Mwarumba S, Denje D, Wambua K, Lowe B, Parry C, Mandaliya K, Bates I: Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital. Transfusion 2009, 49(12):2594-2598.

118. Berkley JA, Bejon P, Mwangi T, Gwer S, Maitland K, Williams TN, Mohammed S, Osier F, Kinyanjui S, Fegan G et al: HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009, 49(3):336-343.

119. Audran R, Lurati-Ruiz F, Genton B, Blythman HE, Ofori-Anyinam O, Reymond C, Corradin G, Spertini F: The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial. PloS one 2009, 4(10):e7304.

120. Nokes DJ, Abwao J, Pamba A, Peenze I, Dewar J, Maghenda JK, Gatakaa H, Bauni E, Scott JA, Maitland K et al: Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS medicine 2008, 5(7):e153.

121. Idro R, Williams TN, Gwer S, Uyoga S, Macharia A, Opi H, Atkinson S, Maitland K, Kager PA, Kwiatkowski D et al: Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area. Epilepsy research 2008, 81(2-3):114-118.

122. Idro R, Gwer S, Kahindi M, Gatakaa H, Kazungu T, Ndiritu M, Maitland K, Neville BG, Kager PA, Newton CR: The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital. BMC pediatrics 2008, 8:5.

123. Heikens GT, Bunn J, Amadi B, Manary M, Chhagan M, Berkley JA, Rollins N, Kelly P, Adamczick C, Maitland K et al: Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. Lancet 2008, 371(9620):1305-1307.

124. Hassall O, Ngina L, Kongo W, Othigo J, Mandaliya K, Maitland K, Bates I: The acceptability to women in Mombasa, Kenya, of the donation and transfusion of umbilical cord blood for severe anaemia in young children. Vox sanguinis 2008, 94(2):125-131.

125. Bejon P, Mohammed S, Mwangi I, Atkinson SH, Osier F, Peshu N, Newton CR, Maitland K, Berkley JA: Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya. The American journal of clinical nutrition 2008, 88(6):1626-1631.

126. Akech SO, Hassall O, Pamba A, Idro R, Williams TN, Newton CR, Maitland K: Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya. Malaria journal 2008, 7:256.

127. Seaton C, Ignas J, Muchohi S, Kokwaro G, Maitland K, Thomson AH: Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition. The Journal of antimicrobial chemotherapy 2007, 59(4):681-689.

128. Maitland K, Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Levin M, Newton CR: Phase III trials required to resolve clinical equipoise over optimal fluid management in children with severe malaria. PLoS clinical trials 2007, 2(2):e2.

129. Khor CC, Vannberg FO, Chapman SJ, Walley A, Aucan C, Loke H, White NJ, Peto T, Khor LK, Kwiatkowski D et al: Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus. Genes and immunity 2007, 8(7):570-576.

130. Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A et al: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature genetics 2007, 39(4):523-528.

131. Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, Crawley J, Fegan G, Bauni E, Peshu N et al: Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children. JAMA : the journal of the American Medical Association 2007, 297(20):2232-2240.

132. Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS et al: Defining childhood severe falciparum malaria for intervention studies. PLoS medicine 2007, 4(8):e251.

133. Maitland K, Berkley JA, Shebbe M, Peshu N, English M, Newton CR: Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS medicine 2006, 3(12):e500.

134. Maitland K: How do we treat children with severe malaria? Advances in experimental medicine and biology 2006, 582:9-21.

135. Maitland K: Severe malaria: lessons learned from the management of critical illness in children. Trends in parasitology 2006, 22(10):457-462.

136. Idro R, Aketch S, Gwer S, Newton CR, Maitland K: Research priorities in the management of severe Plasmodium falciparum malaria in children. Annals of tropical medicine and parasitology 2006, 100(2):95-108.

137. Casals-Pascual C, Kai O, Lowe B, English M, Williams TN, Maitland K, Newton CR, Peshu N, Roberts DJ: Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. Malaria journal 2006, 5:101.

138. Casals-Pascual C, Kai O, Cheung JO, Williams S, Lowe B, Nyanoti M, Williams TN, Maitland K, Molyneux M, Newton CR et al: Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood 2006, 108(8):2569-2577.

139. Bates I, Maitland K: Are laboratory services coming of age in sub-Saharan Africa? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006, 42(3):383-384.

140. Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Newton CR, Levin M, Maitland K: Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS clinical trials 2006, 1(5):e21.

141. Williams TN, Wambua S, Uyoga S, Macharia A, Mwacharo JK, Newton CR, Maitland K: Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 2005, 106(1):368-371.

142. Scott JA, Mwarumba S, Ngetsa C, Njenga S, Lowe BS, Slack MP, Berkley JA, Mwangi I, Maitland K, English M et al: Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002. Antimicrobial agents and chemotherapy 2005, 49(7):3021-3024.

143. Molyneux EM, Maitland K: Intravenous fluids--getting the balance right. The New England journal of medicine 2005, 353(9):941-944.

144. Maitland K, Pamba A, Fegan G, Njuguna P, Nadel S, Newton CR, Lowe B: Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005, 40(1):9-16.

145. Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, Levin M: Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005, 40(4):538-545.

146. Maitland K, Pamba A, English M, Peshu N, Levin M, Marsh K, Newton CR: Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion. British journal of haematology 2005, 128(3):393-400.

147. Maitland K, Newton CR: Acidosis of severe falciparum malaria: heading for a shock? Trends in parasitology 2005, 21(1):11-16.

148. Maitland K, Newton C, Marsh K, Levin M: Volume status in severe malaria: no evidence provided for the degree of filling of the intravascular compartment. PLoS medicine 2005, 2(1):e27; author reply e32.

149. Maitland K, Nadel S, Pollard AJ, Williams TN, Newton CR, Levin M: Management of severe malaria in children: proposed guidelines for the United Kingdom. BMJ 2005, 331(7512):337-343.

150. Idro R, Otieno G, White S, Kahindi A, Fegan G, Ogutu B, Mithwani S, Maitland K, Neville BG, Newton CR: Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria. Malaria journal 2005, 4:57.

151. Berkley JA, Maitland K, Mwangi I, Ngetsa C, Mwarumba S, Lowe BS, Newton CR, Marsh K, Scott JA, English M: Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. BMJ 2005, 330(7498):995.

152. Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA et al: Bacteremia among children admitted to a rural hospital in Kenya. The New England journal of medicine 2005, 352(1):39-47.

153. Berkley J, Mwangi I, Griffiths K, Ahmed I, Mithwani S, English M, Newton C, Maitland K: Assessment of severe malnutrition among hospitalized children in rural Kenya: comparison of weight for height and mid upper arm circumference. JAMA : the journal of the American Medical Association 2005, 294(5):591-597.

154. Bejon P, Mwangi I, Ngetsa C, Mwarumba S, Berkley JA, Lowe BS, Maitland K, Marsh K, English M, Scott JA: Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya. The Journal of antimicrobial chemotherapy 2005, 56(1):232-235.

155. Pamba A, Maitland K: Fluid management of severe falciparum malaria in African children. Tropical doctor 2004, 34(2):67-70.

156. Pamba A, Maitland K: Capillary refill: prognostic value in Kenyan children. Archives of disease in childhood 2004, 89(10):950-955.

157. Otieno H, Were E, Ahmed I, Charo E, Brent A, Maitland K: Are bedside features of shock reproducible between different observers? Archives of disease in childhood 2004, 89(10):977-979.

158. Musumba CO, Pamba AO, Sasi PA, English M, Maitland K: Salicylate poisoning in children: report of three cases. East African medical journal 2004, 81(3):159-163.

159. Maitland K, Pamba A, Newton CR, Lowe B, Levin M: Hypokalemia in children with severe falciparum malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004, 5(1):81-85.

160. Maitland K, Newton C, English M: Intravenous fluids for seriously ill children. Lancet 2004, 363(9404):242-243.

161. Maitland K, Molyneux M: Malaria. Advances in experimental medicine and biology 2004, 549:125-134.

162. Maitland K, Marsh K: Pathophysiology of severe malaria in children. Acta tropica 2004, 90(2):131-140.

163. Maitland K, Makanga M, Williams TN: Falciparum malaria: current therapeutic challenges. Current opinion in infectious diseases 2004, 17(5):405-412.

164. Maitland K, Bunce M, Harding RM, Barnardo MC, Clegg JB, Welsh K, Bowden DK, Williams TN: HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia. Tissue antigens 2004, 64(6):678-686.

165. Berkley JA, Brent A, Mwangi I, English M, Maitland K, Marsh K, Peshu N, Newton CR: Mortality among Kenyan children admitted to a rural district hospital on weekends as compared with weekdays. Pediatrics 2004, 114(6):1737-1738; author reply 1738.

166. Maitland K, Pamba A, Newton CR, Levin M: Response to volume resuscitation in children with severe malaria. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003, 4(4):426-431.

167. Maitland K, Levin M, English M, Mithwani S, Peshu N, Marsh K, Newton CR: Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia. QJM : monthly journal of the Association of Physicians 2003, 96(6):427-434.

168. Maitland K, Bejon P, Newton CR: Malaria. Current opinion in infectious diseases 2003, 16(5):389-395.

169. Goodman A, Williams TN, Maitland K: Ciguatera poisoning in Vanuatu. The American journal of tropical medicine and hygiene 2003, 68(2):263-266.

170. Maitland K, Kyes S, Williams TN, Newbold CI: Genetic restriction of Plasmodium falciparum in an area of stable transmission: an example of island evolution? Parasitology 2000, 120 ( Pt 4):335-343.

171. Maitland K: Temporal association of chickenpox and meningococcal disease in children: a report of three cases. Acta Paediatr 2000, 89(6):744-745.

172. Williams TN, Maitland K, Rees DC, Peto TE, Bowden DK, Weatherall DJ, Clegg JB: Reduced soluble transferrin receptor concentrations in acute malaria in Vanuatu. The American journal of tropical medicine and hygiene 1999, 60(5):875-878.

173. Williams TN, Maitland K: Reply from williams and maitland. Parasitol Today 1999, 15(4):167-168.

174. Williams TN, Maitland K, Martin PM, Weatherall DJ, Clegg JB: Splenic size in homozygous alpha+ thalassaemia. British journal of haematology 1998, 100(3):611-612.

175. Rees DC, Williams TN, Maitland K, Clegg JB, Weatherall DJ: Alpha thalassaemia is associated with increased soluble transferrin receptor levels. British journal of haematology 1998, 103(2):365-369.

176. Maitland K, Williams TN: Malaria mortality: the pacific enigma. Parasitol Today 1998, 14(7):258-259.

177. Maitland K, Williams T: Reply. Parasitol Today 1998, 14(7):293.

178. Barnardo MC, Welsh KI, Vilches C, Maitland K, Bunce M: Allele-specific HLA-B*15 typing by PCR-SSP and its application to four distinct ethnic populations. Tissue antigens 1998, 51(3):293-300.

179. Williams TN, Maitland K, Phelps L, Bennett S, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: Plasmodium vivax: a cause of malnutrition in young children. QJM : monthly journal of the Association of Physicians 1997, 90(12):751-757.

180. Maitland K, Williams TN, Peto TE, Day KP, Clegg JB, Weatherall DJ, Bowden DK: Absence of malaria-specific mortality in children in an area of hyperendemic malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997, 91(5):562-566.

181. Maitland K, Williams TN, Newbold CI: Plasmodium vIvax and P. falciparum: Biological interactions and the possibility of cross-species immunity. Parasitol Today 1997, 13(6):227-231.

182. Maitland K, Williams TN, Kotecka BM, Edstein MD, Rieckmann KH: Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine. Acta tropica 1997, 66(3):155-161.

183. Williams TN, Maitland K, Ganczakowski M, Peto TE, Clegg JB, Weatherall DJ, Bowden DK: Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturity. British journal of haematology 1996, 95(2):266-272.

184. Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TE, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB: High incidence of malaria in alpha-thalassaemic children. Nature 1996, 383(6600):522-525.

185. Maitland K, Williams TN, Bennett S, Newbold CI, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu. Transactions of the Royal Society of Tropical Medicine and Hygiene 1996, 90(6):614-620.

186. Bryan JH, Burwell C, Maitland K, Williams T: Culicine mosquitoes (Diptera: Culicidae) attracted to humans on Espiritu Santo, Vanuatu. Medical and veterinary entomology 1996, 10(1):101-102.

187. Williams TN, Maitland K, Foley DH: Malaria sporozoite rates for Anopheles farauti s.s. Laveran (Diptera: culicidae) from Vanuatu. Annals of tropical medicine and parasitology 1995, 89(3):305-307.

188. Ganczakowski M, Bowden DK, Maitland K, Williams TN, O'Shaughnessy D, Viji J, Lucassen A, Clegg JB, Weatherall DJ: Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young children. British journal of haematology 1995, 89(3):485-495.

189. Brindle PM, Maitland K, Williams TN, Ganczakowski ME: A survey for the rare blood group antigen variants, En(a-), Gerbich negative and Duffy negative on Espiritu Santo, Vanuatu in the South Pacific. Human heredity 1995, 45(4):211-214.

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