Centers for Disease Control and Prevention
Web-Only Appendix – Criteria applied to 24-hour urine samples in the HFUS
A.Table 1: Unweighted Demographic Characteristics Before and After Application of Exclusion Criteria
This appendix describes the methods undertaken by the investigators to address and correct for incomplete urine collections in the Heart Follow-Up Study (HFUS) both pre and post hoc. Undercollection in 24-hour urine samples is a well-established limitation of this measurement method. A limitation of prior investigations using 24-hour samples is the lack of thorough explanation and disclosure of methods used to assess completeness. The absence of this detail contributes to confusion in interpretation of results and comparison across studies and provides little guidance to researchers conducting similar studies.
The study protocol included criteria designed to identify undercollection during the implementation stage. These criteria were developed based upon review of existing literature, review of protocols requested from investigators of prior landmark studies using 24-hour urine collection , and in consultations with experts. The following criteria were determined a priori and applied during study implementation were as follows:
1. The first criteria for assessing completeness of the sample involved elements that were built into the 24-hour collection protocol. If a urine collection was ................
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