SUPPLEMENT - Cambridge University Press



SUPPLEMENT

e-Figure 1. Study flow diagram

[pic]

e-Table 1. Association between the risk of stroke and the cumulative duration and dose of mood stabilizers within the 14-day case period in bipolar patients with the first-time stroke

Characteristic |Case period

Mean(SD) |Control period 1

Mean(SD) |Control period 2

Mean(SD) |Control period 3

Mean(SD) |Control period 4

Mean(SD) |Adjusted risk ratioa |95% C.I. |P valuea | |Cumulative duration (days) | | | | | | | | | |All stroke (n=609) | | | | | | | | | |Carbamazepine |0.35 (1.92) |0.16 (1.27) |0.10 (1.11) |0.23 (1.62) |0.21 (1.48) |1.06* |1.00-1.12 |0.035 | |Valproic acid |1.29 (3.58) |1.06 (3.36) |1.08 (3.37) |0.89 (3.05) |1.04 (3.23) |0.99 |0.97-1.02 |0.613 | |Lithium |0.72 (2.78) |0.56 (2.38) |0.55 (2.40) |0.69 (2.84) |0.49 (2.20) |1.00 |0.97-1.03 |0.893 | |Lamotrigine |0.24 (1.76) |0.19 (1.49) |0.21 (1.57) |0.19 (1.45) |0.11 (1.13) |1.00 |0.96-1.05 |0.867 | |Ischemic stroke (n=294) | | | | | | | | | |Carbamazepine |0.40 (1.94) |0.27 (1.73) |0.12 (1.21) |0.27 (1.73) |0.25 (1.59) |1.04 |0.98-1.10 |0.236 | |Valproic acid |1.20 (3.50) |1.09 (3.46) |1.04 (3.36) |0.80 (2.95) |1.03 (3.19) |0.99 |0.96-1.03 |0.640 | |Lithium |0.74 (2.77) |0.62 (2.47) |0.43 (2.11) |0.91 (3.30) |0.65 (2.51) |1.00 |0.96-1.05 |0.955 | |Lamotrigine |0.13 (1.31) |0.11 (1.11) |0.16 (1.40) |0.13 (1.07) |0.13 (1.29) |0.99 |0.90-1.08 |0.785 | |Hemorrhagic stroke (n=161) | | | | | | | | | |Carbamazepine |0.19 (1.50) |0.07 (0.70) |0.07 (0.87) |0.30 (1.94) |0.27 (1.79) |1.01 |0.91-1.13 |0.849 | |Valproic acid |1.19 (3.31) |0.76 (2.81) |1.01 (3.32) |0.88 (3.06) |0.72 (2.75) |1.01 |0.96-1.06 |0.772 | |Lithium |0.29 (1.74) |0.12 (1.15) |0.69 (2.51) |0.35 (1.92) |0.20 (1.37) |0.95 |0.85-1.05 |0.306 | |Lamotrigine |0.09 (1.10) |0.13 (1.18) |0.14 (1.27) |0.17 (1.56) |0.16 (1.33) |0.95 |0.81-1.11 |0.511 | |Other stroke (n=154) | | | | | | | | | |Carbamazepine |0.41 (2.27) |0.03 (0.33) |0.09 (1.13) |0.09 (1.13) |0.07 (0.69) |1.15* |1.00-1.32 |0.047 | |Valproic acid |1.57 (4.00) |1.31 (3.68) |1.22 (3.45) |1.22 (3.45) |1.40 (3.72) |0.99 |0.94-1.04 |0.634 | |Lithium |1.14 (3.54) |0.90 (3.03) |0.64 (2.76) |0.64 (2.76) |0.48 (2.24) |1.01 |0.96-1.06 |0.773 | |Lamotrigine |0.60 (2.76) |0.42 (2.21) |0.38 (2.09) |0.38 (2.09) |0.03 (0.29) |1.02 |0.96-1.09 |0.542 | | | | | | | | | | | |Cumulative defined daily dose | | | | | | | | | |All stroke (n=609) | | | | | | | | | |Carbamazepine |0.18 (1.13) |0.08 (0.83) |0.06 (0.70) |0.10 (0.71) |0.10 (0.71) |1.06 |0.98-1.13 |0.131 | |Valproic acid |0.65 (2.14) |0.54 (1.94) |0.55 (1.98) |0.49 (1.99) |0.57 (2.00) |0.99 |0.95-1.03 |0.500 | |Lithium |2.88 (12.34) |2.34 (10.59) |2.33 (11.22) |2.69 (11.79) |2.03 (9.92) |1.00 |0.99-1.01 |0.941 | |Lamotrigine |0.10 (0.89) |0.07 (0.66) |0.05 (0.41) |0.07 (0.64) |0.03 (0.34) |1.05 |0.95-1.16 |0.316 | |Ischemic stroke (n=294) | | | | | | | | | |Carbamazepine |0.22 (1.25) |0.16 (1.18) |0.10 (0.91) |0.11 (0.75) |0.11 (0.74) |1.05 |0.96-1.15 |0.296 | |Valproic acid |0.55 (1.77) |0.49 (1.76) |0.49 (1.74) |0.48 (2.06) |0.52 (1.85) |0.98 |0.91-1.04 |0.463 | |Lithium |3.05 (12.99) |2.56 (10.56) |1.87 (10.25) |3.58 (13.69) |2.48 (10.07) |1.00 |0.99-1.01 |0.907 | |Lamotrigine |0.06 (0.64) |0.04 (0.60) |0.04 (0.32) |0.06 (0.70) |0.03 (0.34) |1.04 |0.84-1.28 |0.736 | |Hemorrhagic stroke (n=161) | | | | | | | | | |Carbamazepine |0.09 (0.77) |0.02 (0.19) |0.04 (0.52) |0.12 (0.81) |0.13 (0.87) |1.03 |0.82-1.28 |0.823 | |Valproic acid |0.60 (2.10) |0.32 (1.38) |0.50 (1.90) |0.49 (1.92) |0.51 (2.17) |1.01 |0.94-1.09 |0.819 | |Lithium |1.21 (8.06) |0.49 (4.57) |2.74 (10.88) |1.30 (7.01) |0.83 (5.51) |0.99 |0.97-1.01 |0.398 | |Lamotrigine |0.03 (0.39) |0.05 (0.42) |0.02 (0.26) |0.06 (0.56) |0.06 (0.48) |0.89 |0.56-1.40 |0.611 | |Other stroke (n=154) | | | | | | | | | |Carbamazepine |0.19 (1.20) |0.01 (0.13) |0.02 (0.24) |0.04 (0.49) |0.04 (0.40) |1.13 |0.97-1.31 |0.116 | |Valproic acid |0.90 (2.74) |0.86 (2.63) |0.72 (2.43) |0.52 (1.92) |0.71 (2.09) |0.99 |0.92-1.06 |0.690 | |Lithium |4.31 (14.46) |3.86 (14.28) |2.79 (13.20) |2.42 (11.76) |2.44 (12.77) |1.00 |0.99-1.01 |0.924 | |Lamotrigine |0.28 (1.47) |0.16 (0.94) |0.10 (0.64) |0.10 (0.59) |0.01 (0.07) |1.07 |0.94-1.21 |0.346 | |*p ................
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