University of Florida
Factorial Experiment Worksheet – 23-Factorial Experiment
Journal of Pharmaceutical Sciences, Vol. 99, 1414–1426 (2010)
Response: Y = Particle Size (nm) in contact lenses, 4 replicates per treatment (N=32)
Factors: A = Proportion of Lactic Acid in copolymer (-1=50,+1=75)
B = Time of 2nd sonocation (seconds, -1=10, +1=20)
C = Potency of 2nd sonocation (W?, -1=50, +1=80)
[pic]
Error Sum of Squares = MSE =
Effects: A = lA =
Std. Error: SA = Sum of Squares: SSA = F-Stat: FA =
Critical F (α= 0.05)
[pic]
AB Interaction:
(A|B = -1): (A|B = +1):
(1/2)*[(A|B = +1) - (A|B = -1)] =
ABC Interaction:
(AB|C = -1): (AB|C = +1):
(1/2)*[(AB|C = +1) - (AB|C= -1)] =
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